S. Spindler

发表

P1-450 and P3-450 gene expression and maximum life span in mice.

R. Walford, S. Spindler, A. Koizumi, 1989, Mutation research.

Dietary energy tissue-specifically regulates endoplasmic reticulum chaperone gene expression in the liver of mice.

J. B. Tillman, R. Walford, J. Dhahbi, 1997, The Journal of nutrition.

Bayesian model selection on linear mixed-effects models for comparisons between multiple treatments and a control

James M. Flegal, Lei Gong, S. Spindler, 2015, 1509.07510.

β1-Adrenergic receptor blockade extends the life span of Drosophila and long-lived mice

James M. Flegal, J. Dhahbi, D. Jeske, 2013, AGE.

Temporal linkage between the phenotypic and genomic responses to caloric restriction.

R. Beaver, J. Dhahbi, S. Spindler, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Influence of age and caloric restriction on expression of hepatic genes for xenobiotic and oxygen metabolizing enzymes in the mouse.

R. Walford, S. Spindler, P. L. Mote, 1991, Journal of gerontology.

The response to calorie restriction in mammals shows features also common to hibernation: a cross-adaptation hypothesis.

R. Walford, S. Spindler, 1997, The journals of gerontology. Series A, Biological sciences and medical sciences.

Dietary supplementation with Lovaza and krill oil shortens the life span of long-lived F1 mice

James M. Flegal, S. Spindler, P. Mote, 2014, AGE.

Caloric restriction mimetics: metabolic interventions.

J. Halter, R. Weindruch, R. Floyd, 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

Hepatic gene expression profiling of streptozotocin-induced diabetes.

J. Dhahbi, S. Spindler, P. Mote, 2003, Diabetes technology & therapeutics.

Dietary energy restriction in mice reduces hepatic expression of glucose-regulated protein 78 (BiP) and 94 mRNA.

R. Walford, M. Crew, S. Spindler, 1990, The Journal of nutrition.

expression and UCP-3 δ associated with acute alterations in PPAR Muscle unloading-induced metabolic remodeling is

D. Boffelli, S. Dupré-Aucouturier, D. Desplanches, 2015 .

Reversing the Negative Genomic Effects of Aging with Short-Term Calorie Restriction

S. Spindler, 2001, TheScientificWorldJournal.

Caloric intake alters the efficiency of catalase mRNA translation in the liver of old female mice.

J. B. Tillman, R. Walford, J. Dhahbi, 1998, The journals of gerontology. Series A, Biological sciences and medical sciences.

Glucose regulation of GRP78 gene expression

J. B. Tillman, S. Spindler, P. Mote, 1998, Mechanisms of Ageing and Development.

Dietary Calorie Restriction in Mice Induces Carbamyl Phosphate Synthetase I Gene Transcription Tissue Specifically (*)

J. B. Tillman, R. Walford, J. Dhahbi, 1996, The Journal of Biological Chemistry.

R. Walford, S. Spindler, P. L. Mote, 1990, Mechanisms of Ageing and Development.

Calorie Restriction Enhances the Expression of Key Metabolic Enzymes Associated with Protein Renewal during Aging

S. Spindler, 2001, Annals of the New York Academy of Sciences.

Caloric restriction alters the feeding response of key metabolic enzyme genes

R. Walford, J. Dhahbi, Brian C Rowley, 2001, Mechanisms of Ageing and Development.

UNIVERSITY OF CALIFORNIA RIVERSIDE Fixed-Width Stopping Procedures for Markov Chain Monte Carlo A Dissertation submitted in partial satisfaction of the requirements for the degree of Doctor of Philosophy in Applied Statistics by

James M. Flegal, Y. Liu, S. Chowdhury, 2015 .

Positive and negative thyroid hormone response elements are composed of strong and weak half-sites 10 nucleotides in length.

J. B. Tillman, M. D. Crew, S. Spindler, 1992, Molecular endocrinology.

are abundant in human serum and plasma pseudogenes transcripts from specific YRNA genes and -YRNA fragments derived by processing of

V. Ambros, D. Boffelli, J. Dhahbi, 2015 .

A computer method for scanning and analysis of dot blots.

