B. Ghanayem

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Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and hemoglobin adducts.

Rodney Snyder, M. Churchwell, T. Fennell, 2005, Toxicological sciences : an official journal of the Society of Toxicology.

Regulation of Peroxisome Proliferator-activated Receptor α-Induced Transactivation by the Nuclear Orphan Receptor TAK1/TR4*

A. Medvedev, A. Jetten, Alexander Medvedev, 1998, The Journal of Biological Chemistry.

Comparative Metabolism and Disposition of Trichloroethylene in Cyp2e1–/–and Wild-Type Mice

B. Ghanayem, Dojung Kim, 2006, Drug Metabolism and Disposition.

Ethyl acrylate-induced gastric toxicity. II. Structure-toxicity relationships and mechanism.

R. Maronpot, H. Matthews, B. Ghanayem, 1985, Toxicology and applied pharmacology.

Association of chemically induced forestomach cell proliferation and carcinogenesis.

R. Maronpot, H. Matthews, B. Ghanayem, 1986, Cancer letters.

Ethyl acrylate distribution, macromolecular binding, excretion, and metabolism in male Fisher 344 rats.

H. Matthews, L. Burka, B. Ghanayem, 1987, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Induction of replicative DNA synthesis and PPAR alpha-dependent gene transcription by Wy-14 643 in primary rat hepatocyte and non-parenchymal cell co-cultures.

B. Ghanayem, W. Karam, 1997, Carcinogenesis.

Identification of residues 286 and 289 as critical for conferring substrate specificity of human CYP2C9 for diclofenac and ibuprofen.

L. Li, L. Pedersen, J. Goldstein, 1998, Archives of biochemistry and biophysics.

Identification of human CYP2C19 residues that confer S-mephenytoin 4'-hydroxylation activity to CYP2C9.

J. Goldstein, M. Wester, B. Ghanayem, 2001, Biochemistry.

The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism.

G. Shenfield, J. Miners, J. Goldstein, 1996, Pharmacogenetics.

A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin.

P. Dayer, J. Goldstein, S. Benhamou, 1999, The Journal of pharmacology and experimental therapeutics.

Comparative disposition of 2,3-epoxy-1-propanol (glycidol) in rats following oral and intravenous administration.

A. Nomeir, B. Ghanayem, N. F. Ferrala, 1995, Journal of toxicology and environmental health.

Cytochrome P450 2E1 (CYP2E1) is essential for acrylonitrile metabolism to cyanide: comparative studies using CYP2E1-null and wild-type mice.

Hongbing Wang, B. Ghanayem, B. Chanas, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Disruption of the Mouse Cyclooxygenase 1 Gene

B. Davis, R. Langenbach, S. Morham, 1997 .

The urotoxic effects of N,N'-dimethylaminopropionitrile. 2. In vivo and in vitro metabolism.

M. Farooqui, M. Mumtaz, A. E. Ahmed, 1991, Toxicology and applied pharmacology.

Quantitative determination of gastrointestinal bleeding in rats.

A. E. Ahmed, B. Ghanayem, 1982, Journal of pharmacological methods.

Using Cytochrome P-450 Gene Knock-Out Mice to Study Chemical Metabolism, Toxicity, and Carcinogenicity

Hongbing Wang, S. Sumner, B. Ghanayem, 2000, Toxicologic pathology.

Effects of the carcinogen, acrylonitrile, on forestomach cell proliferation and apoptosis in the rat: comparison with methacrylonitrile.

M. Elwell, B. Ghanayem, S. Eldridge, 1997, Carcinogenesis.

INCREASED BIOACCUMULATION OF URETHANE IN CYP 2 E 1 / VERSUS CYP 2 E 1 / MICE

B. Ghanayem, U. Hoffler, 2005 .

Role of cytochrome P-450 2E1 in methacrylonitrile metabolism and disposition.

F. Gonzalez, L. Burka, B. Ghanayem, 1999, The Journal of pharmacology and experimental therapeutics.

CYP2E1-Catalyzed Oxidation Contributes to the Sperm Toxicity of 1-Bromopropane in Mice1

C. Garner, S. Sumner, J. Davis, 2007, Biology of reproduction.

Differential metabolism of acrylonitrile to cyanide is responsible for the greater sensitivity of male vs female mice: role of CYP2E1 and epoxide hydrolases.

