H. Nukaya

发表

Self-assembled micellar formulation of chafuroside A with improved anti-inflammatory effects in experimental asthma/COPD-model rats.

S. Onoue, S. Yamada, Yosuke Aoki, 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Exposure to heterocyclic amines.

T. Sugimura, K. Wakabayashi, M. Nagao, 1993, Environmental health perspectives.

Adduct Formation at C‐8 of Guanine on in vitro Reaction f the Ultimate Form of 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine with 2′‐Deoxyguanosine and Its Phosphate Esters

T. Sugimura, K. Wakabayashi, M. Nagao, 1992, Japanese journal of cancer research : Gann.

Detection of 2‐Amino‐1‐methyl‐6‐(4‐hydroxyphenyl)imidazo[4,5‐b]pyridine in Broiled Beef

T. Sugimura, K. Wakabayashi, M. Nagao, 1992, Japanese journal of cancer research : Gann.

New 6-O-acyl isoflavone glycosides from soybeans fermented with Bacillus subtilis (natto). I. 6-O-succinylated isoflavone glycosides and their preventive effects on bone loss in ovariectomized rats fed a calcium-deficient diet.

T. Toda, H. Ishida, H. Nukaya, 1999, Biological & pharmaceutical bulletin.

Formation of cholesterol ozonolysis products in vitro and in vivo through a myeloperoxidase-dependent pathway

Susumu Tomono, N. Miyoshi, H. Ohshima, 2011, Journal of Lipid Research.

Isolation and identification of a new mutagen, 2-amino-4-hydroxy-methyl-3,8-dimethylimidazo[4,5-f]quinoxaline (4-CH2OH-8-MeIQx), from beef extract.

T. Sugimura, K. Wakabayashi, M. Takahashi, 1994, Carcinogenesis.

Structural determination of a new mutagenic heterocyclic amine, 2-amino-1,7,9-trimethylimidazo[4,5-g]quinoxaline (7,9-DiMeIgQx), present in beef extract.

T. Sugimura, K. Wakabayashi, Z. Yamaizumi, 1994, Carcinogenesis.

32P-Postlabeling analysis of a DNA adduct, an N2-acetyl derivative of guanine, formed in vitro by methylglyoxal and hydrogen peroxide in combination.

T. Sugimura, K. Wakabayashi, Y. Totsuka, 1996, Mutation research.

N-2 acetylation of 2'-deoxyguanosine by coffee mutagens, methylglyoxal and hydrogen peroxide.

T. Sugimura, M. Nagao, Y. Suwa, 1990, Mutation research.

Quantification of two aromatic amine mutagens, PBTA-1 and PBTA-2, in the yodo river system.

T. Sugimura, K. Wakabayashi, H. Nukaya, 1999, Environmental health perspectives.

Preventive effects of the plant isoflavones, daidzin and genistin, on bone loss in ovariectomized rats fed a calcium-deficient diet.

T. Toda, H. Ishida, H. Nukaya, 1998, Biological & pharmaceutical bulletin.

Identification of a 2-phenylbenzotriazole (PBTA)-type mutagen, PBTA-2, in water from the Nishitakase River in Kyoto.

T. Sugimura, K. Wakabayashi, J. Yamashita, 1998, Chemical research in toxicology.

Isolation and identification of a new 2-phenylbenzotriazole-type mutagen (PBTA-3) in the Nikko river in Aichi, Japan.

T. Sugimura, K. Wakabayashi, H. Nukaya, 2000, Chemical research in toxicology.

Isolation and chemical-structural determination of a novel aromatic amine mutagen in water from the Nishitakase River in Kyoto.

T. Sugimura, K. Wakabayashi, J. Yamashita, 1997, Chemical research in toxicology.

Identification of new mutagenic heterocyclic amines and quantification of known heterocyclic amines.

K. Wakabayashi, M. Takahashi, Z. Yamaizumi, 1995, Princess Takamatsu symposia.

First total synthesis of structurally unique flavonoids and their strong anti-inflammatory effect.

