Henar Vázquez-Villa

发表

Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.

L. Pardo, J. Jiménez-Barbero, F. Mollinedo, 2017, Chemistry.

The reaction of o-alkynylarene and heteroarene carboxaldehyde derivatives with iodonium ions and nucleophiles: a versatile and regioselective synthesis of 1H-isochromene, naphthalene, indole, benzofuran, and benzothiophene compounds.

Henar Vázquez-Villa, A. Ballesteros, José M. González, 2006, Chemistry.

New inhibitors of angiogenesis with antitumor activity in vivo.

M. López-Rodríguez, S. Ortega‐Gutiérrez, E. Pérez-Gómez, 2015, Journal of medicinal chemistry.

Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery

M. Artola, M. López-Rodríguez, C. Fernández‐Tornero, 2021, Journal of medicinal chemistry.

A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways

C. Guaza, S. Ortega‐Gutiérrez, E. Molina-Holgado, 2015, Journal of Neuroimmune Pharmacology.

The Search for Antibacterial Inhibitors Targeting Cell Division Protein FtsZ at Its Nucleotide and Allosteric Binding Sites

S. Huecas, J. Andreu, Henar Vázquez-Villa, 2022, Biomedicines.

New Trends in Aging Drug Discovery

M. López-Rodríguez, S. Ortega‐Gutiérrez, B. Benhamú, 2022, Biomedicines.

A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity.

J. Ballesteros, M. Loza, J. Brea, 2017, Journal of medicinal chemistry.

Progress toward allosteric ligands of metabotropic glutamate 7 (mGlu7) receptor: 2008-present.

A. A. Trabanco, Henar Vázquez-Villa, A. Trabanco, 2019, MedChemComm.

Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for “Diabesity”

J. Ballesteros, M. Loza, J. Brea, 2022, Journal of medicinal chemistry.

The status of the lysophosphatidic acid receptor type 1 (LPA1R)

M. López-Rodríguez, S. Ortega‐Gutiérrez, Henar Vázquez-Villa, 2015 .

2-(Fluoromethoxy)-4′-(S-methanesulfonimidoyl)-1,1′-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D1 Receptor for Parkinson’s Disease

J. Ballesteros, M. Loza, J. Brea, 2022, Journal of medicinal chemistry.

Novel Antagonist of the Type 2 Lysophosphatidic Acid Receptor (LPA2), UCM-14216, Ameliorates Spinal Cord Injury in Mice

Manisha Ray, M. López-Rodríguez, S. Ortega‐Gutiérrez, 2022, Journal of medicinal chemistry.

Regioselective synthesis of substituted naphthalenes: a novel de novo approach based on a metal-free protocol for stepwise cycloaddition of o-alkynylbenzaldehyde derivatives with either alkynes or alkenes.

Henar Vázquez-Villa, A. Ballesteros, J. Barluenga, 2003, Organic letters.

Cyclization of carbonyl groups onto alkynes upon reaction with IPy2BF4 and their trapping with nucleophiles: a versatile trigger for assembling oxygen heterocycles.

Henar Vázquez-Villa, A. Ballesteros, J. Barluenga, 2003, Journal of the American Chemical Society.

Henar Vázquez-Villa, A. Ballesteros, J. Barluenga, 2003, Organic letters.

Copper(II) tetrafluoroborate catalyzed ring-opening reaction of epoxides with alcohols at room temperature.

Henar Vázquez-Villa, A. Ballesteros, J. Barluenga, 2002, Organic letters.

Iridium diamine catalyst for the asymmetric transfer hydrogenation of ketones.

E. Carreira, S. Reber, Henar Vázquez-Villa, 2011, Angewandte Chemie.

Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.

Leonardo Pardo, Bellinda Benhamú, L. Pardo, 2014, Journal of medicinal chemistry.

Transfer Hydrogenation in Water: Enantioselective, Catalytic Reduction of α-Cyano and α-Nitro Substituted Acetophenones.

E. Carreira, O. Soltani, Henar Vázquez-Villa, 2010 .

Transfer hydrogenation in water: enantioselective, catalytic reduction of alpha-cyano and alpha-nitro substituted acetophenones.

