Yosephine Gumulya

Learning epistatic interactions from sequence-activity data to predict enantioselectivity

Mikael Bodén, Julian Zaugg, Yosephine Gumulya, 2017, Journal of Computer-Aided Molecular Design.

Computational tools for directed evolution: a comparison of prospective and retrospective strategies.

Mikael Bodén, Julian Zaugg, Yosephine Gumulya, 2014, Methods in molecular biology.

Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP)

Burkhard Rost, Mikael Bodén, Julian Zaugg, 2019, bioRxiv.

Genetically programmed chiral organoborane synthesis

Frances H. Arnold, Yosephine Gumulya, Kai Chen, 2017, Nature.

Enhancing the Thermal Robustness of an Enzyme by Directed Evolution: Least Favorable Starting Points and Inferior Mutants Can Map Superior Evolutionary Pathways

Manfred T. Reetz, Yosephine Gumulya, M. Reetz, 2011, Chembiochem : a European journal of chemical biology.

Iterative saturation mutagenesis accelerates laboratory evolution of enzyme stereoselectivity: rigorous comparison with traditional methods.

Yosephine Gumulya, Manfred T Reetz, Marco Bocola, 2010, Journal of the American Chemical Society.

Improved PCR method for the creation of saturation mutagenesis libraries in directed evolution: application to difficult-to-amplify templates

Yosephine Gumulya, Joaquin Sanchis, Pankaj Soni, 2008, Applied Microbiology and Biotechnology.

Many Pathways in Laboratory Evolution Can Lead to Improved Enzymes: How to Escape from Local Minima

Yosephine Gumulya, Manfred T Reetz, Joaquin Sanchis, 2012, Chembiochem : a European journal of chemical biology.

Increasing the stability of an enzyme toward hostile organic solvents by directed evolution based on iterative saturation mutagenesis using the B-FIT method.

Yosephine Gumulya, Manfred T Reetz, Pankaj Soni, 2010, Chemical communications.