Hongbing Wang, B. Ghanayem, B. Chanas, 2003, Toxicology and applied pharmacology.

Analysis of Biomarkers of DNA Damage and Mutagenicity in Mice Exposed to Acrylonitrile.

G. Douglas, D. Walker, V. Walker, 2020, Chemical research in toxicology.

An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians.

P. Dayer, J. Goldstein, S. Benhamou, 1998, Pharmacogenetics.

Acrylonitrile-induced gastric mucosal necrosis: role of gastric glutathione.

P. Boor, A. E. Ahmed, B. Ghanayem, 1985, The Journal of pharmacology and experimental therapeutics.

Calcium channel blockers protect against ethanol- and indomethacin-induced gastric lesions in rats.

R. Maronpot, H. Matthews, B. Ghanayem, 1987, Gastroenterology.

Hemolytic anemia, thrombosis, and infarction in male and female F344 rats following gavage exposure to 2-butoxyethanol.

M. Nyska, S. Ward, A. Nyska, 2001, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

Comparison of the acute hematotoxicity of 2-butoxyethanol in male and female F344 rats

S. Ward, A. Nyska, B. Ghanayem, 2000, Human & experimental toxicology.

Dental Pulp Infarction in Female Rats Following Inhalation Exposure to 2-Butoxyethanol

R. Maronpot, A. Nyska, B. Ghanayem, 2000, Toxicologic pathology.

Development of tolerance to 2-butoxyethanol-induced hemolytic anemia and studies to elucidate the underlying mechanisms.

H. Matthews, B. Ghanayem, I. M. Sanchez, 1992, Toxicology and applied pharmacology.

Comparison of the hematologic effects of 2-butoxyethanol using two types of hematology analyzers.

H. Matthews, S. Ward, B. Ghanayem, 1990, Toxicology and applied pharmacology.

Metabolic and cellular basis of 2-butoxyethanol-induced hemolytic anemia in rats and assessment of human risk in vitro.

B. Ghanayem, 1989, Biochemical pharmacology.

Effect of age on the toxicity and metabolism of ethylene glycol monobutyl ether (2-butoxyethanol) in rats.

R. Maronpot, H. Matthews, B. Ghanayem, 1987, Toxicology and applied pharmacology.

Metabolic basis of ethylene glycol monobutyl ether (2-butoxyethanol) toxicity: role of alcohol and aldehyde dehydrogenases.

H. Matthews, L. Burka, B. Ghanayem, 1987, The Journal of pharmacology and experimental therapeutics.

Demonstration of a Temporal Relationship Between Ethyl Acrylate-Induced Forestomach Cell Proliferation and Carcinogenicity

H. Matthews, M. Elwell, B. Ghanayem, 1994, Toxicologic pathology.

Disposition of the flame retardant 1,2-bis(2,4,6-tribromophenoxy)ethane in rats following administration in the diet.

A. Nomeir, B. Ghanayem, P. Markham, 1993, Drug metabolism and disposition: the biological fate of chemicals.

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration

Hyung-Suk Kim, R. Langenbach, S. Morham, 1995, Cell.

Comparative metabolism of methacrylonitrile and acrylonitrile to cyanide using cytochrome P4502E1 and microsomal epoxide hydrolase-null mice.

B. Ghanayem, B. Chanas, Lahouaria Hadri, 2005, Toxicology and applied pharmacology.

Characterization of the toxicity, mutagenicity, and carcinogenicity of methacrylonitrile in F344 Rats and B6C3F1 mice

A. Nyska, B. Ghanayem, 2003, Archives of Toxicology.

Comparative metabolism and disposition of acrylonitrile and methacrylonitrile in rats

Ahmed E. Ahmed, L. Burka, B. Ghanayem, 2011, Archives of Toxicology.

CYTOCHROME P 450 2 E 1 ( CYP 2 E 1 ) IS ESSENTIAL FOR ACRYLONITRILE METABOLISM TO CYANIDE : COMPARATIVE STUDIES USING CYP 2 E 1-NULL AND WILD-TYPE MICE

Hongbing Wang, B. Ghanayem, B. Chanas, 2002 .

