Ling Shen

发表

Comparative evaluation of three different intramuscular delivery methods for DNA immunization in a nonhuman primate animal model.

John R Mascola, Ling Shen, J. Mascola, 2006, Vaccine.

Induction of an AIDS Virus-Related Tuberculosis-Like Disease in Macaques: a Model of Simian Immunodeficiency Virus- Mycobacterium Coinfection

M. Simon, N. Letvin, P. Sehgal, 2002, Infection and Immunity.

Macrophage-targeted Isoniazid-selenium nanoparticles promote innate immunity, inducing synergistic antimicrobial and bactericidal destructions of tuberculosis bacilli.

Jiye Cai, G. Zeng, H. Shen, 2019, Angewandte Chemie.

Macrophage‐Targeted Isoniazid–Selenium Nanoparticles Promote Antimicrobial Immunity and Synergize Bactericidal Destruction of Tuberculosis Bacilli

Jiye Cai, G. Zeng, H. Shen, 2019 .

Antiretroviral Agents Restore Mycobacterium-Specific T-Cell Immune Responses and Facilitate Controlling a Fatal Tuberculosis-Like Disease in Macaques Coinfected with Simian Immunodeficiency Virus andMycobacterium bovis BCG

M. Simon, N. Letvin, P. Sehgal, 2001, Journal of Virology.

Adaptive immune response of Vgamma2Vdelta2+ T cells during mycobacterial infections.

M. Simon, N. Letvin, P. Sehgal, 2002, Science.

Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22, MIP-1alpha, CCL27, IP-10, CCR4, CCR5, CXCR3, PD1, PDL2, IL-3, IFN-beta, TIM1, and TLR2 but low antigen-specific cellular responses.

B. Haynes, W. Jacobs, N. Letvin, 2008, The Journal of infectious diseases.

Tim-3-Expressing CD4+ and CD8+ T Cells in Human Tuberculosis (TB) Exhibit Polarized Effector Memory Phenotypes and Stronger Anti-TB Effector Functions

Boping Zhou, Jianbo Chen, Jiye Cai, 2012, PLoS pathogens.

Cell-Based High-Throughput Screening Assay Identifies 2',2'-Difluoro-2'-deoxycytidine Gemcitabine as a Potential Antipoliovirus Agent.

M. Vignuzzi, H. Shen, Lijun Rong, 2017, ACS infectious diseases.

Intranasal Vaccination with the Recombinant Listeria monocytogenes ΔactA prfA* Mutant Elicits Robust Systemic and Pulmonary Cellular Responses and Secretory Mucosal IgA

B. Haynes, Jianbo Chen, N. Letvin, 2011, Clinical and Vaccine Immunology.

BTLA-Expressing Dendritic Cells in Patients With Tuberculosis Exhibit Reduced Production of IL-12/IFN-α and Increased Production of IL-4 and TGF-β, Favoring Th2 and Foxp3+ Treg Polarization

Chen Chen, Zheng W. Chen, Ling Shen, 2020, Frontiers in Immunology.

Circular RNA TRAPPC6B inhibits intracellular Mycobacterium tuberculosis growth while inducing autophagy in macrophages by targeting microRNA‐874‐3p

H. Shen, Zheng W. Chen, Jiang Pi, 2021, Clinical & translational immunology.

Adoptive Transfer of Phosphoantigen-Specific γδ T Cell Subset Attenuates Mycobacterium tuberculosis Infection in Nonhuman Primates

W. Jacobs, Lixia Qian, Zhuoran Zhang, 2017, The Journal of Immunology.

IL-12+IL-18 Cosignaling in Human Macrophages and Lung Epithelial Cells Activates Cathelicidin and Autophagy, Inhibiting Intracellular Mycobacterial Growth

H. Shen, R. Modlin, Zheng W. Chen, 2018, The Journal of Immunology.

Tuberculous pleurisy drives marked effector responses of γδ, CD4+, and CD8+ T cell subpopulations in humans

H. Shen, Junfa Xu, Zheng W. Chen, 2015, Journal of leukocyte biology.

IL-12 Expands and Differentiates Human Vγ2Vδ2 T Effector Cells Producing Antimicrobial Cytokines and Inhibiting Intracellular Mycobacterial Growth

H. Shen, W. Sha, R. Modlin, 2019, Front. Immunol..

Corrigendum: IL-12 Expands and Differentiates Human Vγ2Vδ2 T Effector Cells Producing Antimicrobial Cytokines and Inhibiting Intracellular Mycobacterial Growth

H. Shen, W. Sha, R. Modlin, 2019, Front. Immunol..

Geminin functions downstream of p53 in K-ras-induced gene amplification of dihydrofolate reductase.

Jinjin Guo, Changyan Chen, T. Nishioka, 2012, Cancer research.

