N. Khan

发表

In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-κB, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-κB is required to prevent it

D. Vaux, B. Callus, J. Lluis, 2011, Cell Death and Differentiation.

RIPK3 promotes cell death NLRP3 inflammasome and interleukin-1 activation in the absence of MLKL

D. Vaux, W. Alexander, I. Wicks, 2017 .

IAPS and ubiquitylation

J. Silke, R. Feltham, N. Khan, 2012, IUBMB life.

In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8*

D. Vaux, J. Silke, J. Lluis, 2011, The Journal of Biological Chemistry.

Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies.

Yigong Shi, G. Kapoor, C. Day, 2014, Journal of medicinal chemistry.

IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis

David L. Vaux, Vinay Tergaonkar, Pascal Schneider, 2007, Cell.

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.

Vinay Tergaonkar, Pascal Schneider, D. Vaux, 2007, Cell.

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

Maryam Rashidi, Warren S. Alexander, Seth L. Masters, 2015, Nature Communications.

Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways

J. Hildebrand, J. Silke, S. Condon, 2017, Cell Death and Differentiation.

TAK1 Is Required for Survival of Mouse Fibroblasts Treated with TRAIL, and Does So by NF-κB Dependent Induction of cFLIPL

D. Vaux, J. Silke, B. Callus, 2010, PloS one.

Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways

J. Hildebrand, J. Silke, S. Condon, 2017, Cell Death & Differentiation.

More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling.

J. Vince, James M. Murphy, N. Khan, 2014, Current opinion in immunology.

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8.

D. Vaux, J. Silke, J. Lluis, 2016, Journal of Biological Chemistry.