P. George

发表

SSR180711, a Novel Selective α7 Nicotinic Receptor Partial Agonist: (1) Binding and Functional Profile

G. Griebel, O. Bergis, L. Rouquier, 2007, Neuropsychopharmacology.

Design and synthesis of a novel series of histamine H3 receptor antagonists through a scaffold hopping strategy.

W. Hurst, P. George, William P Reynolds, 2015, Bioorganic & medicinal chemistry.

Molecular interaction between reversible MAO-A inhibitors and the enzyme. Application to aryloxazolidinone, a prototype series.

J. Wouters, F. Ooms, F. Durant, 2000, Neurobiology.

Ring expansion of cyclic β-amino alcohols induced by diethylaminosulfur trifluoride: synthesis of cyclic amines with a tertiary fluorine at C3.

J. Cossy, P. George, M. Perrin, 2012, The Journal of organic chemistry.

Study of O-glycan sialylation in C6 cultured glioma cells: Evidence for post-translational regulation of Aβ-galactoside α2,3 sialyltransferase activity by N-glycosylation

P. Reboul, P. Louisot, P. George, 1991 .

Study of O-glycan sialylation in C6 cultured glioma cells: regulation of a beta-galactoside alpha 2,3 sialyltransferase activity by Ca2+/calmodulin antagonists and phosphatase inhibitors.

P. Reboul, P. Louisot, P. George, 1992, Biochemical and biophysical research communications.

[11C]SL25.1188, a new reversible radioligand to study the monoamine oxidase type B with PET: Preclinical characterisation in nonhuman primate

O. Curet, Y. Bramoullé, F. Dollé, 2010, Synapse.

Radiosynthesis of (S)-5-methoxymethyl-3-[6-(4,4,4-trifluorobutoxy)benzo[d]isoxazol-3-yl] oxazolidin-2-[11C]one ([11C]SL25.1188), a novel radioligand for imaging monoamine oxidase-B with PET

Y. Bramoullé, F. Dollé, H. Valette, 2008 .

SSR591813, a novel selective and partial alpha4beta2 nicotinic receptor agonist with potential as an aid to smoking cessation.

G. Perrault, P. Soubrié, O. Bergis, 2003, The Journal of pharmacology and experimental therapeutics.

Expert Opinion on Therapeutic Patents

S. Jegham, P. George, 1998 .

Glycoprotein sialyltransferases in eucaryotic cells.

P. Louisot, P. George, P. Broquet, 1991, The International journal of biochemistry.

SL651498: An Anxioselective Compound with Functional Selectivity for a 2 - and a 3 -Containing g -Aminobutyric Acid A (GABA A ) Receptors

G. Perrault, H. Schoemaker, G. Griebel, 2001 .

Phosphinic derivatives as new dual enkephalin-degrading enzyme inhibitors: synthesis, biological properties, and antinociceptive activities.

P. Coric, B. Roques, H. Meudal, 2000, Journal of medicinal chemistry.

Reversible inhibition of type B monoamine oxidase. Theoretical study of model diazo heterocylic compound

J. Wouters, F. Ooms, F. Durant, 1997 .

Efficient synthesis of [11C]befloxatone, a selective radioligand for the in vivo imaging of MAO‐A density using PET

Y. Bramoullé, F. Dollé, M. Bottlaender, 2003 .

Different reactivity of two Brain sialyltransferases towards sulfhydryl reagents. Evidence for a thiol group involved in the nucleotide-sugar binding site of the NeuAcα2-3Galβ1-3GalNAc α(2–6)sialyltransferase

P. Louisot, P. George, P. Broquet, 2005, Glycoconjugate Journal.

Polyamine Participation in the Maturation of Glycoprotein Fucosylation, but not Sialylation, in Rat Small Intestine

P. Louisot, P. George, Marie-Claire Biol-N’garagba, 2002, Pediatric Research.

Spermidine-induced glycoprotein fucosylation in immature rat intestine.

P. Louisot, P. George, M. Biol, 1999, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie.

A possible involvement of endogenous polyamines in the TNF‐α cellular sensitivity

P. Louisot, P. George, C. Levrat, 1998 .

Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part I).

M. Pruniaux, J. A. Sánchez, W. Hurst, 2013, Bioorganic & medicinal chemistry letters.

Study ofO-sialylation of glycoproteins in C6 glioma cells treated with retinoic acid

P. Reboul, P. Louisot, P. George, 1996, Glycoconjugate Journal.

Regioselective cobalt-catalyzed formation of bicyclic 3- and 4-aminopyridines.

V. Gandon, M. Malacria, P. George, 2011, Organic letters.

Synthesis of aminopyridines and aminopyridones by cobalt-catalyzed [2+2+2] cycloadditions involving yne-ynamides: scope, limitations, and mechanistic insights.