T. Nakatsuka, Y. Tomimori, H. Nukaya, 2004, Bioorganic & medicinal chemistry letters.

Genotoxicity of 2-[2-(acetylamino)-4-[bis(2-hydroxyethyl)amino]-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2H-benzotriazole (PBTA-6) and 4-amino-3,3'-dichloro-5,4'-dinitro-biphenyl (ADDB) in goldfish (Carassius auratus) using the micronucleus test and the comet assay.

K. Wakabayashi, N. Kinae, H. Nukaya, 2004, Mutation research.

Study of active substances involved in skin dysfunction induced by crowding stress. I. Effect of crowding and isolation on some physiological variables, skin function and skin blood perfusion in hairless mice.

H. Ishida, H. Nukaya, K. Mitsui, 2003, Biological & pharmaceutical bulletin.

Blue chitin columns for the extraction of heterocyclic amines from cooked meat.

K. Skog, H. Nukaya, J. Bång, 2002, Journal of chromatography. A.

Inhibition of intestinal carcinogenesis by a new flavone derivative, chafuroside, in oolong tea

T. Sugimura, K. Wakabayashi, N. Niho, 2006, Cancer science.

Isolation from beer and structural determination of a potent stimulant of gastrin release.

T. Amachi, Y. Suwa, H. Ishida, 1999, Alcohol and alcoholism.

Antagonistic effect of N-methyltyramine on alpha2-adrenoceptor in mice.

Y. Suwa, K. Kuriyama, H. Ishida, 1999, Japanese journal of pharmacology.

Chromosomal effects of newly identified water pollutants PBTA-1 and PBTA-2 and their possible mother compounds (azo dyes) and intermediates (non-ClPBTAs) in two Chinese hamster cell lines.

K. Wakabayashi, A. Onfelt, H. Nukaya, 2001, Mutation research.

Structure-activity relationship study on alpha1 adrenergic receptor antagonists from beer.

M. Nitta, M. Ishiguro, T. Kan, 2009, Bioorganic & medicinal chemistry letters.

Identification of N2-(deoxyguanosin-8-yl)-2-amino-3,8-dimethyl-imidazo[4,5- f]quinoxaline 3',5'-diphosphate, a major DNA adduct, detected by nuclease P1 modification of the 32P-postlabeling method, in the liver of rats fed MeIQx.

T. Sugimura, K. Wakabayashi, M. Nagao, 1993, Carcinogenesis.

Brevetoxin B1, a new polyether marine toxin from the New Zealand shellfish, Austrovenus stutchburyi

T. Yasumoto, A. Nozawa, K. Yamaguchi, 1995 .

Furan fatty acid as an anti-inflammatory component from the green-lipped mussel Perna canaliculus

I. Abe, T. Asakawa, T. Kan, 2011, Proceedings of the National Academy of Sciences.

Enantioselective total synthesis of aperidine.

T. Asakawa, T. Kan, T. Wakimoto, 2011, Organic letters.

Isolation of stimulants of gastrointestinal motility in beer.

K. Taniyama, Y. Suwa, H. Hori, 2004, Alcoholism, clinical and experimental research.

Inducing substance for abalone larval metamorphosis from the crustose coralline alga Hydrolithon samoense

R. Roberts, K. Suenaga, H. Ishida, 2004 .

Structural determination of two active compounds that bind to the muscarinic M3 receptor in beer.

T. Iwashita, T. Wakimoto, M. Koike, 2007, Alcoholism, clinical and experimental research.

Beer congener stimulates gastrointestinal motility via the muscarinic acetylcholine receptors.

K. Taniyama, Y. Suwa, H. Hori, 2002, Alcoholism, clinical and experimental research.

Studies on Antitussive Principles of Asiasari Radix

H. Nukaya, T. Kosuge, M. Yokota, 1978 .

Concise total synthesis of flavone C-glycoside having potent anti-inflammatory activity

Kiyoshi Tanaka, T. Wakimoto, H. Nukaya, 2004 .

