D. Appella

发表

N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53.

Toshiaki Hara, Daniel H Appella, S. Durell, 2009, Bioorganic & medicinal chemistry.

Probing the structural requirements of peptoids that inhibit HDM2-p53 interactions.

Toshiaki Hara, Michael C. Myers, Daniel H Appella, 2006, Journal of the American Chemical Society.

Improved treatment of cyclic β‐amino acids and successful prediction of β‐peptide secondary structure using a modified force field: AMBER*C

S. Gellman, M. J. Lucero, D. Appella, 2000 .

Non-natural nucleic acids for synthetic biology.

D. Appella, 2009, Current opinion in chemical biology.

Synthesis and Application of LKγT Peptide Nucleic Acids.

D. Appella, K. G. George Rosenker, N. Shank, 2019, Methods in molecular biology.

A cyclopentane conformational restraint for a peptide nucleic acid: design, asymmetric synthesis, and improved binding affinity to DNA and RNA.

Michael C. Myers, T. Hara, M. Witschi, 2003, Organic letters.

The structure-activity profile of mercaptobenzamides' anti-HIV activity suggests that thermodynamics of metabolism is more important than binding affinity to the target.

S. Durell, R. Buckheit, M. Scerba, 2019, European journal of medicinal chemistry.

Targeting DNA G-quadruplex structures with peptide nucleic acids.

I. Panyutin, R. Neumann, D. Appella, 2012, Current pharmaceutical design.

Gamma-substituted peptide nucleic acids constructed from L-lysine are a versatile scaffold for multifunctional display.

D. Appella, E. A. Englund, Ethan A. Englund, 2007, Angewandte Chemie.

Peptide Nucleic Acids

P. Nielsen, D. Appella, 2020, Methods in Molecular Biology.

Theoretical and Experimental Circular Dichroic Spectra of the Novel Helical Foldamer Poly[(1R,2R)-trans-2-aminocyclopentanecarboxylic acid]

S. Gellman, J. Applequist, D. Appella, 1998 .

(S,S)-trans-cyclopentane-constrained peptide nucleic acids. a general backbone modification that improves binding affinity and sequence specificity.

J. Pokorski, M. Witschi, D. Appella, 2004, Journal of the American Chemical Society.

Synthesis and anticancer activities of 6-amino amonafide derivatives

M. Avram, E. Sim, A. Kawamura, 2008, Anti-cancer drugs.

Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA.

S. Mazur, I. Botos, D. Appella, 2021, Nucleic acids research.

Introduction of a triazole amino acid into a peptoid oligomer induces turn formation in aqueous solution.

S. Durell, Yawen Bai, L. Jenkins, 2007, Organic letters.

A new family of small molecules to probe the reactivation of mutant p53.

Michael C. Myers, G. Zambetti, Jinling Wang, 2005, Journal of the American Chemical Society.

An SAMT-247 Microbicide Provides Potent Protection against Intravaginal Simian Immunodeficiency Virus Infection of Rhesus Macaques, whereas an Added Vaccine Component Elicits Mixed Outcomes

E. Appella, M. Robert-Guroff, Eun-Ju Ko, 2020, The Journal of Immunology.

Synthesis of Fmoc-Protected ( S, S)- trans-Cyclopentane Diamine Monomers Enables the Preparation and Study of Conformationally Restricted Peptide Nucleic Acids.

D. Appella, M. Saha, Hongchao Zheng, 2018, Organic letters.

A trapped human PPM1A–phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity

A. Grishaev, S. Durell, E. Appella, 2018, The Journal of Biological Chemistry.

Reaction Kinetics Direct a Rational Synthesis of an HIV-1 Inactivator of Nucleocapsid Protein 7 and Provide Mechanistic Insight into Cellular Metabolism and Antiviral Activity.

J. Deschamps, M. Scerba, D. Appella, 2018, Chemistry.

Peptide nucleic acids with a flexible secondary amine in the backbone maintain oligonucleotide binding affinity.

Michael C. Myers, J. Pokorski, D. Appella, 2004, Organic letters.

