W. Tsai

发表

Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease

J. Orange, R. Siegel, J. Ashwell, 2016, Proceedings of the National Academy of Sciences.

Whole Chromosome Instability induces senescence and promotes SASP

L. Santambrogio, J. Campisi, J. Vijg, 2016, Scientific Reports.

Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus

P. Gregersen, Y. Kotliarov, R. Apps, 2021, Nature Communications.

High throughput pSTAT signaling profiling by fluorescent cell barcoding and computational analysis.

S. Kajigaya, N. Young, M. Gadina, 2019, Journal of immunological methods.

Deficiency of adenosine deaminase 2 triggers adenosine-mediated NETosis and TNF production in patients with DADA2.

K. Jacobson, D. Kastner, D. Stone, 2019, Blood.

Gain-of-function mutations in ALPK1 cause an NF-κB-mediated autoinflammatory disease: functional assessment, clinical phenotyping and disease course of patients with ROSAH syndrome

Alexander H. Yang, D. Kastner, H. Takada, 2022, Annals of the Rheumatic Diseases.

CD 11 b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus

Jessica M. Dorschner, B. Issac, E. Bradshaw, 2017 .

Cerebrospinal Fluid Cytokines Correlate With Aseptic Meningitis and Blood–Brain Barrier Function in Neonatal‐Onset Multisystem Inflammatory Disease: Central Nervous System Biomarkers in Neonatal‐Onset Multisystem Inflammatory Disease Correlate With Central Nervous System Inflammation

M. Gadina, Y. Huang, B. Bielekova, 2017, Arthritis & rheumatology.

Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease

J. Mullikin, E. Remmers, D. Kastner, 2016, Proceedings of the National Academy of Sciences.

Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction

J. O’Shea, A. Remaley, V. Hoffmann, 2017, Arthritis & rheumatology.

PDIA3 epitope-driven immune autoreactivity contributes to hepatic damage in type 2 diabetes

D. Vergani, L. Galluzzi, A. Urbanska, 2022, Science Immunology.

Changes in cardiorespiratory function and fatigue following 12 weeks of exercise training in women with systemic lupus erythematosus: a pilot study

L. Chan, M. Gadina, L. Saligan, 2022, Lupus Science & Medicine.

Supplemental Data Additive Loss-of-Function Mutations in Proteasome-Subunit-Genes induce Type-I-interferon production in CANDLE / PRAAS

E. Remmers, A. Mégarbané, K. Rother, 2015 .

Deubiquitination of proteasome subunits by OTULIN regulates type I IFN production

S. Ozen, R. Topaloğlu, Huanming Yang, 2021, Science advances.

Engineering of an elastic scaffolding polyprotein based on an SH3-binding intrinsically disordered titin PEVK module.

Kuan Wang, W. Tsai, J. Forbes, 2012, Protein expression and purification.

Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors

W. C. Owen, M. Hafner, A. Šedivá, 2018, Annals of the rheumatic diseases.

Janus kinase (JAK) inhibition with baricitinib in refractory juvenile dermatomyositis

L. Yao, B. Feldman, M. Gadina, 2020, Annals of the Rheumatic Diseases.

Reversal of CD8 T-Cell–Mediated Mucocutaneous Graft-Versus-Host-Like Disease by the JAK Inhibitor Tofacitinib

N. Okiyama, J. O’Shea, J. Gutermuth, 2013, The Journal of investigative dermatology.

Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.

J. Mullikin, D. Kastner, W. Gahl, 2020, The New England journal of medicine.

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

J. Mullikin, D. Kastner, Dan Yang, 2019, Nature.

Second Case of HOIP Deficiency Expands Clinical Features and Defines Inflammatory Transcriptome Regulated by LUBAC

L. Notarangelo, D. Kastner, S. Rosenzweig, 2019, Front. Immunol..

Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production.

E. Remmers, D. Kastner, A. Mégarbané, 2016, Journal of Clinical Investigation.

Activated STING in a vascular and pulmonary syndrome.

Ha Won Kim, J. Hughes, J. McElwee, 2014, The New England journal of medicine.

Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early onset autoinflammatory syndrome

J. Mullikin, Yuan Zhang, D. Kastner, 2015, Nature Genetics.

Germline gain-of-function myeloid differentiation primary response gene-88 (MYD88) mutation in a child with severe arthritis.

L. Staudt, J. Tavernier, M. Gadina, 2018, The Journal of allergy and clinical immunology.

Titin PEVK segment: charge-driven elasticity of the open and flexible polyampholyte

A. Jin, G. Gutierrez-Cruz, Kuan Wang, 2006, Journal of Muscle Research & Cell Motility.

Brief Report: Deficiency of Complement 1r Subcomponent in Early‐Onset Systemic Lupus Erythematosus: The Role of Disease‐Modifying Alleles in a Monogenic Disease

E. Remmers, D. Kastner, M. Gadina, 2017, Arthritis & rheumatology.

Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production.

E. Remmers, D. Kastner, A. Mégarbané, 2015, The Journal of clinical investigation.

Somatic Mutations in UBA1 Define a Distinct Subset of Relapsing Polychondritis Patients With VEXAS

D. Kastner, N. Young, Marcus Y. Chen, 2021, Arthritis & rheumatology.

Early-onset stroke and vasculopathy associated with mutations in ADA2.

J. Mullikin, H. Kong, V. Pascual, 2014, The New England journal of medicine.

Erratum: Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type i IFN production (Journal of Clinical Investigation (2015) 125:11 (4196-4211) DOI: 10.1172/JCI81260)

E. Remmers, D. Kastner, A. Mégarbané, 2016 .

Expression of interferon-regulated genes in juvenile dermatomyositis versus Mendelian autoinflammatory interferonopathies

Y. Huang, M. Gadina, I. Targoff, 2020, Arthritis Research & Therapy.

Pharmacokinetics, Pharmacodynamics, and Proposed Dosing of the Oral JAK1 and JAK2 Inhibitor Baricitinib in Pediatric and Young Adult CANDLE and SAVI Patients

M. Gadina, Y. Huang, Paul G. Wakim, 2018, Clinical pharmacology and therapeutics.

Neutrophil subsets and their gene signature associate with vascular inflammation and coronary atherosclerosis in lupus.

Jonathan H. Chung, Hong-Wei Sun, N. Mehta, 2018, JCI insight.

3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine

M. Skobe, M. Veldhoen, K. Alitalo, 2021, Nature Communications.

183 A phase 1B/2A trial of tofacitinib, an oral janus kinase inhibitor, in systemic lupus erythematosus

P. Gregersen, R. Apps, B. Diamond, 2019, Abstracts.

OP0090 CLASSIFICATION OF PATIENTS WITH RELAPSING POLYCHONDRITIS BASED ON SOMATIC MUTATIONS IN UBA1

D. Kastner, M. Gadina, P. Grayson, 2021 .

Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation

J. D. Di Santo, G. Sciumè, G. Peruzzi, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Homozygous variant p. Arg90His in NCF1 is associated with early-onset Interferonopathy: a case report

D. Kastner, D. Kuhns, M. Gadina, 2021, Pediatric Rheumatology.

Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.

K. Dobbs, B. Boisson, J. Toguchida, 2024, Nature immunology.

Interrupting an IFN-γ-dependent feedback loop in the syndrome of pyogenic arthritis with pyoderma gangrenosum and acne

D. Stone, P. Hoffmann, J. Chae, 2024, Annals of the Rheumatic Diseases.

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

D. Kastner, C. Biben, S. Rosenzweig, 2019, Nature.