A. Paulo

发表

R. Moreira, Ana Rita Português Duarte, Enrico Cadoni, 2018, ChemMedChem.

Cytoprotective effect of Coreopsis tinctoria extracts and flavonoids on tBHP and cytokine-induced cell injury in pancreatic MIN6 cells.

Peter M. Jones, P. Houghton, H. Mota-Filipe, 2012, Journal of ethnopharmacology.

Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: synthesis, antiplasmodial activity, and cytotoxicity.

J. Gut, P. Rosenthal, J. Lavrado, 2008, Bioorganic & medicinal chemistry letters.

Synthesis, G‐Quadruplex Stabilisation, Docking Studies, and Effect on Cancer Cells of Indolo[3,2‐b]quinolines with One, Two, or Three Basic Side Chains

Stephan A. Ohnmacht, S. Neidle, J. Lavrado, 2013, ChemMedChem.

Small molecule inhibitors of multidrug resistance gene (MDR1) expression: preclinical evaluation and mechanisms of action.

A. Paulo, S. A. Santos, 2013, Current cancer drug targets.

The flavonoid-rich fraction of Coreopsis tinctoria promotes glucose tolerance regain through pancreatic function recovery in streptozotocin-induced glucose-intolerant rats.

P. Houghton, M. Bronze, H. Mota-Filipe, 2010, Journal of ethnopharmacology.

Recovery of oral glucose tolerance by wistar rats after treatment with Coreopsis tinctoria infusion

Peter M. Jones, P. Houghton, H. Mota-Filipe, 2009, Phytotherapy research : PTR.

Stereoselective Synthesis of Spirooxindole Derivatives Using One-Pot Multicomponent Cycloaddition Reaction and Evaluation of Their Antiproliferative Efficacy

J. Vítor, R. Ghosh, A. Paulo, 2020, ACS omega.

Effects of some natural 5‐hydroxy‐isoflavones on cultured human endothelial cells in presence and absence of hydrogen peroxide

H. Mota-Filipe, A. Paulo, 2006, The Journal of pharmacy and pharmacology.

The opposing effects of the flavonoids isoquercitrin and Sissotrin, isolated from Pterospartum tridentatum, on oral glucose tolerance in rats

H. Mota-Filipe, A. Paulo, C. Borges, 2008, Phytotherapy research : PTR.

Flavonoids of an extract of Pterospartum tridentatum showing endothelial protection against oxidative injury.

H. Mota-Filipe, A. Paulo, R. F. Vitor, 2004, Journal of ethnopharmacology.

Oncogene Expression Modulation in Cancer Cell Lines by DNA G-Quadruplex-Interactive Small Molecules.

A. Francisco, A. Paulo, 2018, Current medicinal chemistry.

Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies.

J. Gut, P. Rosenthal, M. Mota, 2011, Journal of medicinal chemistry.

Steroidal alkaloids from Cryptolepis obtusa.

M. Jimeno, A. Paulo, P. Houghton, 2000, Phytochemistry.

Structural elucidation of natural 2-hydroxy di- and tricarboxylic acids and esters, phenylpropanoid esters and a flavonoid from Autonoë madeirensis using gas chromatographic/electron ionization, electrospray ionization and tandem mass spectrometric techniques.

A. Paulo, C. Dias, C. Borges, 2003, Journal of mass spectrometry : JMS.

Antiplasmodial activity of Cryptolepis sanguinolenta alkaloids from leaves and roots.

D. Warhurst, A. Paulo, P. Houghton, 2000, Planta medica.

Bis-alkylamine quindolone derivatives as new antimalarial leads.

J. Gut, P. Rosenthal, J. Lavrado, 2010, Bioorganic & medicinal chemistry letters.

New alkaloids from Cryptolepis sanguinolenta

A. Paulo, P. Houghton, E. Gomes, 1995 .

Indoloquinolines as scaffolds for drug discovery.

J. Lavrado, R. Moreira, A. Paulo, 2010, Current medicinal chemistry.

Chemotaxonomic analysis of the genus Cryptolepis

P. Houghton, A. Paulo, 2003 .

Comparative in vitro and in vivo antimalarial activity of the indole alkaloids ellipticine, olivacine, cryptolepine and a synthetic cryptolepine analog.

