D. Brand

P. E. Van den Steen, G. Opdenakker, P. Proost, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Monomeric, porous type II collagen scaffolds promote chondrogenic differentiation of human bone marrow mesenchymal stem cells in vitro

F. Dazzi, J. Apperley, E. Gentleman, 2017, Scientific Reports.

TGF-β–Induced CD4+Foxp3+ T Cells Attenuate Acute Graft-versus-Host Disease by Suppressing Expansion and Killing of Effector CD8+ Cells

S. Zheng, N. Olsen, Xuehao Wang, 2014, The Journal of Immunology.

Advances in distinguishing natural from induced Foxp3(+) regulatory T cells.

Zhiyong Guo, Xiaoshun He, S. Zheng, 2013, International journal of clinical and experimental pathology.

Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions

B. Li, S. Zheng, N. Olsen, 2014, Proceedings of the National Academy of Sciences.

Detection of Early Changes in Autoimmune T Cell Phenotype and Function Following Intravenous Administration of Type II Collagen in a TCR-Transgenic Model1

A. Kang, D. Brand, J. Stuart, 2002, The Journal of Immunology.

Adoptive transfer of human gingiva-derived mesenchymal stem cells ameliorates collagen-induced arthritis via suppression of Th1 and Th17 cells and enhancement of regulatory T cell differentiation.

Zhiyong Guo, Xiaoshun He, S. Zheng, 2013, Arthritis and rheumatism.

Administering human adipose-derived mesenchymal stem cells to prevent and treat experimental arthritis.

Bin Zhou, A. Kang, D. Brand, 2011, Clinical immunology.

Beta-caryophyllene prevents the defects in trabecular bone caused by Vitamin D deficiency through pathways instated by increased expression of klotho

W. Gu, Wei Li, D. Brand, 2022, Bone & joint research.

Silencing S1P1 Receptors Regulates Collagen‐V Reactive Lymphocyte‐Mediated Immunobiology in the Transplanted Lung

O. Cummings, T. Fujisawa, E. L. Thompson, 2008, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Vaccination with a recombinant V alpha domain of a TCR prevents the development of collagen-induced arthritis.

E. Ward, D. Brand, M. Ciubotaru, 1995, Journal of immunology.

Collagen-induced arthritis

D. Brand, E. Rosloniec, K. Latham, 2007, Nature Protocols.

Saccharopolyspora rectivirgula Thermophilic Actinomycetes Hypersensitivity Pneumonitis-Causing Proinflammatory Response Induced by Protein Kinase D1 Is Essential for the

Young-In Kim, D. Brand, E. Fitzpatrick, 2010 .

Protein Kinase D1 Is Essential for the Proinflammatory Response Induced by Hypersensitivity Pneumonitis-Causing Thermophilic Actinomycetes Saccharopolyspora rectivirgula

A. Yi, D. Brand, E. Fitzpatrick, 2010, The Journal of Immunology.

Induced CD4+ forkhead box protein-positive T cells inhibit mast cell function and established contact hypersensitivity through TGF-β1.

Xiaoshun He, S. Zheng, B. Ryffel, 2012, The Journal of allergy and clinical immunology.

Differential role of all‐trans retinoic acid in promoting the development of CD4+ and CD8+ regulatory T cells

S. Zheng, B. Ryffel, Zhongmin Liu, 2014, Journal of leukocyte biology.

Phenotypic and functional characteristic of a newly identiﬁed CD 8 + Foxp 3 2 CD 103 + regulatory T cells

S. Zheng, B. Ryffel, Zanxian Xia, 2014 .

Phenotypic and functional characteristic of a newly identified CD 8 + Foxp 3 2 CD 103 + regulatory T cells

S. Zheng, B. Ryffel, Zanxian Xia, 2014 .

Engineered Regulatory T Cells Coexpressing MHC Class II:Peptide Complexes Are Efficient Inhibitors of Autoimmune T Cell Function and Prevent the Development of Autoimmune Arthritis

Zhaohui Qian, D. Brand, E. Rosloniec, 2013, The Journal of Immunology.

Autoimmune Arthritis Function and Prevent the Development of Efficient Inhibitors of Autoimmune T Cell MHC Class II : Peptide Complexes Are Engineered Regulatory T Cells Coexpressing

Zhaohui Qian, D. Brand, E. Rosloniec, 2013 .

