N. Higdon

发表

Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha7 nicotinic acetylcholine receptor agonists.

Brandon J. Margolis, Mihaly Hajos, Thomas J. Raub, 2006, Bioorganic & medicinal chemistry.

Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship.

Thomas J. Raub, E. Wong, R. Hurst, 2006, Journal of medicinal chemistry.

Dopamine receptor agonists differ in their actions on cardiac ion channels.

R. Hurst, N. Higdon, Michael A Clark, 2003, European journal of pharmacology.

Pharmacological characterization of novel cyanoguanidines as vascular KATP channel blockers.

N. Higdon, J. Hester, S. Khan, 1997, The Journal of pharmacology and experimental therapeutics.

Coronary vasorelaxation by nitroglycerin: involvement of plasmalemmal calcium-activated K+ channels and intracellular Ca++ stores.

N. Higdon, S. Khan, K. Meisheri, 1998, The Journal of pharmacology and experimental therapeutics.

Tissue and species variation in the vascular receptor binding of 3H-P1075, a potent KATP opener vasodilator.

N. Higdon, L. V. Buchanan, S. Khan, 1997, The Journal of pharmacology and experimental therapeutics.

A Novel Positive Allosteric Modulator of the α7 Neuronal Nicotinic Acetylcholine Receptor: In Vitro and In Vivo Characterization

D. Bertrand, R. Hurst, M. Hajós, 2005, The Journal of Neuroscience.

Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors.

E. Wong, R. Hurst, M. Hajós, 2005, Journal of medicinal chemistry.

The Selective α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide Hydrochloride] Enhances GABAergic Synaptic Activity in Brain Slices and Restores Auditory Gating Deficits in Anesthetized Rats

R. Hurst, M. Hajós, M. Krause, 2005, Journal of Pharmacology and Experimental Therapeutics.

Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors.

E. Wong, R. Hurst, M. Hajós, 2005, Journal of medicinal chemistry.

The Selective Α 7 Nicotinic Acetylcholine Receptor Agonist Pnu-282987 Enhances Gabaergic Synaptic Activity in Brain Slices and Restores Auditory Gating Deficits in Anesthetized Rats

R. Hurst, M. Hajós, M. Krause, 2022 .

Positive Allosteric Modulators of the α7 Nicotinic Acetylcholine Receptor: SAR Investigation Around PNU-120596.

Brandon J. Margolis, R. Hurst, M. Hajós, 2023, Bioorganic & medicinal chemistry letters.

The Selective α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide Hydrochloride] Enhances GABAergic Synaptic Activity in Brain Slices and Restores Auditory Gating Deficits in Anesthetized Rats

M. Hajós, N. Higdon, T. Wall, 2005, Journal of Pharmacology and Experimental Therapeutics.

The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats.

N. Higdon, W. E. Hoffmann, R. S. Hurst, 2005, The Journal of pharmacology and experimental therapeutics.