P. Wight, S. Spindler, R. Williams, 1985, DNA.

Statin Treatment Increases Lifespan and Improves Cardiac Health in Drosophila by Decreasing Specific Protein Prenylation

Karen Ocorr, Rolf Bodmer, Joseph M. Dhahbi, 2012, PloS one.

Novel Protein Kinase Signaling Systems Regulating Lifespan Identified by Small Molecule Library Screening Using Drosophila

F. Sauer, J. Dhahbi, S. Spindler, 2012, PloS one.

Deoxyribonucleic acid dependent ribonucleic acid polymerase II specific initiation and elongation factors from calf thymus.

S. Spindler, 1979, Biochemistry.

Postprandial induction of chaperone gene expression is rapid in mice.

J. Dhahbi, Brian C Rowley, S. Spindler, 2002, The Journal of nutrition.

Influence on longevity of blueberry, cinnamon, green and black tea, pomegranate, sesame, curcumin, morin, pycnogenol, quercetin, and taxifolin fed iso-calorically to long-lived, F1 hybrid mice.

James M. Flegal, B. Teter, S. Spindler, 2013, Rejuvenation Research.

Aging and restriction of dietary calories increases insulin receptor mRNA, and aging increases glucocorticoid receptor mRNA in the liver of female C3B10RF1 mice.

R. Walford, S. Spindler, P. Mote, 1991, Journal of gerontology.

Metformin improves healthspan and lifespan in mice

E. Mercken, R. de Cabo, D. Ingram, 2013, Nature Communications.

Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice

James M. Flegal, S. Spindler, P. Mote, 2013, AGE.

Sequences essential for activity of the thyroid hormone responsive transcription stimulatory element of the rat growth hormone gene.

P. Wight, S. Spindler, M. Crew, 1988, Molecular endocrinology.

Discrete positive and negative thyroid hormone-responsive transcription regulatory elements of the rat growth hormone gene.

P. Wight, S. Spindler, M. Crew, 1987, The Journal of biological chemistry.

Thyroid hormone regulation of the transfected rat growth hormone promoter.

S. Spindler, M. Crew, 1986, The Journal of biological chemistry.

Cyclic regulation of growth hormone gene transcription in vivo and in vitro.

J. Nyborg, S. Spindler, A. P. Nguyen, 1985, Endocrinology.

Alterations in local chromatin structure accompany thyroid hormone induction of growth hormone gene transcription.

J. Nyborg, S. Spindler, 1986, The Journal of biological chemistry.

Relationship between thyroid and glucocorticoid hormone receptor occupancy, growth hormone gene transcription, and mRNA accumulation.

J. Nyborg, S. Spindler, A. P. Nguyen, 1984, The Journal of biological chemistry.

Screening Candidate Longevity Therapeutics Using Gene-Expression Arrays

S. Spindler, P. Mote, 2007, Gerontology.

Interventions to Slow Aging in Humans: Are We Ready?

M. Vinciguerra, R. de Cabo, B. Kennedy, 2015, Aging cell.

DNA-dependent RNA polymerase II stimulatory factors from calf thymus: purification and structural studies.

S. Blatti, S. Spindler, H. Hodo, 1978, Biochemistry.

Combined statin and angiotensin-converting enzyme (ACE) inhibitor treatment increases the lifespan of long-lived F1 male mice

James M. Flegal, S. Spindler, P. Mote, 2016, AGE.

Nordihydroguaiaretic Acid Extends the Lifespan of Drosophila and Mice, Increases Mortality-Related Tumors and Hemorrhagic Diathesis, and Alters Energy Homeostasis in Mice

James M. Flegal, J. Dhahbi, A. Lublin, 2014, The journals of gerontology. Series A, Biological sciences and medical sciences.

