J. Kearns

发表

Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20.

David Baltimore, Alexander Hoffmann, A. Hoffmann, 2008, Genes & development.

A fourth IkappaB protein within the NF-kappaB signaling module.

Hana Kim, Alexander Hoffmann, Vinay Tergaonkar, 2007, Cell.

Chimeric Antigen Receptor T Cell Therapies: A Review of Cellular Kinetic‐Pharmacodynamic Modeling Approaches

A. Chaudhury, C. June, A. Stein, 2020, Journal of clinical pharmacology.

Integrating Computational and Biochemical Studies to Explore Mechanisms in NF-κB Signaling*

A. Hoffmann, J. Kearns, 2009, Journal of Biological Chemistry.

Current practices for QSP model assessment: an IQ consortium survey

Jason R. Chan, Jangir Selimkhanov, R. Saito, 2022, Journal of pharmacokinetics and pharmacodynamics.

UV as an amplifier rather than inducer of NF-kappaB activity.

Alexander Hoffmann, A. Hoffmann, J. Kearns, 2008, Molecular cell.

A root cause analysis to identify the mechanistic drivers of immunogenicity against the anti-VEGF biotherapeutic brolucizumab

B. Brannetti, V. Sasseville, Alexander Bepperling, 2023, Science Translational Medicine.

Encoding NF- (cid:1) B temporal control in response to TNF: distinct roles for the negative regulators I (cid:1) B (cid:2) and A20

A. Hoffmann, D. Baltimore, Candace L. Lynch, 2008 .

Stabilization of RelB Requires Multidomain Interactions with p100/p52*

A. Hoffmann, G. Ghosh, O. Savinova, 2008, Journal of Biological Chemistry.

A homeostatic model of IκB metabolism to control constitutive NF-κB activity

Andre Levchenko, Alexander Hoffmann, Derren Barken, 2007, Molecular systems biology.

IκBɛ provides negative feedback to control NF-κB oscillations, signaling dynamics, and inflammatory gene expression

Alexander Hoffmann, Jeffrey D. Kearns, A. Hoffmann, 2006, The Journal of cell biology.

Control of RelB during dendritic cell activation integrates canonical and non-canonical NF-κB pathways

A. Hoffmann, J. Ponomarenko, J. Davis-Turak, 2012, Nature Immunology.

A Fourth IκB Protein within the NF-κB Signaling Module

Hana Kim, Alexander Hoffmann, Vinay Tergaonkar, 2007, Cell.

Dual Delayed Feedback Provides Sensitivity and Robustness to the NF-κB Signaling Module

Jeff Hasty, Alexander Hoffmann, Lev S. Tsimring, 2013, PLoS Comput. Biol..

Comment on "Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression"

Andre Levchenko, Raymond Cheong, Alexander Hoffmann, 2005, Science.

MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM

B. Schoeberl, U. Nielsen, A. Raue, 2019, Proceedings of the National Academy of Sciences.

Enhanced Targeting of the EGFR Network with MM-151, an Oligoclonal Anti-EGFR Antibody Therapeutic

U. Nielsen, J. Fitzgerald, O. Burenkova, 2015, Molecular Cancer Therapeutics.

Systems biology driving drug development: from design to the clinical testing of the anti-ErbB3 antibody seribantumab (MM-121)

V. Grantcharova, B. Schoeberl, U. Nielsen, 2017, npj Systems Biology and Applications.

Kinetic control of negative feedback regulators of NF-κB/RelA determines their pathogen- and cytokine-receptor signaling specificity

Alexander Hoffmann, A. Hoffmann, G. Ghosh, 2009, Proceedings of the National Academy of Sciences.

Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation.

A. Hoffmann, S. Miyamoto, Candace L. Lynch, 2011, Immunity.

Promises and pitfalls for recombinant oligoclonal antibodies-based therapeutics in cancer and infectious disease

D. Corti, J. Kearns, 2016, Current Opinion in Immunology.

A Fourth IkB Protein within the NF-kB Signaling Module

A. Hoffmann, C. Benedict, C. Ware, 2007 .

Understanding the role of cross-arm binding efficiency in the activity of monoclonal and multispecific therapeutic antibodies.

B. Harms, A. Lugovskoy, S. Iadevaia, 2014, Methods.

MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations

A. Bardelli, L. Trusolino, A. Bertotti, 2016, Science Translational Medicine.

IκBβ enhances the generation of the low-affinity NFκB/RelA homodimer

Alexander Hoffmann, Jeffrey D. Kearns, Rachel Tsui, 2015, Nature Communications.

A phase 1 study combining the HER3 antibody seribantumab (MM-121) and cetuximab with and without irinotecan

G. MacBeath, G. Shapiro, Sunil Sharma, 2017, Investigational New Drugs.

USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma

Andreas C. Damianou, A. Damianou, Claire Heride, 2020, bioRxiv.

Heteromeric tandem IgG4/IgG1 Fc

B. Schoeberl, U. Nielsen, A. Raue, 2019 .

Crystal structure of EpCAM in complex with scFv

B. Schoeberl, U. Nielsen, A. Raue, 2019 .

Crystal structure of Sema domain of the Met receptor in complex with FAB

B. Schoeberl, U. Nielsen, A. Raue, 2019 .

Anti-brolucizumab immune response as one prerequisite for rare retinal vasculitis/retinal vascular occlusion adverse events

Oliver C. Turner, V. Sasseville, M. Scharenberg, 2023, Science Translational Medicine.

Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C

N. Ostermann, C. Schnell, Toshio Shimizu, 2022, Cancer discovery.

Safety, pharmacology, and preliminary clinical activity of MM-151: An oligocolnal anti-EGFR theraputic in patients with cetuximab-resistant CRC and other refractory solid tumors.

M. Beeram, A. Adjei, B. Wolf, 2015 .

Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making

Jangir Selimkhanov, B. Schoeberl, J. Harrold, 2022, Frontiers in Pharmacology.

IkBb enhances the generation of the low-affinity NFkB/RelA homodimer

A. Hoffmann, G. Ghosh, Candace L. Lynch, 2015 .

Optimizing properties of antireceptor antibodies using kinetic computational models and experiments.

B. Schoeberl, U. Nielsen, B. Harms, 2012, Methods in enzymology.

I k B b enhances the generation of the low-affinity NF k B / RelA homodimer

A. Hoffmann, G. Ghosh, Candace L. Lynch, 2015 .