Kwen-Jen Chang

发表

Synthesis of (1R,4R)-2,5-diazabicyclo[2.2.1]heptane derivatives by an epimerization–lactamization cascade reaction

Jie Yu, Cui Benqiang, Fuchao Yu, 2015 .

The PHI (PHI-27)/corticotropin-releasing factor/enkephalin immunoreactive hypothalamic neuron: possible morphological basis for integrated control of prolactin, corticotropin, and growth hormone secretion.

T. Hökfelt, V. Mutt, L. Terenius, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Chapter 6. Analgesics, Opioids, and Opioid Receptors

Kwen-Jen Chang, O. Lever, J. Mcdermed, 1983 .

The production and characterization of monoclonal antibodies against enkephalins

C. Watt, D. M. Lam, Kwen-Jen Chang, 1985, Neurochemistry International.

Analgesic activity of intracerebroventricular administration of morphiceptin and β-casomorphins: Correlation with the morphine (μ) receptor binding affinity

P. Cuatrecasas, Kwen-Jen Chang, E. Wei, 1982 .

Multiple opiate receptors

P. Cuatrecasas, E. Hazum, Kwen-Jen Chang, 1980, Trends in Neurosciences.

Receptor redistribution induced by hormones and neurotransmitters: Possible relationships to biological functions

P. Cuatrecasas, E. Hazum, Kwen-Jen Chang, 1981, Neuropeptides.

Opioid peptide synthesis in bovine and human adrenal chromaffin cells

Steven P. Wilson, O. H. Viveros, Kwen-Jen Chang, 1981, Peptides.

Synthesis of 5,6-Dihydro-α-Pyrone via Ring-Closing Metathesis and Intramolecular Horner–Wadsworth–Emmons Reactions

Fuchao Yu, Kwen-Jen Chang, Yuehai Shen, 2015 .

Overcoming resistance to TRAIL-induced apoptosis in solid tumor cells by simultaneously targeting death receptors, c-FLIP and IAPs

Tianrui Xu, Ying Huang, Kwen-Jen Chang, 2016, International journal of oncology.

Are opioid peptides co-transmitters in noradrenergic vesicles of sympathetic nerves?

Steven P. Wilson, R. Klein, O. H. Viveros, 1980, Nature.

Chapter 1. Analgesics

Kwen-Jen Chang, O. Lever, J. Mcdermed, 1984 .

The delta receptor

J. Woods, F. Porreca, Kwen-Jen Chang, 2003 .

An in vitro autoradiographic analysis of mu and delta opioid binding in the hippocampal formation of kindled rats

J. McNamara, B. Crain, Kwen-Jen Chang, 1987, Brain Research.

Binding of [3H](+)-BW373U86 to δ-opioid receptors in rat brain membranes

M. Campa, E. Patz, Kwen-Jen Chang, 1996 .

Copper-catalyzed cascade addition/cyclization: highly efficient access to phosphonylated quinoline-2,4(1H,3H)-diones.

Fuchao Yu, Ya-Min Li, Kwen-Jen Chang, 2015, Organic & biomolecular chemistry.

Metal-free oxidative arylphosphination of activated N-substituted-N-arylacrylamide derivatives using K2S2O8

Shangdong Yang, Ya-Min Li, Kwen-Jen Chang, 2014 .

The inhibition of ornithine decarboxylase activity in developing rat tissues by central nervous system β-endorphin is mediated by μ-opioid receptors, but not by δ- or ϵ-opioid receptors

Kwen-Jen Chang, J. Bartolome, M. Bartolome, 1995 .

