J. Hotchkiss

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Acute toxicity testing of chemicals—Opportunities to avoid redundant testing and use alternative approaches

Ian Indans, Stuart Creton, Sean C Gehen, 2010, Critical reviews in toxicology.

Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report.

Marianna Gaça, Miyoung Yoon, Marco Corvaro, 2018, Toxicology in vitro : an international journal published in association with BIBRA.

DNA synthesis and Bcl-2 expression during development of mucous cell metaplasia in airway epithelium of rats exposed to LPS.

Y. Tesfaigzi, J. Harkema, J. F. Harris, 2004, American journal of physiology. Lung cellular and molecular physiology.

Concurrent increases in the storage and release of mucin-like molecules by rat airway epithelial cells in response to bacterial endotoxin.

C. Basbaum, J. Harkema, J. Hotchkiss, 1995, American journal of respiratory cell and molecular biology.

Fluticasone propionate attenuates ozone-induced rhinitis and mucous cell metaplasia in rat nasal airway epithelium.

J. Harkema, H. Cho, J. Hotchkiss, 1998, American journal of respiratory cell and molecular biology.

Effect of blood leucocyte depletion on the inflammatory response of the lung to quartz.

R. Henderson, J. Harkema, J. Hotchkiss, 1991, Toxicology and applied pharmacology.

Responses of rat nasal epithelium to short‐ and long‐term exposures of ozone: Image analysis of epithelial injury, adaptation and repair

E. Barr, J. Harkema, J. Hotchkiss, 1997, Microscopy research and technique.

Effects of concentrated ambient particles on normal and hypersecretory airways in rats.

E. Timm, N. Kaminski, E. Barr, 2004, Research report.

Ozone exposure enhances endotoxin-induced mucous cell metaplasia in rat pulmonary airways.

J. Harkema, J. Wagner, J. Hotchkiss, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Endotoxin enhancement of ozone-induced mucous cell metaplasia is neutrophil-dependent in rat nasal epithelium.

J. Harkema, J. Wagner, J. Hotchkiss, 2001, Toxicological sciences : an official journal of the Society of Toxicology.

Effects of ozone and endotoxin coexposure on rat airway epithelium: potentiation of toxicant-induced alterations.

J. Harkema, J. Wagner, J. Hotchkiss, 2001, Environmental health perspectives.

Response of rat alveolar macrophages to ozone: quantitative assessment of population size, morphology, and proliferation following acute exposure.

R. Henderson, J. Harkema, J. Hotchkiss, 1989, Experimental lung research.

Proliferative responses of rat nasal epithelia to ozone.

R. Henderson, N. Johnson, J. Harkema, 1990, Toxicology and applied pharmacology.

Lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol) synergistically induce apoptosis in murine lymphoid organs.

J. Pestka, R. Roth, J. Harkema, 2000, Toxicological sciences : an official journal of the Society of Toxicology.

Investigation of potential early key events and mode of action for 1,2‐dichloroethane‐induced mammary tumors in female rats

M. LeBaron, D. Boverhof, J. Hotchkiss, 2020, Journal of applied toxicology : JAT.

Tobacco Smoke Control of Mucin Production in Lung Cells Requires Oxygen Radicals AP-1 and JNK*

M. Gallup, C. Basbaum, E. Gensch, 2004, Journal of Biological Chemistry.

Persistent mucin glycoprotein alterations in equine recurrent airway obstruction.

C. Basbaum, J. Harkema, N. E. Robinson, 2001, American journal of physiology. Lung cellular and molecular physiology.

A small proline-rich protein, SPRR1, is upregulated early during tobacco smoke-induced squamous metaplasia in rat nasal epithelia.

P. Wright, J. Th’ng, J. Harkema, 1996, American journal of respiratory cell and molecular biology.

Assessment of the respiratory sensitization potential of proteins using an enhanced mouse intranasal test (MINT).