Genetics and Functional Mechanisms of STAT3 Polymorphisms in Human Tuberculosis

H. Shen, W. Sha, Zheng W. Chen, 2021, Frontiers in Cellular and Infection Microbiology.

Multidrug-resistant tuberculosis (MDR-TB) strain infection in macaques results in high bacilli burdens in airways, driving broad innate/adaptive immune responses

H. Shen, Wenzhe Ho, Zhuoran Zhang, 2018, Emerging Microbes & Infections.

Adjunctive Zoledronate + IL-2 administrations enhance anti-tuberculosis Vγ2Vδ2 T-effector populations, and improve treatment outcome of multidrug-resistant tuberculosis1

H. Shen, W. Sha, M. Guo, 2022, Emerging microbes & infections.

DR*W201/P65 Tetramer Visualization of Epitope-Specific CD4 T-Cell during M. tuberculosis Infection and Its Resting Memory Pool after BCG Vaccination

G. Zeng, Zheng W. Chen, Ling Shen, 2009, PloS one.

Immunogenicity of Recombinant Fiber-Chimeric Adenovirus Serotype 35 Vector-Based Vaccines in Mice and Rhesus Monkeys

K. Mansfield, M. Lifton, M. Havenga, 2005, Journal of Virology.

CTLA-4 blockade reverses the Foxp3+ T-regulatory-cell suppression of anti-tuberculosis T-cell effector responses

Wenhong Zhang, Jing Wu, Zheng W. Chen, 2020, bioRxiv.

The Role of CD4+CD8+ T Cells in HIV Infection With Tuberculosis

K. Liang, Yang Liu, Ling Shen, 2022, Frontiers in Public Health.

Immune gene networks of mycobacterial vaccine-elicited cellular responses and immunity.

N. Letvin, Zheng W. Chen, Ling Shen, 2007, The Journal of infectious diseases.

Simian Immunodeficiency Virus Evades a Dominant Epitope-Specific Cytotoxic T Lymphocyte Response Through a Mutation Resulting in the Accelerated Dissociation of Viral Peptide and MHC Class I

D. Watkins, A. Craiu, M. Kuroda, 2000 .

MIR337-3p Enhances Mycobacterial Pathogenicity Involving TLR4/MYD88 and STAT3 Signals, Impairing VDR Antimicrobial Response and Fast-Acting Immunity

H. Shen, W. Sha, Ling Shen, 2021, Frontiers in Immunology.

monocytogenes Listeria Nonhuman Primates Inoculated with 2 T Cells in δ 2 V γ of HMBPP-Specific V Multieffector-Functional Immune Responses

Zheng W. Chen, Ling Shen, Crystal Y. Chen, 2012 .

Listeria monocytogenes Non-human Primates Inoculated with 2 T Cells in δ 2 V γ of HMBPP-Specific V Multieffector-Functional Immune Responses

Zheng W. Chen, Ling Shen, Crystal Y. Chen, 2012 .

Mannosylated graphene oxide as macrophage-targeted delivery system for enhanced intracellular M.tuberculosis killing efficiency.

Jiye Cai, G. Zeng, H. Shen, 2019, Materials science & engineering. C, Materials for biological applications.

Frequency and functional profile of circulating TCRαβ+ double negative T cells in HIV/TB co-infection

K. Liang, Ling Shen, W. Guo, 2022, BMC Infectious Diseases.

A CD4+CD161+ T-Cell Subset Present in Unexposed Humans, Not Tb Patients, Are Fast Acting Cells That Inhibit the Growth of Intracellular Mycobacteria Involving CD161 Pathway, Perforin, and IFN-γ/Autophagy

H. Shen, W. Sha, R. Modlin, 2021, Frontiers in Immunology.

Immunization of Vγ2Vδ2 T cells programs sustained effector memory responses that control tuberculosis in nonhuman primates

W. Jacobs, H. Shen, S. Porcelli, 2019, Proceedings of the National Academy of Sciences.

Bis-biguanide dihydrochloride inhibits intracellular replication of M. tuberculosis and controls infection in mice

G. Zeng, H. Shen, Lijun Rong, 2016, Scientific Reports.

SHIV antigen immunization alters patterns of immune responses to SHIV/malaria coinfection and protects against life-threatening SHIV-related malaria.

N. Letvin, N. Freitag, Zheng W. Chen, 2013, The Journal of infectious diseases.

Sensitization of Human Pancreatic Cancer Cells Harboring Mutated K-ras to Apoptosis

Sung-Hoon Kim, Changyan Chen, Ling Shen, 2012, PloS one.

Ifnar gene variants influence gut microbial production of palmitoleic acid and host immune responses to tuberculosis

Xinchun Chen, G. Zeng, J. Cui, 2022, Nature Metabolism.