Soybean Oil Is More Obesogenic and Diabetogenic than Coconut Oil and Fructose in Mouse: Potential Role for the Liver

F. Sladek, J. Dhahbi, K. Chellappa, 2015, PloS one.

DNA-dependent RNA polymerase III from Acanthamoeba castellanii. A rapid procedure for the large scale preparation of homogeneous enzyme.

G. Duester, J. D'Alessio, M. Paule, 1978, Journal of Biological Chemistry.

A rapid and facile procedure for the preparation of RNA polymerase I from Acanthamoeba castellanii. Purification and subunit structure.

G. Duester, J. D'Alessio, M. Paule, 1978, Journal of Biological Chemistry.

Structure and regulation of the mouse GRP78 (BiP) promoter by glucose and calcium ionophore.

J. B. Tillman, R. Walford, S. Spindler, 1995, Gene.

Caloric restriction: From soup to nuts

S. Spindler, 2010, Ageing Research Reviews.

Biological Effects of Calorie Restriction: Implications for Modification of Human Aging

S. Spindler, 2010 .

Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells

Eugene Bolotin, F. Sladek, M. Waterman, 2015, Molecular and Cellular Biology.

MicroRNAs Circulate in the Hemolymph of Drosophila and Accumulate Relative to Tissue microRNAs in an Age-Dependent Manner

J. Dhahbi, H. Atamna, S. Spindler, 2016, Genomics insights.

Additive regulation of hepatic gene expression by dwarfism and caloric restriction.

A. Bartke, J. Dhahbi, Xinping Cui, 2004, Physiological genomics.

Deep Sequencing of Serum Small RNAs Identifies Patterns of 5′ tRNA Half and YRNA Fragment Expression Associated with Breast Cancer

David I. K. Martin, D. Boffelli, J. Dhahbi, 2014, Biomarkers in cancer.

5'-YRNA fragments derived by processing of transcripts from specific YRNA genes and pseudogenes are abundant in human serum and plasma.

David Martin, D. Boffelli, J. Dhahbi, 2013, Physiological genomics.

CALL FOR PAPERS NextGen Sequencing Technology-based Dissection of Physiological Systems 5=-YRNA fragments derived by processing of transcripts from specific YRNA genes and pseudogenes are abundant in human serum and plasma

D. Boffelli, J. Dhahbi, H. Atamna, 2013 .

Promoter independent down-regulation of the firefly luciferase gene by T3 and T3 receptor in CV1 cells

J. B. Tillman, S. Spindler, Hyoung-Son Kim, 1993, Molecular and Cellular Endocrinology.

Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms

T. Breit, M. Moorhouse, J. Hoeijmakers, 2008, PLoS genetics.

Alpha and beta thyroid hormone receptors bind immediately adjacent to the rat growth hormone gene TATA box in a negatively hormone-responsive promoter region.

S. Spindler, H. Kim, D. Crone, 1990, The Journal of biological chemistry.

Growth hormone gene transcription is regulated by thyroid and glucocorticoid hormones in cultured rat pituitary tumor cells.

J. Baxter, S. Mellon, S. Spindler, 1982, The Journal of biological chemistry.

Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice

J. Dhahbi, S. Spindler, P. Mote, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Aging alters hepatic expression of insulin receptor and c-jun mRNA in the mouse.

R. Walford, S. Spindler, P. L. Mote, 1991, Mutation research.

Protein turnover, energy metabolism, aging, and caloric restriction

J. Dhahbi, S. Spindler, P. Mote, 2003 .

Calories and aging alter gene expression for gluconeogenic, glycolytic, and nitrogen-metabolizing enzymes.

J. B. Tillman, R. Walford, J. Dhahbi, 1999, The American journal of physiology.

Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.

Xuan Liu, J. Dhahbi, Joy C. Lin, 2014, Molecular cell.

Aging of the Liver

J. Dhahbi, S. Spindler, 2003 .

Use of microarray biomarkers to identify longevity therapeutics

S. Spindler, 2006, Aging cell.

Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction

S. Spindler, 2005, Mechanisms of Ageing and Development.

Review of the literature and suggestions for the design of rodent survival studies for the identification of compounds that increase health and life span

S. Spindler, 2011, AGE.

5′ tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction

David I. K. Martin, D. Boffelli, J. Dhahbi, 2013, BMC Genomics.

