D. Haigh

发表

Differential affinity of FLIP and procaspase 8 for FADD’s DED binding surfaces regulates DISC assembly

P. Johnston, D. Longley, M. Sgobba, 2014, Nature Communications.

Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity.

G. Hofmann, G. Burton, R. Sarisky, 2007, Bioorganic & medicinal chemistry letters.

Abstract LB-037: Development and preclinical assessment of a first-in-class small molecule inhibitor of the major cell death regulator protein FLIP

P. Johnston, D. Longley, J. Majkut, 2015 .

Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis

M. Sgobba, P. Kiely, C. Holohan, 2012, Cell Death and Differentiation.

Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.

R. Hamatake, Z. Hong, Shawn P. Williams, 2014, Journal of medicinal chemistry.

The synthesis of BRL 49653 : a novel and potent antihyperglycaemic agent

David Haigh, Stephen A. Smith, M. Cawthorne, 1994 .

The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives.

R. Ife, D. Haigh, D. G. Smith, 1999, Bioorganic & medicinal chemistry letters.

Asymmetric synthesis of an N-acylpyrrolidine for inhibition of HCV polymerase.

Mary M. Jackson, Roy C. Flanagan, M. Slater, 2008, The Journal of organic chemistry.

Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies

S. Byers, S. Dakshanamurthy, L. Shapiro, 2013, Oncotarget.

Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate.

David Haigh, Malcolm Ellis, George Burton, 2007, Journal of medicinal chemistry.

3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).

M. Saunders, R. Ife, D. Haigh, 2001, Bioorganic & medicinal chemistry letters.

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.

J W Yates, A. Reith, J. Holder, 2000, Chemistry & biology.

5-aryl-pyrazolo[3,4-b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

R. Ife, D. M. Hickey, D. Haigh, 2003, Bioorganic & medicinal chemistry letters.

[594] GSK625433; A NOVEL AND HIGHLY POTENT INHIBITOR OF THE HCV NS5B POLYMERASE

Stephen A. Smith, F. Nerozzi, M. Slater, 2007 .