F. Cruzalegui

发表

Polo-like kinase 1: a potential therapeutic option in combination with conventional chemotherapy for the management of patients with triple-negative breast cancer.

Emmanuel Barillot, Anne Vincent-Salomon, Guillem Rigaill, 2013, Cancer research.

TTK/hMPS1 Is an Attractive Therapeutic Target for Triple-Negative Breast Cancer

Emmanuel Barillot, Anne Vincent-Salomon, Guillem Rigaill, 2013, PloS one.

Sensitivity to PI3K and AKT inhibitors is mediated by divergent molecular mechanisms in subtypes of DLBCL.

G. Ott, G. Lenz, S. Barry, 2017, Blood.

Regulation of intrasteric inhibition of the multifunctional calcium/calmodulin-dependent protein kinase.

A. Means, M. Rosenfeld, B. Kemp, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site

C. Wernstedt, P. Huber, S. Souchelnytskyi, 2007, Oncogene.

ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry

R. Treisman, E. Cano, F. Cruzalegui, 1999, Oncogene.

Synthesis and pharmacological evaluation of thieno[2,3-b]pyridine derivatives as novel c-Src inhibitors.

J. Boutin, S. Goldstein, C. Brulé, 2011, Bioorganic & medicinal chemistry.

Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain.

R. Hanley, F. Cruzalegui, A. Means, 1989, Nucleic acids research.

The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c‐fos transcription in response to UV light.

R. Treisman, M. Price, F. Cruzalegui, 1996, The EMBO journal.

Src family tyrosine kinases-driven colon cancer cell invasion is induced by Csk membrane delocalization

F. Hollande, A. Sirvent, J. Pannequin, 2010, Oncogene.

Differential gene expression from a single transcription unit during spermatogenesis.

A. Means, F. Cruzalegui, 1993, Recent progress in hormone research.

GEM-DeCan: Improving tumor immune microenvironment profiling by the integration of novel gene expression and DNA methylation deconvolution signatures

Nina Verstraete, M. Kuo, M. Madrid-Mencía, 2022 .

GEM-DeCan: Improved tumor immune microenvironment profiling through novel gene expression and DNA methylation signatures predicts immunotherapy response

V. Pancaldi, Nina Verstraete, M. Kuo, 2021, bioRxiv.

Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of indolylpyrazolones and indolylpyridazinedione.

B. Pfeiffer, M. Prudhomme, R. Golsteyn, 2006, European journal of medicinal chemistry.

Biochemical characterization of the multifunctional Ca2+/calmodulin-dependent protein kinase type IV expressed in insect cells.

A. Means, F. Cruzalegui, 1993, Journal of Biological Chemistry.

Calcium-regulated protein kinase cascades and their transcription factor targets

H. Bading, F. Cruzalegui, 2000, Cellular and Molecular Life Sciences CMLS.

Design, synthesis and evaluation of new 6-substituted-5-benzyloxy-4-oxo-4H-pyran-2-carboxamides as potential Src inhibitors

B. Pfeiffer, C. Logé, F. Cruzalegui, 2008 .

Calmodulin-dependent protein kinase II mediates inactivation of MPF and CSF upon fertilization of Xenopus eggs

D. Fesquet, J. Cavadore, M. Dorée, 1993, Nature.

Functional significance of co-occurring mutations in PIK3CA and MAP3K1 in breast cancer

E. Harrington, Á. Avivar-Valderas, Marcello Maresca, 2018, Oncotarget.

Defining actionable mutations for oncology therapeutic development

Jonathan R. Dry, Zhongwu Lai, J. Carl Barrett, 2016, Nature Reviews Cancer.

Therapeutics , Targets , and Chemical Biology Polo-like Kinase 1 : A Potential Therapeutic Option in Combination with Conventional Chemotherapy for the Management of Patients with Triple-Negative Breast Cancer

E. Barillot, A. Vincent-Salomon, S. Roman-Roman, 2013 .

PLK 1 as a therapeutic target in triple-negative breast cancer 1 1 Polo-like kinase 1 : a potential therapeutic option in combination with conventional chemotherapy for the management of patients with triple-negative breast cancer

E. Barillot, A. Vincent-Salomon, S. Roman-Roman, 2012 .

Control of Recruitment and Transcription-Activating Function of CBP Determines Gene Regulation by NMDA Receptors and L-Type Calcium Channels

H. Bading, G. Hardingham, F. Cruzalegui, 1999, Neuron.

c‐Jun functions as a calcium‐regulated transcriptional activator in the absence of JNK/SAPK1 activation

H. Bading, G. Hardingham, F. Cruzalegui, 1999, The EMBO journal.

Intermittent High-Dose Scheduling of AZD8835, a Novel Selective Inhibitor of PI3Kα and PI3Kδ, Demonstrates Treatment Strategies for PIK3CA-Dependent Breast Cancers

O. Delpuech, S. Green, Á. Avivar-Valderas, 2016, Molecular Cancer Therapeutics.

Protein kinases: From targets to anti-cancer drugs.

