C. Farady

发表

Improving the species cross-reactivity of an antibody using computational design.

Benjamin D. Sellers, Benjamin D Sellers, Matthew P Jacobson, 2009, Bioorganic & medicinal chemistry letters.

Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP3 inflammasome assembly

Kaiwen W. Chen, P. Brož, C. Farady, 2019, The EMBO journal.

Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm

R. Skoda, S. Rai, S. Méndez-Ferrer, 2022, Nature Communications.

ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157

A. Kaykas, Kathleen A. Worringer, G. Elain, 2017, Neuroscience Letters.

Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors.

F. Sirockin, E. Valeur, C. Wiesmann, 2018, Bioorganic & medicinal chemistry letters.

Kallikrein-related Peptidase 7

F. Kolb, L. Mayr, C. Farady, 2013 .

Mechanisms of macromolecular protease inhibitors.

C. Craik, C. Farady, 2010, Chembiochem : a European journal of chemical biology.

Protease Inhibitors: Mechanisms

C. Craik, C. Farady, 2008 .

Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design*

Jennifer Legac, Iain D Kerr, C. Craik, 2009, The Journal of Biological Chemistry.

Pharmacological inhibition of IKKβ dampens NLRP3 inflammasome activation after priming in the human myeloid cell line THP-1.

J. Eder, P. Erbel, A. Schlapbach, 2021, Biochemical and biophysical research communications.

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

H. Stahlberg, D. Müller, S. Hiller, 2016, The EMBO journal.

Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis

T. Reinheckel, R. Backofen, C. Kreutz, 2023, Science Signaling.

Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway

C. Craik, A. Welm, A. Bhatt, 2007, Proceedings of the National Academy of Sciences.

Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GvHD.

D. Munn, J. Serody, S. Jameson, 2019, Blood.

A reverse binding motif that contributes to specific protease inhibition by antibodies.

Aida Baharuddin, C. Craik, M. Ward, 2012, Journal of molecular biology.

Crystal structure of NLRP3 NACHT domain with an inhibitor defines mechanism of inflammasome inhibition.

N. Stiefl, C. Dekker, J. Eder, 2021, Journal of molecular biology.

Evaluation of protein kinase D auto-phosphorylation as biomarker for NLRP3 inflammasome activation

B. Roediger, Joëlle Rubert, C. Farady, 2021, bioRxiv.

The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1).

C. Craik, Susan M. Miller, Charles S Craik, 2007, Journal of molecular biology.

Tyrosine kinase inhibitors trigger lysosomal damage-associated cell lysis to activate the NLRP3 inflammasome

T. Reinheckel, R. Backofen, C. Parker, 2022, bioRxiv.

Tumor detection by imaging proteolytic activity.

C. Craik, B. Hann, J. Marks, 2010, Cancer research.

Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition.

C. Craik, Charles S Craik, Eric L Schneider, 2008, Journal of molecular biology.

Structural Characterization and Determinants of Specificity of Single-Chain Antibody Inhibitors of Membrane-Type Serine Protease 1

C. Farady, 2006 .

Award Number: W81XWH-05-1-0300 TITLE: Structural Characterization and Determinants of Specificity of Single-Chain Antibody Inhibitors of Membrane-Type Serine Protease 1 PRINCIPAL INVESTIGATOR:

C. Farady, 2006 .

Fragment‐Based Protein–Protein Interaction Antagonists of a Viral Dimeric Protease

C. Craik, Gregory M Lee, Kaitlin R Hulce, 2016, ChemMedChem.

Selective MALT1 paracaspase inhibition does not block TNF-α production downstream of TLR4 in myeloid cells.

N. Stoehr, C. Farady, F. Bornancin, 2017, Immunology letters.

IL-1β promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells

T. Schroeder, J. Passweg, R. Skoda, 2023, bioRxiv.

Improving the species cross-reactivity of an antibody using computational design.

Benjamin D. Sellers, C. Craik, M. Jacobson, 2009, Bioorganic & medicinal chemistry letters.

Degradation of recombinant proteins by Chinese hamster ovary host cell proteases is prevented by matriptase‐1 knockout

E. Oakeley, Sandrine Romand, Holger Laux, 2018, Biotechnology and bioengineering.

Discovery of Potent, Orally Bioavailable, Tricyclic NLRP3 Inhibitors.

N. Stiefl, J. Velcicky, P. Janser, 2024, Journal of medicinal chemistry.

A reverse binding motif that contributes to specific protease inhibition by antibodies.

C. Craik, M. Ward, D. Goetz, 2012, Journal of molecular biology.

Fragment‐Based Protein–Protein Interaction Antagonists of a Viral Dimeric Protease

C. Craik, Gregory M Lee, Kaitlin R Hulce, 2016, ChemMedChem.

ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157

A. Kaykas, Kathleen A. Worringer, G. Elain, 2017, Neuroscience Letters.