T. Kiyota

发表

Importance of hydrophobic region in amphiphilic structures of alpha-helical peptides for their gene transfer-ability into cells.

T. Hirayama, T. Niidome, H. Aoyagi, 1998, Biochemical and biophysical research communications.

Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1).

G. Poda, C. Arrowsmith, M. Schapira, 2016, Journal of medicinal chemistry.

Automated molecular formula determination by tandem mass spectrometry (MS/MS).

Christophe Deprez, Cristina Draghici, Yasuo Konishi, 2009, The Analyst.

Nanotubules formed by highly hydrophobic amphiphilic alpha-helical peptides and natural phospholipids.

Tohru Inoue, Tohru Inoue, Sannamu Lee, 2003, Biophysical journal.

Morphological behavior of acidic and neutral liposomes induced by basic amphiphilic alpha-helical peptides with systematically varied hydrophobic-hydrophilic balance.

T. Inoue, S. Lee, T. Kiyota, 1999, Biophysical journal.

A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity

T. Ketela, K. Nouri, R. Al-awar, 2021, JCI insight.

Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma

A. Edwards, A. Bullock, R. Al-awar, 2020, Journal of medicinal chemistry.

Cabazitaxel-conjugated nanoparticles for docetaxel-resistant and bone metastatic prostate cancer.

Bryan Hoang, Shyh-Dar Li, M. J. Ernsting, 2017, Cancer letters.

Leveraging an Open Science Drug Discovery Model to Develop CNS Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma.

A. Edwards, S. Cramp, G. Poda, 2020, Journal of medicinal chemistry.

Roles of peptide-peptide charge interaction and lipid phase separation in helix-helix association in lipid bilayer.

Minenosuke Matsutani, Sannamu Lee, T. Kiyota, 2002, Biochimica et biophysica acta.

Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy.

P. Goodwin, V. Stambolic, R. Al-awar, 2016, Cell metabolism.

Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)

G. Poda, C. Arrowsmith, M. Schapira, 2021, bioRxiv.

Taxines from the needles of Taxus wallichiana.

Y. Konishi, P. Stefanowicz, J. Prasain, 2001, Phytochemistry.

Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma.

G. Poda, R. Al-awar, C. Strathdee, 2021, Journal of medicinal chemistry.

Leveraging Open Science Drug Development for PET: Preliminary Neuroimaging of 11C-Labeled ALK2 Inhibitors

N. Vasdev, D. Smil, A. Aman, 2021, ACS medicinal chemistry letters.

A mammalian genetic system to screen for small molecules capable of disrupting protein-protein interactions.

E. Purisima, Y. Konishi, D. Banville, 2004, Analytical chemistry.

Efficient purification of paclitaxel from yews using high-performance displacement chromatography technique.

Y. Konishi, Jin-Ming Gao, T. Kiyota, 2011, Journal of chromatography. A.

Picosecond Infrared Laser Mass Spectrometry Identifies a Metabolite Array for 10 s Diagnosis of Select Skin Cancer Types: A Proof-of-Concept Feasibility Study.

A. Zarrine-Afsar, B. Wilson, H. Berman, 2022, Analytical chemistry.

Drug evolution concept in drug design: 1. Hybridization method.

Y. Konishi, T. Kiyota, A. Kluczyk, 2004, Journal of medicinal chemistry.

Drug evolution: p-aminobenzoic acid as a building block.

Y. Konishi, P. Stefanowicz, T. Kiyota, 2002, Current medicinal chemistry.

One-step purification of palmatine and its derivative dl-tetrahydropalmatine from Enantia chlorantha using high-performance displacement chromatography.

Y. Konishi, Jin-Ming Gao, T. Kiyota, 2008, Journal of chromatography. A.

Structure-Activity Relationship of USP5 Inhibitors.

C. Arrowsmith, M. Schapira, R. Al-awar, 2021, Journal of medicinal chemistry.

Characterization of yeastolate fractions that promote insect cell growth and recombinant protein production

Amine Kamen, Yasuo Konishi, Y. Konishi, 2007, Cytotechnology.