A novel preventive strategy against HIV-1 infection: combinatorial use of inhibitors targeting the nucleocapsid and fusion proteins

E. Appella, L. Jenkins, Jingyu Zhu, 2017, Emerging Microbes &Infections.

Multivalent LKγ-PNA oligomers bind to a human telomere DNA G-rich sequence to form quadruplexes.

D. Appella, Elizabeth E. Rastede, Pankaj Gupta, 2015, Bioorganic & medicinal chemistry letters.

PPG Peptide Nucleic Acids that Promote DNA Guanine Quadruplexes

I. Panyutin, R. Neumann, D. Appella, 2014, Chembiochem : a European journal of chemical biology.

Quadruplex formation is necessary for stable PNA invasion into duplex DNA of BCL2 promoter region

Timur I. Gaynutdinov, I. Panyutin, R. Neumann, 2011, Nucleic acids research.

Stabilization of G-quadruplex in the BCL2 promoter region in double-stranded DNA by invading short PNAs

Timur I. Gaynutdinov, I. Panyutin, R. Neumann, 2009, Nucleic acids research.

Cyclopropane PNA: Observable triplex melting in a PNA constrained with a 3-membered ring

Michael C. Myers, J. Pokorski, D. Appella, 2005 .

G-quadruplex formation between G-rich PNA and homologous sequences in oligonucleotides and supercoiled plasmid DNA.

Timur I. Gaynutdinov, I. Panyutin, R. Neumann, 2015, Nucleic acid therapeutics.

Targeting a Dark Excited State of HIV-1 Nucleocapsid by Antiretroviral Thioesters Revealed by NMR Spectroscopy.

G. Clore, L. Deshmukh, V. Tugarinov, 2018, Angewandte Chemie.

Methoxyethylamino-numonafide is an efficacious and minimally toxic amonafide derivative in murine models of human cancer.

Sui Huang, Yanning Liu, Qun Xu, 2011, Neoplasia.

Is an Efficacious and Minimally Toxic Amonafide Derivative in Murine Models of Human Cancer 1

Yanning Liu, Qun Xu, G. Lou, 2011 .

Formation of Short, Stable Helices in Aqueous Solution by β-Amino Acid Hexamers

S. Durell, S. Gellman, J. Barchi, 1999 .

Recognition of HIV-TAR RNA using neomycin-benzimidazole conjugates.

D. Arya, Sunil Kumar, N. Ranjan, 2013, Bioorganic & medicinal chemistry letters.

Discovery of Novel Small-Molecule Scaffolds for the Inhibition and Activation of WIP1 Phosphatase from a RapidFire Mass Spectrometry High-Throughput Screen.

E. Appella, M. Hall, Hongmao Sun, 2022, ACS pharmacology & translational science.

Click dimers to target HIV TAR RNA conformation.

D. Arya, W. Robinson, Sunil Kumar, 2012, Biochemistry.

Preclinical evaluation of a mercaptobenzamide and its prodrug for NCp7-targeted inhibition of human immunodeficiency virus

A. Wang, E. Hughes, M. Scerba, 2016, Antiviral Research.

A one-pot preparation of N-2-mercaptobenzoyl-amino amides.

D. Appella, William C Trenkle, R. Bahde, 2011, Tetrahedron letters.

Residue-based control of helix shape in β-peptide oligomers

Douglas R. Powell, Joseph J. Barchi, Samuel H. Gellman, 1997, Nature.

Asymmetric Conjugate Reduction of α,β-Unsaturated Esters Using a Chiral Phosphine−Copper Catalyst

S. Buchwald, Y. Moritani, R. Shintani, 1999 .

Asymmetric Hydrogenation of Unfunctionalized Tetrasubstituted Olefins with a Cationic Zirconocene Catalyst

S. Buchwald, D. Appella, Malisa V. Troutman, 1999 .

β-Peptide Foldamers: Robust Helix Formation in a New Family of β-Amino Acid Oligomers

Samuel H. Gellman, Laurie A. Christianson, Daniel H. Appella, 1996 .

Synthesis and Structural Characterization of Helix-Forming β-Peptides: trans-2-Aminocyclopentanecarboxylic Acid Oligomers

S. Gellman, M. R. Richards, D. Appella, 1999 .

Aziridination of aliphatic alkenes catalyzed by N-heterocyclic carbene copper complexes.