Gene expression and physiologic responses of the heart to the initiation and withdrawal of caloric restriction.

J. Dhahbi, T. Tsuchiya, S. Spindler, 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

Vitamin D receptor displays DNA binding and transactivation as a heterodimer with the retinoid X receptor, but not with the thyroid hormone receptor

J. B. Tillman, M. Galligan, M. Haussler, 1999, Journal of cellular biochemistry.

Identification of potential caloric restriction mimetics by microarray profiling.

G. Fahy, J. Dhahbi, S. Spindler, 2005, Physiological genomics.

R. Walford, S. Spindler, A. Koizumi, 1987, Endocrinology.

Circulating small non coding RNA signature in head and neck squamous cell carcinoma

Y. N. Lopez, P. Golusiński, K. Lamperska, 2015, Oncotarget.

Deep sequencing identifies circulating mouse miRNAs that are functionally implicated in manifestations of aging and responsive to calorie restriction

David I. K. Martin, D. Boffelli, J. Dhahbi, 2013, Aging.

Dietary energy restriction in mice negatively regulates hepatic glucose-regulated protein 78 (GRP78) expression at the posttranscriptional level.

J. B. Tillman, R. Walford, J. Dhahbi, 1996, The Journal of nutrition.

DNA-dependent RNA polymerase II from Acanthamoeba castellanii. Large scale preparation and subunit composition.

J. D'Alessio, M. Paule, S. Spindler, 1979, The Journal of biological chemistry.

Minimum Size Survival Analysis Sampling Plans for Comparing Multiple Treatment Groups to a Single Control Group

Daniel R. Jeske, James M. Flegal, D. Jeske, 2014 .

Conserved and tissue-specific genic and physiologic responses to caloric restriction and altered IGFI signaling in mitotic and postmitotic tissues.

J. Dhahbi, S. Spindler, 2007, Annual review of nutrition.

Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice

James M. Flegal, S. Spindler, P. Mote, 2014, AGE.

Dietary supplementation with Lovaza and krill oil shortens the life span of long-lived F1 mice

James M. Flegal, S. Spindler, P. Mote, 2014, AGE.

β1-Adrenergic receptor blockade extends the life span of Drosophila and long-lived mice

Daniel R. Jeske, James M. Flegal, J. Dhahbi, 2013, AGE.

5′ tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction

D. Boffelli, J. Dhahbi, H. Atamna, 2013, BMC Genomics.

Circulating microRNA signature of genotype‐by‐age interactions in the long‐lived Ames dwarf mouse

M. Masternak, J. Dhahbi, H. Atamna, 2015, Aging cell.

Deep Sequencing Reveals Novel MicroRNAs and Regulation of MicroRNA Expression during Cell Senescence

David I. K. Martin, D. Boffelli, J. Dhahbi, 2011, PloS one.

Chaperone-mediated regulation of hepatic protein secretion by caloric restriction.

J. B. Tillman, R. Walford, J. Dhahbi, 2001, Biochemical and biophysical research communications.

mRNA-Seq reveals complex patterns of gene regulation and expression in the mouse skeletal muscle transcriptome associated with calorie restriction.

D. Boffelli, J. Dhahbi, H. Atamna, 2012, Physiological genomics.

Thyroid hormone transcriptional regulatory region of the growth hormone gene.

J. Nyborg, S. Spindler, M. Crew, 1989, Endocrine research.

Caloric restriction: From soup to nuts

S. Spindler, 2010, Ageing Research Reviews.

Gene expression and physiologic responses of the heart to the initiation and withdrawal of caloric restriction.

J. Dhahbi, T. Tsuchiya, S. Spindler, 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

Development of a bioassay to screen for chemicals mimicking the anti-aging effects of calorie restriction.

H. Hayashi, Toshimitsu Komatsu, T. Chiba, 2010, Biochemical and biophysical research communications.