Quantitation of chafurosides A and B in tea leaves and isolation of prechafurosides A and B from oolong tea leaves.

T. Miyase, T. Wakimoto, H. Ishida, 2009, Journal of agricultural and food chemistry.

Comparative concentrations of brevetoxins PbTx-2, PbTx-3, BTX-B1 and BTX-B5 in cockle, Austrovenus stutchburyi, greenshell mussel, Perna canaliculus, and Pacific oyster, Crassostrea gigas, involved neurotoxic shellfish poisoning in New Zealand.

A. Nozawa, H. Ishida, H. Nukaya, 2004, Toxicon : official journal of the International Society on Toxinology.

Cardiac glycosides: 5. Stereoselective syntheses of digitoxigenin α-D, β-D, α-L, and β-L-glucosides

H. Nukaya, D. S. Fullerton, H. Rathore, 1985 .

Study of the pharmacological effect of the bile salt, sodium scymnol sulfate, from Rhizoprionodon acutus. III. Protective effect of scymnol against vascular endothelial cell damage in a rat peripheral arterial occlusion model.

H. Nakayasu, H. Ishida, H. Nukaya, 1999, Biological & pharmaceutical bulletin.

Study of the pharmacological effect of the bile salt, sodium scymnol sulfate, from Rhizoprionodon acutus. II. Prophylactic effect of scymnol on lesion development in a rat peripheral arterial occlusion model.

H. Nakayasu, H. Ishida, H. Nukaya, 1998, Biological & pharmaceutical bulletin.

Study on the Bile Salt, Sodium Scymnol Sulfate, from Lamna ditropis. III. The Structures of a New Sodium Scymnol Sulfate and New Anhydroscymnols

H. Ishida, H. Nukaya, T. Kosuge, 1992 .

Study on the Bile Salt from Megamouth Shark. I. The Structures of a New Bile Alcohol, 7-Deoxyscymnol, and Its New Sodium Sulfates

H. Nakayasu, H. Ishida, H. Nukaya, 1996 .

Identification of 1,3,6-Trinitropyrene as a Major Mutagen in Organic Extracts of Surface Soil from Nagoya City, Japan

S. Yoshida, H. Nukaya, Kazuhiko Takahashi, 2006 .

The 2-phenylbenzotriazole-type water pollutant PBTA-2 has cytochalasin B-mimetic activity.

K. Wakabayashi, S. Tadokoro, H. Sakamoto, 2000, Mutation research.

Isolation and identification of a novel aromatic amine mutagen produced by the Maillard reaction.

K. Wakabayashi, Y. Totsuka, H. Nukaya, 2009, Chemical research in toxicology.

Concise synthesis of chafurosides A and B.

T. Kan, T. Wakimoto, H. Nukaya, 2009, Organic letters.

Isolation of inhibitors of TPA-induced mouse ear edema from Hoelen, Poria cocos.

H. Ishida, H. Nukaya, H. Fukazawa, 1996, Chemical & pharmaceutical bulletin.

Isolation and Identification of 5-Hydroxymaltol, a Mutagenic Substance in Glucose Pyrolysate

T. Sugimura, K. Wakabayashi, M. Nagao, 1983 .

Genotoxic activation of 2-phenylbenzotriazole-type compounds by human cytochrome P4501A1 and N-acetyltransferase expressed in Salmonella typhimurium umu strains.

Keiji Wakabayashi, Yoshiyasu Terao, Haruo Nukaya, 2008, Mutation research.

Inhibitory effects of whisky congeners on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice.

Y. Akao, Y. Nozawa, T. Itoh, 2010, Journal of agricultural and food chemistry.

Induction of SCEs in CHL cells by dichlorobiphenyl derivative water pollutants, 2-phenylbenzotriazole (PBTA) congeners and river water concentrates.

