J. McWilliams

发表

In Situ Mid-Infrared Spectroscopy for Process Development

B. Izzo, R. Reamer, D. Conlon, 2007 .

Highly enantioselective hydrogenation of aromatic-heteroaromatic ketones.

Cheng-yi Chen, R. Reamer, C. McWilliams, 2003, Organic letters.

Asymmetric synthesis of vabicaserin via oxidative multicomponent annulation and asymmetric hydrogenation of a 3,4-substituted quinolinium salt.

Ross A. Miller, J. McWilliams, V. Dragan, 2013, Organic letters.

(R)‐ and (S)‐2,2′‐Bis(bis(3,5‐dimethylphenyl)phosphanyl)‐1,1′‐binaphthalene

J. McWilliams, 2015 .

Enantioselective hydrogenation of an α-alkoxy substituted ketone with chiral ruthenium (phosphinoferrocenyl)oxazoline complexes

D. Tellers, Yong-kui Sun, J. McWilliams, 2006 .

Early chemical development at Legacy Wyeth Research.

J. McWilliams, Karen Sutherland, Michael K. O’Brien, 2011, Drug discovery today.

Highly diastereoselective heterogeneously catalyzed hydrogenation of enamines for the synthesis of chiral beta-amino acid derivatives.

E. Njolito, D. Tellers, J. Armstrong, 2004, Journal of the American Chemical Society.

Stereoelectronic Effect in Ligand Design: Enantioselective Rh-Catalyzed Hydrogenation of Alkyl Cyclic Tetrasubstituted Enamides and Concise Synthesis of (R)-Tofacitinib.

Jason Mustakis, J. McWilliams, Wenjun Tang, 2019, Angewandte Chemie.

Stereoelectronic Effects in Ligand Design: Enantioselective Rhodium‐Catalyzed Hydrogenation of Aliphatic Cyclic Tetrasubstituted Enamides and Concise Synthesis of ( R )‐Tofacitinib

Shu Yu, Jason Mustakis, J. McWilliams, 2019, Angewandte Chemie.

Highly regioselective Friedländer annulations with unmodified ketones employing novel amine catalysts: syntheses of 2-substituted quinolines, 1,8-naphthyridines, and related heterocycles.

R. Volante, P. Reider, Roger N. Farr, 2003, The Journal of organic chemistry.

Preparation of a clinically investigated ras farnesyl transferase inhibitor

R. Volante, P. Reider, R. Reamer, 2003 .

Development of a Nitrene-Type Rearrangement for the Commercial Route of the JAK1 Inhibitor Abrocitinib

Barbara J. Sitter, Brian P. Jones, Nga M. Do, 2020 .

Deprotection of N-Boc Groups under Continuous-Flow High-Temperature Conditions.

Shu Yu, J. McWilliams, P. Dorff, 2019, The Journal of organic chemistry.

The Evolving State of Continuous Processing in Pharmaceutical API Manufacturing: A Survey of Pharmaceutical Companies and Contract Manufacturing Organizations

Timothy M. Braden, Ayman D. Allian, S. May, 2018 .

Practical and Science-Based Strategy for Establishing Acceptable Intakes for Drug Product N-Nitrosamine Impurities

Krista L Dobo, A. Kalgutkar, Andrew Fleetwood, 2022, Chemical research in toxicology.

Early Process Development of an Irreversible Epidermal Growth Factor Receptor (EGFR) T790 M Inhibitor

Barbara J. Sitter, J. McWilliams, N. Keene, 2019, Organic Process Research & Development.

New Efficient Asymmetric Synthesis of Taranabant, a CB1R Inverse Agonist for the Treatment of Obesity

D. Zewge, Yong-kui Sun, Cheng-yi Chen, 2009 .

Enantioselective hydrogenation of N-H imines.