6&bgr;-Hydroxytestosterone, a Cytochrome P450 1B1-Testosterone–Metabolite, Mediates Angiotensin II–Induced Renal Dysfunction in Male Mice

L. Navar, F. Gonzalez, K. Malik, 2016, Hypertension.

Type V Collagen-Induced Oral Tolerance Plus Low-Dose Cyclosporine Prevents Rejection of MHC Class I and II Incompatible Lung Allografts1

I. Yoshino, I. Petrache, K. Yasufuku, 2009, The Journal of Immunology.

Incompatible Lung Allografts Rejection of MHC Class I and II Plus Low-Dose Cyclosporine Prevents Type V Collagen-Induced Oral Tolerance

I. Yoshino, I. Petrache, K. Yasufuku, 2009 .

1,25-Dihydroxyvitamin D3 and 20-Hydroxyvitamin D3 Upregulate LAIR-1 and Attenuate Collagen Induced Arthritis

Wei Li, A. Slominski, A. Yi, 2021, International journal of molecular sciences.

Role of Citrullinated Collagen in Autoimmune Arthritis

A. Yi, D. Brand, J. Stuart, 2022, International journal of molecular sciences.

The CII-specific autoimmune T-cell response develops in the presence of FTY720 but is regulated by enhanced Treg cells that inhibit the development of autoimmune arthritis

K. Hasty, D. Brand, E. Rosloniec, 2016, Arthritis Research & Therapy.

Pathogenesis of collagen‐induced arthritis: modulation of disease by arthritogenic T‐cell epitope location

A. Kang, D. Brand, J. Stuart, 2004, Immunology.

Efficacy of modified recombinant type II collagen in modulating autoimmune arthritis.

A. Kang, D. Brand, J. Stuart, 2004, Arthritis and rheumatism.

Immunogenicity and Arthritogenicity of Recombinant CB10 in B10.RIII Mice1

A. Kang, D. Brand, J. Stuart, 2000, The Journal of Immunology.

Recombinant CB10 in B10.RIII Mice Immunogenicity and Arthritogenicity of

D. Brand, J. Stuart, L. Myers, 2022 .

IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants.

O. Cummings, R. Braun, Junchao Cai, 2007, The Journal of clinical investigation.

Ameliorating effects of Gö6976, a pharmacological agent that inhibits protein kinase D, on collagen-induced arthritis

Young-In Kim, A. Yi, K. Hasty, 2019, PloS one.

Inhibition of bleomycin-induced pulmonary fibrosis through pre-treatment with collagen type V.

R. Braun, R. Love, M. Iwashima, 2010, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

T Cells Stimulated by an Analog Peptide of Type II Collagen Require FcR γ to Secrete IL-4 and Suppress Autoimmune Arthritis

D. Brand, S. Kleinau, J. Stuart, 2013 .

Characterization of inhibitory T cells induced by an analog of type II collagen in an HLA-DR1 humanized mouse model of autoimmune arthritis

M. Kimata, A. Kang, D. Brand, 2012, Arthritis Research & Therapy.

T cells stimulated with an analog peptide of type II collagen require the Fc receptor γ-chain to secrete interleukin-4 and suppress autoimmune arthritis in mice.

A. Kang, D. Brand, S. Kleinau, 2011, Arthritis and rheumatism.

A shift in the collagen V antigenic epitope leads to T helper phenotype switch and immune response to self‐antigen leading to chronic lung allograft rejection

G. Patterson, T. Mohanakumar, R. Hachem, 2012, Clinical and experimental immunology.

Polyclonal CD4+Foxp3+ Treg cells induce TGFβ-dependent tolerogenic dendritic cells that suppress the murine lupus-like syndrome.

S. Zheng, B. Ryffel, P. Kiela, 2012, Journal of molecular cell biology.

TGFb-dependent tolerogenic dendritic cells that suppress the murine lupus-like syndrome

S. Zheng, B. Ryffel, P. Kiela, 2012 .

Characterization of T cell phenotype and function in a double transgenic (collagen-specific TCR/HLA-DR1) humanized model of arthritis

A. Kang, A. Postlethwaite, D. Brand, 2014, Arthritis Research & Therapy.

Antigen-specific TGF- β -induced regulatory T cells but not natural Tregs ameliorate autoimmune arthritis by shifting the balance of Th17 toward Treg cells

B. Ryffel, A. David, Zhongmin Liu, 2015 .

A Bilayer Osteochondral Scaffold with Self‐Assembled Monomeric Collagen Type‐I, Type‐II, and Polymerized Chondroitin Sulfate Promotes Chondrogenic and Osteogenic Differentiation of Mesenchymal Stem Cells

J. Czernuszka, Chaozong Liu, N. Rashidi, 2021, Advanced NanoBiomed Research.

A protocol to develop T helper and Treg cells in vivo

S. Zheng, N. Olsen, Weiqian Chen, 2017, Cellular & Molecular Immunology.

Transfer of Tolerance to Collagen Type V Suppresses T-Helper-Cell-17 Lymphocyte-Mediated Acute Lung Transplant Rejection

R. Braun, S. Fain, W. Burlingham, 2009, Transplantation.

Anti‐Type V Collagen Lymphocytes that Express IL‐17 and IL‐23 Induce Rejection Pathology in Fresh and Well‐Healed Lung Transplants

T. Fujisawa, J. Blum, D. Wilkes, 2006, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Suppression of immune responses in collagen-induced arthritis by a rationally designed CD80-binding peptide agent.