Qun Xu, D. Appella, 2008, Organic letters.

Synthesis and Characterization of trans-2-Aminocyclohexanecarboxylic Acid Oligomers: An Unnatural Helical Secondary Structure and Implications for β-Peptide Tertiary Structure

I. Karle, S. Gellman, D. Appella, 1999 .

Synthesis of β-Alkyl Cyclopentanones in High Enantiomeric Excess via Copper-Catalyzed Asymmetric Conjugate Reduction

S. Buchwald, Y. Moritani, D. Appella, 2000 .

Solution Conformations of Helix-Forming β-Amino Acid Homooligomers

S. Gellman, D. Appella, Xiaolin L. Huang, 2000 .

Practical synthesis of trans-tert-butyl-2-aminocyclopentylcarbamate and resolution of enantiomers.

Qun Xu, D. Appella, 2006, The Journal of organic chemistry.

(R,R,R)-2,5-diaminocylohexanecarboxylic acid, a building block for water-soluble, helix-forming beta-peptides.

S. Gellman, D. Appella, T. L. Raguse, 2000, The Journal of organic chemistry.

Solid-phase synthesis and screening of N-acylated polyamine (NAPA) combinatorial libraries for protein binding.

L. Jenkins, J. Kopp, Jaclyn A Iera, 2010, Bioorganic & medicinal chemistry letters.

Residue-based control of helix shape in beta-peptide oligomers.

S. Gellman, D. Powell, X. Huang, 1997, Nature.

Synthesis of gamma-substituted peptide nucleic acids: a new place to attach fluorophores without affecting DNA binding.

D. Appella, Ethan A. Englund, 2005, Organic letters.

PNA Clamping in Nucleic Acid Amplification Protocols to Detect Single Nucleotide Mutations Related to Cancer

D. Appella, Munira F. Fouz, Munira F. Fouz, 2020, Molecules.

An efficient synthesis of a probe for protein function: 2,3-diaminopropionic acid with orthogonal protecting groups.

H. Gopi, D. Appella, Ethan A. Englund, 2004, Organic letters.

[9] Peptide Nucleic Acid Microarrays Made with (S,S)‐trans‐Cyclopentane‐Constrained Peptide Nucleic Acids

J. Pokorski, M. Witschi, D. Appella, 2006 .

PNA-DNA duplexes, triplexes, and quadruplexes are stabilized with trans-cyclopentane units.

Qun Xu, M. Witschi, D. Appella, 2006, Journal of the American Chemical Society.

Combinatorial Synthesis, Screening, and Binding Studies of Highly Functionalized Polyamino-amido Oligomers for Binding to Folded RNA

J. Pokorski, D. Appella, 2012, Journal of nucleic acids.

Inhibition of Multidrug Resistance by SV40 Pseudovirion Delivery of an Antigene Peptide Nucleic Acid (PNA) in Cultured Cells

M. Gottesman, C. Kimchi-Sarfaty, P. E. Lund, 2011, PloS one.

An Intravaginal Ring for the Simultaneous Delivery of an HIV-1 Maturation Inhibitor and Reverse-Transcriptase Inhibitor for Prophylaxis of HIV Transmission.

Justin T. Clark, P. Kiser, D. Appella, 2015, Journal of pharmaceutical sciences.

Induction of apoptosis promoted by Bang52; a small molecule that downregulates Bcl-x(L).

G. Zambetti, S. Mazur, M. Rossi, 2009, Bioorganic & medicinal chemistry letters.

6‐Methoxyethylamino‐numonafide inhibits hepatocellular carcinoma xenograft growth as a single agent and in combination with sorafenib

Min Huang, A. Mazar, Yanning Liu, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cyclopentane-modified PNA improves the sensitivity of nanoparticle-based scanometric DNA detection.

Chad A Mirkin, Daniel H Appella, Jwa-Min Nam, 2005, Chemical communications.

Programmable Multivalent Display of Receptor Ligands using Peptide Nucleic Acid Nanoscaffolds

S. Durell, R. Ghirlando, D. Roberts, 2012, Nature Communications.

Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).

