A. Wegener

发表

Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90.

Astrid Zimmermann, Djordje Musil, Hans-Michael Eggenweiler, 2012, Bioorganic & medicinal chemistry letters.

Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects

Catherine Jorand Lebrun, Andrea Unzue Lopez, Daniel Kuhn, 2020, J. Chem. Inf. Model..

Structural and biophysical characterization of the Syk activation switch.

Djordje Musil, Jörg Bomke, Daniel Schwarz, 2012, Journal of molecular biology.

Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses

Aroop Sircar, O. Tarcic, Adam S. Lazorchak, 2022, Journal for ImmunoTherapy of Cancer.

Identification of Methionine Aminopeptidase-2 (MetAP-2) inhibitor M8891, a Clinical Compound for the Treatment of Cancer.

F. Rohdich, D. Musil, B. Blume, 2019, Journal of medicinal chemistry.

Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells

D. Dorsch, S. Bröer, F. Rahimi, 2019, The Journal of Biological Chemistry.

Analysis of CheA histidine phosphorylation and its influence on protein stability by high-resolution element and electrospray mass spectrometry.

W. Lehmann, R. Kellner, A. Wegener, 2005, Analytical chemistry.

Discovery of Evobrutinib: An Oral, Potent and Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases.

M. Camps, A. Follis, B. Huck, 2019, Journal of medicinal chemistry.

In-depth biophysical analysis of interactions between therapeutic antibodies and the extracellular domain of the epidermal growth factor receptor.

A. Krah, J. Bomke, K. Steffens, 2012, Analytical biochemistry.

Functional Analysis of Hsp70 Inhibitors

M. Mayer, B. Bukau, D. Musil, 2013, PloS one.

Protein conformational flexibility modulates kinetics and thermodynamics of drug binding

R. Wade, M. Frech, J. Bomke, 2017, Nature Communications.

Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology.

M. Nowak, S. Minguzzi, M. Król, 2021, Journal of medicinal chemistry.

Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models.

Daniel Kuhn, D. Dorsch, F. Rohdich, 2021, Journal of medicinal chemistry.

Protein conformational flexibility modulates kinetics and thermodynamics of drug binding

R. Wade, M. Frech, P. Matias, 2017, Nature Communications.

Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design

B. Leuthner, A. Wegener, F. Sorrell, 2023, ChemMedChem.

Discovery of Cycloalkyl[c]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α Inhibitors.

M. Nowak, D. Musil, Liming Dong, 2023, Journal of medicinal chemistry.

Sulfur as the key element for quantitative protein analysis by capillary liquid chromatography coupled to element mass spectrometry.

W. Lehmann, R. Kellner, A. Eisenmenger, 2003, Angewandte Chemie.