M. Srinivasan, R. Eri, J. Blum, 2007, Arthritis and rheumatism.

Generation of glycosylated remnant epitopes from human collagen type II by gelatinase B.

P. E. Van den Steen, G. Opdenakker, P. Proost, 2004, Biochemistry.

The function of BAFF on T helper cells in autoimmunity.

Zhiyong Guo, Xiaoshun He, S. Zheng, 2014, Cytokine & growth factor reviews.

Metalloproteinase Inhibition Has Differential Effects on Alloimmunity, Autoimmunity, and Histopathology in the Transplanted Lung

O. Cummings, Gerald N. Smith, E. Mickler, 2007, Transplantation.

Model of Autoimmune Arthritis of Mice in an HLA-DR1 Humanized Mouse Joints Cell Repertoire Infiltrates the Arthritic An Autoantigen-Specific, Highly Restricted T

D. Brand, E. Rosloniec, K. Whittington, 2010 .

Collagen antibody-induced arthritis in mice: development of a new arthritogenic 5-clone cocktail of monoclonal anti-type II collagen antibodies.

S. Yoshino, T. Saito, D. Brand, 2009, Journal of immunological methods.

T Cell Immunity to Type II Collagen in the Biobreeding Rat: The Identification and Characterization of RT1u-Restricted T Cell Epitopes on α1(II)1

A. Kang, D. Brand, E. Rosloniec, 2004, The Journal of Immunology.

Relevance of Posttranslational Modifications for the Arthritogenicity of Type II Collagen1

J. Myllyharju, A. Kang, M. Bodo, 2004, The Journal of Immunology.

T Cell Immunity to Type II Collagen in the Biobreeding Rat: The Identification and Characterization of RT1-Restricted T Cell Epitopes on 1(II)

D. Brand, E. Rosloniec, L. Myers, 2004 .

The mouse model of collagen-induced arthritis.

A. Kang, D. Brand, E. Rosloniec, 2004, Methods in molecular medicine.

for the Arthritogenicity of Type II Collagen Relevance of Posttranslational Modifications

J. Myllyharju, M. Bodo, D. Brand, 2004 .

Molecular definition and characterization of recombinant bovine CB8 and CB10: immunogenicity and arthritogenicity.

A. Kang, D. Brand, J. Stuart, 1999, Clinical immunology.

Characterization of Non-Invasively Induced Post-Traumatic Osteoarthritis in Mice

A. Yi, Y. Jeong, K. Hasty, 2022, Antioxidants.

Robust Characterization of Non-Invasive Post-Traumatic Osteoarthritis Mouse Model

Y. Jeong, K. Hasty, Do-Gyoon Kim, 2021, bioRxiv.

Direct Visualization of Protease Action on Collagen Triple Helical Structure

Sidney R. Cohen, P. E. Van den Steen, G. Opdenakker, 2010, PloS one.

Nucleosides from Phlebotomus papatasi Salivary Gland Ameliorate Murine Collagen-Induced Arthritis by Impairing Dendritic Cell Functions

J. Ribeiro, F. Cunha, J. Valenzuela, 2011, The Journal of Immunology.

Dendritic Cell Functions Collagen-Induced Arthritis by Impairing Salivary Gland Ameliorate Murine Phlebotomus papatasi Nucleosides from

J. Ribeiro, W. Verri, A. Sá-Nunes, 2011 .

Influence of the shared epitope on the elicitation of experimental autoimmune arthritis biomarkers

A. Karydis, Jiwen Luo, I. Sandal, 2021, PloS one.

The role of Syk in peripheral T cells.

A. Kang, A. Yi, D. Brand, 2018, Clinical immunology.

Collagen‐Induced Arthritis Mouse Model

D. Brand, E. Rosloniec, K. Whittington, 2021, Current protocols.

Immunogenicity of recombinant type IX collagen in murine collagen-induced arthritis.

