K. Embrey

发表

KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe

P. Kolasinska-Zwierz, J. Breed, J. Debreczeni, 2019, Nature Communications.

Pyrrolamide DNA Gyrase Inhibitors: Fragment-Based Nuclear Magnetic Resonance Screening To Identify Antibacterial Agents

Ning Gao, Haihong Ni, Oluyinka Green, 2011, Antimicrobial Agents and Chemotherapy.

Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation.

Malcolm Anderson, Jason G Kettle, Alexander L Breeze, 2015, Journal of medicinal chemistry.

Mapping Hidden Residual Structure within the Myc bHLH-LZ Domain Using Chemical Denaturant Titration.

M. Blackledge, J. Nissink, M. R. Jensen, 2019, Structure.

Variable‐temperature and pH studies of a DNA minor groove binder, Hoechst 32985, by 1H NMR spectroscopy

D. Craik, K. Cross, M. Coles, 1994 .

Use of transferred nuclear-Overhauser-effect spectroscopy to measure the bound conformation of a disulphide-replaced analogue of glutathione disulphide as an inhibitor of yeast glutathione reductase.

K. Douglas, K. Embrey, J. McKie, 1994, European journal of biochemistry.

MTH1 Substrate Recognition—An Example of Specific Promiscuity

J. Breed, J. Nissink, Michal Bista, 2016, PloS one.

Structural Basis for Targeting the Folded P-Loop Conformation of c-MET

C. Stubbs, I. Dale, U. Börjesson, 2020, ACS medicinal chemistry letters.

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

T. Mustelin, C. Brightling, N. Bond, 2015, Nature Communications.

Bromodomain Interactions with Acetylated Histone 4 Peptides in the BRD4 Tandem Domain: Effects on Domain Dynamics and Internal Flexibility

M. Akke, G. Holdgate, K. Embrey, 2022, Biochemistry.

Structure guided lead generation for M. tuberculosis thymidylate kinase (Mtb TMK): discovery of 3-cyanopyridone and 1,6-naphthyridin-2-one as potent inhibitors.

S. Prasad, J. Tucker, A. Gill, 2015, Journal of medicinal chemistry.

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

J. A. Hendricks, David M. Wilson, S. Kazmirski, 2018, Nature Communications.

Rational inhibitor design, synthesis and NMR spectroscopic study by transferred nuclear overhauser spectroscopy of novel inhibitors of cinnamyl alcohol dehydrogenase, a critical enzyme in lignification.

J. Grima-Pettenati, K. Douglas, K. Embrey, 1999, Journal of enzyme inhibition.

ENHANCED BINDING OF A HEXACYCLIC AMIDINE ANALOGUE OF HOECHST 33258 TO THE MINOR GROOVE OF DNA : 1H NMR AND UV MELTING STUDIES WITH THE DECAMER DUPLEX D(GGTAATTACC)2

M. Searle, K. Embrey, C. Bostock-Smith, 1997 .

Sequence-specific interaction of Hoechst 33258 with the minor groove of an adenine-tract DNA duplex studied in solution by 1H NMR spectroscopy

M. S. Searle, K. J. Embrey, M. Searle, 1990, Nucleic Acids Res..

Interaction of Hoechst 33258 with the minor groove of the A + T-rich DNA duplex d(GGTAATTACC)2 studied in solution by NMR spectroscopy.

D. Craik, M. Searle, K. Embrey, 1993, European journal of biochemistry.

1H, 13C and 15N resonance assignment for the human K-Ras at physiological pH

A. Breeze, A. Golovanov, K. Embrey, 2012, Biomolecular NMR Assignments.

Structure-based design of protein tyrosine phosphatase-1B inhibitors.

Jon Read, Alexander L Breeze, A. Breeze, 2005, Bioorganic & medicinal chemistry letters.

Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase.

Jon Read, Alexander L Breeze, Richard A Norman, 2005, Biochemistry.

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.

Fiona Pachl, A. Pike, M. O’Connor, 2021, Journal of medicinal chemistry.

Stability and solubility engineering of the EphB4 tyrosine kinase catalytic domain using a rationally designed synthetic library.

M. McAlister, R. Overman, K. Embrey, 2013, Protein engineering, design & selection : PEDS.

Biophysical methods in early drug discovery

G. Holdgate, K. Embrey, Gareth Davies, 2019, ADMET & DMPK.

Dynamic studies of H-Ras•GTPγS interactions with nucleotide exchange factor Sos reveal a transient ternary complex formation in solution

A. Golovanov, N. Vajpai, K. Embrey, 2016, Scientific Reports.

From fragments to leads: novel bacterial NAD+-dependent DNA ligase inhibitors

Matthew D. Miller, C. Eyermann, L. Otterbein, 2015 .

Segmental Isotope Labelling of an Individual Bromodomain of a Tandem Domain BRD4 Using Sortase A

K. Embrey, A. Milbradt, R. Bobby, 2016, PloS one.

Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence*

A. Breeze, A. Golovanov, N. Vajpai, 2015, The Journal of Biological Chemistry.

1H, 13C and 15N resonance assignment for the human K-Ras at physiological pH

A. Breeze, A. Golovanov, K. Embrey, 2013, Biomolecular NMR assignments.

Myc phosphorylation in its basic helix–loop–helix region destabilizes transient α-helical structures, disrupting Max and DNA binding

J. Nissink, J. Waltho, M. Cliff, 2018, The Journal of Biological Chemistry.

Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition

J. Pascal, Ji-Chun Yang, D. Neuhaus, 2020, bioRxiv.

Structural Basis for Targeting the Folded P-Loop Conformation of c-MET

C. Stubbs, I. Dale, U. Börjesson, 2020, ACS medicinal chemistry letters.

KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe

P. Kolasinska-Zwierz, J. Breed, J. Debreczeni, 2019, Nature Communications.

A study of the binding requirements of calyculin A and dephosphonocalyculin A with PP1, development of a molecular recognition model for the binding interactions of the okadaic acid class of compounds with PP1.

R. Quinn, G. Pierens, K. Embrey, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Probing the interaction of Hoechst 33258 with an A–T rich oligonucleotide duplex using 1H NMR spectroscopy

D. Craik, M. Searle, K. Embrey, 1991 .

Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor

E. Hennessy, T. Moss, C. Stubbs, 2023, Journal of medicinal chemistry.

A homology model of the three-dimensional structure of human O6-alkylguanine-DNA alkyltransferase based on the crystal structure of the C-terminal domain of the Ada protein from Escherichia coli.

D. Marks, J. Wibley, K. Douglas, 1995, Anti-cancer drug design.

Design of rigid protein–protein interaction inhibitors enables targeting of undruggable Mcl-1

D. Hargreaves, E. Chiarparin, S. Degorce, 2023, Proceedings of the National Academy of Sciences of the United States of America.