Novel opiate binding sites selective for benzomorphan drugs

P. Cuatrecasas, E. Hazum, Kwen-Jen Chang, 1981 .

Noradrenaline binding and the search for catecholamine receptors

P. Cuatrecasas, V. Sica, I. Parikh, 1974, Nature.

ENKEPHALINS IN ADRENOMEDULLARY CHROMAFFIN CELLS AND SYMPATHETIC NERVES

O. H. Viveros, E. Diliberto, E. Hazum, 1981 .

Increased δ, but not μ, opiate receptor binding in the medulla oblongata of Long-Evans rats following 5-day water deprivation

W. Severs, Kwen-Jen Chang, B. Hwang, 1986, Brain Research.

Immunohistochemical localization of enkephalin in rat brain and spinal cord

P. Cuatrecasas, M. Sar, Richard J. Miller, 1978, The Journal of comparative neurology.

Opioid peptides induce reduction of enkephalin receptors in cultured neuroblastoma cells

S. Blanchard, Kwen-Jen Chang, R. Eckel, 1982, Nature.

Arylnitration of alkenes by nitration/C–H functionalization cascade using AgNO3 and HOAc

Shangdong Yang, Ya-Min Li, Kwen-Jen Chang, 2014 .

An atom-economic green approach: oxidative synthesis of functionalized 1,4-dihydropyridines from N,N-dimethylenaminones and amines

Hui Xu, Bei Zhou, Fuchao Yu, 2015 .

Distribution and pharmacology of the enkephalins and related opiate peptides

C. Beddell, P. Cuatrecasas, Richard J. Miller, 1978 .

Regulation of Opioid Receptors

S. Blanchard, Kwen-Jen Chang, 1988 .

Recent History on Delta Opioid Receptors and Ligands: Biased Mechanisms, and Opioid Delta-Mu and Delta-Kappa Receptor Heteromers

Kwen-Jen Chang, Yuehai Shen, Shou-pu Yi, 2015 .

The opioid receptor triple agonist DPI-125 produces analgesia with less respiratory depression and reduced abuse liability

Kwen-Jen Chang, R. Su, Chenling Pan, 2017, Acta Pharmacologica Sinica.

Bio-available selective IAP inhibitor dual-activated TRAIL-induced apoptosis via caspase-mediated pathway in human colorectal cancer

Ying Huang, Kwen-Jen Chang, Yuehai Shen, 2017 .

Characterization of δ Opioid Receptors in Lung Cancer Using a Novel Nonpeptidic Ligand

M. J. Bishop, G. Bepler, M. Campa, 1996 .

Localization of enkephalin‐like immunoreactivity to identified axonal and neuronal populations of the rat hippocampus

N. Brecha, Kwen-Jen Chang, Christine Gall, 1981, The Journal of comparative neurology.

A practical nickel-catalyzed reductive alkylation of amidophenyl bromides

Fan Yang, Ya-Min Li, Kwen-Jen Chang, 2014 .

A Practical Nickel‐Catalyzed Reductive Alkylation of Amidophenyl Bromides.

Fan Yang, Ya-Min Li, Kwen-Jen Chang, 2015 .

Plasma β-Casomorphin-7 Immunoreactive Peptide Increases after Milk Intake in Newborn but not in Adult Dogs

G. Haddad, C. Rosen, Kwen-Jen Chang, 1989, Pediatric Research.

Opioid peptides have actions on the immune system

Kwen-Jen Chang, 1984, Trends in Neurosciences.

Down regulation of δ but not μ opioid receptors in the hippocampal slice associated with loss of physiological response

E. Bostock, R. Dingledine, R. Valentino, 1983 .

Role of disulphide and sulphydryl groups in clustering of enkephalin receptors in neuroblastoma cells

P. Cuatrecasas, E. Hazum, Kwen-Jen Chang, 1979, Nature.

Insulin-like growth factor-1 and dibutyryl CAMP induce differentiation and decrease opioid receptor binding activity in N4TG1 neuroblastoma cells

Kwen-Jen Chang, Wen-Xiao Lu, Wenfei Lu, 1991, Molecular and Cellular Neuroscience.

48 – Visualization of Enkephalin Receptors by Image-Intensified Fluorescence Microscopy

P. Cuatrecasas, S. Blanchard, Kwen-Jen Chang, 1989 .

Opposite effects of the δ- and μ-opioid receptor agonists on ventilation in conscious adult dogs

G. Haddad, Kwen-Jen Chang, J. I. Schaeffer, 1984, Brain Research.

Introduction: The Biology of Receptors

Kwen-Jen Chang, Ying-fu Su, 1993 .

