E. Varfolomeev

发表

Intracellular regulation of TNF activity in health and disease.

D. Vučić, E. Varfolomeev, 2018, Cytokine.

(Un)expected roles of c-IAPs in apoptotic and NFκB signaling pathways

D. Vučić, Domagoj Vucic, Eugene Varfolomeev, 2008 .

Tumor Necrosis Factor An Apoptosis JuNKie?

A. Ashkenazi, E. Varfolomeev, Avi Ashkenazi, 2004, Cell.

Cellular Inhibitors of Apoptosis Are Global Regulators of NF-κB and MAPK Activation by Members of the TNF Family of Receptors

H. Maecker, K. Deshayes, K. Zobel, 2012, Science Signaling.

MAPK Activation by Members of the TNF Family of Receptors Cellular Inhibitors of Apoptosis Are Global Regulators

H. Maecker, K. Deshayes, K. Zobel, 2012 .

Inhibitor of apoptosis proteins: fascinating biology leads to attractive tumor therapeutic targets.

D. Vučić, E. Varfolomeev, 2011, Future oncology.

IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

Vishva M. Dixit, V. Dixit, J. Blankenship, 2007, Cell.

Molecular Determinants of Kinase Pathway Activation by Apo2 Ligand/Tumor Necrosis Factor-related Apoptosis-inducing Ligand*

D. Lawrence, H. Maecker, A. Ashkenazi, 2005, Journal of Biological Chemistry.

c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation*

W. Fairbrother, K. Deshayes, K. Zobel, 2008, Journal of Biological Chemistry.

Dominant negative MORT1/FADD rescues mice from CD95 and TNF‐induced liver failure

P. Galle, S. Strand, A. Lohse, 2003, Hepatology.

Caspase-8 Serves Both Apoptotic and Nonapoptotic Roles1

T. Kang, A. Waisman, R. Haffner, 2004, The Journal of Immunology.

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

J. Beckmann, N. Chiannilkulchai, K. Avraham, 1998, Immunity.

OTUB1 modulates c‐IAP1 stability to regulate signalling pathways

D. Arnott, K. Deshayes, D. Kirkpatrick, 2013, The EMBO journal.

X Chromosome-linked Inhibitor of Apoptosis Regulates Cell Death Induction by Proapoptotic Receptor Agonists

A. Ashkenazi, W. Fairbrother, H. Wong, 2009, The Journal of Biological Chemistry.

Targeting inhibitor of apoptosis proteins for therapeutic intervention.

D. Vučić, E. Varfolomeev, Chudi O. Ndubaku, 2009, Future medicinal chemistry.

The Inhibitor of Apoptosis Protein Fusion c-IAP2·MALT1 Stimulates NF-κB Activation Independently of TRAF1 AND TRAF2*

V. Dixit, W. Fairbrother, S. Wayson, 2006, Journal of Biological Chemistry.

Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination

S. Hymowitz, A. M. Giannetti, W. Fairbrother, 2011, Science.

RIP1 post-translational modifications.

D. Vučić, E. Varfolomeev, 2022, The Biochemical journal.

Exploring cell death mechanisms by analyzing signaling cascades of the TNF/NGF receptor family.

R. Adar, I. Mett, D. Wallach, 1996, Behring Institute Mitteilungen.

Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death

J. Webster, D. Kirkpatrick, K. Newton, 2016, Cell Death and Differentiation.

RIP1 kinase activity is critical for skin inflammation but not for viral propagation

Min Xu, J. Webster, Summer Park, 2020, Journal of leukocyte biology.

How are the regulators regulated? The search for mechanisms that impose specificity on induction of cell death and NF-κB activation by members of the TNF/NGF receptor family

D. Wallach, M. Boldin, G. Cantarella, 2002, Arthritis research.

Nonapoptotic Roles Caspase-8 Serves Both Apoptotic And

T. Kang, A. Waisman, R. Haffner, 2004 .

Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists.

S. Hymowitz, W. Fairbrother, K. Deshayes, 2009, ACS chemical biology.

FADD is involved in liver regeneration

P. Galle, A. Lohse, F. Rückert, 2014 .

MORT1/FADD is involved in liver regeneration.

P. Galle, A. Lohse, D. Wallach, 2005, World journal of gastroenterology.

c-IAP1 AND c-IAP2 ARE CRITICAL MEDIATORS OF TNF α -INDUCED NF- κ B ACTIVATION

W. Fairbrother, K. Deshayes, K. Zobel, 2008 .

Structural requirements for inducible shedding of the p55 tumor necrosis factor receptor.