I. Davies, F. Gosselin, Xumu Zhang, 2009, Journal of the American Chemical Society.

Efficient synthesis of chiral phenethylamines : preparation, asymmetric hydrogenation, and mild deprotection of ene-trifluoroacetamides

J. McWilliams, Dale R. Mowrey, S. Allwein, 2006 .

Catalytic enantioselective hydrogenation of N-alkoxycarbonyl hydrazones: a practical synthesis of chiral hydrazines.

L. Tan, J. McWilliams, N. Yoshikawa, 2010, Organic letters.

Asymmetric synthesis of α-amino acid derivatives via an electrophilic amination of chiral amide cuprates with Li t-butyl-N-tosyloxycarbamate

J. Armstrong, R. Volante, J. McWilliams, 1997 .

An efficient catalyst for Pd-catalyzed carbonylation of aryl arenesulfonates.

Yong-kui Sun, J. McWilliams, J. Balsells, 2006, Organic letters.

Highly Regioselective Friedlaender Annulations with Unmodified Ketones Employing Novel Amine Catalysts: Syntheses of 2-Substituted Quinolines, 1,8-Naphthyridines, and Related Heterocycles.

R. Volante, P. Reider, Roger N. Farr, 2003 .

Optimizing an Asymmetric Homologation in a Tandem Asymmetric Homologation–Homoaldol Process

R. Reamer, J. McWilliams, 2007 .

Enantioselective nitrile anion cyclization to substituted pyrrolidines. A highly efficient synthesis of (3S,4R)-N-tert-butyl-4-arylpyrrolidine-3-carboxylic acid.

R. Reamer, John Y. L. Chung, J. McWilliams, 2005, The Journal of organic chemistry.

Catalytic enantioselective hydrogenation of N-alkoxycarbonyl hydrazones: a practical synthesis of chiral hydrazines.

L. Tan, J. McWilliams, N. Yoshikawa, 2010, Organic letters.

Mild preparation of allylic tartaramide acetals in DMF

G. Molander, J. McWilliams, 1996 .

Asymmetric Synthesis of α‐Amino Acid Derivatives via an Electrophilic Amination of Chiral Amide Cuprates with Li tert‐Butyl‐N‐ tosyloxycarbamate.

J. Armstrong, J. McWilliams, N. Zheng, 1997 .

Tandem asymmetric transformations: An asymmetric 1,2-migration from a higher order zincate coupled with a stereoselective homoaldol reaction

J. Armstrong, R. Volante, P. Reider, 1996 .

Continuous Production of Anhydrous tert-Butyl Hydroperoxide in Nonane Using Membrane Pervaporation and Its Application in Flow Oxidation of a γ-Butyrolactam

Shelly X. Li, Bryan M. Li, M. Johnson, 2018 .

Efficient synthesis of a trisubstituted 1,6-naphthyridone from acetonedicarboxylate and regioselective Suzuki arylation.

R. Reamer, John Y. L. Chung, J. McWilliams, 2005, The Journal of organic chemistry.

Predicting relative efficiency of amide bond formation using multivariate linear regression

A. Bahamonde, M. Sigman, J. McWilliams, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Thiol addition to aryl propargyl alcohols under mild conditions: an accelerating neighboring group effect

J. McWilliams, P. Maligres, M. Waters, 2000 .

Palladium-Catalyzed Synthesis of Aryl Sulfides from Aryl Triflates

R. Volante, J. McWilliams, N. Zheng, 1998 .

Applying Statistical Design of Experiments and Automation to the Rapid Optimization of Metal-Catalyzed Processes in Process Development

Yong-kui Sun, D. Mathre, David J. Mathre, 2005 .

Practical Considerations and Examples in Adapting Amidations to Continuous Flow Processing in Early Development

Bryan Li, Gerald A. Weisenburger, James Christopher McWilliams, 2020 .

Continuous flow aminolysis under high temperature and pressure

S. G. Ruggeri, David C. Limburg, J. McWilliams, 2020, Journal of Flow Chemistry.