Comparative Disposition of Acrylonitrile and Methacrylonitrile: Quantitative Whole-Body Autoradiographic Studies in Rats

Ahmed E. Ahmed, B. Ghanayem, S. Jacob, 1996 .

Comparative disposition of acrylonitrile and methacrylonitrile: quantitative whole-body autoradiographic studies in rats.

A. E. Ahmed, B. Ghanayem, S. Jacob, 1996, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Assessment of the acute acrylonitrile-induced neurotoxicity in rats.

M. Farooqui, M. Mumtaz, A. E. Ahmed, 1991, Neurotoxicology and teratology.

Acrylonitrile-induced gastrointestinal hemorrhage and the effects of metabolism modulation in rats.

A. E. Ahmed, B. Ghanayem, 1983, Toxicology and applied pharmacology.

Kinetics of Trihalogenated Acetic Acid Metabolism and Isoform Specificity in Liver Microsomes

I. Schultz, B. Ghanayem, S. Saghir, 2011, International journal of toxicology.

Comparison of the testicular effects of 2-methoxyethanol (ME) in rats and guinea pigs.

R. Chapin, R. Wine, B. Ghanayem, 1994, Experimental and molecular pathology.

Assessment of the Haemolytic Activity of 2-Butoxyethanol and its Major Metabolite, Butoxyacetic Acid, in Various Mammals Including Humans

B. Ghanayem, B I Ghanayem, C A Sullivan, 1993, Human & experimental toxicology.

Calcium channel blockers protect against ethylene glycol monomethyl ether (2-methoxyethanol)-induced testicular toxicity.

R. Chapin, B. Ghanayem, 1990, Experimental and molecular pathology.

Spermatocyte toxicity of 2-methoxyethanol (ME) in rats and guinea pigs: evidence for the induction of apoptosis.

R. Chapin, R. Wine, B. Ghanayem, 1995, Toxicology and applied pharmacology.

Styrene metabolism in rats, mice, and humans

T. Fennell, S. Sumner, G. Johanson, 2001 .

Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin.

P. Dayer, J. Goldstein, U. Meyer, 1998, The Journal of pharmacology and experimental therapeutics.

Identification of New Human CYP 2 C 19 Alleles ( CYP 2 C 19 * 6 and CYP 2 C 19 * 2 B ) in a Caucasian Poor Metabolizer of Mephenytoin 1

P. Dayer, J. Goldstein, U. Meyer, 1998 .

Acrylonitrile is a multisite carcinogen in male and female B6C3F1 mice.

J. Haseman, J. Bucher, A. Nyska, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Diet-induced obesity is associated with hyperleptinemia, hyperinsulinemia, hepatic steatosis, and glomerulopathy in C57Bl/6J mice

D. Malarkey, K. Hobbie, G. Travlos, 2009, Endocrine.

Diet-Induced Obesity in Male Mice Is Associated with Reduced Fertility and Potentiation of Acrylamide-Induced Reproductive Toxicity1

Grace E Kissling, G. Kissling, G. Travlos, 2010, Biology of reproduction.

Diet-Induced Obesity in Male Mice Is Associated with Reduced Fertility and Potentiation of Acrylamide- Induced Reproductive Toxicity 1

G. Kissling, G. Travlos, B. Ghanayem, 2009 .

Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans.

S. Kitareewan, J. Goldstein, J. Lasker, 1994, Biochemistry.

Inhibition of urethane-induced carcinogenicity in cyp2e1-/- in comparison to cyp2e1+/+ mice.

B. Ghanayem, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups.

Ernest Hodgson, H. Mohrenweiser, J. Goldstein, 2003, Pharmacogenetics.

INCREASED BIOACCUMULATION OF URETHANE IN CYP2E1-/- VERSUS CYP2E1+/+ MICE

B. Ghanayem, U. Hoffler, 2005, Drug Metabolism and Disposition.

Inhibition of urethane-induced genotoxicity and cell proliferation in CYP2E1-null mice.