L. Ala‐Kokko, A. Kang, M. Bodo, 2002, Arthritis and rheumatism.

Influence of telopeptides, fibrils and crosslinking on physicochemical properties of Type I collagen films

J. Czernuszka, D. Brand, R. Walton, 2010, Journal of materials science. Materials in medicine.

Development of Tri‐Layered Biomimetic Atelocollagen Scaffolds with Interfaces for Osteochondral Tissue Engineering

J. Czernuszka, Guangdong Zhou, Huitang Xia, 2022, Advanced healthcare materials.

A self-organising biomimetic collagen/nano-hydroxyapatite-glycosaminoglycan scaffold for spinal fusion

J. Czernuszka, Aman Sharma, H. Ye, 2017, Journal of Materials Science.

Collagenaceous, thiol-containing proteins of cnidarian nematocysts: A comparison of the chemistry and protein distribution patterns in two types of cnidae

D. Brand, R. Blanquet, M. Phelan, 1993 .

Cutting Edge: All-Trans Retinoic Acid Sustains the Stability and Function of Natural Regulatory T Cells in an Inflammatory Milieu

S. Zheng, H. Fan, Zhongmin Liu, 2010, The Journal of Immunology.

Bone loss and aggravated autoimmune arthritis in HLA-DRβ1-bearing humanized mice following oral challenge with Porphyromonas gingivalis

S. Zheng, M. Radic, P. Mydel, 2016, Arthritis Research & Therapy.

lncRNA‐PDPK2P promotes hepatocellular carcinoma progression through the PDK1/AKT/Caspase 3 pathway

S. Zheng, Jingyuan Zhao, W. Pan, 2019, Molecular oncology.

Synergistic effect of TGF‐β superfamily members on the induction of Foxp3+ Treg

S. Zheng, Xuehao Wang, W. Shi, 2009, European journal of immunology.

Analog peptides of type II collagen can suppress arthritis in HLA-DR4 (DRB1*0401) transgenic mice

A. Kang, D. Brand, Y. Sakurai, 2006, Arthritis research & therapy.

Antigen-specific transforming growth factor β-induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17/Treg cell balance from Th17 predominance to Treg cell predominance.

S. Zheng, B. Ryffel, Zhongmin Liu, 2012, Arthritis and rheumatism.

Integrated analysis of 10 lymphoma datasets identifies E2F8 as a key regulator in Burkitt's lymphoma and mantle cell lymphoma.

Dahai Liu, Wen-Xing Li, Hua You, 2019, American journal of translational research.

Role of SMAD and Non-SMAD Signals in the Development of Th17 and Regulatory T Cells

S. Zheng, Y. Chai, Xuehao Wang, 2010, The Journal of Immunology.

Role of TNF–TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications

S. Zheng, Sujuan Yang, D. Brand, 2018, Front. Immunol..

Immunopathogenesis of Collagen Arthritis

A. Kang, D. Brand, E. Rosloniec, 2003, Springer Seminars in Immunopathology.

In Vivo Attenuation of Antibody-Mediated Acute Renal Allograft Rejection by Ex Vivo TGF-β-Induced CD4+Foxp3+ Regulatory T Cells

S. Zheng, Qiquan Sun, D. Brand, 2017, Front. Immunol..

Therapeutic potential of TGF-β-induced CD4+ Foxp3+ regulatory T cells in autoimmune diseases

S. Zheng, Zhongmin Liu, D. Brand, 2011, Autoimmunity.

Targeting IL-2: an unexpected effect in treating immunological diseases

S. Zheng, D. Brand, Congxiu Ye, 2018, Signal Transduction and Targeted Therapy.

Off-Target Deletion of Conditional Dbc1 Allele in the Foxp3YFP-Cre Mouse Line under Specific Setting

S. Zheng, N. Olsen, J. Bellanti, 2019, Cells.

mPGES1-Dependent Prostaglandin E2 (PGE2) Controls Antigen-Specific Th17 and Th1 Responses by Regulating T Autocrine and Paracrine PGE2 Production

L. Crofford, M. Ward, J. Woodward, 2018, The Journal of Immunology.

Induction of autoimmune arthritis in HLA-DR4 (DRB1*0401) transgenic mice by immunization with human and bovine type II collagen.