K. Wakabayashi, Y. Totsuka, H. Nukaya, 2009, Mutation research.

Identification of N-(deoxyguanosin-8-yl)-2-amino-3,4-dimethylimidazo[4,5-f]quinoline (dG-C8-MeIQ) as a major adduct formed by MeIQ with nucleotides in vitro with DNA in vivo.

T. Sugimura, K. Wakabayashi, M. Nagao, 1994, Carcinogenesis.

Mutation spectra in Salmonella TA98, TA100, and TA104 of two phenylbenzotriazole mutagens (PBTA-1 and PBTA-2) detected in the Nishitakase River in Kyoto, Japan.

D. DeMarini, S. Landi, K. Wakabayashi, 1999, Mutation research.

Identification of N-2- -2-amino-3,8-dimethylimidazo quinoxaline 3,5-diphosphate, a major DNA adduct, detected by nuclease P1 modification of the 32P-postlabeling method, in the liver of rats fed MeIQx

T. Sugimura, K. Wakabayashi, M. Nagao, 1993 .

Mutagenicity and Levels of 2-Phenylbenzotriazole (PBTA)-type Mutagens in Sewage Effluent, River Water, Sediment and Drinking Water Collected from the Yodo River System, Japan

K. Wakabayashi, H. Nukaya, Tetsushi Watanabe, 2006 .

Synthesis and mutagenicity of a new mutagen, 2-amino-1,7,9-trimethylimidazo[4,5-g]quinoxaline, and its analog.

H. Nukaya, T. Shiozawa, Y. Terao, 1994, Chemical & pharmaceutical bulletin.

Confirmation of brevetoxin metabolism in cockle, Austrovenus stutchburyi, and greenshell mussel, Perna canaliculus, associated with New Zealand neurotoxic shellfish poisoning, by controlled exposure to Karenia brevis culture.

P. McNabb, P. Holland, A. Nozawa, 2004, Toxicon : official journal of the International Society on Toxinology.

Whiskey congeners suppress LPS/IFNγ-induced NO production in murine macrophage RAW 264 cells by inducing heme oxygenase-1 expression.

T. Itoh, T. Wakimoto, M. Ando, 2012, Journal of agricultural and food chemistry.

Cytotoxicity of coffee in human intestinal cells in vitro and its inhibition by peroxidase.

Y. Suwa, S. Itagaki, H. Nukaya, 1992, Toxicology in vitro : an international journal published in association with BIBRA.

Mutagens in coffee and other beverages.

T. Sugimura, K. Wakabayashi, M. Nagao, 1986, Environmental health perspectives.

Identification of methylglyoxal as a major mutagen in wood and bamboo pyroligneous acids

H. Nukaya, M. Asanoma, Aya Onoda, 2016, Bioscience, biotechnology, and biochemistry.

The Steroidal Alkaloid Tomatidine and Tomatidine-Rich Tomato Leaf Extract Suppress the Human Gastric Cancer-Derived 85As2 Cells In Vitro and In Vivo via Modulation of Interferon-Stimulated Genes

K. Wakabayashi, Y. Kamei, S. Miura, 2022, Nutrients.

Simultaneous determination of 2-phenylbenzotriazole-type mutagens, PBTA-1 through -8, in river water by liquid chromatography-tandem mass spectrometry.

K. Wakabayashi, H. Harino, H. Moriwaki, 2004, Journal of environmental monitoring : JEM.

Chemical synthesis of a novel aromatic amine mutagen isolated from water of the Nishitakase River in Kyoto and a possible route of its formation.

T. Sugimura, K. Wakabayashi, H. Nukaya, 1998, Chemical research in toxicology.

Levels and behavior of 2-phenylbenzotoriazole-type mutagens in the effluent of a sewage treatment plant.

