M. Nagahama

发表

Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway.

T. Watanabe, K. Nakayama, K. Murakami, 1991, Journal of Biological Chemistry.

A critical role for highly conserved Glu(610) residue of oligopeptidase B from Trypanosoma brucei in thermal stability.

A. Tsuji, K. Yuasa, Nor Ismaliza Mohd Ismail, 2010, Journal of biochemistry.

Engineering of alpha1-antitrypsin variants selective for subtilisin-like proprotein convertases PACE4 and PC6: importance of the P2' residue in stable complex formation of the serpin with proprotein convertase.

A. Tsuji, K. Yuasa, M. Nagahama, 2007, Protein engineering, design & selection : PEDS.

A critical role for the carboxy terminal region of the proprotein convertase, PACE4A, in the regulation of its autocatalytic activation coupled with secretion.

I. Wada, A. Tsuji, M. Nagahama, 2002, Biochemical and Biophysical Research Communications - BBRC.

Biosynthetic processing and quaternary interactions of proprotein convertase SPC4 (PACE4)

K. Mori, A. Tsuji, M. Nagahama, 1998, FEBS letters.

Transcriptional Regulation of cGMP-Dependent Protein Kinase II (cGK-II) in Chondrocytes

A. Tsuji, K. Yuasa, M. Nagahama, 2010, Bioscience, biotechnology, and biochemistry.

Subtilisin‐like proprotein convertase paired basic amino acid‐cleaving enzyme 4 is required for chondrogenic differentiation in ATDC5 cells

H. Ishikawa, A. Tsuji, T. Kawano, 2012, The FEBS journal.

A cellular model of albumin endocytosis uncovers a link between membrane and nuclear proteins

H. Ueda, M. Nangaku, Yuko Kajiho, 2020, Journal of Cell Science.

Subtilisin-like proprotein convertases, PACE4 and PC8, as well as furin, are endogenous proalbumin convertases in HepG2 cells.

T. Martin, K. Mori, M. Gillespie, 1999, Journal of biochemistry.

Transcriptional regulation of fibrillin‐2 gene by E2F family members in chondrocyte differentiation

A. Tsuji, K. Yuasa, M. Nagahama, 2009, Journal of cellular biochemistry.

A Novel Phospholipase A1 with Sequence Homology to a Mammalian Sec23p-interacting Protein, p125*

M. Tagaya, H. Arai, J. Aoki, 2002, The Journal of Biological Chemistry.

UBXD1 is a VCP-interacting protein that is involved in ER-associated degradation.

M. Tagaya, A. Tsuji, K. Tani, 2009, Biochemical and biophysical research communications.

Sequence requirements for precursor cleavage within the constitutive secretory pathway.

T. Watanabe, K. Nakayama, K. Murakami, 1992, The Journal of biological chemistry.

WDR74 participates in an early cleavage of the pre-rRNA processing pathway in cooperation with the nucleolar AAA-ATPase NVL2.

H. Sudo, M. Nagahama, N. Hiraishi, 2018, Biochemical and biophysical research communications.

Irreversible hyperoxidation of peroxiredoxin 2 is caused by tert-butyl hydroperoxide in human red blood cells

Y. Ogasawara, M. Nagahama, Y. Ishida, 2014, FEBS open bio.

Consensus sequence for precursor processing at mono-arginyl sites. Evidence for the involvement of a Kex2-like endoprotease in precursor cleavages at both dibasic and mono-arginyl sites.

T. Watanabe, K. Nakayama, K. Murakami, 1992, The Journal of biological chemistry.

A novel human PACE4 isoform, PACE4E is an active processing protease containing a hydrophobic cluster at the carboxy terminus.

H. Nagamune, K. Mori, A. Tsuji, 1997, Journal of biochemistry.

Inactivation of proprotein convertase, PACE4, by alpha1-antitrypsin Portland (alpha1-PDX), a blocker of proteolytic activation of bone morphogenetic protein during embryogenesis: evidence that PACE4 is able to form an SDS-stable acyl intermediate with alpha1-PDX.

K. Mori, A. Tsuji, M. Nagahama, 1999, Journal of biochemistry.

Purification and characterization of furin, a Kex2-like processing endoprotease, produced in Chinese hamster ovary cells.

S. Takahashi, K. Takada, K. Nakayama, 1992, The Journal of biological chemistry.

Substrate specificity of prorenin converting enzyme of mouse submandibular gland. Analysis using site-directed mutagenesis.

