Yong Zhu

发表

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

Kam Y. J. Zhang, James Tsai, Nikolas K. Haass, 2008, Proceedings of the National Academy of Sciences.

Design and synthesis of dual inhibitors targeting snail and histone deacetylase for the treatment of solid tumour cancer.

T. Lu, Hongmei Li, Ran Wei, 2021, European journal of medicinal chemistry.

Transferrin-inspired vehicles based on pH-responsive coordination bond to combat multidrug-resistant breast cancer.

N. Lu, Lei Xing, Mei Zhang, 2017, Biomaterials.

Design and synthesis of HDAC inhibitors to enhance the therapeutic effect of diffuse large B-cell lymphoma by improving metabolic stability and pharmacokinetic characteristics.

Yadong Chen, Hongmei Li, Ran Wei, 2021, European journal of medicinal chemistry.

Rhodium‐Catalyzed Arylative Transformations of Propargylic Diols: Dual Role of the Rhodium Catalyst

T. Lu, X. Dou, Na Liu, 2018 .

Design, synthesis and biological evaluation of indole derivatives as novel inhibitors targeting B-Raf kinase

Haichun Liu, Yanmin Zhang, T. Lu, 2014 .

Phosphine‐Catalyzed Domino Reactions of Allenoates with N‐Hydroxyphthalimides: Direct Method to 3 a‐Hydroxyisoxazolo[3,2‐a]isoindol‐8(3 aH)‐one Derivatives

T. Lu, Qingfa Zhou, Yong Zhu, 2017 .

Design, synthesis and biological evaluation of novel isoindolinone derivatives as potent histone deacetylase inhibitors.

T. Lu, Yadong Chen, Hongmei Li, 2019, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of β-carboline derivatives as novel inhibitors targeting B-Raf kinase.

Haichun Liu, T. Lu, Yadong Chen, 2012, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of urea-based benzamides derivatives as HDAC inhibitors

T. Ran, T. Lu, Weifang Tang, 2017, Medicinal Chemistry Research.

Synthesis and antitumor activity of novel diaryl ether hydroxamic acids derivatives as potential HDAC inhibitors

T. Lu, Yadong Chen, Weifang Tang, 2012, Archives of Pharmacal Research.

Progress on HDAC 6 Structure and Its Crystal Complexes

T. Lu, Yong Zhu, Hao Cui, 2019 .

Novel 2, 5-diketopiperazine derivatives as potent selective histone deacetylase 6 inhibitors: Rational design, synthesis and antiproliferative activity.

Aubry K. Miller, Raphael R. Steimbach, Ding Li, 2019, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of 2,3-dihydroimidazo[1,2- c ]quinazoline derivatives as novel phosphatidylinositol 3-kinase and histone deacetylase dual inhibitors

T. Lu, Yadong Chen, Xin Chen, 2017 .

Inhibitors of cell cycle checkpoint target Wee1 kinase – a patent review (2003–2022)

Yadong Chen, Yong Zhu, Zhenlin Tu, 2022, Expert opinion on therapeutic patents.

Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.

P. Beroza, R. Motter, R. Neitz, 2013, Bioorganic & medicinal chemistry letters.

Design and synthesis of highly TRAIL expression HDAC inhibitors based on ONC201 to promote apoptosis of colorectal cancer.

Yadong Chen, Hongmei Li, Yong Zhu, 2022, European journal of medicinal chemistry.

Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.

Paul Beroza, Zhao Ren, Dean R Artis, 2013, Bioorganic & medicinal chemistry letters.

Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors.

P. Beroza, Jiangli Yan, H. Sham, 2013, Bioorganic & medicinal chemistry letters.

Including Explicit Water Molecules as Part of the Protein Structure in MM/PBSA Calculations

Yong-Liang Zhu, Paul Beroza, Dean R. Artis, 2014, J. Chem. Inf. Model..

Design, synthesis and biological evaluation of 2-amino-N-(2-aminophenyl)thiazole-5-carboxamide derivatives as novel Bcr-Abl and histone deacetylase dual inhibitors

T. Lu, Yadong Chen, Xin Chen, 2016 .

Design, Synthesis and Biological Evaluation of Novel Benzoylimidazole Derivatives as Raf and Histone Deacetylases Dual Inhibitors.

Yadong Chen, Jianzhao Qi, Yu Jiao, 2019, Chemical and pharmaceutical bulletin.

Discovery of novel phenoxybenzamide analogues as Raf/HDAC dual inhibitors.

T. Lu, Hongmei Li, Xin Chen, 2019, Bioorganic & medicinal chemistry letters.

Investigation on the isoform selectivity of histone deacetylase inhibitors using chemical feature based pharmacophore and docking approaches.

Shuai Lu, T. Lu, Huifang Li, 2010, European journal of medicinal chemistry.

Synthesis and antitumor activity of novel diaryl ether hydroxamic acids derivatives as potential HDAC inhibitors

Yadong Chen, Weifang Tang, Xin Chen, 2012, Archives of pharmacal research.

Review and prospects of targeted therapies for Spleen tyrosine kinase (SYK).

Weifang Tang, Yong Zhu, Zhaozhao Wang, 2023, Bioorganic & medicinal chemistry.