A. Pierré

发表

Polo-like kinase 1: a potential therapeutic option in combination with conventional chemotherapy for the management of patients with triple-negative breast cancer.

Emmanuel Barillot, Anne Vincent-Salomon, Guillem Rigaill, 2013, Cancer research.

TTK/hMPS1 Is an Attractive Therapeutic Target for Triple-Negative Breast Cancer

Emmanuel Barillot, Anne Vincent-Salomon, Guillem Rigaill, 2013, PloS one.

Covalent binding to glutathione of the DNA-alkylating antitumor agent, S23906-1.

C. Bailly, C. Tardy, M. Kouach, 2003, European journal of biochemistry.

Characterization of novel checkpoint kinase 1 inhibitors by in vitro assays and in human cancer cells treated with topoisomerase inhibitors.

G. Ferry, J. Boutin, B. Pfeiffer, 2011, Life sciences.

Stereospecific synthesis of 5-substituted 2-bisarylthiocyclopentane carboxylic acids as specific matrix metalloproteinase inhibitors.

A. Chollet, A. Pierré, G. Tucker, 2003, Journal of medicinal chemistry.

Histology and sensitivity to anticancer drugs of two human non-small cell lung carcinomas implanted in the pleural cavity of nude mice.

L. Kraus-Berthier, A. Pierré, G. Atassi, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Novel 5-azaindolocarbazoles as cytotoxic agents and Chk1 inhibitors.

B. Pfeiffer, J. Hickman, R. Golsteyn, 2008, Bioorganic & medicinal chemistry.

Semi-synthesis, topoisomerase I and kinases inhibitory properties, and antiproliferative activities of new rebeccamycin derivatives.

C. Bailly, P. Renard, B. Pfeiffer, 2003, Bioorganic & medicinal chemistry.

In vitro cytotoxicity of S16020-2, a new olivacine derivative

E. Bisagni, A. Pierré, S. Léonce, 2004, Investigational New Drugs.

Analogues of antifungal tjipanazoles from rebeccamycin.

C. Bailly, M. Sancelme, P. Renard, 2004, Bioorganic & medicinal chemistry.

Syntheses and antiproliferative activities of rebeccamycin analogues bearing two 7-azaindole moieties.

P. Renard, B. Pfeiffer, M. Prudhomme, 2003, Bioorganic & medicinal chemistry.

Design, synthesis, and evaluation of novel thienopyrrolizinones as antitubulin agents.

P. Renard, S. Rault, V. Lisowski, 2004, Journal of medicinal chemistry.

Design, synthesis and antiproliferative activity of tripentones: a new series of antitubulin agents.

P. Renard, S. Rault, V. Lisowski, 2001, Bioorganic & medicinal chemistry letters.

A transesterification reaction is implicated in the covalent binding of benzo[b]acronycine anticancer agents with DNA and glutathion.

C. Bailly, H. Vezin, M. Kouach, 2004, Bioorganic & medicinal chemistry.

Synthesis and antitumor activity of the metformin platinum (IV) complex. Crystal structure of the tetrachloro(metformin)platinum (IV) dimethylsulfoxide solvate.

G. Morgant, A. Pierré, S. Léonce, 1997, Journal of inorganic biochemistry.

Rebeccamycin Derivatives as Dual DNA-Damaging Agents and Potent Checkpoint Kinase 1 Inhibitors

L. Meijer, P. Peixoto, B. Pfeiffer, 2008, Molecular Pharmacology.

Antitumor activity of S 16020-2 in two orthotopic models of lung cancer

L. Kraus-Berthier, A. Pierré, G. Atassi, 1997, Anti-cancer drugs.

Relationship between the cellular accumulation and the cytotoxicity of S12363, a new vinca alkaloid derivative

J. Boutin, G. Lavielle, A. Pierré, 2004, Cancer Chemotherapy and Pharmacology.

Comparison of the pharmacological profile of an olivacine derivative and a potential prodrug

S. Goldstein, L. Kraus-Berthier, A. Pierré, 2002, Cancer Chemotherapy and Pharmacology.

Acronycine derivatives as promising antitumor agents.