Pathogenic Events in a Nonhuman Primate Model of Oral Poliovirus Infection Leading to Paralytic Poliomyelitis

M. Vignuzzi, R. Andino, Lixia Qian, 2017, Journal of Virology.

Gene-Based Vaccination with a Mismatched Envelope Protects against Simian Immunodeficiency Virus Infection in Nonhuman Primates

J. Mascola, N. Letvin, G. Nabel, 2012, Journal of Virology.

Combined megaplex TCR isolation and SMART-based real-time quantitation methods for quantitating antigen-specific T cell clones in mycobacterial infection.

N. Letvin, Zheng W. Chen, Ling Shen, 2006, Journal of immunological methods.

Phenotype and function of peripheral blood γδ T cells in HIV infection with tuberculosis

K. Liang, Ling Shen, W. Guo, 2022, Frontiers in Cellular and Infection Microbiology.

Expansion, Reexpansion, and Recall-Like Expansion of Vγ2Vδ2 T Cells in Smallpox Vaccination and Monkeypox Virus Infection

Zheng W. Chen, Ling Shen, Jialin Jin, 2009, Journal of Virology.

Simian Immunodeficiency Virus Evades a Dominant Epitope-Specific Cytotoxic T Lymphocyte Response Through a Mutation Resulting in the Accelerated Dissociation of Viral Peptide and MHC Class I1

D. Watkins, A. Craiu, M. Kuroda, 2000, The Journal of Immunology.

Viral Peptide and MHC Class I Resulting in the Accelerated Dissociation of Lymphocyte Response Through a Mutation Dominant Epitope-Specific Cytotoxic T Simian Immunodeficiency Virus Evades a

D. Watkins, A. Craiu, M. Kuroda, 2000 .

The TCR Repertoire of an Immunodominant CD8+ T Lymphocyte Population1

M. Kuroda, N. Letvin, J. E. Schmitz, 2001, The Journal of Immunology.

Antigen-specific Vγ2Vδ2 T effector cells confer homeostatic protection against pneumonic plaque lesions

H. Jomaa, A. Reichenberg, M. Hintz, 2009, Proceedings of the National Academy of Sciences.

Inhibition of Adaptive Vγ2Vδ2+ T-Cell Responses during Active Mycobacterial Coinfection of Simian Immunodeficiency Virus SIVmac-Infected Monkeys

M. Simon, N. Letvin, P. Sehgal, 2003, Journal of Virology.

Inhibition of Adaptive V (cid:2) 2V (cid:3) 2 (cid:1) T-Cell Responses during Active Mycobacterial Coinfection of Simian Immunodeﬁciency Virus SIVmac-Infected Monkeys

M. Simon, N. Letvin, P. Sehgal, 2003 .

Development of Vγ2Vδ2+ T Cell Responses during Active Mycobacterial Coinfection of Simian Immunodeficiency Virus-Infected Macaques Requires Control of Viral Infection and Immune Competence of CD4+ T Cells

N. Letvin, P. Sehgal, Zheng W. Chen, 2004 .

Down‐regulation of macaque ΓΔ+ T cells in lymphoid compartments after rectal infection with SIVsmmPBj14

N. Letvin, P. Fultz, I. Davis, 2000 .

Nanocages engineered from Bacillus Calmette-Guerin facilitate protective Vγ2Vδ2 T cell immunity against Mycobacterium tuberculosis infection

G. Zeng, H. Shen, Jiang Pi, 2022, Journal of Nanobiotechnology.

Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection

Xiaohui Xie, G. Zeng, Hui Zhang, 2015, Proceedings of the National Academy of Sciences.

Tuberculosis-Induced Variant IL-4 mRNA Encodes a Cytokine Functioning As Growth Factor for (E)-4-Hydroxy-3-Methyl-But-2-Enyl Pyrophosphate-Specific Vγ2Vδ2 T Cells1

Zhongdao Wu, Zheng W. Chen, Ling Shen, 2009, The Journal of Immunology.

)-4-Hydroxy-3-Methyl-But-2-Enyl E Factor for ( Encodes a Cytokine Functioning As Growth Tuberculosis-Induced Variant IL-4 mRNA

Zhongdao Wu, Zheng W. Chen, Ling Shen, 2008 .

Adaptive Immune Response of Vγ2Vδ2+ T Cells During Mycobacterial Infections

M. Simon, N. Letvin, P. Sehgal, 2002, Science.

Selective Destruction of Interleukin 23–Induced Expansion of a Major Antigen–Specific &ggr;&dgr; T-Cell Subset in Patients With Tuberculosis

H. Shen, Zheng W. Chen, Ling Shen, 2016, The Journal of infectious diseases.

Clinical Latency and Reactivation of AIDS-Related Mycobacterial Infections

N. Letvin, P. Sehgal, Zheng W. Chen, 2004, Journal of Virology.

Phosphoantigen/IL2 Expansion and Differentiation of Vγ2Vδ2 T Cells Increase Resistance to Tuberculosis in Nonhuman Primates

H. Jomaa, W. Jacobs, N. Letvin, 2013, PLoS pathogens.

23-valent pneumococcal polysaccharide vaccine elicits hierarchical antibody and cellular responses in healthy and tuberculosis-cured elderly, and HIV-1-infected subjects.

