J. Eiki

发表

Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase.

Teruyuki Nishimura, K. Kamata, M. Mitsuya, 2004, Structure.

Effect of short‐term treatment with sitagliptin or glibenclamide on daily glucose fluctuation in drug‐naïve Japanese patients with type 2 diabetes mellitus

T. Kadowaki, R. Suzuki, T. Moritoyo, 2018, Diabetes, obesity & metabolism.

Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators.

K. Kamata, M. Mitsuya, T. Nishimura, 2009, Bioorganic & medicinal chemistry letters.

Discovery of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators.

M. Ishikawa, Y. Ogino, T. Nishimura, 2009, Bioorganic & medicinal chemistry letters.

Comorbidities and Complications in Japanese Patients with Type 2 Diabetes Mellitus: Retrospective Analyses of J-DREAMS, an Advanced Electronic Medical Records Database.

K. Ueki, M. Ohsugi, K. Iglay, 2021, Diabetes research and clinical practice.

Patient characteristics associated with improvement in glycemic control following addition of an oral antidiabetic drug to DPP-4 inhibitor monotherapy in Japanese patients with type 2 diabetes mellitus (JDDM 60)

H. Maegawa, K. Yamazaki, A. Kanatsuka, 2021, Diabetology International.

Interindividual Variations in Metabolism and Pharmacokinetics of 3-(6-Methylpyridine-3-yl-sulfanyl)-6-(4H-[1,2,4]triazole-3-yl-sulfanyl)-N-(1,3-thiazole-2-yl)-2-pyridine carboxamide, a Glucokinase Activator, in Rats Caused by the Genetic Polymorphism of CYP2D1

M. Chiba, J. Eiki, T. Hasegawa, 2014, Drug Metabolism and Disposition.

Pharmacokinetic and Pharmacodynamic Properties of the Glucokinase Activator MK-0941 in Rodent Models of Type 2 Diabetes and Healthy Dogs

J. Berger, A. Kadotani, K. Fujii, 2011, Molecular Pharmacology.

Factors associated with the glucose‐lowering efficacy of sitagliptin in Japanese patients with type 2 diabetes mellitus: Pooled analysis of Japanese clinical trials

N. Tajima, S. Engel, J. Eiki, 2019, Journal of diabetes investigation.

Impact of small-molecule glucokinase activator on glucose metabolism and beta-cell mass.

Y. Terauchi, T. Kadowaki, N. Kubota, 2009, Endocrinology.

Effect of long‐term treatment with a small‐molecule glucokinase activator on glucose metabolism, lipid profiles and hepatic function

Y. Terauchi, A. Nakamura, J. Eiki, 2011, Journal of diabetes investigation.

Effects of celiac superior mesenteric ganglionectomy on glucose homeostasis and hormonal changes during oral glucose tolerance testing in rats.

M. Odawara, M. Kikuchi, Atsushi Kumakura, 2013, Endocrine journal.

Chronic treatment with a glucokinase activator delays the onset of hyperglycaemia and preserves beta cell mass in the Zucker diabetic fatty rat

M. Erion, J. Woods, E. Zycband, 2012, Diabetologia.

An Allosteric Activator of Glucokinase Impairs the Interaction of Glucokinase and Glucokinase Regulatory Protein and Regulates Glucose Metabolism*

A. Kadotani, T. Nishimura, J. Eiki, 2006, Journal of Biological Chemistry.

Structure-activity relationships of 3,5-disubstituted benzamides as glucokinase activators with potent in vivo efficacy.

N. Hashimoto, M. Chiba, T. Nishimura, 2009, Bioorganic & medicinal chemistry.

Ventromedial Hypothalamic Glucokinase Is an Important Mediator of the Counterregulatory Response to Insulin-Induced Hypoglycemia

T. Becker, B. Levin, J. Eiki, 2008, Diabetes.

Metabolic impact of overexpression of liver glycogen synthase with serine-to-alanine substitutions in rat primary hepatocytes.

A. Kadotani, Takao Nakamura, A. Kanatani, 2007, Archives of biochemistry and biophysics.

Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators.

K. Kamata, M. Mitsuya, T. Nishimura, 2009, Bioorganic & medicinal chemistry letters.

Dynamics of plasma active GLP-1 versus insulin and glucose concentrations during GLP-1 infusion in rat model of postprandial hyperglycemia.

T. Yada, J. Eiki, 2011, Endocrine journal.

A selective small molecule glucagon-like peptide-1 secretagogue acting via depolarization-coupled Ca(2+) influx.

T. Yada, S. Ito, A. Kanatani, 2009, Journal of Endocrinology.

Metabolic activation of N-thiazol-2-yl benzamide as glucokinase activators: Impacts of glutathione trapping on covalent binding.

N. Hashimoto, M. Chiba, T. Nishimura, 2010, Bioorganic & medicinal chemistry letters.

Discovery of potent and orally active 3-alkoxy-5-phenoxy-N-thiazolyl benzamides as novel allosteric glucokinase activators.

M. Chiba, K. Kamata, T. Nishimura, 2009, Bioorganic & medicinal chemistry.

Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing.

V. Routh, L. Gaspers, B. Levin, 2006, Diabetes.

Relationship among Brain and Blood Glucose Levels and Spontaneous and Glucoprivic Feeding

T. Becker, N. Sanders, B. Levin, 2009, The Journal of Neuroscience.

The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators.

N. Hashimoto, K. Kamata, T. Nishimura, 2009, Bioorganic & medicinal chemistry.

Discovery and structure-activity relationships of a novel class of quinazoline glucokinase activators.

M. Chiba, K. Kamata, M. Mitsuya, 2009, Bioorganic & medicinal chemistry letters.

Treatment patterns and satisfaction in patients with type 2 diabetes newly initiating oral monotherapy with antidiabetic drugs in Japan: results from the prospective Real-world Observational Study on Patient Outcomes in Diabetes (RESPOND)

I. Shimomura, T. Kadowaki, H. Watada, 2022, BMJ Open Diabetes Research & Care.

A small-molecule glucokinase activator lowers blood glucose in the sulfonylurea-desensitized rat.

Yun-ping Zhou, Bei B. Zhang, Hiroki Takano, 2010, European journal of pharmacology.

Correction: Treatment patterns and satisfaction in patients with type 2 diabetes newly initiating oral monotherapy with antidiabetic drugs in Japan: results from the prospective Real-world Observational Study on Patient Outcomes in Diabetes (RESPOND)

I. Shimomura, T. Kadowaki, H. Watada, 2022, BMJ Open Diabetes Research & Care.