J. Hickman, F. Tillequin, A. Pierré, 2002, Anti-cancer drugs.

Synthesis, antitumor activity, and mechanism of action of benzo[b]chromeno[6,5-g][1,8]naphthyridin-7-one analogs of acronycine.

B. Pfeiffer, Wen Tian, L. Kraus-Berthier, 2014, Journal of medicinal chemistry.

An unusual DNA binding compound, S23906, induces mitotic catastrophe in cultured human cells.

B. Pfeiffer, J. Hickman, R. Golsteyn, 2010, Cancer letters.

Covalent binding of antitumor benzoacronycines to double-stranded DNA induces helix opening and the formation of single-stranded DNA: unique consequences of a novel DNA-bonding mechanism.

E. De Pauw, C. Bailly, P. Colson, 2005, Molecular cancer therapeutics.

Alkylation of Guanine in DNA by S23906-1, a Novel Potent Antitumor Compound Derived from the Plant Alkaloid Acronycine†

C. Bailly, J. Hickman, M. Kouach, 2002 .

Induction of cyclin E and inhibition of DNA synthesis by the novel acronycine derivative S23906-1 precede the irreversible arrest of tumor cells in S phase leading to apoptosis.

B. Pfeiffer, J. Hickman, M. Koch, 2001, Molecular pharmacology.

Binding characteristics of novel nonsteroidal antiestrogens to the rat uterine estrogen receptors

F. Labrie, C. Martel, L. Provencher, 1998, The Journal of Steroid Biochemistry and Molecular Biology.

Novel benzopyridothiadiazepines as potential active antitumor agents.

P. Renard, B. Pfeiffer, P. Chavatte, 2005, Journal of medicinal chemistry.

General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors.

A. Chollet, A. Pierré, G. Tucker, 2001, Bioorganic & medicinal chemistry letters.

S16020-2, a new highly cytotoxic antitumor olivacine derivative: DNA interaction and DNA topoisomerase II inhibition.

A. Jacquemin-Sablon, J. Markovits, A. Pierré, 1998, Molecular pharmacology.

Novel bicyclic oxazolone derivatives as anti-angiogenic agents.

A. Pierré, N. Guilbaud, M. Burbridge, 2002, Bioorganic & medicinal chemistry letters.

In vitro andin vivo circumvention of multidrug resistance by Servier 9788, a novel triazinoaminopiperidine derivative

L. Kraus-Berthier, A. Pierré, S. Léonce, 1992, Investigational New Drugs.

Synthesis and cytotoxic activity of benzo[c][1,7] and [1,8]phenanthrolines analogues of nitidine and fagaronine.

C. Bailly, P. Colson, B. Pfeiffer, 2004, Bioorganic & medicinal chemistry.

Novel antitumor indenoindole derivatives targeting DNA and topoisomerase II.

C. Bailly, P. Colson, L. Kraus-Berthier, 2004, Biochemical pharmacology.

Influence of the Stereoisomeric Position of the Reactive Acetate Groups of the Benzo[b]Acronycine derivative S23906-1 on Its DNA Alkylation, Helix-Opening, Cytotoxic, and Antitumor Activities

C. Bailly, B. Pfeiffer, F. Tillequin, 2009, Molecular Pharmacology.

Synthesis of N,N′‐Disubstituted 3‐Aminobenzo[c] and [d]Azepin‐2‐ones as Potent and Specific Farnesyl Transferase Inhibitors.

J. Fauchère, J. Hickman, A. Pierré, 2004 .

Syntheses and antitumor targeting G1 phase of the cell cycle of benzoyldihydroisoquinolines and related 1-substituted isoquinolines.

P. Renard, D. Caignard, R. Enriz, 2002, Journal of medicinal chemistry.

Syntheses and antiproliferative activities of 7-azarebeccamycin analogues bearing one 7-azaindole moiety.