H. Shen, Zheng W. Chen, Peng Zhang, 2018, Clinical immunology.

Immunological and Virological Mechanisms of Vaccine-Mediated Protection Against SIV and HIV

Mario Roederer, Raphael Gottardo, Gary J. Nabel, 2013, Nature.

Tuberculosis-sensitized monocytes sustain immune response of interleukin-37.

Chen Chen, Zheng W. Chen, Ling Shen, 2016, Molecular immunology.

Immune Distribution and Localization of Phosphoantigen-Specific Vγ2Vδ2 T Cells in Lymphoid and Nonlymphoid Tissues in Mycobacterium tuberculosis Infection

B. Haynes, W. Jacobs, N. Letvin, 2007, Infection and Immunity.

Immune distribution and localization of phosphoantigen-specific Vgamma2Vdelta2 T cells in lymphoid and nonlymphoid tissues in Mycobacterium tuberculosis infection.

B. Haynes, W. Jacobs, N. Letvin, 2008, Infection and immunity.

Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys

M. Hudgens, J. Mascola, D. Montefiori, 2011, Science Translational Medicine.

TRIM5 modulates penile mucosal acquisition of simian immunodeficiency virus in rhesus monkeys

B. Korber, P. Hraber, J. Mascola, 2011 .

The TRIM5 Gene Modulates Penile Mucosal Acquisition of Simian Immunodeficiency Virus in Rhesus Monkeys

B. Korber, P. Hraber, J. Mascola, 2011, Journal of Virology.

Virus Inhibition Activity of Effector Memory CD8+ T Cells Determines Simian Immunodeficiency Virus Load in Vaccinated Monkeys after Vaccine Breakthrough Infection

R. Koup, D. Douek, N. Letvin, 2012, Journal of Virology.

Multieffector-Functional Immune Responses of HMBPP-Specific Vγ2Vδ2 T Cells in Nonhuman Primates Inoculated with Listeria monocytogenes ΔactA prfA*

Zheng W. Chen, Ling Shen, Crystal Y. Chen, 2012, The Journal of Immunology.

A Critical Role for CD8 T Cells in a Nonhuman Primate Model of Tuberculosis

William R. Jacobs, Norman L. Letvin, Lisa Halliday, 2009, PLoS pathogens.

Breakthrough Infection Vaccinated Monkeys after Vaccine Immunodeficiency Virus Load in T Cells Determines Simian + CD8Virus Inhibition Activity of Effector Memory

R. Koup, D. Douek, N. Letvin, 2023 .

Immune Distribution and Localization of Phosphoantigen-Speciﬁc V (cid:2) 2V (cid:3) 2 T Cells in Lymphoid and Nonlymphoid Tissues in Mycobacterium tuberculosis Infection (cid:1)

B. Haynes, W. Jacobs, N. Letvin, 2007 .

Prolonged Dominance of Clonally Restricted CD4+ T Cells in Macaques Infected with Simian Immunodeficiency Viruses

N. Letvin, H. McClure, Dejiang Zhou, 2000, Journal of Virology.

Correction: IL-12+IL-18 Cosignaling in Human Macrophages and Lung Epithelial Cells Activates Cathelicidin and Autophagy, Inhibiting Intracellular Mycobacterial Growth

H. Shen, R. Modlin, Zheng W. Chen, 2019, The Journal of Immunology.

In Vivo T-Lymphocyte Activation and Transient Reduction of Viral Replication in Macaques Infected with Simian Immunodeficiency Virus

M. Simon, N. Letvin, P. Sehgal, 2001, Journal of Virology.

T Cell Receptor V ~ Repertoire in an Acute Infection of Rhesus Monkeys with Simian Immunodeficiency Viruses and a Chimeric Simian-Human Immunodeficiency Virus

J. Sodroski, N. Letvin, Dejiang Zhou, 2003 .

Fast‐acting γδ T‐cell subpopulation and protective immunity against infections

H. Shen, Zheng W. Chen, A. Qaqish, 2020, Immunological reviews.

This information is current as T Lymphocyte Population + CD 8 The TCR Repertoire of an Immunodominant

M. Kuroda, N. Letvin, J. E. Schmitz, 2001 .

Breakthrough Infection Vaccinated Monkeys after Vaccine Immunodeficiency Virus Load in T Cells Determines Simian + CD8Inhibition Activity of Effector Memory

R. Koup, N. Letvin, G. Nabel, 2014 .