J. Hasler

发表

Genetic polymorphism of CYP2D6 and CYP2C19 in East- and Southern African populations including psychiatric patients

S. Kaaya, C. Masimirembwa, C. Dandara, 2001, European Journal of Clinical Pharmacology.

Effects of chloroquine treatment on antioxidant enzymes in rat liver and kidney.

J. Hasler, T. Magwere, Yogeshkumar S. Naik, 1997, Free radical biology & medicine.

Isolation of geodiastatins 1 and 2 from the marine sponge Geodia mesotriaena.

G. Pettit, J. Hasler, J. Rideout, 1981, Journal of natural products.

Genetic polymorphism of cytochrome P4501A1, microsomal epoxide hydrolase, and glutathione S-transferases M1 and T1 in Zimbabweans and Venda of southern Africa.

C. Masimirembwa, C. Dandara, D. Sommers, 1998, Pharmacogenetics.

Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity.

J. Halpert, G. Szklarz, L. Kaminsky, 1994, Molecular pharmacology.

Effects of DIMBOA on detoxification enzymes of the aphid Rhopalosiphum padi (Homoptera: aphididae).

S. Mukanganyama, H. Niemeyer, C. C. Figueroa, 2003, Journal of insect physiology.

Proposed reductive metabolism of artemisinin by glutathione transferases in vitro

S. Mukanganyama, B. Mannervik, M. Widersten, 2001, Free radical research.

The molecular and enzyme kinetic basis for the diminished activity of the cytochrome P450 2D6.17 (CYP2D6.17) variant. Potential implications for CYP2D6 phenotyping studies and the clinical use of CYP2D6 substrate drugs in some African populations.

C. Masimirembwa, J. Hasler, T. E. Bapiro, 2002, Biochemical pharmacology.

The effect of schistosomiasis on the covalent binding of 2-acetylaminofluorene to mouse liver macromolecules in vivo and in vitro.

C. Nyathi, J. Hasler, C. Chetsanga, 1990, Biochemical pharmacology.

Genetic polymorphism of cytochrome P450 CYP2D6 in Zimbabwean population.

M. Ingelman-Sundberg, C. Masimirembwa, I. Johansson, 1993, Pharmacogenetics.

Escherichia coli expression and characterization of cytochromes P450 2B11, 2B1, and 2B5.

J. Halpert, J. Hasler, G. John, 1994, Archives of Biochemistry and Biophysics.

Genetic Polymorphism of Cytochrome P450 1A1 (CYP1A1) and Glutathione Transferases (M1, T1 and P1) among Africans

S. Kaaya, K. Sommers, C. Dandara, 2002, Clinical chemistry and laboratory medicine.

Characterisation of praziquantel metabolism by rat liver microsomes using cytochrome P450 inhibitors.

C. Masimirembwa, J. Hasler, Julia A. Hasler, 1994, Biochemical pharmacology.

Phenotyping and genotyping of S‐mephenytoin hydroxylase (cytochrome P450 2C19) in a Shona population of Zimbabwe

M. Ingelman-Sundberg, L. Bertilsson, C. Masimirembwa, 1995, Clinical pharmacology and therapeutics.

Genetic Polymorphism of Drug Metabolising Enzymes in African Populations: Implications for the Use of Neuroleptics and Antidepressants

C. Masimirembwa, J. Hasler, 1997, Brain Research Bulletin.

Arylamine N-acetyltransferase (NAT2) genotypes in Africans: the identification of a new allele with nucleotide changes 481C>T and 590G>A.

S. Kaaya, C. Masimirembwa, C. Dandara, 2003, Pharmacogenetics.

Low CYP1A2 activity in rural Shona children of Zimbabwe

C. Masimirembwa, B. Tang, W. Kalow, 1995, Clinical pharmacology and therapeutics.

Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s.

C. Masimirembwa, C M Masimirembwa, J. Hasler, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Isolation of geodiatoxins 2-4 from the marine sponge Geodia mesotriaena.

G. Pettit, J. Hasler, J. Rideout, 1990, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.

The interaction of selected natural products with human recombinant glutathione transferases

R. Hayeshi, S. Mukanganyama, J. Hasler, 2004, Phytotherapy research : PTR.

The effect of experimental Schistosoma mattheei infection on hepatic drug metabolism in BALB/c mice.