C. Bailly, P. Renard, B. Pfeiffer, 2003, Journal of medicinal chemistry.

Synthesis and biological evaluation of 7-azaindolocarbazoles

C. Bailly, P. Renard, B. Pfeiffer, 2002 .

Synthesis of a novel series of cytotoxic bisindole alkaloids.

R. Hocquemiller, G. Lewin, A. Pierré, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and Cytotoxic Activity of Benzopyranoxanthone Analogues of Benzo[b]acronycine and Psorospermine

P. Renard, B. Pfeiffer, F. Tillequin, 2001 .

Synthesis and cytotoxic activity of pyranocoumarins of the seselin and xanthyletin series.

P. Renard, A. Skaltsounis, P. Magiatis, 1998, Journal of Natural Products.

Cytotoxic and antitumoral properties in a series of new, ring D modified, olivacine analogues.

S. Goldstein, L. Kraus-Berthier, A. Pierré, 2005, Bioorganic & medicinal chemistry.

Synthesis and cytotoxic and antitumor activity of esters in the 1,2-dihydroxy-1,2-dihydroacronycine series.

A. Skaltsounis, F. Tillequin, L. Kraus-Berthier, 1996, Journal of medicinal chemistry.

New alpha-amino phosphonic acid derivatives of vinblastine: chemistry and antitumor activity.

J. Boutin, G. Lavielle, A. Pierré, 1991, Journal of medicinal chemistry.

Design, synthesis, and antiproliferative activity of some new pyrazole-fused amino derivatives of the pyranoxanthenone, pyranothioxanthenone, and pyranoacridone ring systems: a new class of cytotoxic agents.

A. Skaltsounis, H. Pratsinis, P. Magiatis, 2002, Journal of medicinal chemistry.

Synthesis and biological evaluation of novel naphthocarbazoles as potential anticancer agents.

P. Peixoto, C. Bailly, D. Caignard, 2005, Journal of medicinal chemistry.

Synthesis and biological activity of 6H-isoindolo[2,1-a]indol-6-ones, analogues of batracylin, and related compounds.

P. Renard, B. Pfeiffer, C. Monneret, 2006, European journal of medicinal chemistry.

Synthesis and antiproliferative activity of basic ethers of 1,2-dihydropyrrolo[1,2-a]indole, 6H-isoindolo[2,1-a]indole, and 6H-benz[5,6]isoindolo[2,1-a]indole.

P. Renard, B. Pfeiffer, C. Monneret, 2003, Oncology research.

Synthesis and biological activity of sulfonamide derivatives of epipodophyllotoxin.

P. Renard, B. Pfeiffer, C. Monneret, 2004, Journal of medicinal chemistry.

Preclinical antitumor activity of a new Vinca alkaloid derivative, S 12363.

M. Poupon, G. Lavielle, L. Kraus-Berthier, 1991, Cancer research.

Synthesis and cytotoxic activity of tetracenomycin D and of saintopin analogues.

P. Renard, B. Pfeiffer, B. Renoux, 2002, Bioorganic & medicinal chemistry.

Synthesis and Cytotoxic Evaluation of Novel Thiazolocarbazoles. Part II1

P. Renard, B. Pfeiffer, G. Guillaumet, 2003, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and Cytotoxic Evaluation of Novel Thiazolocarbazoles

P. Renard, B. Pfeiffer, G. Guillaumet, 2002, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and Cytotoxic Activity of Thiazolofluorenone Derivatives

P. Renard, B. Pfeiffer, G. Guillaumet, 2004, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and cytotoxic and antitumor activity of benzo[b]pyrano[3, 2-h]acridin-7-one analogues of acronycine.

P. Renard, B. Pfeiffer, F. Tillequin, 2000, Journal of medicinal chemistry.

Induction of apoptosis in HL-60 leukemia and B16 melanoma cells by the acronycine derivative S23906-1.

C. Bailly, J. Hickman, J. Kluza, 2002, Biochemical pharmacology.

Benzopyridooxathiazepine derivatives as novel potent antimitotic agents.