S. Peddada, D. Dixon, B. Ghanayem, 2005, Mutation research.

Recombinant CYP3A4*17 Is Defective in Metabolizing the Hypertensive Drug Nifedipine, and the CYP3A4*17 Allele May Occur on the Same Chromosome as CYP3A5*3, Representing a New Putative Defective CYP3A Haplotype

J. Goldstein, D. Bell, Su-Jun Lee, 2005, Journal of Pharmacology and Experimental Therapeutics.

Hemoglobin degradation, lipid peroxidation, and inhibition of Na+/K(+)-ATPase in rat erythrocytes exposed to acrylonitrile.

M. Farooqui, M. Mumtaz, A. E. Ahmed, 1990, Journal of biochemical toxicology.

Cytochrome P450 2E1 (CYP2E1) Is the Principal Enzyme Responsible for Urethane Metabolism: Comparative Studies Using CYP2E1-Null and Wild-Type Mice

H. El-Masri, B. Ghanayem, U. Hoffler, 2003, Journal of Pharmacology and Experimental Therapeutics.

Cytochrome P 450 2 E 1 ( CYP 2 E 1 ) Is the Principal Enzyme Responsible for Urethane Metabolism : Comparative Studies Using CYP 2 E 1-Null and Wild-Type Mice

H. El-Masri, B. Ghanayem, U. Hoffler, 2003 .

Bioactivation of 1,1-Dichloroethylene by CYP2E1 and CYP2F2 in Murine Lung

Ashish Sharma, C. Reilly, Christopher A Reilly, 2004, Journal of Pharmacology and Experimental Therapeutics.

Bioactivation of 1 , 1-Dichloroethylene by CYP 2 E 1 and CYP 2 F 2 in Murine

Ashish Sharma, C. Reilly, G. Yost, 2004 .

Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.

R. Baldwin, C. Reilly, G. Yost, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid.

J. Goldstein, D. Zeldin, B. Ghanayem, 2001, Pharmacogenetics.

In vivo biotransformation and biliary excretion of 1-14C-acrylonitrile in rats

A. E. Ahmed, B. Ghanayem, A. E. Ahmed, 1982, Archives of Toxicology.

Investigation of xenobiotics metabolism, genotoxicity, and carcinogenicity using Cyp2e1(-/-) mice.

B. Ghanayem, U. Hoffler, 2007, Current drug metabolism.

Discovery of new potentially defective alleles of human CYP2C9.

H. Mohrenweiser, J. Goldstein, S. Ferguson, 2004, Pharmacogenetics.

Role of cytochrome P450 2E1 in the metabolism of acrylamide and acrylonitrile in mice.

F. Gonzalez, T. Fennell, S. Sumner, 1999, Chemical research in toxicology.

Comparison of Germ Cell Mutagenicity in Male CYP2E1-Null and Wild-Type Mice Treated with Acrylamide: Evidence Supporting a Glycidamide-Mediated Effect

M. D. Shelby, M. Shelby, K. Witt, 2005, Biology of reproduction.

Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: evidence consistent with a glycidamide-mediated effect.

R R Tice, R. Tice, K. Witt, 2005, Mutation research.

Studies on the mechanism of acetonitrile toxicity. I: Whole body autoradiographic distribution and macromolecular interaction of 2-14C-acetonitrile in mice.

A. E. Ahmed, B. Ghanayem, G. I. Hussein, 1992, Pharmacology & toxicology.

Identification and functional characterization of new potentially defective alleles of human CYP2C19.

H. Mohrenweiser, J. Goldstein, S. Ferguson, 2002, Pharmacogenetics.

Structure-activity relationships for the in vitro hematotoxicity of N-alkoxyacetic acids, the toxic metabolites of glycol ethers.

H. Matthews, B. Ghanayem, L. T. Burka, 1989, Chemico-biological interactions.

EFFECT OF METHACRYLONITRILE ON CYTOCHROME P-450 2E1 (CYP2E1) EXPRESSION IN MALE F344 RATS

Hongbing Wang, B. Ghanayem, B. Chanas, 2002, Journal of toxicology and environmental health. Part A.

Physiologically based pharmacokinetics of 2-butoxyethanol and its major metabolite, 2-butoxyacetic acid, in rats and humans.

R A Corley, R. Corley, B. Ghanayem, 1994, Toxicology and applied pharmacology.