A. Woods, D. Zaller, A. Kang, 1998, Journal of immunology.

with Human and Bovine Type II Collagen (DRB1*0401) Transgenic Mice by Immunization Induction of Autoimmune Arthritis in HLA-DR4

A. Woods, D. Zaller, D. Brand, 1998 .

An HLA-DR1 Transgene Confers Susceptibility to Collagen-induced Arthritis Elicited with Human Type II Collagen

A. Woods, D. Zaller, D. Altmann, 1997, The Journal of experimental medicine.

An HLA-DR 1 Transgene Confers Susceptibility to Collagen-induced Arthritis Elicited with Human Type II Collagen

A. Woods, D. Zaller, D. Altmann, 1997 .

Leukocyte-associated immunoglobulin-like receptor 1 inhibits T-cell signaling by decreasing protein phosphorylation in the T-cell signaling pathway

A. Kang, A. Yi, D. Brand, 2020, The Journal of Biological Chemistry.

An Autoantigen-Specific, Highly Restricted T Cell Repertoire Infiltrates the Arthritic Joints of Mice in an HLA-DR1 Humanized Mouse Model of Autoimmune Arthritis

Zhaohui Qian, D. Brand, E. Rosloniec, 2010, The Journal of Immunology.

Porphyromonas gingivalis oral infection exacerbates the development and severity of collagen-induced arthritis

G. Núñez, W. Giannobile, J. Marchesan, 2013, Arthritis Research & Therapy.

20S-Hydroxyvitamin D3, a Secosteroid Produced in Humans, Is Anti-Inflammatory and Inhibits Murine Autoimmune Arthritis

Wei Li, A. Slominski, R. Tuckey, 2021, Frontiers in Immunology.

CD80 Binding Polyproline Helical Peptide Inhibits T Cell Activation*

M. Srinivasan, R. Eri, J. Blum, 2005, Journal of Biological Chemistry.

All-Trans Retinoic Acid Promotes TGF-β-Induced Tregs via Histone Modification but Not DNA Demethylation on Foxp3 Gene Locus

Wei Shi, Zanxian Xia, Song Guo Zheng, 2011, PloS one.

Modulation of collagen-induced arthritis by adenovirus-mediated intra-articular expression of modified collagen type II

Janice A. Zawaski, M. Gaber, A. Kang, 2010, Arthritis research & therapy.

Collagen in a TCR-Transgenic Model Intravenous Administration of Type II Cell Phenotype and Function Following Detection of Early Changes in Autoimmune T

A. Kang, D. Brand, J. Stuart, 2001 .

Induced T regulatory cells suppress osteoclastogenesis and bone erosion in collagen-induced arthritis better than natural T regulatory cells

S. Zheng, P. Conti, R. Park, 2012, Annals of the rheumatic diseases.

Cytochrome P450 1B1 Contributes to the Development of Angiotensin II-Induced Aortic Aneurysm in Male Apoe(-/-) Mice.

F. Gonzalez, K. Malik, S. Thirunavukkarasu, 2016, The American journal of pathology.

Autoantibodies to murine type II collagen in collagen-induced arthritis: a comparison of susceptible and nonsusceptible strains.

A. Kang, D. Brand, T. Marion, 1996, Journal of immunology.

Infusion of GMSCs relieves autoimmune arthritis by suppressing the externalization of neutrophil extracellular traps via PGE2-PKA-ERK axis.

S. Zheng, Yang Liu, D. Brand, 2023, Journal of advanced research.

Characterisation of freeze-dried type II collagen and chondroitin sulfate scaffolds

D. Brand, J. Czernuszka, M. Tamaddon, 2013, Journal of Materials Science: Materials in Medicine.

Characterization of the T cell determinants in the induction of autoimmune arthritis by bovine alpha 1(II)-CB11 in H-2q mice.

A. Kang, D. Brand, J. Stuart, 1994, Journal of immunology.

Identification of MHC class II and TCR binding residues in the type II collagen immunodominant determinant mediating collagen-induced arthritis.

D. Brand, J. Stuart, E. Rosloniec, 1996, Cellular immunology.

Collagen‐Induced Arthritis

A. Kang, D. Brand, E. Rosloniec, 2010, Current protocols in immunology.

Inflammasome-independent Role of Apoptosis-associated Speck-like Protein Containing a CARD (ASC) in T Cell Priming Is Critical for Collagen-induced Arthritis*

L. Joosten, M. Netea, K. Boyd, 2010, The Journal of Biological Chemistry.

Peptide ligand structure and I-Aq binding avidity influence T cell signaling pathway utilization.

A. Kang, A. Yi, D. Brand, 2015, Clinical immunology.

The Role of Leukocyte-Associated Ig-like Receptor-1 in Suppressing Collagen-Induced Arthritis

J. Coligan, A. Kang, D. Brand, 2017, The Journal of Immunology.

Cross-linking electrospun type II collagen tissue engineering scaffolds with carbodiimide in ethanol.

G. Bowlin, D. Simpson, C. Barnes, 2007, Tissue engineering.

Arthritis Receptor-1 in Suppressing Collagen-Induced The Role of Leukocyte-Associated Ig-like

J. Coligan, A. Kang, D. Brand, 2017 .