Haiying Bao

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High throughput chromatography strategies for potential use in the formal process characterization of a monoclonal antibody

N. Tugcu, D. Roush, Matthew G. Petroff, 2016, Biotechnology and bioengineering.

The Mechanism of Action of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine Involves a Second Metabolic Pathway Leading to β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine 5′-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

M. Otto, Haiying Bao, E. Murakami, 2007, Antimicrobial Agents and Chemotherapy.

Mechanism of Action of (-)-(2R,4R)-1-(2-hydroxymethyl-1,3-dioxolan-4-yl)thymine as an anti-HIV agent

Christopher M. Bailey, M. Otto, K. Anderson, 2007, Antiviral chemistry & chemotherapy.

Role of Lipoyl Domains in the Function and Regulation of Mammalian Pyruvate Dehydrogenase Complex

T. Roche, Y. Hiromasa, Haiying Bao, 2008 .

Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1.

Jianchun Dong, T. Roche, Y. Hiromasa, 2003, European journal of biochemistry.

Central Organization of Mammalian Pyruvate Dehydrogenase (PD) Complex and Lipoyl Domain–Mediated Activated Function and Control of PD Kinases and Phosphatase 1

Jianchun Dong, T. Roche, Y. Hiromasa, 2003 .

High‐throughput techniques to evaluate the effect of ligand density for impurity separations with multimodal cation exchange resins

D. Roush, K. Lacki, E. Brekkan, 2016 .

Deciphering key regulators of Inonotus hispidus petroleum ether extract involved in anti-tumor through whole transcriptome and proteome analysis in H22 tumor-bearing mice model.

Haiying Bao, Zhijun Li, 2022, Journal of ethnopharmacology.

PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication

M. Otto, D. Smee, C. Espiritu, 2010, Antimicrobial Agents and Chemotherapy.

Mechanism of Activation of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase

M. Otto, L. Stuyver, R. Schinazi, 2007, Antimicrobial Agents and Chemotherapy.

Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine

M. Otto, C. Espiritu, A. Lam, 2011, Antimicrobial Agents and Chemotherapy.

Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of (cid:1) - D -2 (cid:2) -Deoxy-2 (cid:2) - (cid:3) -Fluoro-2 (cid:2) - (cid:1) - C -Methylguanosine (cid:1) †

M. Otto, C. Espiritu, A. Lam, 2011 .

Evaluation of the in vitro anti-HBV activity of clevudine in combination with other nucleoside/ nucleotide inhibitors

T. Tolstykh, Haiying Bao, E. Murakami, 2010, Antiviral therapy.

PSI-7851, a Pronucleotide of (cid:1) - D -2 (cid:2) -Deoxy-2 (cid:2) -Fluoro-2 (cid:2) - C -Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication (cid:1)

M. Otto, D. Smee, C. Espiritu, 2010 .

Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP.

T. Roche, Y. Hiromasa, Xiaohua Yan, 2004, Biochemistry.

Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP.

T. Roche, Xiaohua Yan, Haiying Bao, 2004, Biochemistry.

Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates.

M. Sofia, R. Mosley, Haiying Bao, 2011, Journal of medicinal chemistry.

Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977

M. Otto, C. Espiritu, A. Lam, 2010, The Journal of Biological Chemistry.

Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661.

M. Otto, C. Espiritu, A. Lam, 2011, Antiviral research.

The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.

M. Otto, Haiying Bao, E. Murakami, 2008, Antimicrobial agents and chemotherapy.

Use of 2'-spirocyclic ethers in HCV nucleoside design.

C. Espiritu, A. Lam, M. Sofia, 2014, Journal of medicinal chemistry.

Synthesis and anti-HCV activity of 3',4'-oxetane nucleosides.

M. Otto, M. Sofia, B. Ross, 2010, Bioorganic & medicinal chemistry letters.

A 2′-Deoxy-2′-Fluoro-2′-C-Methyl Uridine Cyclopentyl Carbocyclic Analog and Its Phosphoramidate Prodrug as Inhibitors of HCV NS5B Polymerase

C. Espiritu, M. Sofia, Jian Liu, 2012, Nucleosides, nucleotides & nucleic acids.

β-D-2'-α-F-2'-β-C-Methyl-6-O-substituted 3',5'-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: a structure-activity relationship study.

M. Otto, C. Espiritu, A. Lam, 2012, Bioorganic & medicinal chemistry letters.

[590] INHIBITION OF HCV REPLICATION BY PSI-6130: MECHANISM OF BIOCHEMICAL ACTIVATION AND INHIBITION

M. Otto, J. Symons, Haiying Bao, 2007 .

Metabolic Activation of the Anti-Hepatitis C Virus Nucleotide Prodrug PSI-352938

M. Otto, A. Lam, M. Sofia, 2012, Antimicrobial Agents and Chemotherapy.

Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance

M. Otto, A. Lam, M. Sofia, 2014, Antimicrobial Agents and Chemotherapy.

Role of membrane structure on the filtrate flux during monoclonal antibody filtration through virus retentive membranes

A. Zydney, Z. Li, J. Hung, 2022, Biotechnology progress.

Antibody retention by virus filtration membranes: Polarization and sieving effects

A. Zydney, Z. Li, J. Hung, 2020 .

Tumor suppressive microRNA‐485‐5p targets PRRX1 in human skin melanoma cells, regulating epithelial–mesenchymal transition and apoptosis

Xiaolin Wu, Haiying Bao, 2021, Cell biology international.

Cation exchange as a single polishing step for conjugated peptides

N. Tugcu, Francis Insaidoo, Haiying Bao, 2022, Biotechnology progress (Print).

High throughput chromatography strategies for potential use in the formal process characterization of a monoclonal antibody

N. Tugcu, D. Roush, Matthew G. Petroff, 2016, Biotechnology and Bioengineering.

A practical strategy for using miniature chromatography columns in a standardized high‐throughput workflow for purification development of monoclonal antibodies

John P Welsh, Matthew G Petroff, Patricia Rowicki, 2014, Biotechnology progress.

Domain antibody downstream process optimization: High‐throughput strategy and analytical methods

Haiying Bao, Thomas O. Linden, Jennifer M. Pollard, 2016 .