S. Stokes

发表

Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design

M. Drysdale, N. Foloppe, P. Webb, 2015, Oncotarget.

Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.

Rhys D O Jones, S. Guichard, W. Shao, 2018, Journal of medicinal chemistry.

An efficient one-pot synthesis of 2-bromo-6-aryl[5H]pyrrolo[2,3-b]pyrazines

Rafal P. Wiewiora, D. Whittaker, S. St-Gallay, 2015 .

Discovery of a series of 2-(pyridinyl)pyrimidines as potent antagonists of GPR40

M. Waring, P. Macfaul, D. Baker, 2015 .

Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153).

C. A. Roberts, A. Rabow, M. Waring, 2016, Journal of medicinal chemistry.

Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4.

L. Drew, R. Anjum, Yafeng Xue, 2018, Bioorganic & medicinal chemistry.

Synthesis of ynone trifluoroborates toward functionalized pyrazoles.

J. P. Harrity, J. Kirkham, S. Stokes, 2012, Organic letters.

An efficient route to the α-methyl ester of L-glutamic acid, and its conversion into cis-5-hydroxy-L-pipecolic acid

D. Adams, P. Bailey, S. Stokes, 1996 .

Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes.

Andrew G. Leach, A. Plowright, Robert D. M. Davies, 2012, Bioorganic & medicinal chemistry letters.

Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.

B. Davis, M. Drysdale, N. Foloppe, 2012, Bioorganic & medicinal chemistry.

Practical synthesis of 3,3-substituted dihydroquinoxalin-2-ones from aryl 1,2-diamines using the Bargellini reaction

James S. Scott, S. Stokes, T. Alanine, 2016 .

Synthesis of anti and syn hydroxy-iso-evoninic acids.

A. White, S. Stokes, A. Spivey, 2012, Organic & biomolecular chemistry.

An enantiospecific synthesis of allosamizoline

S. Stokes, N. Simpkins, A. Whittle, 1992 .

A simple and efficient synthesis of N-benzoyl ureas

Nathaniel G. Martin, S. Stokes, 2012 .

An enantiospecific total synthesis of allosamizoline

S. Stokes, N. Simpkins, A. Whittle, 1992 .

An Efficient Route to the α‐Methyl Ester of L‐Glutamic Acid, and Its Conversion into cis‐5‐Hydroxy‐L‐pipecolic Acid.

D. Adams, P. Bailey, S. Stokes, 1996 .

Pd-Catalyzed C-H aziridination of 3,3,5,5-tetrasubstituted piperazin-2-ones.

C. A. Roberts, James S. Scott, S. Stokes, 2017, Organic & biomolecular chemistry.

Towards the enantioselective synthesis of (-)-euonyminol--preparation of a fully functionalised lower-rim model.

S. Woodhead, M. Webber, A. White, 2013, Organic & biomolecular chemistry.

Abstract 5674: Discovery of AZD9833, an oral small molecule selective degrader of the estrogen receptor (SERD)

James S. Scott, T. Moss, C. Morrow, 2020 .

Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity

Nathaniel G. Martin, Robert D. M. Davies, P. Macfaul, 2013 .

Discovery of AZD9833, a potent and orally bioavailable selective estrogen receptor degrader and antagonist.

O. Delpuech, J. Breed, J. Nissink, 2020, Journal of medicinal chemistry.

Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase.

Mike Wood, Ben Davis, Terry Shaw, 2017, Journal of medicinal chemistry.

Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists.

Nathaniel G. Martin, Robert D. M. Davies, Alastair J. H. Brown, 2014, Journal of medicinal chemistry.

Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833.

Paul R. J. Davey, James S. Scott, B. Barlaam, 2020, ACS medicinal chemistry letters.

Synthesis and configuration of the cyclin-dependent kinase inhibitor roscovitine and its enantiomer

P. Fischer, Shudong Wang, S. McClue, 2001 .

Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists.

J. Breed, J. Nissink, Paul R. J. Davey, 2023, Journal of medicinal chemistry.

Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4.

L. Drew, R. Anjum, Yafeng Xue, 2018, Bioorganic & medicinal chemistry.