DPI-3290 [(+)-3-((α-R)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. I. A Mixed Opioid Agonist with Potent Antinociceptive Activity

Michael J. Bishop, Kwen-Jen Chang, M. J. Bishop, 2003, Journal of Pharmacology and Experimental Therapeutics.

A Novel Naphthyridine Derivative, 3u, Induces Necroptosis at Low Concentrations and Apoptosis at High Concentrations in Human Melanoma A375 Cells

Shengjiao Yan, Kwen-Jen Chang, Guanlin Wang, 2018, International journal of molecular sciences.

History of Delta Receptors

Kwen-Jen Chang, 2003 .

Mixed Opioid Receptor Agonists as a New Class of Agents for the Treatment of Moderate to Severe Pain

Kwen-Jen Chang, P. Gengo, 2003 .

Chapter 8 Pharmacology and molecular biology of opioid receptors

H. Pettit, Kwen-Jen Chang, Paul H. K. Lee, 1997 .

The hypothalamic arcuate nucleus-median eminence complex: Immunohistochemistry of transmitters, peptides and DARPP-32 with special reference to coexistence in dopamine neurons

P. Greengard, T. Hökfelt, H. Hemmings, 1986, Brain Research Reviews.

DPI-3290 [(+)-3-((α-R)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. II. A Mixed Opioid Agonist with Potent Antinociceptive Activity and Limited Effects on Respiratory Function

H. Pettit, Kwen-Jen Chang, P. Gengo, 2003, Journal of Pharmacology and Experimental Therapeutics.

Quantitative autoradiographic analysis of Mu and delta opioid binding sites in the rat hippocampal formation

J. McNamara, B. Crain, Kwen-Jen Chang, 1986, The Journal of comparative neurology.

Tyrosine-iodination converts the δ-opioid peptide antagonist TIPP to an agonist

P. Schiller, T. M. Nguyen, N. N. Chung, 1995 .

ARD-353 [4-((2R,5S)-4-(R)-(4-Diethylcarbamoylphenyl)(3-hydroxyphenyl)methyl)-2,5-dimethylpiperazin-1-ylmethyl)benzoic Acid], A Novel Nonpeptide δ Receptor Agonist, Reduces Myocardial Infarct Size without Central Effects

Kwen-Jen Chang, G. Gross, Kwen-Jen Chang, 2006, Journal of Pharmacology and Experimental Therapeutics.

DPI-221 [4-((α-S)-α-((2S,5R)-2,5-Dimethyl-4-(3-fluorobenzyl)-1-piperazinyl)benzyl)-N,N-diethylbenzamide]: A Novel Nonpeptide δ Receptor Agonist Producing Increased Micturition Interval in Normal Rats

Jane P. Chang, Kwen-Jen Chang, J. Chang, 2005, Journal of Pharmacology and Experimental Therapeutics.

DPI-221 [4-((alpha-s)-alpha-((2s,5r)-2,5-dimethyl-4-(3-fluorobenzyl)-1-piperazinyl)benzyl)-N,N-diethylbenzamide]: a novel nonpeptide delta receptor agonist producing increased micturition interval in normal rats.

J. Chang, Kwen-Jen Chang, P. Gengo, 2005, The Journal of pharmacology and experimental therapeutics.

Homology modeling and 3D-QSAR study of benzhydrylpiperazine δ opioid receptor agonists

Zhili Zuo, Chenling Pan, Hao Meng, 2019, Comput. Biol. Chem..

Inhibition of c-FLIP by RNAi enhances sensitivity of the human osteogenic sarcoma cell line U2OS to TRAIL-induced apoptosis.

Ying Huang, Ya-ping Zhang, Kwen-Jen Chang, 2015, Asian Pacific journal of cancer prevention : APJCP.