V. Gandon, M. Malacria, P. George, 2012, Chemistry.

Synthesis and benzodiazepine receptor (ω receptor) affinities of 3-substituted derivatives of pyrrolo[2,3-c]pyridine-5-carboxylate, a novel class of ω1 selective ligands

H. Schoemaker, Sunil Singh, P. Potier, 1999 .

Synthesis of 2,2-Disubstituted Azaindolines by Intramolecular Cyclization in Acidic Media

P. George, T. Métro, M. Sevrin, 2011 .

Dietary spermidine and spermine participate in the maturation of galactosyltransferase activity and glycoprotein galactosylation in rat small intestine.

P. Louisot, P. George, M. Biol, 2001, The Journal of nutrition.

Pharmacological profile of the imidazopyridine zolpidem at benzodiazepine receptors and electrocorticogram in rats

S. Z. Langer, S. Arbilla, P. George, 1985, Naunyn-Schmiedeberg's Archives of Pharmacology.

Enantioselective desymmetrization of meso bicyclic hydrazines: a novel approach to the asymmetric synthesis of polysubstituted amino cyclopentanic cores.

S. Gougeon, P. George, L. Micouin, 2002, The Journal of organic chemistry.

Asymmetric routes towards polyfunctionalized pyrrolidines: application to the synthesis of alkaloid analogues

A. Zaparucha, A. Chiaroni, P. George, 2003 .

Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones

P. George, M. Crozet, P. Vanelle, 2005, Molecules.

A New General Route to Novel Azomethine Ylides for Cycloaddition Reactions

P. George, N. Kunesch, H. Husson, 2002 .

A reversible monoamine oxidase A inhibitor, befloxatone: structural approach of its mechanism of action.

J. Wouters, F. Durant, S. Jegham, 1999, Bioorganic & medicinal chemistry.

Enantioselective desymmetrization of meso bicyclic hydrazines: a novel approach to the asymmetric synthesis of polysubstituted amino cyclopentanic cores.

S. Gougeon, P. George, L. Micouin, 2002, The Journal of organic chemistry.

Neurochemical, Electrophysiological and Pharmacological Profiles of the Selective Inhibitor of the Glycine Transporter-1 SSR504734, a Potential New Type of Antipsychotic

R. Depoortère, G. Perrault, G. Griebel, 2005, Neuropsychopharmacology.

Effect of Desipramine on a Glycoprotein Sialyltransferase Activity in C6 Cultured Glioma Cells

P. Louisot, P. George, P. Broquet, 1990, Journal of neurochemistry.

PHOSPHOLIPIDS REACYLATION AND PALMITOYLCOA CONTROL TUMOUR NECROSIS FACTOR-α SENSITIVITY

P. Louisot, D. Ardail, P. George, 2001 .

Evidence for an O-glycan sialylation system in brain. Characterization of a beta-galactoside alpha 2,3-sialyltransferase from rat brain regulating the expression of an alpha-N-acetylgalactosaminide alpha 2,6-sialyltransferase activity.

P. Louisot, P. George, P. Broquet, 1989, European journal of biochemistry.

Synthesis and biological evaluation of analogues of M6G.

Y. Troin, P. George, I. Ripoche, 2011, European journal of medicinal chemistry.

A Convenient Synthesis 7,8-Dihydroisoquinolin-5(6H)-One

J. Frost, P. George, P. Lardenois, 1996 .

Synthesis and in vivo imaging properties of [11C]befloxatone: a novel highly potent positron emission tomography ligand for mono-amine oxidase-A.

C. Lartizien, O. Curet, Y. Bramoullé, 2003, Bioorganic & medicinal chemistry letters.

Mapping the Cerebral Monoamine Oxidase Type A: Positron Emission Tomography Characterization of the Reversible Selective Inhibitor [11C]Befloxatone

O. Curet, Y. Bramoullé, F. Dollé, 2003, Journal of Pharmacology and Experimental Therapeutics.

Biochemical and Molecular Action of Nutrients Dietary Spermidine and Spermine Participate in the Maturation of Galactosyltransferase Activity and Glycoprotein Galactosylation in Rat Small Intestine 1

P. Louisot, P. George, M. Biol, 2001 .

SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair.

P. Soubrié, M. Schumacher, Y. Claustre, 2002, The Journal of pharmacology and experimental therapeutics.

Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia

G. Griebel, J. Stemmelin, D. Boulay, 2008, Pharmacology Biochemistry and Behavior.

Study of retinoic acid effect upon retinoic acid receptors beta (RAR-beta) in C6 cultured glioma cells.

P. Reboul, P. Louisot, P. George, 1995, Biochemistry and molecular biology international.

SL651498, a GABAA receptor agonist with subtype-selective efficacy, as a potential treatment for generalized anxiety disorder and muscle spasms.

G. Perrault, H. Schoemaker, G. Griebel, 2003, CNS drug reviews.

SL651498: An Anxioselective Compound with Functional Selectivity for α2- and α3-Containing γ-Aminobutyric AcidA (GABAA) Receptors

G. Perrault, H. Schoemaker, G. Griebel, 2001 .

Mitsunobu N3-alkylation of 1,3,4-oxadiazol-2(3H)-ones

F. Galli, A. Nedelec, A. Lochead, 1999 .

Imidazopyridines: towards novel hypnotic and anxiolytic drugs.