D. Wallach, C. Brakebusch, E. Varfolomeev, 1994, The Journal of biological chemistry.

Self-association of the Death Domains of the p55 Tumor Necrosis Factor (TNF) Receptor and Fas/APO1 Prompts Signaling for TNF and Fas/APO1 Effects (*)

J. Camonis, I. Mett, D. Wallach, 1995, The Journal of Biological Chemistry.

Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).

Zhaoyang Wen, Brigitte Maurer, Vickie Tsui, 2012, Journal of medicinal chemistry.

TWEAK Attenuates the Transition from Innate to Adaptive Immunity

D. Lawrence, D. Danilenko, H. Maecker, 2005, Cell.

Roles of c-IAP proteins in TNF receptor family activation of NF-κB signaling.

D. Vučić, E. Varfolomeev, T. Goncharov, 2015, Methods in molecular biology.

Cell death induction by receptors of the TNF family: towards a molecular understanding

P. Vandenabeele, W. Fiers, D. Wallach, 1997, FEBS letters.

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

Vishva M Dixit, V. Dixit, J. Blankenship, 2007, Cell.

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

Adam R. Johnson, M. van Lookeren Campagne, J. Webster, 2019, Cell Death & Differentiation.

Delineation of the cell-extrinsic apoptosis pathway in the zebrafish

A. Ashkenazi, S. Hymowitz, H. Stern, 2006, Cell Death and Differentiation.

The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells

A. Zarrin, S. Warming, J. Hackney, 2020, Science Signaling.

Structure of human RIPK1 kinase domain in complex with GNE684

Adam R. Johnson, M. van Lookeren Campagne, J. Webster, 2019 .

The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation

Z. Modrušan, J. DeVoss, A. Zarrin, 2017, Science Signaling.

Tumor-cell resistance to death receptor–induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax

Peter Schow, D. Lawrence, A. Ashkenazi, 2002, Nature Medicine.

CASH, a Novel Caspase Homologue with Death Effector Domains*

Y. Goltsev, D. Wallach, E. Varfolomeev, 1997, The Journal of Biological Chemistry.

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain (*)

J. Camonis, I. Mett, D. Wallach, 1995, The Journal of Biological Chemistry.

Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury

K. Stark, J. Webster, E. Verschueren, 2021, Cell Death & Disease.

Immunoblot Analysis of the Regulation of TNF Receptor Family-Induced NF-κB Signaling by c-IAP Proteins.

D. Vučić, E. Varfolomeev, T. Goncharov, 2021, Methods in molecular biology.

IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition

W. Fairbrother, B. Alicke, S. Gould, 2022, Cell Death & Disease.

Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1).

D. Arnott, J. Blankenship, W. Fairbrother, 2009, The Biochemical journal.

APRIL-Deficient Mice Have Normal Immune System Development

D. Lawrence, D. Seshasayee, A. Ashkenazi, 2004, Molecular and Cellular Biology.

Characterization of ML-IAP protein stability and physiological role in vivo.

J. Zha, W. Fairbrother, K. Deshayes, 2012, The Biochemical journal.

Ubiquitination profiling identifies sensitivity factors for IAP antagonist treatment.

Alexandre Masselot, Donald S Kirkpatrick, Corey E Bakalarski, 2015, The Biochemical journal.

(Un)expected roles of c-IAPs in apoptotic and NFkappaB signaling pathways.

D. Vučić, Domagoj Vucic, Eugene Varfolomeev, 2008, Cell cycle.

Immunoaffinity enrichment coupled to quantitative mass spectrometry reveals ubiquitin-mediated signaling events.

Donald S Kirkpatrick, D. Kirkpatrick, Lilian Phu, 2015, Journal of molecular biology.

Death-receptor activation halts clathrin-dependent endocytosis

D. Lawrence, R. Scheller, D. Arnott, 2006, Proceedings of the National Academy of Sciences.

Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS

K. Stark, J. Webster, O. Foreman, 2020, Cell Death & Differentiation.

Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.

W. Fairbrother, K. Deshayes, K. Zobel, 2006, ACS chemical biology.

Tumor necrosis factor receptor and Fas signaling mechanisms.

Y. Goltsev, D. Wallach, M. Boldin, 1999, Annual review of immunology.

A potential mechanism of "cross-talk" between the p55 tumor necrosis factor receptor and Fas/APO1: proteins binding to the death domains of the two receptors also bind to each other

D. Wallach, M. Boldin, E. Varfolomeev, 1996, The Journal of experimental medicine.

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

Adam R. Johnson, M. van Lookeren Campagne, J. Webster, 2019, Cell Death & Differentiation.