E. Carreira, O. Soltani, Henar Vázquez-Villa, 2010, Organic letters.

Synthesis of Indoles upon Sequential Reaction of 3‐Alkynylpyrrole‐2‐carboxaldehydes with Iodonium Ions and Alkenes. Preparation of Related Benzofuran and Benzothiophene Derivatives

Henar Vázquez-Villa, A. Ballesteros, J. Barluenga, 2005 .

Iridium diamine catalyst for the asymmetric transfer hydrogenation of ketones.

E. Carreira, S. Reber, Henar Vázquez-Villa, 2011, Angewandte Chemie.

Effective GTP-replacing FtsZ inhibitors and antibacterial mechanism of action.

P. Chacón, M. Artola, S. Sieber, 2015, ACS chemical biology.

Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer.

W. Klapper, M. Artola, J. Flores, 2015, Journal of the National Cancer Institute.

The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system.

F. Guimarães, I. Galve-Roperh, M. Guzmán, 2013, The international journal of neuropsychopharmacology.

A novel agonist of the type 1 lysophosphatidic acid receptor (LPA1), UCM-05194, shows efficacy in neuropathic pain amelioration.

J. Chun, A. Ferrer-Montiel, R. Rivera, 2019, Journal of medicinal chemistry.

New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.

L. Pardo, A. Planas, J. Ramos, 2011, Journal of medicinal chemistry.

C. Guaza, S. Ortega‐Gutiérrez, E. Molina-Holgado, 2015, Journal of Neuroimmune Pharmacology.

The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo.

Gianluigi Caltabiano, Leonardo Pardo, Bellinda Benhamú, 2014, Journal of medicinal chemistry.

Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ.

P. Chacón, M. Artola, I. Barasoain, 2013, ACS chemical biology.

Allosteric modulators targeting GPCRs

M. López-Rodríguez, B. Benhamú, Henar Vázquez-Villa, 2020 .

Development of molecular probes for the human 5-HT(6) receptor.

J. A. González-Vera, E. Junquera, E. Aicart, 2010, Journal of medicinal chemistry.

Development of Fluorescent Ligands for the Human 5-HT1A Receptor.

E. Junquera, E. Aicart, M. López-Rodríguez, 2010, ACS medicinal chemistry letters.

Chemoproteomic Approach to Explore the Target Profile of GPCR ligands: Application to 5-HT1A and 5-HT6 Receptors.

J. A. González-Vera, J. López, Ainoa Rueda-Zubiaurre, 2016, Chemistry.

Cannabinoid receptor CB 2 drives HER 2 pro-oncogenic signaling in breast cancer

W. Klapper, M. Artola, J. Flores, 2015 .

Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.

L. Pardo, M. López-Rodríguez, B. Benhamú, 2014, Journal of medicinal chemistry.

A new serotonin 5-HT6 receptor antagonist with procognitive activity – Importance of a halogen bond interaction to stabilize the binding

L. Pardo, J. A. González-Vera, M. López-Rodríguez, 2017, Scientific Reports.

Chemoproteomic Approach to Explore the Target Profile of GPCR ligands: Application to 5-HT1A and 5-HT6 Receptors.

J. A. González-Vera, J. López, Ainoa Rueda-Zubiaurre, 2016, Chemistry.

The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo.

J. C. Gómez-Tamayo, L. Pardo, M. López-Rodríguez, 2014, Journal of medicinal chemistry.

New serotonin 5-HT1A receptor agonists endowed with antinociceptive activity in vivo.

J. Ramos, M. López-Rodríguez, B. Benhamú, 2013, Journal of medicinal chemistry.

Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ.

P. Chacón, M. Artola, I. Barasoain, 2013, ACS chemical biology.

Cancer-Stem-Cell Phenotype-Guided Discovery of a Microbiota-Inspired Synthetic Compound Targeting NPM1 for Leukemia

M. López-Rodríguez, B. Benhamú, Henar Vázquez-Villa, 2024, JACS Au.

The structural assembly switch of cell division protein FtsZ probed with fluorescent allosteric inhibitors

M. López-Rodríguez, E. Ramírez-Aportela, S. Huecas, 2016, Chemical science.