Piperidines et piperazines de diarylmethyle opioides

M. Collins, Kwen-Jen Chang, R. Mcnutt, 1993 .

Immunohistochemical localization of enkephalin in rat brain and spinal cord.

P. Cuatrecasas, M. Sar, W. Stumpf, 1978, The Journal of comparative neurology.

Localization of enkephalin‐like immunoreactivity to identified axonal and neuronal populations of the rat hippocampus

N. Brecha, Kwen-Jen Chang, Christine Gall, 1981, The Journal of comparative neurology.

Interaction of iodinated enkephalin analogues with opiate receptors.

P. Cuatrecasas, R. Miller, Kwen-Jen Chang, 1978, Life sciences.

Radioimmunoassay and characterization of enkephalins in rat tissues.

P. Cuatrecasas, R. Miller, B. Cooper, 1978, The Journal of biological chemistry.

Multiple opiate receptors: different regional distribution in the brain and differential binding of opiates and opioid peptides.

P. Cuatrecasas, B. Cooper, E. Hazum, 1979, Molecular pharmacology.

Delta-opioid ligands reverse alfentanil-induced respiratory depression but not antinociception.

Kwen-Jen Chang, K. Chang, Ying-fu Su, 1998, The Journal of pharmacology and experimental therapeutics.

Multiple opiate receptors

P. Cuatrecasas, E. Hazum, Kwen-Jen Chang, 1980, Trends in Neurosciences.

The hypothalamic arcuate nucleus-median eminence complex: Immunohistochemistry of transmitters, peptides and DARPP-32 with special reference to coexistence in dopamine neurons

P. Greengard, T. Hökfelt, H. Hemmings, 1986, Brain Research Reviews.

Repeated electroconvulsive shock downregulates the opioid receptors in rat brain

C. Mitchell, Y. Nakata, Kwen-Jen Chang, 1985, Brain Research.

Opiate-like materials in the adrenal medulla: evidence for storage and secretion with catecholamines.

O. H. Viveros, E. Diliberto, E. Hazum, 1979, Molecular pharmacology.

Rapid degradation of [3H]leucine-enkephalin by intact neuroblastoma cells.

P. Cuatrecasas, E. Hazum, Kwen-Jen Chang, 1979, Life sciences.

A CONFORMATIONAL ANALYSIS FOR LEUCINE‐ENKEPHALIN USING ACTIVITY AND BINDING DATA OF SYNTHETIC ANALOGUES

C. Beddell, P. Cuatrecasas, R. Clark, 1977, British journal of pharmacology.

Quantitative aspects of hormone-receptor interactions of high affinity. Effect of receptor concentration and measurement of dissociation constants of labeled and unlabeled hormones.

P. Cuatrecasas, Kwen-Jen Chang, S. Jacobs, 1975, Biochimica et biophysica acta.

Early postnatal development of calmodulin-dependent protein kinase II in rat brain.

S. Burgess, P. Cuatrecasas, H. Levine, 1985, Biochemical and biophysical research communications.

Novel opiate binding sites selective for benzomorphan drugs.

P. Cuatrecasas, E. Hazum, Kwen-Jen Chang, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Convulsive effects of systemic administration of the delta opioid agonist BW373U86 in mice.

H. Mosberg, J. Woods, S. Comer, 1993, The Journal of pharmacology and experimental therapeutics.

A novel, potent and selective nonpeptidic delta opioid receptor agonist BW373U86.

J. L. Howard, G. Rigdon, J L Howard, 1993, The Journal of pharmacology and experimental therapeutics.

Increased biological activity of dimers of oxymorphone and enkephalin: possible role of receptor crosslinking.

P. Cuatrecasas, E. Hazum, Kwen-Jen Chang, 1982, Biochemical and biophysical research communications.

Antagonistic modulation between the delta opioid agonist BW373U86 and the mu opioid agonist fentanyl in mice.

H. Pettit, Kwen-Jen Chang, K. Chang, 1997, The Journal of pharmacology and experimental therapeutics.