Michael L. Miller

发表

A Convenient Synthesis of 2,2,4-Trimethylcyclohexane-1,3-Dione: A Useful Precursor for The Taxoid a Ring

Michael L. Miller, Partha S. Ray, 2006 .

Abstract C160: New class of DNA-alkylating agents with a suitable tolerability profile created for use in antibody-drug conjugates (ADCs).

Emily E. Reid, E. K. Maloney, J. Pinkas, 2013 .

Abstract C162: Antibody-Drug Conjugates (ADCs) with novel IGN DNA-alkylating agents display potent antigen-specific activity against hematologic and solid tumor xenograft models.

Emily E. Reid, E. K. Maloney, J. Pinkas, 2013 .

Folate receptor-specific antitumor activity of EC131, a folate-maytansinoid conjugate.

J. Reddy, R. Chari, V. Goldmacher, 2007, Cancer research.

Design, synthesis, and biological evaluation of new-generation taxoids.

D. Bar-Sagi, J. Veith, S. Horwitz, 2008, Journal of medicinal chemistry.

Antibody Co-Administration Can Improve Systemic and Local Distribution of Antibody–Drug Conjugates to Increase In Vivo Efficacy

Greg M. Thurber, J. Pinkas, Y. Setiady, 2020, Molecular Cancer Therapeutics.

Synthesis and biological evaluation of novel taxoids designed for targeted delivery to tumors.

E. Baloglu, R. Chari, V. Goldmacher, 2004, Bioorganic & medicinal chemistry letters.

Site-Specific Conjugation of the Indolinobenzodiazepine DGN549 to Antibodies Affords Antibody-Drug Conjugates with an Improved Therapeutic Index as Compared with Lysine Conjugation.

E. K. Maloney, T. Keating, R. Chari, 2019, Bioconjugate chemistry.

Optimizing lysosomal activation of antibody-drug conjugates (ADCs) by incorporation of novel cleavable dipeptide linkers.

E. K. Maloney, Rajeeva Singh, T. Keating, 2019, Molecular pharmaceutics.

Synthesis of Highly Potent N-10 Amino-Linked DNA-Alkylating Indolinobenzodiazepine Antibody-Drug Conjugates (ADCs).

E. K. Maloney, Rajeeva Singh, Y. Setiady, 2019, ACS medicinal chemistry letters.

Effect of Linker Stereochemistry on the Activity of Indolinobenzodiazepine Containing Antibody-Drug Conjugates (ADCs).

E. K. Maloney, Rui Wu, R. Chari, 2019, ACS medicinal chemistry letters.

Design, synthesis and evaluation of novel, potent DNA alkylating agents and their antibody-drug conjugates (ADCs).

E. K. Maloney, R. Chari, M. McShea, 2019, Bioorganic & medicinal chemistry letters.

A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody–Drug Conjugates (ADCs)

E. K. Maloney, J. Pinkas, Rajeeva Singh, 2018, Molecular Cancer Therapeutics.

Abstract 647: SeriMabs: N-terminal serine modification enables modular, site-specific payload incorporation into antibody-drug conjugates (ADCs)

E. K. Maloney, J. Pinkas, T. Keating, 2015 .

A New Class of Antibody–Drug Conjugates with Potent DNA Alkylating Activity

E. K. Maloney, J. Pinkas, Rajeeva Singh, 2016, Molecular Cancer Therapeutics.

Platinum-catalyzed hydrosilylation of C60: synthesis of a novel fullerene–siloxane polymer

R. West, Michael L. Miller, 1999 .

Design, synthesis and structure-activity relationships of novel taxane-based multidrug resistance reversal agents.

S. Chakravarty, M. Baer, I. Ojima, 2005, Journal of medicinal chemistry.

Synthesis of taxoids with improved cytotoxicity and solubility for use in tumor-specific delivery.

E. Baloglu, R. Chari, V. Goldmacher, 2004, Journal of medicinal chemistry.

Macrocycle Formation by Ring-Closing Metathesis. Application to the Syntheses of Novel Macrocyclic Taxoids

I. Ojima, Michael L. Miller, Songnian Lin, 2000 .

Antibody—Drug Conjugates: An Emerging Concept in Cancer Therapy

R. Chari, Michael L. Miller, W. Widdison, 2014 .

Antibody-drug conjugates: an emerging concept in cancer therapy.

R. Chari, Wayne C Widdison, Ravi V J Chari, 2014, Angewandte Chemie.

Synthesis of novel C2-C3'N-linked macrocyclic taxoids by means of highly regioselective Heck macrocyclization.

X. Geng, I. Ojima, Michael L. Miller, 2003, Organic letters.

An intramolecular 1,3-dipolar cycloaddition approach to a pyrimidoazepinone derivative. A potentially useful intermediate towards the synthesis of pyrimidoazepine based folic acid derivatives

Michael L. Miller, P. S. Ray, 1996 .

Synthesis of 5-Amino-9-benzyl-6-formyl-4-methoxy-2-pivaloylamino-7,8-dihydropyrimido[4,5-b]azepine. A potentially useful intermediate towards the synthesis of pyrimidoazepine based folic acid derivatives

Michael L. Miller, P. S. Ray, 1996 .

Synthesis of acid and two of its conformationally-restricted analogs

Michael L. Miller, P. S. Ray, M. W. Read, 1999 .

Synthesis of 5‐Amino‐9‐benzyl‐6‐formyl‐4‐methoxy‐2‐pivaloylamino‐7,8‐ dihydropyrimido(4,5‐b)azepine. A Potentially Useful Intermediate Towards the Synthesis of Pyrimidoazepine Based Folic Acid Derivatives.

Michael L. Miller, P. S. Ray, 1996 .

Biocompatibility of Mesoporous Silica Nanoparticles?

Yi Shi, A. D. Di Pasqua, Michael L. Miller, 2016 .

Detection of Nonhematologic Neoplasms by Routine Flow Cytometry Analysis.

G. Bhagat, G. Vlad, B. Alobeid, 2019, American journal of clinical pathology.

Tetracycline-Containing MCM-41 Mesoporous Silica Nanoparticles for the Treatment of Escherichia coli

S. Chavala, Yu-Chieh Wang, Yi Shi, 2015, Molecules.

Effects of Space Radiation on Humoral and Cellular Immunity in Rhesus Monkeys.

W. H. Stone, Michael L. Miller, 1992 .

Late Immunobiological Effects of Space Radiation

W. H. Stone, Michael L. Miller, 1990 .

Abstract 2644: Antibody-drug conjugates (ADCs) with a novel DNA-alkylating agent, DGN462, are highly potent in vitro and in vivo against human cancer models

E. K. Maloney, R. Chari, N. Fishkin, 2014 .

Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodies.

I. Ojima, R. Chari, V. Goldmacher, 2004, Bioorganic & medicinal chemistry letters.

Some Silicon Polymers of C60(Buckminsterfullerene)

R. West, T. Gunji, Michael L. Miller, 1994 .

Platinum(IV) cisplatin derivative trans, cis, cis-bis(heptanoato)amine(cyclohexylamine)dichloridoplatinum(IV) has an enhanced therapeutic index compared to cisplatin for the treatment of non-small cell lung cancer

Yi Shi, A. Pasqua, Michael L. Miller, 2014 .

Tumor accumulation of neutron-activatable holmium-containing mesoporous silica nanoparticles in an orthotopic non-small cell lung cancer mouse model

Lei Peng, A. Pasqua, M. Jay, 2012 .

ChemInform Abstract: Chemistry and Chemical Biology of Taxane Anticancer Agents

I. Ojima, Michael L. Miller, 2002 .