M. Eberlin, W. Tadei, J. Lavrado, 2012, Phytomedicine : international journal of phytotherapy and phytopharmacology.

New (Iso)quinolinyl-pyridine-2,6-dicarboxamide G-Quadruplex Stabilizers. A Structure-Activity Relationship Study

Pedro R. Magalhães, Bruno L. Victor, Jorge Vítor, 2021, Pharmaceuticals.

Indolo[3,2‐c]quinoline G‐Quadruplex Stabilizers: a Structural Analysis of Binding to the Human Telomeric G‐Quadruplex

Stephan A. Ohnmacht, S. Neidle, J. Lavrado, 2015, ChemMedChem.

Major Achievements in the Design of Quadruplex-Interactive Small Molecules

Bruno L. Victor, A. Paulo, E. Mendes, 2022, Pharmaceuticals.

C-11 diamino cryptolepine derivatives NSC748392, NSC748393, and NSC748394: anticancer profile and G-quadruplex stabilization.

S. Neidle, J. Lavrado, A. Reszka, 2010, Bioorganic & medicinal chemistry letters.

Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype.

D. Wirth, Ralph Mazitschek, R. Moreira, 2015, European journal of medicinal chemistry.

Cryptolepis sanguinolenta activity against diarrhoeal bacteria.

J. Cabrita, A. Paulo, I. Pires, 1994, Journal of ethnopharmacology.

A new Δ7,22 sterol from the bulbs of Autonoë madeirensis

M. Jimeno, A. Paulo, C. Dias, 2005 .

Structural elucidation of natural 2-hydroxy di- and tricarboxilic acids and esters, phenylpropanoid esters, and flavonoids extracted from the bulbs of Autonoë madeirensis using GC-EIMS, ESIMS and MS/MS techniques

A. Paulo, C. Dias, C. Borges, 2003 .

N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: design, synthesis and antiplasmodial activity.

J. Gut, P. Rosenthal, T. Egan, 2015, Bioorganic & medicinal chemistry.

Bis-alkylamine Indolo[3,2-b]quinolines as hemozoin ligands: implications for antimalarial cytostatic and cytocidal activities.

J. Gut, P. Rosenthal, J. Lavrado, 2014, Journal of medicinal chemistry.

KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines

Stephan A. Ohnmacht, S. Neidle, J. Lavrado, 2015, Scientific Reports.

Targeting Promoter Quadruplex Nucleic Acids for Cancer Therapy

S. Neidle, A. Paulo, C. C. Castillo, 2017 .

Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives

Stephan A. Ohnmacht, S. Neidle, J. Lavrado, 2015, PloS one.

Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation

D. Trisciuoglio, L. Altucci, A. Mai, 2020, Cancers.

G-Quadruplexes in c-MYC Promoter as Targets for Cancer Therapy

A. Paulo, E. Mendes, Israa M Aljnadi, 2023, Biomedicines.

Combining 1,3‐Ditriazolylbenzene and Quinoline to Discover a New G‐Quadruplex‐Interactive Small Molecule Active against Cancer Stem‐Like Cells

S. Neidle, J. Lavrado, Jorge Vítor, 2019, ChemMedChem.

Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives.

J. Lavrado, J. McKerrow, R. Moreira, 2012, Bioorganic & medicinal chemistry letters.

1H NMR spectroscopic identification of protonable sites in cryptolepines with C‐11 substituents containing two amino functionalities

J. Lavrado, K. Douglas, R. Moreira, 2012, Magnetic resonance in chemistry : MRC.

Indoloquinolines as scaffolds for the design of potent G-quadruplex ligands.

A. Paulo, E. Mendes, Israa M Aljnadi, 2022, Bioorganic & Medicinal Chemistry Letters.

Cryptolepine and quindoline: understanding their photophysics.

J. Lavrado, J. Martinho, Sandra N. Pinto, 2017, Physical chemistry chemical physics : PCCP.

2-(4'-aminobenzenamine)-pyrimidine, a new alpha-antagonist from Autonoë madeirensis.

P. Houghton, J. Hawkes, A. Paulo, 2003, Planta medica.

Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype.

D. Wirth, Ralph Mazitschek, R. Moreira, 2015, European journal of medicinal chemistry.