J. Hasler, Yogeshkumar S. Naik, 1994, Journal of veterinary pharmacology and therapeutics.

The effect of chloroquine on the pharmacokinetics and metabolism of praziquantel in rats and in humans

C. Masimirembwa, J. Hasler, Yogeshkumar S. Naik, 1994, Biopharmaceutics & drug disposition.

Human cytochromes P450

P. Beaune, M. Waterman, R. Estabrook, 1999 .

Inhibitory effects of antiparasitic drugs on cytochrome P450 2D6

C. Masimirembwa, I. Johansson, J. Hasler, 2004, European Journal of Clinical Pharmacology.

The African‐specific CYP2D6*17 allele encodes an enzyme with changed substrate specificity

M. Ingelman-Sundberg, L. Bertilsson, L. Gustafsson, 2002, Clinical pharmacology and therapeutics.

Inhibition of glutathione S‐transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance

S. Mukanganyama, B. Mannervik, M. Widersten, 2002, International journal of cancer.

Population Diversity and Pharmacogenomics in Africa

C. Masimirembwa, C. Dandara, J. Hasler, 2014 .

The effect of schistosomiasis on the activation of aflatoxin B1.

C. Nyathi, J. Hasler, C. Chetsanga, 1986, Research communications in chemical pathology and pharmacology.

Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells

C. Masimirembwa, T. Andersson, J. Hasler, 2002, European Journal of Clinical Pharmacology.

Artemisinin and thiabendazole are potent inhibitors of cytochrome P450 1A2 (CYP1A2) activity in humans

C. Masimirembwa, J. Sayi, J. Hasler, 2005, European Journal of Clinical Pharmacology.

A survey of urinary aflatoxin in Zimbabwe.

C. Nyathi, J. Hasler, C. F. Mutiro, 1987, International journal of epidemiology.

[Transmissible gastroenteritis (TGE) in Switzerland: antibody persistence after infection and seroepidemiologic studies of the significance of the TGE virus as the cause of diarrhea].

J. Hasler, H. Keller, M. Bereiter, 1988, Schweizer Archiv für Tierheilkunde.

[Are non-bovine Artiodactyla IBR virus reservoirs? II. Seroepidemiologic studies on goats, sheep, swine and wild Artiodactyla in Switzerland].

J. Hasler, M. Engels, 1986, Schweizer Archiv fur Tierheilkunde.

Protease-mediated Inflammation: An In Vitro Human Keratinocyte-based Screening Tool for Anti-inflammatory Drug Nanocarrier Systems

R. Haag, M. Meinke, U. Blume-Peytavi, 2018 .

Frequency of –163 C > A and 63 C > G single nucleotide polymorphism of cytochrome P450 1A2 in two African populations

C. Dandara, J. Sayi, J. Hasler, 2004, Clinical chemistry and laboratory medicine.

Impact of climate change on diseases in sustainable arable crop systems: CLIMDIS

J. West, W. Angus, B. Fitt, 2011 .

Lack of effect of chloroquine on the debrisoquine (CYP2D6 and S-mephenytoin (CYP2C19) hydroxylation phenotypes.

C. Masimirembwa, L. Gustafsson, M. Dahl, 2003, British journal of clinical pharmacology.

Phenotyping of the glutathione S-transferase M1 polymorphism in Zimbabweans and the effects of chloroquine on blood glutathione S-transferases M1 and A.

C. Masimirembwa, S. Mukanganyama, J. Hasler, 1997, Clinica chimica acta; international journal of clinical chemistry.

Phenotype and genotype analysis of debrisoquine hydroxylase (CYP2D6) in a black Zimbabwean population Reduced enzyme activity and evaluation of metabolic correlation of CYP2D6 probe drugs

M. Ingelman-Sundberg, C. Masimirembwa, I. Johansson, 1996, European Journal of Clinical Pharmacology.

The influence of dietary fat on hepatic bioactivation of aflatoxin B1 in rats.

H. Fuhrmann, C. Nyathi, J. Hasler, 1994, Research communications in chemical pathology and pharmacology.

The effect of diet on aflatoxin B1 binding to hepatic macromolecules in rats.

H. Fuhrmann, C. Nyathi, J. Hasler, 1993, Research communications in chemical pathology and pharmacology.