D. Boverhof, J. Hotchkiss, M. Woolhiser, 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Role of neutrophils in the synergistic liver injury from monocrotaline and bacterial lipopolysaccharide exposure.

P. Ganey, R. Roth, J. Hotchkiss, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Long-lasting effects of chronic ozone exposure on rat nasal epithelium.

M. Gallup, C. Basbaum, E. Barr, 1999, American journal of respiratory cell and molecular biology.

Mucous cell metaplasia in rat nasal epithelium after a 20-month exposure to ozone: a morphometric study of epithelial differentiation.

W. Griffith, J. Harkema, J. Hotchkiss, 1997, American journal of respiratory cell and molecular biology.

Comparison of acute ozone-induced nasal and pulmonary inflammatory responses in rats.

R. Henderson, J. Harkema, J. Hotchkiss, 1989, Toxicology and applied pharmacology.

In vivo effects of endotoxin on DNA synthesis in rat nasal epithelium

J. Harkema, J. Hotchkiss, 1993, Microscopy research and technique.

Antibodies to mouse lung capillary endothelium.

S. Kennel, D. Allison, H. Witschi, 1988, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Quantitation of a murine lung endothelial cell protein, P112, with a double monoclonal antibody assay.

S. Kennel, T. Lankford, B. Hughes, 1988, Laboratory investigation; a journal of technical methods and pathology.

Mucin genes in horse airways: MUC5AC, but not MUC2, may play a role in recurrent airway obstruction.

N. E. Robinson, P. Venta, J. Hotchkiss, 2010, Equine veterinary journal.

Platelet activating factor stimulates rapid mucin secretion in rat nasal airways in vivo.

J. Harkema, J. Hotchkiss, M. Stam, 1993, Experimental lung research.

Neutrophil-dependent and neutrophil-independent alterations in the nasal epithelium of ozone-exposed rats.

J. Harkema, J. Hotchkiss, C. B. Bennett, 2000, American journal of respiratory and critical care medicine.

Specific biological effects of an anti-rat PMN antiserum intraperitoneally infected into f344/n rats.

J. Harkema, J. Hotchkiss, A. Rebar, 1995, Veterinary clinical pathology.

In vivo effects of endotoxin on intraepithelial mucosubstances in rat pulmonary airways. Quantitative histochemistry.

J. Harkema, J. Hotchkiss, Jack R. Harkema, 1992, The American journal of pathology.

Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression.

R. Wu, G. Dolganov, J. Fahy, 2001, American journal of respiratory and critical care medicine.

Endotoxin potentiates ozone-induced mucous cell metaplasia in rat nasal epithelium.

J. Harkema, M. Fanucchi, J. Hotchkiss, 1998, Toxicology and applied pharmacology.

Kinetics of nasal epithelial cell loss and proliferation in F344 rats following a single exposure to 0.5 ppm ozone.

N. Johnson, J. Harkema, J. Hotchkiss, 1997, Toxicology and applied pharmacology.

In vivo effects of transient neutrophil influx on nasal respiratory epithelial mucosubstances. Quantitative histochemistry.

R. Henderson, J. Harkema, J. Hotchkiss, 1988, The American journal of pathology.

Expression of the Bcl-2 protein in nasal epithelia of F344/N rats during mucous cell metaplasia and remodeling.

J. Harkema, J. Hotchkiss, J. Tesfaigzi, 1998, American journal of respiratory cell and molecular biology.

Glutathione and GSH-dependent enzymes in bronchoalveolar lavage fluid cells in response to ozone.

R. Henderson, J. Hotchkiss, D. Boehme, 1992, Experimental and molecular pathology.

A draining lymph node assay (DLNA) for assessing the sensitizing potential of proteins.

D. Boverhof, B. Gollapudi, J. Hotchkiss, 2010, Toxicology letters.

Synergistic hepatotoxicity from coexposure to bacterial endotoxin and the pyrrolizidine alkaloid monocrotaline.

