F. van Goethem

发表

Mouse lymphoma thymidine kinase gene mutation assay: Follow‐up meeting of the international workshop on Genotoxicity testing—Aberdeen, Scotland, 2003—Assay acceptance criteria, positive controls, and data evaluation

Isao Yoshimura, Julie Clements, Masamitsu Honma, 2006, Environmental and molecular mutagenesis.

Methods to evaluate and improve the injection site tolerability of intravenous formulations prior to first-in-human testing.

A. De Smedt, L. Lammens, G. Eichenbaum, 2013, Journal of pharmacological and toxicological methods.

Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates?

A. Crawford, P. D. de Witte, Camila V. Esguerra, 2015, Journal of applied toxicology : JAT.

Mouse lymphoma thymidine kinase gene mutation assay: meeting of the International Workshop on Genotoxicity Testing, San Francisco, 2005, recommendations for 24-h treatment.

Julie Clements, Masamitsu Honma, Wolfgang Muster, 2007, Mutation research.

Screening for phospholipidosis induced by central nervous drugs: comparing the predictivity of an in vitro assay to high throughput in silico assays.

G. Verheyen, N. Mesens, F. van Goethem, 2010, Toxicology in vitro : an international journal published in association with BIBRA.

Development of a new opacitometer for the bovine corneal opacity and permeability (BCOP) assay.

P. Vanparys, A. De Smedt, F. van Goethem, 2010, Toxicology in vitro : an international journal published in association with BIBRA.

Addressing Genotoxicity Risk in Lead Optimization: A PDE10A Inhibitor Case Study

Hinrich W. H. Göhlmann, Bie M. P. Verbist, H. Göhlmann, 2018, Early Drug Development.

Flow cytometric analysis of micronucleated reticulocytes: Time‐ and dose‐dependent response of known mutagens in mice, using multiple blood sampling

P. Vanparys, A. De Smedt, A. Lampo, 2005, Environmental and molecular mutagenesis.

Prevalidation of a new in vitro reconstituted human cornea model to assess the eye irritating potential of chemicals.

P. Vanparys, B. De Wever, N. Alépée, 2006, Toxicology in vitro : an international journal published in association with BIBRA.

Cosmetics Europe multi-laboratory pre-validation of the SkinEthic™ reconstituted human corneal epithelium test method for the prediction of eye irritation.

A. De Smedt, B. De Wever, N. Alépée, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

Cosmetics Europe multi-laboratory pre-validation of the EpiOcular™ reconstituted human tissue test method for the prediction of eye irritation.

A. De Smedt, B. De Wever, N. Alépée, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

The Mucosal Toxicity of Different Benzalkonium Chloride Analogues Evaluated with an Alternative Test Using Slugs

Jean Paul Remon, Els Adriaens, Phillipe Vanparys, 2001, Pharmaceutical Research.

Comparative evaluation of the in vitro micronucleus test and the alkaline single cell gel electrophoresis assay for the detection of DNA damaging agents: genotoxic effects of cobalt powder, tungsten carbide and cobalt-tungsten carbide.

M. Kirsch‐Volders, D. Lison, F. van Goethem, 1997, Mutation research.

The evolving role of investigative toxicology in the pharmaceutical industry

R. Weaver, F. Pognan, T. Steger-Hartmann, 2023, Nature Reviews Drug Discovery.

Optimizing drug discovery by Investigative Toxicology: Current and future trends.

Uwe Marx, Scott Boyer, Mardas Daneshian, 2018, ALTEX.

Frequency and DNA content of micronuclei in rat parenchymal liver cells during experimental hepatocarcinogenesis.

P. Castelain, M. Kirsch‐Volders, F. van Goethem, 1993, Carcinogenesis.

Flow cytometric analysis of micronuclei in mammalian cell cultures: past, present and future.

John Nicolette, Anthony Lynch, Freddy Van Goethem, 2011, Mutagenesis.

Follow‐up actions from positive results of in vitro genetic toxicity testing

Andreas Czich, Véronique Thybaud, Kristine L Witt, 2011, Environmental and molecular mutagenesis.

Interlaboratory evaluation of a flow cytometric, high content in vitro micronucleus assay.

Stephen D Dertinger, Jacky Van Gompel, Freddy Van Goethem, 2008, Mutation research.

Suitable top concentration for tests with mammalian cells: mouse lymphoma assay workgroup.

Julie Clements, Masamitsu Honma, Wolfgang Muster, 2011, Mutation research.

Integrating High-Dimensional Transcriptomics and Image Analysis Tools into Early Safety Screening: Proof of Concept for a New Early Drug Development Strategy.

Willem Talloen, Bie M. P. Verbist, Freddy Van Goethem, 2015, Chemical research in toxicology.

Optimisation of the cell cultivation methods in the embryonic stem cell test results in an increased differentiation potential of the cells into strong beating myocard cells.

A. K. Peters, P. Vanparys, A. De Smedt, 2008, Toxicology in vitro : an international journal published in association with BIBRA.

AI/ML Models to Predict the Severity of Drug-Induced Liver Injury for Small Molecules.

M. Aleo, H. Geys, C. Alhambra, 2023, Chemical research in toxicology.

An Adult Stem Cell Proliferation Assay in the Flatworm Model Macrostomum lignano to Predict the Carcinogenicity of Compounds

Colin R. Janssen, J. Remon, M. Plusquin, 2015 .

Optimizing drug discovery by Investigative Toxicology: Current and future trends.

Joshua D. Kangas, Rex E FitzGerald, S. Polak, 2018, ALTEX.