Chemical genetics screen identifies COPB2 tool compounds that alters ER stress response and induces RTK dysregulation in lung cancer cells.

M. Tyers, G. Poda, V. Wong, 2021, Journal of molecular biology.

Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor.

G. Poda, K. Packman, G. Privé, 2023, ACS medicinal chemistry letters.

Picosecond Infrared Laser Desorption Mass Spectrometry Identifies Medulloblastoma Subgroups on Intrasurgical Timescales.

A. Zarrine-Afsar, J. Rutka, D. Munoz, 2019, Cancer research.

Design and synthesis of amphiphilic alpha-helical model peptides with systematically varied hydrophobic-hydrophilic balance and their interaction with lipid- and bio-membranes.

S. Lee, T. Kiyota, G. Sugihara, 1996, Biochemistry.

Rapid determination of medulloblastoma subgroup affiliation with mass spectrometry using a handheld picosecond infrared laser desorption probe† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc01974b Click here for additional data file.

Howard J. Ginsberg, A. Zarrine-Afsar, J. Rutka, 2017, Chemical science.

Mass Spectrometry Imaging Reveals a Gradient of Cancer-like Metabolic States in the Vicinity of Cancer Not Seen in Morphometric Margins from Microscopy.

A. Zarrine-Afsar, J. Rutka, C. McIntosh, 2021, Analytical chemistry.

Molecular formula analysis by an MS/MS/MS technique to expedite dereplication of natural products.

Cristina Draghici, Yasuo Konishi, E. Purisima, 2007, Analytical chemistry.

Structure Activity Relationship of USP5 Allosteric Inhibitors

C. Arrowsmith, M. Schapira, R. Al-awar, 2021, bioRxiv.

An Artificially Designed Pore-forming Protein with Anti-tumor Effects*

L. Ellerby, D. Bredesen, W. Arap, 2003, Journal of Biological Chemistry.

The Effect of D-Amino Acid-Containing Basic Peptides with Different Hydrophobicity on the Antimicrobial and Cytotoxic Activity

M. Oka, Sannamu Lee, T. Kiyota, 2000 .

De novo design, synthesis, and characterization of a pore-forming small globular protein and its insertion into lipid bilayers.

S. Lee, T. Kiyota, G. Sugihara, 1997, Biochemistry.

De Novo-designed Peptide Transforms Golgi-specific Lipids into Golgi-like Nanotubules*

D. Bredesen, Y. Niidome, N. Takami, 2001, The Journal of Biological Chemistry.

Study on the packing geometry, stoichiometry, and membrane interaction of three analogs related to a pore-forming small globular protein.

H. Sakamoto, S. Lee, Y. Aso, 2000, Biopolymers.

Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity.

Mojca Mattiazzi Usaj, Sheena C. Li, A. Gingras, 2023, Cell chemical biology.

N- and C-Terminal Effect of Amphiphilic α-Helical Peptides on the Interaction with Model- and Bio-Membranes

Sannamu Lee, T. Kiyota, G. Sugihara, 1998 .

A. Zarrine-Afsar, J. Rutka, Michael D. Taylor, 2017, Chemical science.

Efficient purification of paclitaxel from yews using high-performance displacement chromatography technique.

Y. Konishi, Jin-Ming Gao, T. Kiyota, 2011, Journal of chromatography. A.

Metabolic Lipids in Melanoma Enable Rapid Determination of Actionable BRAF-V600E Mutation with Picosecond Infrared Laser Mass Spectrometry in 10 s.

A. Zarrine-Afsar, H. Berman, Michael Woolman, 2023, Analytical chemistry.

A Workflow for Meaningful Interpretation of Classification Results from Handheld Ambient Mass Spectrometry Analysis Probes

A. Zarrine-Afsar, Michael Woolman, T. Kiyota, 2024, International journal of molecular sciences.