P. Ganey, R. Roth, J. Harkema, 2000, Toxicology and applied pharmacology.

Reexamination of Respiratory Tract Responses in Rats, Mice, and Rhesus Monkeys Chronically Exposed to Inhaled Chlorine

A. Jarabek, K. Morgan, J. Harkema, 1996 .

Enhancement of nasal inflammatory and epithelial responses after ozone and allergen coexposure in Brown Norway rats.

J. Harkema, J. Wagner, J. Hotchkiss, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Interspecies comparison of cellular localization of the cyanide metabolizing enzyme rhodanese within olfactory mucosa

J. Lewis, J. Harkema, A. Dahl, 1992, The Anatomical record.

A rat monoclonal antibody specific for murine type 1 pneumocytes.

S. Kennel, J. Harkema, J. Hotchkiss, 1992, Experimental and molecular pathology.

Nasal cytochrome P450 2A: identification, regional localization, and metabolic activity toward hexamethylphosphoramide, a known nasal carcinogen.

K. Nikula, A. Dahl, J. Hotchkiss, 1997, Toxicology and applied pharmacology.

Inflammatory and epithelial responses during the development of ozone-induced mucous cell metaplasia in the nasal epithelium of rats.

J. Harkema, H Y Cho, J A Hotchkiss, 1999, Toxicological sciences : an official journal of the Society of Toxicology.

Ozone- and endotoxin-induced mucous cell metaplasias in rat airway epithelium: novel animal models to study toxicant-induced epithelial transformation in airways.

J. Harkema, J. Hotchkiss, 1993, Toxicology letters.

Regional differences in the effects of mainstream cigarette smoke on stored mucosubstances and DNA synthesis in F344 rat nasal respiratory epithelium.

B. T. Chen, J. Harkema, G. Finch, 1995, Toxicology and applied pharmacology.

Expert consensus on an in vitro approach to assess pulmonary fibrogenic potential of aerosolized nanomaterials

David Allen, Christie M. Sayes, Arti Ahluwalia, 2016, Archives of Toxicology.

Biochemical and morphologic responses of rat nasal epithelia to hyperoxia.

K. Nikula, J. Harkema, P. Sabourin, 1991, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Chromosome damage in rat pulmonary alveolar macrophages following ozone inhalation.

R. Henderson, A. Brooks, W. Griffith, 1990, Mutation research.

Chlorpyrifos PBPK/PD model for multiple routes of exposure

Charles Timchalk, M. Bartels, T. Poet, 2014, Xenobiotica; the fate of foreign compounds in biological systems.

Pyridine induction of Sprague-Dawley rat renal cytochrome P4502E1: immunohistochemical localization and quantitation.

F. Hahn, R. Novak, A. Dahl, 1995, Toxicology letters.

Thermoregulation and its influence on toxicity assessment.

D. Miller, P. Hinderliter, P. Spencer, 2008, Toxicology.

Inhalation exposure to ethylene induces eosinophilic rhinitis and nasal epithelial remodeling in Fischer 344 rats.

J. Harkema, C. Brandenberger, L. Pottenger, 2015, Chemico-biological interactions.

Developing a framework for assessing chemical respiratory sensitization: A workshop report.

Janine Ezendam, Ian Kimber, Antti Karjalainen, 2016, Regulatory toxicology and pharmacology : RTP.

Respiratory sensitization and allergy: current research approaches and needs.

Darrell R Boverhof, Alan Poole, B Bhaskar Gollapudi, 2008, Toxicology and applied pharmacology.

Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity.

David Allen, Pilar Prieto, Alicia Paini, 2018, Toxicology in vitro : an international journal published in association with BIBRA.

Effect of cumulative ozone exposure on ozone-induced nasal epithelial hyperplasia and secretory metaplasia in rats.

