Patrick S Lee

发表

SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo

Stephen K Burley, Spencer Emtage, Shane Atwell, 2009, Molecular Cancer Therapeutics.

Origins of inward torquoselectivity by silyl groups and other sigma-acceptors in electrocyclic reactions of cyclobutenes.

K N Houk, K. Houk, Patrick S. Lee, 2003, Journal of the American Chemical Society.

Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: Uncovering a New Role for MexMN-OprM in Efflux of β-Lactams and a Novel Regulatory Circuit (MmnRS) Controlling MexMN Expression

Z. Zwirko, J. Walker, C. Dean, 2018, Antimicrobial Agents and Chemotherapy.

Photochemistry of ketones adsorbed on size/shape selective zeolites. A supramolecular approach to persistent carbon centered radicals

Hege S. Beard, K. Houk, N. Turro, 1998 .

Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications

John A. Tallarico, M. Schirle, J. Tallarico, 2018, bioRxiv.

Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications

M. Schirle, J. Tallarico, D. Nomura, 2018, bioRxiv.

Promiscuity and the Conformational Rearrangement of Drug‐Like Molecules: Insight from the Protein Data Bank

Patrick S. Lee, Z. Sweeney, Patrick S Lee, 2015, ChemMedChem.

Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase.

R. Jain, Daniel J. Poon, Shejin Zhu, 2015, Bioorganic & medicinal chemistry letters.

Energetic preferences for alpha,beta versus beta,gamma unsaturation.

D. Boger, W. L. Jorgensen, Patrick S Lee, 2004, The Journal of organic chemistry.

Two Distinct Mechanisms of Inhibition of LpxA Acyltransferase Essential for Lipopolysaccharide Biosynthesis.

S. Subramanian, E. Ornelas, Sylvia Ma, 2020, Journal of the American Chemical Society.

Two distinct mechanisms of small molecule inhibition of LpxA acyltransferase essential for lipopolysaccharide biosynthesis

C. Ho, M. Li, S. Subramanian, 2019, bioRxiv.

Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline.

W. Shu, C. Bellamacina, G. Tonn, 2018, Journal of medicinal chemistry.

A Standard Set of Pericyclic Reactions of Hydrocarbons for the Benchmarking of Computational Methods: The Performance of ab Initio, Density Functional, CASSCF, CASPT2, and CBS-QB3 Methods for the Prediction of Activation Barriers, Reaction Energetics, and Transition State Geometries

Andrew G. Leach, K. Houk, V. Güner, 2003 .

Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase.

Jianwen A. Feng, P. McEwan, Lawren C. Wu, 2018, Journal of medicinal chemistry.

Mutations Reducing In Vitro Susceptibility to Novel LpxC Inhibitors in Pseudomonas aeruginosa and Interplay of Efflux and Nonefflux Mechanisms

J. Walker, C. Dean, S. W. Barnes, 2019, Antimicrobial Agents and Chemotherapy.

Structure Based Design of Potent Selective Inhibitors of Protein Kinase D1 (PKD1).

Jianwen A. Feng, P. McEwan, R. Godemann, 2019, ACS medicinal chemistry letters.

Altering the allowed/forbidden gap in cyclobutene electrocyclic reactions: experimental and theoretical evaluations of the effect of planarity constraints.

K. Houk, S. Sakai, Patrick S. Lee, 2003, Journal of the American Chemical Society.

Ligand efficient tetrahydro-pyrazolopyridines as inhibitors of ERK2 kinase.

M. Lindvall, R. Jain, Daniel J. Poon, 2015, Bioorganic & medicinal chemistry letters.

Selective inhibition of MET protein receptor tyrosine kinase by SGX523

J. M. Sauder, S. Burley, J. Blaney, 2007 .

Modulateurs de kinase hétérocycliques

J. Hendle, P. Bounaud, E. Jefferson, 2008 .