L. Ozcan

发表

Hepatic Glucagon Signaling Regulates PCSK9 and Low-Density Lipoprotein Cholesterol

H. Okamoto, J. Gromada, Erika S Wittchen, 2019, Circulation research.

Suppression of Adaptive Immune Cell Activation Does Not Alter Innate Immune Adipose Inflammation or Insulin Resistance in Obesity

A. Ferrante, I. Tabas, L. Ozcan, 2015, PloS one.

Role of endoplasmic reticulum stress in metabolic disease and other disorders.

I. Tabas, L. Ozcan, 2012, Annual review of medicine.

Interference with ER stress and restoration of efferocytosis in the treatment of advanced atherosclerosis

I. Tabas, E. Thorp, L. Ozcan, 2012 .

An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1.

R. Pestell, Wei Wang, R. Ramakrishnan, 2019, Blood.

Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance

E. Chen, M. Blüher, M. Czech, 2018, Nature.

Pivotal role of calcium/calmodulin-dependent protein kinase II in ER stress-induced apoptosis

I. Tabas, L. Ozcan, 2010, Cell cycle.

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways.

Mark E. Anderson, E. Olson, R. Bassel-Duby, 2009, The Journal of clinical investigation.

Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia

Stefano Spolitu, John A. Zadroga, L. Ozcan, 2022, bioRxiv.

Proprotein convertase subtilisin/kexin type 9 and lipid metabolism

Stefano Spolitu, W. Dai, John A. Zadroga, 2019, Current opinion in lipidology.

A New Activator of Hepatocyte CaMKII in Fasting and Type 2 Diabetes

I. Tabas, L. Ozcan, 2018, Diabetes.

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway

J. Backs, G. Fredman, I. Tabas, 2014, Proceedings of the National Academy of Sciences.

Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity

S. Cremers, M. Gaestel, B. Hubbard, 2015, Diabetes.

Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling.

E. Olson, J. Backs, I. Tabas, 2013, Cell metabolism.

Allosteric MAPKAPK2 inhibitors improve plaque stability in advanced atherosclerosis

B. Hubbard, I. Tabas, Arif Yurdagul, 2021, bioRxiv.

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

I. Tabas, Gang Li, L. Ozcan, 2010, The Journal of cell biology.

Targeting soluble DPP-4 for insulin resistance: Origin matters.

I. Tabas, L. Ozcan, D. Ghorpade, 2020, The Journal of clinical endocrinology and metabolism.

Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity

M. Bessler, Keiko Nakamura, I. Tabas, 2020, The Journal of clinical investigation.

Endoplasmic reticulum stress plays a central role in development of leptin resistance.

Jason Chung, Sumit Sarkar, Umut Ozcan, 2009, Cell metabolism.

Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.

M. Sahin, B. Manning, E. Yilmaz, 2008, Molecular cell.

Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity.

J. Yates, D. Accili, A. Fukamizu, 2012, Cell metabolism.

Calcium signalling and ER stress in insulin resistance and atherosclerosis

I. Tabas, I Tabas, L. Ozcan, 2016, Journal of internal medicine.

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis.

B. Ueberheide, J. Auwerx, KyeongJin Kim, 2017, Gastroenterology.

Common Therapeutic Targets in Cardiometabolic Disease

G. Fredman, I. Tabas, L. Ozcan, 2014, Science Translational Medicine.

Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance

H. Singer, Sonal A Patel, L. Ozcan, 2021, Molecular metabolism.

CAMKII&ggr; suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis

A. Tall, G. Fredman, I. Tabas, 2017, The Journal of clinical investigation.

A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose.

H. Yost, A. Vella, W. Holland, 2018, Cell reports.

Endoplasmic Reticulum Stress in Cardiometabolic Disorders

L. Ozcan, 2012, Current Atherosclerosis Reports.

Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance.

M. Bessler, R. Pestell, I. Tabas, 2016, Cell reports.

Hepatocyte DACH 1 Is Incr eased in Obesity via Nuclear Exclusion of HDAC 4 and Promotes Hepatic Insulin Resistance Graphical

M. Bessler, R. Pestell, I. Tabas, 2016 .

More than a gut feeling

L. Ozcan, 2019, Science Translational Medicine.

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

I. Tabas, Gang Li, L. Ozcan, 2010, The Journal of cell biology.

Targeting NASH with OxPL neutralization

L. Ozcan, 2019, Science Translational Medicine.

A new player in hunger games

L. Ozcan, 2019, Science Translational Medicine.

Endoplasmic reticulum stress plays a central role in development of leptin resistance.

M. Myers, S. Sarkar, Ayse Seda Ergin, 2009, Cell metabolism.

Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.

M. Sahin, B. Manning, E. Yilmaz, 2008, Molecular cell.

Common Therapeutic Targets in Cardiometabolic Disease

G. Fredman, I. Tabas, L. Ozcan, 2014, Science Translational Medicine.

Insulin sensitization by hepatic FoxO deletion is insufficient to lower atherosclerosis in mice

Niroshan Shanmugarajah, L. Ozcan, Kendra Zhong, 2023, bioRxiv.

Rap1 in the Context of PCSK9, Atherosclerosis, and Diabetes

L. Ozcan, Amesh K. Sarecha, Heena Agarwal, 2023, Current atherosclerosis reports.