F. Cruzalegui, 2010, Annales pharmaceutiques francaises.

Specific Oncogenic Activity of the Src-Family Tyrosine Kinase c-Yes in Colon Carcinoma Cells

Jean A. Boutin, J. Boutin, F. Cogé, 2011, PloS one.

LRP5 regulates the expression of STK40, a new potential target in triple-negative breast cancers

S. Roman-Roman, T. Dubois, B. Tesson, 2018, Oncotarget.

Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells

Emmanuel Barillot, Philippe Hupé, Anne Vincent-Salomon, 2008, Breast Cancer Research.

Combined Inhibition of PI3Kβ and mTOR Inhibits Growth of PTEN-null Tumors

S. Barry, O. Delpuech, Á. Avivar-Valderas, 2018, Molecular Cancer Therapeutics.

Inhibiting PI3Kβ with AZD8186 Regulates Key Metabolic Pathways in PTEN-Null Tumors

S. Barry, O. Delpuech, Á. Avivar-Valderas, 2017, Clinical Cancer Research.

TIPIN depletion leads to apoptosis in breast cancer cells

A. Nicolas, S. Roman-Roman, M. Debatisse, 2015, Molecular oncology.

S49076 Is a Novel Kinase Inhibitor of MET, AXL, and FGFR with Strong Preclinical Activity Alone and in Association with Bevacizumab

G. Ferry, J. Boutin, J. Hickman, 2013, Molecular Cancer Therapeutics.

Small Molecule Therapeutics S 49076 Is a Novel Kinase Inhibitor of MET , AXL , and FGFR with Strong Preclinical Activity Alone and in Association with Bevacizumab

G. Ferry, J. Boutin, J. Hickman, 2013 .

Transcriptome Analysis of Wnt3a-Treated Triple-Negative Breast Cancer Cells

Guillem Rigaill, David Gentien, Thierry Dubois, 2015, PloS one.

Mechanisms controlling gene expression by nuclear calcium signals.

H. Bading, G. Hardingham, F. Cruzalegui, 1998, Cell calcium.

A novel non-phosphorylated potential antitumoral peptide inhibits STAT3 biological activity.

Wang-Qing Liu, C. Garbay, F. Cruzalegui, 2009, Biochimie.

A novel Ca2+/calmodulin-dependent protein kinase and a male germ cell-specific calmodulin-binding protein are derived from the same gene

A. Means, G. Slaughter, T. Ono, 1991, Molecular and cellular biology.

AZD8186 study 1: phase I study to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and preliminary anti-tumour activity of AZD8186 in patients with advanced castration-resistant prostate cancer (CRPC), squamous non-small cell lung cancer, triple negative breast cancer an

S. Barry, G. Shapiro, J. Bono, 2016 .

The use of nonradioactive DNA probes for the characterization of Leishmania isolates from Peru.

A. Llanos-Cuentas, F. Cruzalegui, J. Arévalo, 1988, American Journal of Tropical Medicine and Hygiene.

Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors.

N. Foloppe, J. Murray, R. Hubbard, 2021, Journal of medicinal chemistry.

Abstract 5130: Integrative approaches for the identification of therapeutic targets in basal like breast cancer from multi-level molecular data

E. Barillot, A. Vincent-Salomon, S. Roman-Roman, 2012 .

315 W0180 novel anti-VISTA antibody: Rationale for target patient population and first-in-human trial design in monotherapy and in combination with anti-PD1 antibody

I. Melero, A. Marabelle, C. Gomez-Roca, 2020, Journal for ImmunoTherapy of Cancer.

Sensitivity to PI3K and AKT inhibitors is mediated by divergent molecular mechanisms in subtypes of DLBCL.

G. Ott, G. Lenz, S. Barry, 2017, Blood.

Structure‐Based Design and Synthesis of Harmine Derivatives with Different Selectivity Profiles in Kinase versus Monoamine Oxidase Inhibition

B. Bálint, F. Cruzalegui, A. Kotschy, 2017, ChemMedChem.

Src Family Tyrosine Kinases-driven Colon Cancer Cell Invasion Is Induced by Csk Membrane Delocalisation Supplementary Figure 1. the Impact of Csk Depletion on in Vitro Sfk Activities

F. Hollande, J. Pannequin, L. Veracini, 2010 .