P. Renard, B. Pfeiffer, S. Gallet, 2009, Bioorganic & medicinal chemistry.

Synthesis and antiproliferative activity of a cyclic analog of dolastatin 10.

S. Thoret, J. Poncet, P. Jouin, 1998, Bioorganic & medicinal chemistry letters.

New purines and purine analogs as modulators of multidrug resistance.

L. Kraus-Berthier, A. Pierré, S. Léonce, 1996, Journal of medicinal chemistry.

2,2-Dimethyl-2H-anthra[2,3-b]pyran-6,11-diones: a new class of cytotoxic compounds.

P. Renard, A. Skaltsounis, P. Magiatis, 2001, Bioorganic & medicinal chemistry.

Synthesis and CHK1 inhibitory potency of Hymenialdisine analogues.

J. Hickman, R. Golsteyn, J. Parmentier, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and cytotoxic activity of dimeric analogs of acronycine in the benzo[b]pyrano[3,2-h]acridin-7-one series.

B. Pfeiffer, F. Tillequin, T. Gaslonde, 2007, Chemical & pharmaceutical bulletin.

An Efficient Method for the Preparation of Antitumoral α‐Keto‐imines Benzyldihydroisoquinolines by Selective Benzylic Oxidation with C/Pd in Acetonitrile.

P. Renard, D. Caignard, A. Bermejo, 2002 .

Synthesis of N,N'-disubstituted 3-aminobenzo[c] and [d]azepin-2-ones as potent and specific farnesyl transferase inhibitors.

J. Fauchère, J. Hickman, A. Pierré, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of novel benzodioxinocarbazoles (BDCZs) as potential anticancer agents.

D. Caignard, S. Routier, A. Pierré, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and biological activities of indolocarbazoles bearing amino acid residues.

C. Bailly, M. Sancelme, B. Pfeiffer, 2001, European journal of medicinal chemistry.

Physicochemical and pharmacological properties of the antitumor ellipticine derivative 2-(diethylamino-2-ethyl)9-hydroxy ellipticinium-chloride, HCl.

P. Gros, C. Paoletti, C. Auclair, 1987, Cancer research.

Synthesis and biological activities of isogranulatimide analogues.

C. Bailly, B. Pfeiffer, J. Hickman, 2007, Bioorganic & medicinal chemistry.

Synthesis and cytotoxic activity of acronycine derivatives modified at the pyran ring.

A. Skaltsounis, F. Tillequin, A. Pierré, 1996, Chemical & pharmaceutical bulletin.

Synthesis and cytotoxic activity of benzo[a]acronycine and benzo[b]acronycine substituted on the A ring.

B. Pfeiffer, F. Tillequin, T. Gaslonde, 2011, European journal of medicinal chemistry.

Synthesis and cytotoxic activity of psorospermin and acronycine analogues in the 3-propyloxy-acridin-9(10H)-one and -benzo[b]acridin-125H-one series.

B. Pfeiffer, Marie-Christine Lallemand, F. Tillequin, 2010, European journal of medicinal chemistry.

Synthesis, cytotoxic activity, and DNA binding properties of antitumor cis-1,2-dihydroxy-1,2-dihydrobenzo[b]acronycine cinnamoyl esters.

B. Pfeiffer, F. Tillequin, T. Gaslonde, 2009, Bioorganic & medicinal chemistry.

Structure-activity relationships in the acronycine and benzo[b]acronycine series: role of the pyran ring.

B. Pfeiffer, F. Tillequin, T. Gaslonde, 2008, European journal of medicinal chemistry.

Synthesis, cytotoxic activity, and mechanism of action of furo[2,3-c]acridin-6-one and benzo[b]furo[3,2-h]acridin-6-one analogues of psorospermin and acronycine.

B. Pfeiffer, Marie-Christine Lallemand, F. Tillequin, 2008, Journal of medicinal chemistry.

Generation of replication-dependent double-strand breaks by the novel N2-G-alkylator S23906-1.

