S. Ballaron

发表

Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy.

Gang Liu, P. Hajduk, S. Fesik, 2003, Journal of the American Chemical Society.

Potent Inhibition of NFAT Activation and T Cell Cytokine Production by Novel Low Molecular Weight Pyrazole Compounds*

Julie A. Wilkins, U. Warrior, Yung-wu Chen, 2001, The Journal of Biological Chemistry.

Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit.

G. L. Hamilton, K. Longenecker, H. Sham, 2007, Bioorganic & medicinal chemistry letters.

3,5-Bis(trifluoromethyl)pyrazoles: a novel class of NFAT transcription factor regulator.

Xiaoping Zhou, U. Warrior, C. Wegner, 2000, Journal of medicinal chemistry.

Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors.

K. Longenecker, H. Sham, K. Stewart, 2006, Bioorganic & medicinal chemistry letters.

Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin‐mediated angioedema

J. Segreti, R. Fryer, J. Trevillyan, 2008, British journal of pharmacology.

Inhibition of p56lckTyrosine Kinase by Isothiazolones

U. Warrior, Yung-wu Chen, P. Wiedeman, 1999 .

The mouse ear inflammatory response to topical arachidonic acid.

D. A. Spires, J. Young, C. J. Bedord, 1984, The Journal of investigative dermatology.

Antifungal rapamycin analogues with reduced immunosuppressive activity.

H. Ding, J. Trevillyan, A. Sarthy, 2000, Bioorganic & medicinal chemistry letters.

AAV2/6 Gene Therapy in a Murine Model of Fabry Disease Results in Supraphysiological Enzyme Activity and Effective Substrate Reduction

S. S. St Martin, R. Desnick, M. Holmes, 2020, Molecular therapy. Methods & clinical development.

Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.

K. Longenecker, J. Segreti, H. Sham, 2006, Journal of medicinal chemistry.

TH1 and TH2 cytokine inhibition by 3,5-bis(trifluoromethyl)pyrazoles, a novel class of immunomodulators.

Julie A. Wilkins, U. Warrior, M. Nakane, 2002, Cellular immunology.

Acne-like chronic inflammatory activity of Propionibacterium acnes preparations in an animal model: correlation with ability to stimulate the reticuloendothelial system.

J. Young, A. Allison, C. Cummins, 1985, The Journal of investigative dermatology.

Intradermal injection of Propionibacterium acnes: a model of inflammation relevant to acne.

J. Young, S. Ballaron, S. M. Puhvel, 1984, The Journal of investigative dermatology.

Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors.

K. Longenecker, H. Sham, Xiaofen Li, 2007, Journal of medicinal chemistry.

Transglutaminase activity in human and rabbit ear comedogenesis: a histochemical study.

S. Ballaron, W. Epstein, L. D. De Young, 1984, The Journal of investigative dermatology.

Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separate and can be differentially modulated by pharmacologic agents

J. Young, S. Ballaron, L. Young, 1989, Agents and Actions.

Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.

Gang Liu, Cristina M Rondinone, P. Hajduk, 2003, Journal of medicinal chemistry.

Potent, selective inhibitors of protein tyrosine phosphatase 1B.

Gang Liu, P. Hajduk, C. Abad-Zapatero, 2003, Bioorganic & medicinal chemistry letters.

Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

K. Longenecker, H. Sham, R. Fryer, 2006, Journal of medicinal chemistry.

Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B.

Gang Liu, P. Hajduk, S. Fesik, 2003, Journal of medicinal chemistry.

Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors.

Vincent S Stoll, K. Longenecker, V. Stoll, 2006, Biochemistry.

Inhibition of human epidermal transglutaminases in vitro and in vivo by tyrosinamidomethyl dihydrohaloisoxazoles.

L. Goldsmith, W. Akers, S. Ballaron, 1991, The Journal of investigative dermatology.

Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.

Gang Liu, Hongyu Zhao, Cristina M Rondinone, 2003, Journal of medicinal chemistry.

Leflunomide interferes with pyrimidine nucleotide biosynthesis

H. Cherwinski, J. Young, J. Ransom, 1995, Inflammation Research.

The effect of topical drugs on mouse ear epidermal transglutaminase activity.

S. Ballaron, L. D. De Young, 1982, The Journal of investigative dermatology.

Zotarolimus, a Novel Sirolimus Analogue With Potent Anti-proliferative Activity on Coronary Smooth Muscle Cells and Reduced Potential for Systemic Immunosuppression

Yung-wu Chen, J. Trevillyan, G. Carter, 2007, Journal of cardiovascular pharmacology.

Inhibition of p56(lck) tyrosine kinase by isothiazolones.

U. Warrior, P. Wiedeman, J. Trevillyan, 1999, Archives of biochemistry and biophysics.

Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions

D. Agard, E. Masliah, G. Tóth, 2019, Scientific Reports.

Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors.

P. Hajduk, C. Abad-Zapatero, C. Rondinone, 2004, Bioorganic & medicinal chemistry letters.

Identification of a monoacid-based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B.

P. Hajduk, C. Abad-Zapatero, Xiaofen Li, 2003, Bioorganic & Medicinal Chemistry Letters.

Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.

Gang Liu, C. Abad-Zapatero, Xiaofen Li, 2003, Bioorganic & medicinal chemistry letters.

Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.

H. Sham, Xiaofen Li, D. Beno, 2006, Journal of Medicinal Chemistry.

Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B.

P. Hajduk, S. Fesik, C. Abad-Zapatero, 2003, Journal of medicinal chemistry.