Joe C. Wu

发表

A nucleotide binding site in caspase-9 regulates apoptosome activation.

Hua Zou, David Chereau, and Alfred P. Spada, 2005 .

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

Stephen F. Betz, Stephen W. Fesik, Edward T. Olejniczak, 2000, Nature.

NMR Structure and Mutagenesis of the Third Bir Domain of the Inhibitor of Apoptosis Protein XIAP*

Stephen W. Fesik, A. Gunasekera, Chaohong Sun, 2000, The Journal of Biological Chemistry.

Enhanced selectivity profile of pyrazole-urea based DFG-out p38alpha inhibitors.

S. Kazmirski, A. Cheng, F. Féru, 2010, Bioorganic & medicinal chemistry letters.

KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients

Yan Zhang, Mark R. Emmett, Alan G. Marshall, 2009, Proceedings of the National Academy of Sciences.

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

F. Jiang, Beth L. Pietrak, T. Riera, 2014, Nature Communications.

Function of activation loop tyrosine phosphorylation in the mechanism of c-Kit auto-activation and its implication in sunitinib resistance.

Yan Zhang, J. English, Jonathan P DiNitto, 2010, Journal of biochemistry.

Structure-activity relationships within a series of caspase inhibitors: effect of leaving group modifications.

J. Díaz, A. Schmitz, T. Deckwerth, 2003, Bioorganic & medicinal chemistry letters.

Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney disease.

Y. Tao, Jun Kim, R. Schrier, 2005, Proceedings of the National Academy of Sciences of the United States of America.

First-in-class pan caspase inhibitor developed for the treatment of liver disease.

N. Chen, J. Díaz, K. Valentino, 2005, Journal of medicinal chemistry.

Catalysis by Isomeric Forms of Covalently Labeled F1-ATPase

V. Joshi, Joe C. Wu, Jui H. Wang, 1989 .

Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.

A. Sauter, J. Díaz, A. Schmitz, 2004, Bioorganic & medicinal chemistry letters.

Protein kinase inhibitors: breakthrough medicines and the next generation

J. English, T. Sawyer, Joe C. Wu, 2013, Expert opinion on investigational drugs.

Structure-activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads.

N. Chen, J. Díaz, A. Schmitz, 2005, Bioorganic & medicinal chemistry letters.

Regulation of the Apaf-1/Caspase-9 Apoptosome by Caspase-3 and XIAP*

Chaohong Sun, S. Fesik, R. Armstrong, 2003, The Journal of Biological Chemistry.

Bcl-xL Functions Downstream of Caspase-8 to Inhibit Fas- and Tumor Necrosis Factor Receptor 1-induced Apoptosis of MCF7 Breast Carcinoma Cells*

L. Fritz, K. Tomaselli, J. Krebs, 1998, The Journal of Biological Chemistry.

Activation of Membrane-associated Procaspase-3 Is Regulated by Bcl-2

A. Schmitz, R. Armstrong, L. Fritz, 1999, The Journal of cell biology.

Continuous fluorescence-based method for assessing dicer cleavage efficiency reveals 3' overhang nucleotide preference.

Leyu Wang, Joe C. Wu, J. P. DiNitto, 2010, BioTechniques.

Molecular mechanisms of drug resistance in tyrosine kinases cAbl and cKit

Joe C. Wu, J. P. DiNitto, 2011, Critical reviews in biochemistry and molecular biology.

Conformational restrictions in the active site of unliganded human caspase‐3

C. Ni, K. R. Ely, Chenglong Li, 2003, Journal of molecular recognition : JMR.

Structural and functional analysis of caspase active sites.

A. Spada, K. Tomaselli, Joe C. Wu, 2003, Biochemistry.

The Design, Synthesis and Potential Utility of Fluorescence Probes that Target DFG‐out Conformation of p38α for High Throughput Screening Binding Assay

S. Kazmirski, A. Cheng, Qing Cao, 2009, Chemical biology & drug design.

Drug binding and resistance mechanism of KIT tyrosine kinase revealed by hydrogen/deuterium exchange FTICR mass spectrometry

Xiu Yu, Elizabeth A Lunney, K. Gajiwala, 2010, Protein science : a publication of the Protein Society.

Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?

S. Kazmirski, J. Penzotti, H. Tecle, 2009, Bioorganic & medicinal chemistry letters.

Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization.

N. Chen, J. Díaz, A. Schmitz, 2002, Bioorganic & medicinal chemistry letters.

Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization.

J. Díaz, L. Fritz, K. Tomaselli, 2002, Bioorganic & medicinal chemistry letters.

Long‐term protection of brain tissue from cerebral ischemia by peripherally administered peptidomimetic caspase inhibitors

M. Rudin, A. Sauter, A. Schmitz, 2001 .

Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor.

J. Adams, K. Grozinger, J. Wu, 1990, Science.

A simple kinetic method for rapid mechanistic analysis of reversible enzyme inhibitors.

Joe C. Wu, Chung-Jeng Lai, 2003, Assay and drug development technologies.