D. Strasser

发表

Qua titative assess e t of the effects of the selective S 1 P 1 receptor odulator

T. Lehr, J. Dingemanse, A. Krause, 2018 .

Monitoring inflammatory heterogeneity with multiple biomarkers for multidimensional endotyping of asthma.

I. Agache, C. Akdis, K. Izuhara, 2018, The Journal of allergy and clinical immunology.

Preclinical to clinical translation of cenerimod, a novel S1P1 receptor modulator, in systemic lupus erythematosus

A. Stalder, J. Ryge, P. Groenen, 2020, RMD Open.

Pharmacological Characterization of Aprocitentan, a Dual Endothelin Receptor Antagonist, Alone and in Combination with Blockers of the Renin Angiotensin System, in Two Models of Experimental Hypertension

J. Ménard, M. Iglarz, M. Clozel, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Modeling the Effect of the Selective S1P1 Receptor Modulator Ponesimod on Subsets of Blood Lymphocytes

T. Lehr, J. Dingemanse, A. Krause, 2017, Pharmaceutical Research.

A fragment-based in situ combinatorial approach to identify high-affinity ligands for unknown binding sites.

Xiaohua Jiang, Beat Ernst, Oliver Schwardt, 2010, Angewandte Chemie.

Biomarker‐guided clinical development of the first‐in‐class anti‐inflammatory FPR2/ALX agonist ACT‐389949

A. Stalder, P. Groenen, J. Dingemanse, 2017, British journal of clinical pharmacology.

Identification of Cathepsin L as a Potential Sex-Specific Biomarker for Renal Damage

A. Stalder, A. Klenk, M. Clozel, 2011, Hypertension.

Sex comparison on long-lasting behavioral and physiological disturbances induced by single shock experience in rats

Patrizia Haegler, D. Strasser, M. Steiner, 2012, Physiology & Behavior.

Genetic screening for Niemann–Pick disease type C in adults with neurological and psychiatric symptoms: findings from the ZOOM study

D. Balding, D. Linden, P. Bauer, 2013, Human molecular genetics.

CXCR7 Antagonism Reduces Acute Lung Injury Pathogenesis

F. Lehembre, M. Martinic, D. Strasser, 2021, Frontiers in Pharmacology.

Endothelin ETA Receptor Blockade, by Activating ETB Receptors, Increases Vascular Permeability and Induces Exaggerated Fluid Retention

M. Iglarz, M. Clozel, D. Strasser, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Pharmacokinetics, pharmacodynamics, tolerability and prediction of clinically effective dose of ACT‐774312: A novel CRTH2 antagonist

J. Dingemanse, P. Sidharta, D. Lott, 2019, Basic & clinical pharmacology & toxicology.

A novel CRTH2 antagonist: Single‐ and multiple‐dose tolerability, pharmacokinetics, and pharmacodynamics of ACT‐453859 in healthy subjects

J. Zisowsky, P. Groenen, J. Dingemanse, 2015, Journal of clinical pharmacology.

Granulomatous lung inflammation is nanoparticle type-dependent

J. Bernaudin, S. Lebecque, A. Calender, 2018, Experimental lung research.

Pharmacokinetic/Pharmacodynamic Modelling of Receptor Internalization with CRTH2 Antagonists to Optimize Dose Selection

J. Zisowsky, P. Groenen, J. Dingemanse, 2016, Clinical Pharmacokinetics.

Examining the role of endogenous orexins in hypothalamus–pituitary–adrenal axis endocrine function using transient dual orexin receptor antagonism in the rat

D. Strasser, R. Studer, F. Jenck, 2013, Psychoneuroendocrinology.

Attenuation of murine sclerodermatous models by the selective S1P1 receptor modulator cenerimod

T. Matsushita, K. Takehara, Y. Hamaguchi, 2019, Scientific Reports.

Development of a decision-making biomarker for CRTH2 antagonism in clinical studies

J. Zisowsky, P. Groenen, M. Holdener, 2015 .

RECEPTORS BLOCKADE , BY ACTIVATING ET B RECEPTORS , INCREASES VASCULAR PERMEABILITY AND INDUCES EXAGGERATED FLUID RETENTION

M. Iglarz, M. Clozel, D. Strasser, 2017 .

2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists.

M. Bolli, Stefan Abele, A. Treiber, 2010, Journal of medicinal chemistry.

Activation of IL5R and CRTH2 on Human Eosinophils Elicit a Similar Molecular Response and Reveal a Synergistic Effect

P. Groenen, D. Strasser, B. Renault, 2018 .

Impact of high‐altitude therapy on type‐2 immune responses in asthma patients

C. Akdis, M. Akdiş, H. Duchna, 2019, Allergy.

Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.

L. Prade, D. Ritz, R. Lange, 2012, Bioorganic & medicinal chemistry letters.

Discovery of Clinical Candidate ACT-777991, a Potent CXCR3 Antagonist for Antigen-Driven and Inflammatory Pathologies.

M. Martinic, E. Meyer, S. Froidevaux, 2023, Journal of medicinal chemistry.

A Multipurpose First‐in‐Human Study With the Novel CXCR7 Antagonist ACT‐1004‐1239 Using CXCL12 Plasma Concentrations as Target Engagement Biomarker

H. E. Meyer zu Schwabedissen, M. Al-Ibrahim, J. Dingemanse, 2021, Clinical pharmacology and therapeutics.

Low molecular weight antagonists of the myelin-associated glycoprotein: synthesis, docking, and biological evaluation.

A. Vedani, G. Rossato, O. Schwardt, 2010, Journal of medicinal chemistry.

Serum IL‐5 and IL‐13 consistently serve as the best predictors for the blood eosinophilia phenotype in adult asthmatics

I. Agache, C. Akdis, A. Klenk, 2016, Allergy.

Immunoaffinity targeted mass spectrometry analysis of human plasma samples reveal an imbalance of active and inactive CXCL10 in primary Sjögren's Syndrome disease patients.

A. Schmidt, A. Sebastian, R. Welford, 2020, Journal of proteome research.

Kinetic and thermodynamic properties of MAG antagonists.

O. Schwardt, B. Ernst, H. Koliwer-Brandl, 2010, Carbohydrate research.

Differential Effects of the Dual Orexin Receptor Antagonist Almorexant and the GABAA-α1 Receptor Modulator Zolpidem, Alone or Combined with Ethanol, on Motor Performance in the Rat

D. Strasser, F. Jenck, M. Steiner, 2011, Neuropsychopharmacology.

Plasma neurofilament light, glial fibrillary acidic protein and lysosphingolipid biomarkers for pharmacodynamics and disease monitoring of GM2 and GM1 gangliosidoses patients

R. Giugliani, P. Groenen, E. Mengel, 2022, Molecular genetics and metabolism reports.

Eosinophilic oesophagitis: relevance of mast cell infiltration

A. Stalder, A. Straumann, P. Groenen, 2018, Histopathology.