P. George, J. Allen, A. Wick, 1991, Farmaco.

Selectivity for Omega-Receptor Subtypes as a Strategy for the Development of Anxiolytic Drugs

K. Lloyd, S. Z. Langer, S. Arbilla, 1990, Pharmacopsychiatry.

Molecular structure and stereoelectronic properties of sarmazenil--a weak inverse agonist at the omega modulatory sites (benzodiazepine receptors): comparison with bretazenil and flumazenil.

F Durant, F. Durant, B López-Romero, 1998, Bioorganic & medicinal chemistry.

Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents

Thomas Bertrand, Bailin Zhang, Lionel Bert, 2015, Scientific Reports.

SSR181507, A Dopamine D2 Receptor Antagonist and 5-HT1A Receptor Agonist. I: Neurochemical and Electrophysiological Profile

H. Schoemaker, P. Soubrié, Y. Claustre, 2003, Neuropsychopharmacology.

Design and synthesis of novel imidazo[1,2-a]quinoxalines as PDE4 inhibitors.

M. Strub, J. Fabréguettes, Grégori Gerebtzoff, 2004, Bioorganic & medicinal chemistry.

SL65.0155, A Novel 5-Hydroxytryptamine4 Receptor Partial Agonist with Potent Cognition-Enhancing Properties

P. Soubrié, O. Bergis, J. Bockaert, 2002, Journal of Pharmacology and Experimental Therapeutics.

Effect of retinoic acid on two glycosyltransferase activities in C6 cultured glioma cells.

P. Reboul, P. Louisot, P. George, 1990, The International journal of biochemistry.

Pharmaceutical compositions containing nicotine and their application into tobacco weaning

B. Scatton, S. Jegham, P. George, 1999 .

Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases.

L. Meijer, Ana Corrionero, M. Lindberg, 2023, Journal of medicinal chemistry.

Monoamine oxidase A and B inhibitors

S. Jegham, P. George, 1998 .

In vivo Quantification of Monoamine Oxidase A in Baboon Brain: A PET Study Using [11C]befloxatone and the Multi-Injection Approach

M. Grégoire, J. Delforge, O. Curet, 2010, Journal of Cerebral Blood Flow and Metabolism.

Polymer-supported electron-rich diene for hetero Diels-Alder reactions

A. Mann, M. Hibert, P. George, 2003 .

SL25.1131 [3(S),3a(S)-3-Methoxymethyl-7-[4,4,4-trifluorobutoxy]-3,3a,4,5-tetrahydro-1,3-oxazolo[3,4-a]quinolin-1-one], a New, Reversible, and Mixed Inhibitor of Monoamine Oxidase-A and Monoamine Oxidase-B: Biochemical and Behavioral Profile

C. Carter, O. Curet, B. Scatton, 2004, Journal of Pharmacology and Experimental Therapeutics.

Chemical biology: contribution to molecular therapeutic innovation--a new role for chemistry? Report from the thematic symposium organized by the SCT (French Medicinal Chemistry Society), November 26th, 2013.

P. George, J. Sapi, Frédéric Schmidt, 2014, ACS chemical biology.

Characterization of the physico-chemical properties of the imidazopyridine derivative Alpidem. Comparison with Zolpidem

G. Georges, D. P. Vercauteren, F. Durant, 1993 .

Interfacing chemical biology and drug discovery: report from the 50th International Conference on Medicinal Chemistry of the SCT (French Medicinal Chemistry Society), July 2-4, 2014, Rouen, France.

Frédéric Schmidt, Janos Sapi, Luc Van Hijfte, 2014, ACS chemical biology.

Identification and profiling of 3,5-dimethyl-isoxazole-4-carboxylic acid [2-methyl-4-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)phenyl] amide as histamine H(3) receptor antagonist for the treatment of depression.

Nicolas Moindrot, W. Hurst, P. George, 2013, Bioorganic & medicinal chemistry letters.

Discovery of a potent, selective, and orally bioavailable histamine H3 receptor antagonist SAR110068 for the treatment of sleep-wake disorders.

G. Griebel, W. Hurst, Lothar Schwink, 2013, Bioorganic & medicinal chemistry letters.

Molecular lipophilicity potential by CLIP, a reliable tool for the description of the 3D distribution of lipophilicity: application to 3-phenyloxazolidin-2-one, a prototype series of reversible MAOA inhibitors.

S Collin, F Durant, J. Wouters, 1998, Bioorganic & medicinal chemistry letters.

Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B.

L. Meijer, S. Knapp, Andreas Krämer, 2023, Journal of medicinal chemistry.

In vivo Quantification of Monoamine Oxidase A in Baboon Brain: A PET Study Using [11C]befloxatone and the Multi-Injection Approach

M. Grégoire, J. Delforge, O. Curet, 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

SL651498: an anxioselective compound with functional selectivity for alpha2- and alpha3-containing gamma-aminobutyric acid(A) (GABA(A)) receptors.

G. Perrault, H. Schoemaker, G. Griebel, 2001, Journal of Pharmacology and Experimental Therapeutics.