Basil P. Hubbard

发表

A conserved NAD+ binding pocket that regulates protein-protein interactions during aging

L. Aravind, Vera Gorbunova, L. Aravind, 2017, Science.

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

Dudley Lamming, D. Sinclair, K. Howitz, 2013, Science.

Kinase-targeted cancer therapies: progress, challenges and future directions

H. Rupasinghe, K. S. Bhullar, A. Jha, 2018, Molecular Cancer.

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.

R. de Cabo, D. Sinclair, R. Coppari, 2012, Cell metabolism.

SRT1720 improves survival and healthspan of obese mice

E. Mercken, R. de Cabo, M. Gorospe, 2011, Scientific reports.

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis.

D. Sinclair, C. Palmeira, B. Hubbard, 2012, Biochimica et biophysica acta.

Lifespan and healthspan extension by resveratrol.

K. S. Bhullar, B. Hubbard, Basil P. Hubbard, 2015, Biochimica et biophysica acta.

SRT1720 improves survival and healthspan of obese mice

E. Mercken, R. de Cabo, M. Gorospe, 2011, Scientific reports.

Small molecule SIRT1 activators for the treatment of aging and age-related diseases.

D. Sinclair, B. Hubbard, Basil P. Hubbard, 2014, Trends in pharmacological sciences.

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

E. Mercken, D. Sinclair, N. Price, 2013, Cell.

SIRT1 Activation by Small Molecules

David P. Carney, T. Riera, B. Hubbard, 2010, The Journal of Biological Chemistry.

Identification of a SIRT1 mutation in a family with type 1 diabetes.

D. Sinclair, B. Glaser, F. Pociot, 2013, Cell metabolism.

Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay.

D. Sinclair, B. Hubbard, Basil P. Hubbard, 2013, Methods in molecular biology.

Guide RNAs containing universal bases enable Cas9/Cas12a recognition of polymorphic sequences

J. Jovel, B. Hubbard, Amanda R. Krysler, 2022, Nature Communications.

The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction

D. Sinclair, G. Amdam, B. Hubbard, 2012, Aging.

Identification and Characterization of Novel Receptor-Interacting Serine/Threonine‐Protein Kinase 2 Inhibitors Using Structural Similarity Analysis

S. Baksh, D. Brocks, S. Gibson, 2018, The Journal of Pharmacology and Experimental Therapeutics.

A conserved NAD+ binding pocket that regulates protein-protein interactions during aging

L. Aravind, D. Sinclair, S. Moniot, 2017, Science.

Tripeptide IRW Upregulates NAMPT Protein Levels in Cells and Obese C57BL/6J Mice.

C. Camacho, Jianping Wu, K. S. Bhullar, 2021, Journal of agricultural and food chemistry.

Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity

Jinho Park, J. Jovel, B. Hubbard, 2018, Nature Communications.

Tripeptide IRW initiates differentiation in osteoblasts differentiation via the RUNX2 pathway.

Jianping Wu, K. S. Bhullar, Nan Shang, 2019, Biochimica et biophysica acta. General subjects.

Siglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket

R. Derda, Matthew S Macauley, L. Mahal, 2023, Nature communications.

An examination of stress resistance and lifespan extension in the honey bee, Apis mellifera

D. Sinclair, G. Amdam, B. Hubbard, 2013 .

Continuous directed evolution of DNA-binding proteins to improve TALEN specificity

David R. Liu, Jeffry D Sander, J Keith Joung, 2015, Nature Methods.

Small molecule SIRT 1 activators for the treatment of aging and age-related diseases

D. Sinclair, B. Hubbard, Basil P. Hubbard, 2014 .

Identification of Drug Resistance Genes Using a Pooled Lentiviral CRISPR/Cas9 Screening Approach.

B. Hubbard, E. Kerek, Basil P. Hubbard, 2021, Methods in molecular biology.

Matrix metalloproteinase-2 mediates ribosomal RNA transcription by cleaving nucleolar histones

M. Hendzel, R. Schulz, Javier A. García-Vilas, 2020, bioRxiv.

Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism

D. Sinclair, B. Hubbard, Jun Li, 2013, Cell cycle.

A conserved acetylation switch enables pharmacological control of tubby-like protein stability

A. Waskiewicz, B. Hubbard, O. Julien, 2020, The Journal of biological chemistry.

Methods for Measuring CRISPR/Cas9 DNA Cleavage in Cells.

J. Jovel, B. Hubbard, Basil P. Hubbard, 2021, Methods in molecular biology.

In Vitro Assays for Comparing the Specificity of First- and Next-Generation CRISPR/Cas9 Systems.

B. Hubbard, Basil P. Hubbard, Christopher R. Cromwell, 2021, Methods in molecular biology.

Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein*

R. de Cabo, Y. Zong, D. Sinclair, 2011, The Journal of Biological Chemistry.

Lipid phosphate phosphatase-2 promotes tumor growth through increased c-Myc expression

R. Godbout, B. Hubbard, D. Brindley, 2022, Theranostics.

CRISPR-Click Enables Dual-Gene Editing with Modular Synthetic sgRNAs.

Matthew S Macauley, E. Osman, J. Gibbs, 2022, Bioconjugate chemistry.

Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene

D. Sinclair, Han-Woong Lee, Y. Suh, 2013, Cell cycle.

A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer.

Yongneng Zhang, Aristeidis E. Boukouris, Sotirios D. Zervopoulos, 2022, Cell reports.

Identification and Characterization of Novel Receptor-Interacting Serine / Threonine ‐ Protein Kinase 2 Inhibitors Using Structural Similarity Analysis s

S. Baksh, D. Brocks, S. Gibson, 2018 .

Resveratrol and Resveratrol-Aspirin Hybrid Compounds as Potent Intestinal Anti-Inflammatory and Anti-Tumor Drugs

S. Baksh, J. Dyck, K. S. Bhullar, 2020, Molecules.