K. Wakabayashi, H. Nukaya, Tetsushi Watanabe, 2003, Mutation research.

Synthesis of 2-phenylbenzotriazole-type mutagens, PBTA-5 and PBTA-6, and their detection in river water from Japan.

T. Sugimura, K. Wakabayashi, T Sugimura, 2001, Mutation research.

Identification of 2-[2-(acetylamino)-4-amino-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2H-benzotriazole (PBTA-4) as a potent mutagen in river water in Kyoto and Aichi prefectures, Japan.

T. Sugimura, K. Wakabayashi, T Sugimura, 2001, Mutation research.

Mutagenic activity of 2-phenylbenzotriazole derivatives related to a mutagen, PBTA-1, in river water.

K. Wakabayashi, H. Nukaya, H. Sawanishi, 1999, Mutation research.

Mutagenicity of two 2-phenylbenzotriazole derivatives, 2-[2-(acetylamino)-4-(diethylamino)-5-methoxyphenyl]-5-amino- 7-bromo-4-chloro-2H-benzotriazole and 2-[2-(acetylamino)-4-(diallylamino)-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2H-benzotriazole and their detection in river water in Japan.

Yoshifumi Takahashi, Tomoyuki Takahashi, K. Wakabayashi, 2002, Mutagenesis.

Isolation and identification of non-chlorinated phenylbenzotriazole (non-ClPBTA)-type mutagens in the Ho River in Shizuoka Prefecture, Japan.

Hiroshi Ohba, Keiji Wakabayashi, Yoshiyasu Terao, 2006, Mutation research.

Genotoxic activity of 1-nitropyrene in water from the Yodo River, Japan.

T. Ohe, H. Nukaya, 1996, The Science of the total environment.

Mutagenicity of methylglyoxal in coffee.

T. Sugimura, M. Nagao, S. Nishimura, 1982, Gan.

Seasonal fluctuation of the mutagenicity of river water in Fukui, Japan, and the contribution of 2-phenylbenzotriazole-type mutagens.

Yoshifumi Takahashi, Tomoyuki Takahashi, K. Wakabayashi, 2002, Mutation research.

Identification of a new mutagenic polychlorinated biphenyl derivative in the Waka River, Wakayama, Japan, showing activation of an aryl hydrocarbon receptor-dependent transcription.

T. Sugimura, K. Wakabayashi, H. Nukaya, 2002, Chemical research in toxicology.

Study on neurotoxic shellfish poisoning involving the oyster, Crassostrea gigas, in New Zealand.

H. Ishida, H. Nukaya, T. Kosuge, 1996, Toxicon : official journal of the International Society on Toxinology.

Isolation and structure determination of a new marine neurotoxin from the New Zealand shellfish, Austrovenus stutchburyi.

H. Kaspar, A. Nozawa, H. Ishida, 1994, Toxicon : official journal of the International Society on Toxinology.

Study on the bile salt, sodium scymnol sulfate, from Rhizoprionodon acutus. II. The structures of scymnol, anhydroscymnol and sodium scymnol sulfate.

H. Ishida, H. Nukaya, T. Kosuge, 1991, Chemical & pharmaceutical bulletin.

Study on the bile salt, sodium scymnol sulfate, from Rhizoprionodon acutus. IV. Structures of chimaerol and sodium chimaerol sulfate in the bile of Lamna ditropis and Rhizoprionodon acutus.

H. Ishida, H. Nukaya, T. Kosuge, 1994, Chemical & pharmaceutical bulletin.

Exposure to heterocyclic amines.

T. Sugimura, K. Wakabayashi, M. Nagao, 1993, Environmental health perspectives.

Liver cancer and precancerous changes in rats induced by the basic fraction of tryptophan pyrolysate.

H. Ohgaki, K. Wakabayashi, H. Nukaya, 1981, Cancer letters.

Quantification of two aromatic amine mutagens, PBTA-1 and PBTA-2, in the yodo river system.

N. Bleehen, P. Workman, R. White, 1999, Environmental health perspectives.