R. Henderson, J. Harkema, J. Hotchkiss, 1991, Experimental lung research.

Pathogenesis and Persistence of Increased Epithelial Mucosubstances in the Nasal Airways of Rats and Mice Episodically Exposed to Ethylene

J. Harkema, J. Wagner, J. Hotchkiss, 2020, Toxicologic pathology.

Endotoxin or cytokines attenuate ozone-induced DNA synthesis in rat nasal transitional epithelium.

J. Harkema, J. Hotchkiss, 1992, Toxicology and applied pharmacology.

Acute toxicologic and neurotoxic effects of inhaled 1,2-dichloroethane in adult Fischer 344 rats.

J. Maurissen, J. Hotchkiss, M. Woolhiser, 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing.

Menghang Xia, Anna Forsby, Judy Strickland, 2017, Toxicology in vitro : an international journal published in association with BIBRA.

Neutrophil involvement in the retention and clearance of dust intratracheally instilled into the lungs of F344/N rats.

J. Harkema, J. Hotchkiss, D. Bice, 1997, Experimental lung research.

In vitro culture of microdissected rat nasal airway tissues.

C. Plopper, J. Harkema, M. Fanucchi, 1999, American journal of respiratory cell and molecular biology.

Aerosol generation and characterization of multi-walled carbon nanotubes exposed to cells cultured at the air-liquid interface

C. Sayes, J. Hotchkiss, Monita Sharma, 2015, Particle and Fibre Toxicology.

Enhanced hepatic expression of P450IIE1 following inhalation exposure to pyridine.

R. Novak, A. Dahl, J. Hotchkiss, 1993, Toxicology and Applied Pharmacology.

In vivo effects of endotoxin on nasal epithelial mucosubstances: quantitative histochemistry.

J. Harkema, J. Hotchkiss, 1991, Experimental lung research.

Effects of pre-existing rhinitis on ozone-induced mucous cell metaplasia in rat nasal epithelium.

J. Harkema, J. Hotchkiss, C. B. Bennett, 1999, Toxicology and applied pharmacology.

Effects of 0.12 and 0.80 ppm Ozone on Rat Nasal and Nasopharyngeal Epithelial Mucosubstances: Quantitative Histochemistry

R. Henderson, J. Harkema, J. Hotchkiss, 1989, Toxicologic pathology.

Consequences of prolonged inhalation of ozone on F344/N rats: collaborative studies. Part XII: Atrophy of bone in nasal turbinates.

P. Catalano, J. Harkema, J. Hotchkiss, 1997, Research report.

Assessment of the immunotoxic potential of trichloroethylene and perchloroethylene in rats following inhalation exposure

D. Boverhof, J. Hotchkiss, M. Woolhiser, 2013, Journal of immunotoxicology.

Evaluation of a toxicogenomic approach to the local lymph node assay (LLNA).

Darrell R Boverhof, B Bhaskar Gollapudi, D. Boverhof, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

TITLE : Developing a Framework for Assessing Respiratory Sensitization : A Workshop Report

S. Tarlo, S. Enoch, C. North, 2018 .

Developing a framework for assessing respiratory sensitization: A workshop report

S. Tarlo, S. Enoch, C. North, 2016 .

Aerosol generation and characterization of multi-walled carbon nanotubes exposed to cells cultured at the air-liquid interface

Christie M. Sayes, Monita Sharma, C. Sayes, 2015, Particle and Fibre Toxicology.

Regional Differences in Ozone-Induced Nasal Epithelial Cell Proliferation in F344 Rats: Comparison with Computational Mass Flux Predictions of Ozone Dosimetry

J. Harkema, J. Kimbell, G. Hatch, 1994, Inhalation Toxicology.

Rat monoclonal antibodies to mouse lung components for analysis of fibrosis.

S. Kennel, L. Foote, D. Allison, 1987, Experimental and molecular pathology.

Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity.

Daniel M. Wilson, G. Patlewicz, W. Casey, 2018, Toxicology in vitro : an international journal published in association with BIBRA.