C. Tardy, R. Golsteyn, V. Poindessous, 2006, Cancer research.

Synthesis and cytotoxic activity of acronycine analogues in the benzo[c]pyrano[3,2-h]acridin-7-one and naphtho[1,2-b][1,7] and [1,10]-phenanthrolin-7(14H)-one series.

B. Pfeiffer, J. Bongui, F. Tillequin, 2005, Chemical & pharmaceutical bulletin.

Design, synthesis, and cytotoxic activity of Michael acceptors and enol esters in the benzo[b]acronycine series.

C. Bailly, B. Pfeiffer, F. Tillequin, 2005, Chemical & pharmaceutical bulletin.

Synthesis and cytotoxic activity of pyranocarbazole analogues of ellipticine and acronycine.

B. Pfeiffer, F. Tillequin, Hanh Trinh-van-Dufat, 2004, Chemical & pharmaceutical bulletin.

Synthesis and cytotoxic and antitumor activity of 1,2-dihydroxy-1,2-dihydrobenzo[b]acronycine diacid hemiesters and carbamates.

P. Renard, B. Pfeiffer, F. Tillequin, 2004, Chemical & pharmaceutical bulletin.

Structure-activity relationships and mechanism of action of antitumor benzo[b]pyrano[3,2-h]acridin-7-one acronycine analogues.

C. Bailly, P. Renard, B. Pfeiffer, 2003, Journal of medicinal chemistry.

Marked antitumor activity of a new potent acronycine derivative in orthotopic models of human solid tumors.

B. Pfeiffer, J. Hickman, F. Tillequin, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Ring Expansion Reactions of Acronycine to Fused 1,4-Oxazepine and 1,4-Dioxepin Systems

A. Skaltsounis, F. Tillequin, P. Magiatis, 2000 .

New carboxylic acid derivatives of 7-oxo-2,3,7,14- tetrahydro-1H-benzo [b] pyrano [3,2 h] acridine, their process for the preparation and pharmaceutical compositions containing them

P. Renard, B. Pfeiffer, F. Tillequin, 1999 .

Synthesis and Cytotoxic and Antitumor Activity of Esters in the 1,2- Dihydroxy-1,2-dihydroacronycine Series.

A. Skaltsounis, F. Tillequin, L. Kraus-Berthier, 1997 .

Design, synthesis and antiproliferative activity of tripentones: a new series of antitubulin agents.

P. Renard, S. Rault, V. Lisowski, 2001, Bioorganic & medicinal chemistry letters.

Pharmacological properties of a new alpha-aminophosphonic acid derivative of vinblastine.

J. Boutin, G. Lavielle, A. Pierré, 1990, Anticancer research.

New cytotoxic analogues of annonaceous acetogenins.

P. Renard, R. Grée, B. Renoux, 2001, Anti-cancer drug design.

Synthesis and cytotoxic activity of acetogenin analogues.

P. Renard, R. Grée, B. Renoux, 2000, Bioorganic & Medicinal Chemistry Letters.

Synthesis of mono- and bisdihydrodipyridopyrazines and assessment of their DNA binding and cytotoxic properties.

C. Bailly, P. Colson, P. Renard, 2004, Journal of medicinal chemistry.

Characterization of a Large Panel of Patient-Derived Tumor Xenografts Representing the Clinical Heterogeneity of Human Colorectal Cancer

Philippe Dessen, Hany Soliman, Peggy Dartigues, 2012, Clinical Cancer Research.

Design of novel antitumor DNA alkylating agents: the benzacronycine series.

C. Bailly, F. Tillequin, T. Gaslonde, 2004, Current medicinal chemistry. Anti-cancer agents.

Parallel liquid synthesis of N,N'-Disubstituted 3-amino azepin-2-ones as potent and specific farnesyl transferase inhibitors.

J. Fauchère, J. Hickman, A. Pierré, 2003, Bioorganic & medicinal chemistry.