B. Szczepankiewicz

发表

Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy.

Gang Liu, P. Hajduk, S. Fesik, 2003, Journal of the American Chemical Society.

Synthesis of purines and other fused imidazoles from acyclic amidines and guanidines.

B. Szczepankiewicz, J. Rohde, R. Kurukulasuriya, 2005, Organic letters.

Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.

Chaohong Sun, E. Olejniczak, Eric F. Johnson, 2006, Journal of medicinal chemistry.

Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.

Eric F. Johnson, C. Abad-Zapatero, H. Sham, 2006, Journal of medicinal chemistry.

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

F. Jiang, Beth L. Pietrak, T. Riera, 2014, Nature Communications.

The effects of diminishing albumin binding to some Endothelin receptor antagonists.

K. Marsh, J. R. Wu-wong, W. Chiou, 1998, Life sciences.

Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: targeting the gatekeeper residue and beyond.

H. Sham, R. Gum, D. Haasch, 2006, Bioorganic & medicinal chemistry letters.

Optimization of 2,4-diaminopyrimidines as GHS-R antagonists: side chain exploration.

H. Sham, C. Collins, Gang Liu, 2006, Bioorganic & medicinal chemistry letters.

Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors.

K. Longenecker, H. Sham, K. Stewart, 2006, Bioorganic & medicinal chemistry letters.

Discovery and pharmacological evaluation of growth hormone secretagogue receptor antagonists.

E. Bush, H. Sham, D. Beno, 2006, Journal of medicinal chemistry.

2,4-diaminopyrimidine derivatives as potent growth hormone secretagogue receptor antagonists.

E. Bush, H. Sham, D. Beno, 2006, Journal of medicinal chemistry.

Structure-activity relationship studies on tetralin carboxamide growth hormone secretagogue receptor antagonists.

Jyoti R. Patel, H. Sham, C. Collins, 2005, Bioorganic & medicinal chemistry letters.

Potential drug targets and progress towards pharmacologic inhibition of hepatic glucose production.

A. Souers, S. Richards, B. Szczepankiewicz, 2003, Current medicinal chemistry.

Prospects for pharmacologic inhibition of hepatic glucose production.

A. Souers, S. Richards, B. Szczepankiewicz, 2003, Current medicinal chemistry.

Pharmacology of A-216546: a highly selective antagonist for endothelin ET(A) receptor.

K. Marsh, J. Wu-Wong, B. Dayton, 1999, European journal of pharmacology.

Aromatic heterocycle-based DPP-IV inhibitors: xanthines and related structural types.

B. Szczepankiewicz, R. Kurukulasuriya, 2007, Current topics in medicinal chemistry.

A novel method for suppression of the abnormal Fischer indole synthesis

C. Heathcock, B. Szczepankiewicz, 1997 .

New antimitotic agents with activity in multi-drug-resistant cell lines and in vivo efficacy in murine tumor models.

S. Rosenberg, S. L. Gwaltney, R. B. Credo, 2001, Journal of medicinal chemistry.

Synthesis of purines and other fused imidazoles from acyclic amidines and guanidines.

B. Szczepankiewicz, J. Rohde, R. Kurukulasuriya, 2005, Organic letters.

Total Synthesis of Diplamine, a Cytotoxic Pyridoacridine Alkaloid from a Pacific Tunicate

C. Heathcock, B. Szczepankiewicz, 1994 .

Synthesis of carba-NAD and the structures of its ternary complexes with SIRT3 and SIRT5.

F. Jiang, C. Mao, R. Perni, 2012, The Journal of organic chemistry.

Electrochemical Properties of Some Biologically Active Quinone Derivatives: Furanquinones, Pyridoquinones, and Diplamine, a Cytotoxic Pyridoacridine Alkaloid

K. Lawson, J. Gross, Danni Liu, 1997 .

Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors.

H. Sham, T. Surowy, C. Collins, 2008, Bioorganic & medicinal chemistry letters.

Inhibition of protein tyrosine phosphatase 1B as a potential treatment of diabetes and obesity.

Gang Liu, Gang Liu, T. Lubben, 2004, Current pharmaceutical design.

Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.

Gang Liu, Cristina M Rondinone, P. Hajduk, 2003, Journal of medicinal chemistry.

Potent, selective inhibitors of protein tyrosine phosphatase 1B.

Gang Liu, P. Hajduk, C. Abad-Zapatero, 2003, Bioorganic & medicinal chemistry letters.

Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B.

Gang Liu, P. Hajduk, S. Fesik, 2003, Journal of medicinal chemistry.

Potent and selective non-cysteine-containing inhibitors of protein farnesyltransferase.

S. Ng, D. Augeri, S. Rosenberg, 1998, Journal of medicinal chemistry.

Inhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages.

Gang Liu, Lydia Tabernero, Debbie C. Mulhearn, 2009, The Journal of antimicrobial chemotherapy.

Pyrrolidine-3-carboxylic acids as endothelin antagonists. 4. Side chain conformational restriction leads to ET(B) selectivity.

A. Tasker, K. Marsh, M. Winn, 1999, Journal of Medicinal Chemistry.

SIRT1 Activation by Small Molecules

David P. Carney, T. Riera, B. Hubbard, 2010, The Journal of Biological Chemistry.

Frontiers in Medicinal Chemistry

S. A. Hutchinson, H. Wolfson, R. Nussinov, 2016 .

Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors.

P. Hajduk, C. Abad-Zapatero, C. Rondinone, 2004, Bioorganic & medicinal chemistry letters.

Identification of a monoacid-based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B.

P. Hajduk, C. Abad-Zapatero, Xiaofen Li, 2003, Bioorganic & medicinal chemistry letters.

One-step, nonenzymatic synthesis of O-acetyl-ADP-ribose and analogues from NAD and carboxylates.

R. Perni, B. Szczepankiewicz, Karsten Koppetsch, 2011, The Journal of organic chemistry.

Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B.

P. Hajduk, S. Fesik, C. Abad-Zapatero, 2003, Journal of medicinal chemistry.