S. Durell, E. Appella, L. Jenkins, 2011, Biochemistry.

Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens

E. Appella, M. Hall, Hongmao Sun, 2019, The Journal of Biological Chemistry.

A Click Chemistry Approach to Identify Protein Targets of Cancer Chemopreventive Phenethyl Isothiocyanate.

F. Chung, R. Goldman, Deyun Wang, 2014, RSC advances.

Cyclopentane peptide nucleic acid: Gold nanoparticle conjugates for the detection of nucleic acids in a microfluidic format

N. Morgan, D. Appella, K. Oshaben, 2021, Biopolymers.

Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen.

P. Simister, S. Feller, A. Hamilton, 2013, Bioorganic & medicinal chemistry.

Quantification of plasma HIV RNA using chemically-engineered peptide nucleic acids

T. Chun, Travis Hoppe, I. Hewlett, 2014, Nature Communications.

Colorimetric detection of anthrax DNA with a Peptide nucleic acid sandwich-hybridization assay.

Ning Zhang, Daniel H Appella, D. Appella, 2007, Journal of the American Chemical Society.

Vaccine plus microbicide effective in preventing vaginal SIV transmission in macaques

E. Appella, A. Gutowska, D. Venzon, 2023, Nature Microbiology.

Alkyl-substituted N-methylaryl-N'-aryl-4-aminobenzamides: A new series of small molecule inhibitors for Wip1 phosphatase.

E. Appella, S. Mazur, Subrata Debnath, 2022, European journal of medicinal chemistry.

Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer.

E. Appella, M. Schito, Qun Xu, 2010, Nature chemical biology.

Chemical Features Important for Activity in a Class of Inhibitors Targeting the Wip1 Flap Subdomain

E. Appella, S. Mazur, Subrata Debnath, 2018, ChemMedChem.

A Small Molecular Scaffold for Selective Inhibition of Wip1 Phosphatase

S. Durell, E. Appella, H. Yamaguchi, 2008, ChemMedChem.

Inhibition of HIV Maturation via Selective Unfolding and Cross-Linking of Gag Polyprotein by a Mercaptobenzamide Acetylator.

G. Clore, J. Louis, L. Deshmukh, 2019, Journal of the American Chemical Society.

Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication.

R. Ptak, K. Jeang, P. Legault, 2009, Bioorganic & medicinal chemistry letters.

Cyclopentane FIT-PNAs: bright RNA sensors.

E. Yavin, D. Appella, Hongchao Zheng, 2020, Chemical communications.

Variation of Tetrahydrofurans in Thyclotides Enhances Oligonucleotide Binding and Cellular Uptake of Peptide Nucleic Acids

S. Mazur, I. Botos, D. Appella, 2023, JACS Au.

Probing Mercaptobenzamides as HIV Inactivators via Nucleocapsid Protein 7

S. Durell, R. Buckheit, T. Hartman, 2017, ChemMedChem.

Photoinduced Cycloaddition and Ene Reactions of 2,7-Cyclooctadienone: Experimental and Computational Studies of a Cyclopentyl Oxyallyl Intermediate

D. Appella, J. Pauls, A. Matlin, 1999 .

A Click Chemistry Approach to Identify Protein Targets of Cancer Chemopreventive Phenethyl Isothiocyanate.

F. Chung, R. Goldman, Deyun Wang, 2014, RSC advances.

Allosteric modulation of β-cell M3 muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice

J. Wess, S. Hattar, M. Rossi, 2019, Proceedings of the National Academy of Sciences.

Enhanced oligonucleotide binding to self-assembled nanofibers.

S. Stupp, J. Pokorski, D. Appella, 2005, Bioconjugate chemistry.

PNA-Based Multivalent Scaffolds Activate the Dopamine D2 Receptor.

D. Sibley, D. Appella, K. G. George Rosenker, 2015, ACS medicinal chemistry letters.

Programmable Nanoscaffolds That Control Ligand Display to a G-Protein-Coupled Receptor in Membranes To Allow Dissection of Multivalent Effects

Steven M. Moss, S. Durell, K. Jacobson, 2014, Journal of the American Chemical Society.