Effects of dose, age, inhibition of metabolism and elimination on the toxicokinetics of 2-butoxyethanol and its metabolites.

H. Matthews, B. Ghanayem, J. M. Sanders, 1990, The Journal of pharmacology and experimental therapeutics.

Metabolism and disposition of ethylene glycol monobutyl ether (2-butoxyethanol) in rats.

H. Matthews, B. Ghanayem, J. M. Sanders, 1987, Drug metabolism and disposition: the biological fate of chemicals.

Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes.

J. Goldstein, J A Goldstein, J. Lasker, 1996, Drug metabolism and disposition: the biological fate of chemicals.

Single dose blood toxicokinetics of methacrylonitrile in the F344 rat.

B. Ghanayem, K. Demby, I. M. Sanchez, 1993, Toxicology and applied pharmacology.

Identification of Residues 99, 220, and 221 of Human Cytochrome P450 2C19 as Key Determinants of Omeprazole Hydroxylase Activity (*)

L. Pedersen, J. Goldstein, B. Ghanayem, 1996, The Journal of Biological Chemistry.

Ethyl acrylate-induced gastric toxicity. I. Effect of single and repetitive dosing.

R. Maronpot, H. Matthews, B. Ghanayem, 1985, Toxicology and applied pharmacology.

Role of chemically induced cell proliferation in ethyl acrylate-induced forestomach carcinogenesis.

R. Maronpot, H. Matthews, B. Ghanayem, 1991, Progress in clinical and biological research.

Relationship between the time of sustained ethyl acrylate forestomach hyperplasia and carcinogenicity.

R. Maronpot, H. Matthews, M. Elwell, 1993, Environmental health perspectives.

Ethyl acrylate-induced gastric toxicity. III. Development and recovery of lesions.

R. Maronpot, H. Matthews, B. Ghanayem, 1986, Toxicology and applied pharmacology.

Studies on the mechanism of urotoxic effects of N,N'-dimethylaminopropionitrile in rats and mice. 1. Biochemical and morphologic characterization of the injury and its relationship to metabolism.

M. Farooqui, M. Mumtaz, A. E. Ahmed, 1991, Journal of Toxicology and Environmental Health, Part A.

Pulmonary Bronchiolar Cytotoxicity and Formation of Dichloroacetyl Lysine Protein Adducts in Mice Treated with Trichloroethylene

D. Putt, L. Lash, B. Ghanayem, 2006, Journal of Pharmacology and Experimental Therapeutics.

Ocular thrombosis and retinal degeneration induced in female F344 rats by 2-butoxyethanol

R. Maronpot, A. Nyska, B. Ghanayem, 1999, Human & experimental toxicology.

Effect of Dose Volume on the Toxicokinetics of Acrylamide and Its Metabolites and 2-Deoxy-d-glucose

B. Ghanayem, Re Bai, L. T. Burka, 2009, Drug Metabolism And Disposition.

Identification of residues 99, 220, and 221 of human cytochrome P450 2C19 as key determinants of omeprazole activity.

J. Goldstein, L. Li, J A Goldstein, 1996, The Journal of biological chemistry.

Disseminated Thrombosis and Bone Infarction in Female Rats Following Inhalation Exposure to 2-Butoxyethanol

R. Maronpot, A. Nyska, G. Travlos, 1999, Toxicologic pathology.

Prevention of acrylonitrile-induced gastrointestinal bleeding by sulfhydryl compounds, atropine and cimetidine.

A. E. Ahmed, B. Ghanayem, 1986, Research communications in chemical pathology and pharmacology.

Nonoxidative metabolism of 2-butoxyethanol via fatty acid conjugation in Fischer 344 rats.

B. Kaphalia, B. Ghanayem, G. Ansari, 1996, Journal of toxicology and environmental health.

Excretion and identification of methacrylonitrile metabolites in the bile of male F344 rats.

B. Ghanayem, L. T. Burka, 1996, Drug metabolism and disposition: the biological fate of chemicals.

Effects of dose, strain, and dosing vehicle on methacrylonitrile disposition in rats and identification of a novel-exhaled metabolite.

B. Ghanayem, I. M. Sanchez, L. T. Burka, 1992, Drug metabolism and disposition: the biological fate of chemicals.