K. Nakayama, K. Murakami, M. Nagahama, 1990, The Journal of biological chemistry.

Mapping of Functional Domains of γ-SNAP*

M. Tagaya, K. Tani, M. Nagahama, 2003, The Journal of Biological Chemistry.

Exploration of Salmonella effector mutant strains on MTR4 and RRP6 degradation.

N. Akimitsu, Kentaro Kawata, Y. Wada, 2020, Bioscience trends.

Determination of functional regions of p125, a novel mammalian Sec23p-interacting protein.

H. Hauri, M. Tagaya, K. Tani, 2000, Biochemical and biophysical research communications.

Subtilisin-like proprotein convertase PACE4 is required for skeletal muscle differentiation.

A. Tsuji, K. Yuasa, M. Nagahama, 2009, Journal of biochemistry.

Trafficking of cGMP-dependent protein kinase II via interaction with Rab11.

A. Tsuji, K. Yuasa, M. Nagahama, 2008, Biochemical and biophysical research communications.

N-ethylmaleimide-sensitive factor is associated with the nuclear envelope.

M. Tagaya, K. Tani, T. Horigome, 2000, Biochemical and biophysical research communications.

MPP6 stimulates both RRP6 and DIS3 to degrade a specified subset of MTR4-sensitive substrates in the human nucleus

S. Seno, H. Matsuda, S. Masuda, 2022, Nucleic acids research.

Isolation and biochemical characterization of two forms of RD21 from cotyledons of daikon radish (Raphanus sativus).

A. Tsuji, K. Yuasa, M. Nagahama, 2008, Journal of biochemistry.

The AAA-ATPase NVL2 is a component of pre-ribosomal particles that interacts with the DExD/H-box RNA helicase DOB1.

M. Tagaya, A. Tsuji, K. Tani, 2006, Biochemical and biophysical research communications.

Regulation of the Golgi structure by the α subunits of heterotrimeric G proteins

M. Tagaya, K. Tani, H. Itoh, 2000 .

Gaf-1b is an alternative splice variant of Gaf-1/Rip11.

M. Tagaya, K. Tani, M. Nagahama, 2003, Biochemical and biophysical research communications.

Identification of SVIP as an Endogenous Inhibitor of Endoplasmic Reticulum-associated Degradation*

S. Fang, M. Tagaya, Yongwang Zhong, 2007, Journal of Biological Chemistry.

Implication of sphingolipid metabolism in the stability of the Golgi apparatus.

M. Tagaya, K. Tani, A. Yamamoto, 2000, Journal of cell science.

Inactivation of Gαz causes disassembly of the Golgi apparatus

T. Shinohara, M. Tagaya, K. Tani, 2002, Journal of Cell Science.

cGMP-dependent protein kinase I is involved in neurite outgrowth via a Rho effector, rhotekin, in Neuro2A neuroblastoma cells.

A. Tsuji, K. Yuasa, M. Nagahama, 2012, Biochemical and biophysical research communications.

Purification and characterization of cathepsin B‐like cysteine protease from cotyledons of daikon radish, Raphanus sativus

A. Tsuji, K. Yuasa, M. Nagahama, 2008, The FEBS journal.

Dominant‐negative effect of mutant valosin‐containing protein in aggresome formation

N. Hattori, M. Tagaya, A. Kakizuka, 2006, FEBS Letters.

Evidence that differentiates between precursor cleavages at dibasic and Arg-X-Lys/Arg-Arg sites.

K. Nakayama, Y. Misumi, Y. Ikehara, 1991, Journal of biochemistry.

Transcriptional regulation of subtilisin-like proprotein convertase PACE4 by E2F: possible role of E2F-mediated upregulation of PACE4 in tumor progression.

A. Tsuji, K. Yuasa, M. Nagahama, 2007, Gene.

Systematic Analysis of Targets of Pumilio-Mediated mRNA Decay Reveals that PUM1 Repression by DNA Damage Activates Translesion Synthesis.

Toshimichi Yamada, N. Akimitsu, T. Kawamura, 2020, Cell reports.

Alzheimer’s Disease-Associated Alternative Splicing of CD33 Is Regulated by the HNRNPA Family Proteins

Y. Kino, Motoaki Yanaizu, M. Nagahama, 2023, Cells.

Prorenin is sorted into the regulated secretory pathway independent of its processing to renin in mouse pituitary AtT‐20 cells

M. Nagahama, K. Hatsuzawa, K. Nakayama, 1989, FEBS letters.

NVL2 is a nucleolar AAA-ATPase that interacts with ribosomal protein L5 through its nucleolar localization sequence.

