Patrick K. Tumwebaze

发表

The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC

Jonathan J. Juliano, Steven R. Meshnick, Azra C. Ghani, 2019, bioRxiv.

Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum

P. Rosenthal, J. Legac, Patrick K. Tumwebaze, 2021, Malaria journal.

Decreased susceptibility to dihydrofolate reductase inhibitors associated with genetic polymorphisms in Ugandan Plasmodium falciparum isolates.

J. Bailey, O. Aydemir, S. Nsobya, 2021, The Journal of infectious diseases.

Changing Antimalarial Drug Resistance Patterns Identified by Surveillance at Three Sites in Uganda

P. Rosenthal, G. Dorsey, M. Kamya, 2016, The Journal of infectious diseases.

Improvement of asparagine ethylenediamines as anti-malarial Plasmodium-selective proteasome inhibitors.

P. Rosenthal, P. Singh, P. Meinke, 2019, Journal of medicinal chemistry.

Automated Recognition of Plasmodium falciparum Parasites from Portable Blood Levitation Imaging

D. Akin, U. Demirci, B. Greenhouse, 2022, Advanced science.

The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC

J. Bailey, R. Verity, O. Watson, 2019, Nature Communications.

Fitness Consequences of Plasmodium falciparum pfmdr1 Polymorphisms Inferred from Ex Vivo Culture of Ugandan Parasites

P. Rosenthal, B. Greenhouse, Patrick K. Tumwebaze, 2013, Antimicrobial Agents and Chemotherapy.

Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda

J. Bailey, S. Nsobya, J. Legac, 2022, Nature Communications.

Changing Prevalence of Potential Mediators of Aminoquinoline, Antifolate, and Artemisinin Resistance Across Uganda.

J. Bailey, P. Rosenthal, G. Dorsey, 2020, The Journal of infectious diseases.

Lack of Artemisinin Resistance in Plasmodium falciparum in Uganda Based on Parasitological and Molecular Assays

P. Rosenthal, S. Nsobya, Patrick K. Tumwebaze, 2015, Antimicrobial Agents and Chemotherapy.

Drug susceptibility of Plasmodium falciparum in eastern Uganda: a longitudinal phenotypic and genotypic study

J. Bailey, O. Aydemir, S. Nsobya, 2021, The Lancet. Microbe.

Impact of Antimalarial Treatment and Chemoprevention on the Drug Sensitivity of Malaria Parasites Isolated from Ugandan Children

J. Gut, P. Rosenthal, D. Havlir, 2015, Antimicrobial Agents and Chemotherapy.

Tools for mass screening of G6PD deficiency: validation of the WST8/1-methoxy-PMS enzymatic assay in Uganda

C. Drakeley, S. Staedke, M. De Niz, 2013, Malaria Journal.

Intermittent Preventive Treatment with Dihydroartemisinin-Piperaquine in Ugandan Schoolchildren Selects for Plasmodium falciparum Transporter Polymorphisms That Modify Drug Sensitivity

S. Brooker, P. Rosenthal, G. Dorsey, 2016, Antimicrobial Agents and Chemotherapy.

Modeling Prevention of Malaria and Selection of Drug Resistance with Different Dosing Schedules of Dihydroartemisinin-Piperaquine Preventive Therapy during Pregnancy in Uganda

P. Rosenthal, D. Havlir, Erika K Wallender, 2018, Antimicrobial Agents and Chemotherapy.

Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance

M. Foley, P. Rosenthal, P. Bhanot, 2018, Proceedings of the National Academy of Sciences.

Changing Antimalarial Drug Sensitivities in Uganda

P. Rosenthal, S. Nsobya, Patrick K. Tumwebaze, 2017, Antimicrobial Agents and Chemotherapy.

Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria

F. Gamo, E. Fang, Yen-Liang Chen, 2022, Journal of medicinal chemistry.

The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance

R. Price, P. Rosenthal, D. Fidock, 2021, Science Translational Medicine.

Resistance to some, but not other dimeric lindenane sesquiterpenoid esters is mediated by mutations in a Plasmodium falciparum esterase.

P. Rosenthal, M. Cassera, J. H. Butler, 2020, ACS infectious diseases.

Validation of the ligase detection reaction fluorescent microsphere assay for the detection of Plasmodium falciparum resistance mediating polymorphisms in Uganda

P. Rosenthal, J. Tappero, M. Kamya, 2014, Malaria Journal.

Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors─Part II.

M. Foley, J. Vendôme, N. Liverton, 2023, Journal of medicinal chemistry.

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

P. Rosenthal, M. Llinás, D. Fidock, 2021, bioRxiv.

Impact of Intermittent Preventive Treatment During Pregnancy on Plasmodium falciparum Drug Resistance–Mediating Polymorphisms in Uganda

P. Rosenthal, D. Havlir, Erika K Wallender, 2017, The Journal of infectious diseases.

Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.

P. Rosenthal, K. Reynolds, D. Caridha, 2020, Journal of medicinal chemistry.

Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline

J. Bailey, O. Aydemir, S. Nsobya, 2023, Microbiology spectrum.

Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors

J. Bailey, A. Gould, O. Aydemir, 2022, Antimicrobial agents and chemotherapy.

Development of a highly selective Plasmodium falciparum proteasome inhibitor with anti-malaria activity in humanized mice.

P. Rosenthal, J. Vendôme, M. Michino, 2021, Angewandte Chemie.

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.

David M. Shackleford, E. Winzeler, P. Rathod, 2021, Journal of medicinal chemistry.

Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates

J. Bailey, A. Vaidya, P. Rosenthal, 2021, Antimicrobial agents and chemotherapy.

Evolution of Partial Resistance to Artemisinins in Malaria Parasites in Uganda.

G. Dorsey, M. Kamya, S. Nsobya, 2023, The New England journal of medicine.

Changing Antimalarial Drug Sensitivities in Uganda

P. Rosenthal, S. Nsobya, Patrick K. Tumwebaze, 2017, Antimicrobial Agents and Chemotherapy.

Impact of Short-Term Storage on Ex Vivo Antimalarial Susceptibilities of Fresh Ugandan Plasmodium falciparum Isolates

S. Nsobya, P. Rosenthal, Patrick K. Tumwebaze, 2022, Antimicrobial agents and chemotherapy.

Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases.

E. Winzeler, Jinhua Wang, Patrick K. Tumwebaze, 2024, Journal of medicinal chemistry.