T. Shinohara, M. Tagaya, K. Tani, 2004, Molecular biology of the cell.

Interaction properties of human TRAMP‐like proteins and their role in pre‐rRNA 5′ETS turnover

H. Sudo, M. Nagahama, Y. Ishida, 2016, FEBS letters.

Expression of a deletion mutant of the prosegment of human prorenin in Chinese hamster ovary cells

M. Nagahama, H. Hori, K. Nakayama, 1989, FEBS letters.

Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi

M. Tohyama, N. Dohmae, M. Tagaya, 2004, The EMBO journal.

Interplay between Transcription and RNA Degradation

Toshimichi Yamada, N. Akimitsu, M. Nagahama, 2018 .

SVIP is a novel VCP/p97-interacting protein whose expression causes cell vacuolation.

M. Tagaya, A. Yamamoto, K. Tani, 2003, Molecular biology of the cell.

p125 Is Localized in Endoplasmic Reticulum Exit Sites and Involved in Their Organization*

M. Tagaya, A. Yamamoto, K. Tani, 2005, Journal of Biological Chemistry.

Functional characterization of Asp‐317 mutant of human renin expressed in COS cells

M. Nagahama, H. Hori, T. Yamauchi, 1988, FEBS letters.

Diminished nuclear RNA decay upon Salmonella infection upregulates antibacterial noncoding RNAs

T. Jensen, Toshimichi Yamada, N. Akimitsu, 2018, The EMBO journal.

Interactome analysis of the Tudor domain-containing protein SPF30 which associates with the MTR4-exosome RNA-decay machinery under the regulation of AAA-ATPase NVL2.

M. Nagahama, N. Hiraishi, Y. Ishida, 2021, The international journal of biochemistry & cell biology.

Systematic Analysis of Targets of Pumilio (PUM)-Mediated mRNA Decay Identifies a Role of PUM1 in Regulating DNA Damage Response Pathway

Yutaka Suzuki, Toshimichi Yamada, N. Akimitsu, 2018 .

Identification of Functional Targets Reveals that the Suppression of Pumilio-mediated mRNA Decay Increases Cell Resistance to DNA Damage in Human Cells

Toshimichi Yamada, N. Akimitsu, T. Kawamura, 2018, bioRxiv.

AAA-ATPase NVL2 acts on MTR4-exosome complex to dissociate the nucleolar protein WDR74.

M. Nagahama, N. Hiraishi, Y. Ishida, 2015, Biochemical and biophysical research communications.

Brucella effectors NyxA and NyxB target SENP3 to modulate the subcellular localisation of nucleolar proteins

C. Buchrieser, J. Borg, J. Gorvel, 2021, bioRxiv.

NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing.

A. Tsuji, K. Yuasa, H. Sudo, 2015, Biochemical and biophysical research communications.

Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion

M. Tagaya, A. Yamamoto, K. Tani, 2004, The EMBO journal.

A proteomic approach reveals transient association of reticulocalbin-3, a novel member of the CREC family, with the precursor of subtilisin-like proprotein convertase, PACE4.

A. Tsuji, K. Yuasa, M. Nagahama, 2006, The Biochemical journal.

Site-directed mutagenesis of human prorenin. Substitution of three arginine residues in the propeptide with glutamine residues yields active prorenin.

T. Watanabe, K. Murakami, M. Nagahama, 1990, Journal of biochemistry.

Sequence requirements for prohormone processing in mouse pituitary AtT-20 cells. Analysis using prorenins as model substrates.

K. Nakayama, K. Murakami, M. Nagahama, 1991, European journal of biochemistry.

Reticulon 3 is involved in membrane trafficking between the endoplasmic reticulum and Golgi.

H. Hauri, M. Tagaya, K. Tani, 2005, Biochemical and biophysical research communications.

Effects of propeptide deletion on human renin secretion from mouse pituitary AtT‐20 cells

K. Nakayama, K. Murakami, M. Nagahama, 1990, FEBS letters.

Purification and characterization of furin, a Kex2-like processing endoprotease, produced in Chinese hamster ovary cells.

S. Takahashi, K. Murakami, M. Nagahama, 1992, The Journal of biological chemistry.