H. Hung

发表

Ornithine decarboxylase prevents tumor necrosis factor alpha-induced apoptosis by decreasing intracellular reactive oxygen species

P. Hsu, G.-Y. Liu, Y. Hung, 2005, Apoptosis.

The functional haplotype of peptidylarginine deiminase IV (S55G, A82V and A112G) associated with susceptibility to rheumatoid arthritis dominates apoptosis of acute T leukemia Jurkat cells

Chien-Yu Lin, Guang-Yaw Liu, P. Hsu, 2007, Apoptosis.

Overexpression of ornithine decarboxylase suppresses thapsigargin-induced apoptosis

Hue Lee, Guang-Yaw Liu, P. Hsu, 2010, Molecules and cells.

miR-302 Attenuates Mutant Huntingtin-Induced Cytotoxicity through Restoration of Autophagy and Insulin Sensitivity

Wei‐Jen Chen, S. Singh, Guang-Yaw Liu, 2021, International journal of molecular sciences.

Dibenzoylmethane, hydroxydibenzoylmethane and hydroxymethyldibenzoylmethane inhibit phorbol-12-myristate 13-acetate‑induced breast carcinoma cell invasion.

Y. Tzeng, Guang-Yaw Liu, Y. Liao, 2015, Molecular medicine reports.

Structure of Stenotrophomonas maltophilia FeoA complexed with zinc: a unique prokaryotic SH3-domain protein that possibly acts as a bacterial ferrous iron-transport activating factor.

S. Chou, A. H. Wang, H. Hung, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Overexpression of peptidylarginine deiminase IV features in apoptosis of haematopoietic cells

Guang-Yaw Liu, P. Hsu, G.-Y. Liu, 2006, Apoptosis.

Hydroxydibenzoylmethane induces apoptosis through repressing ornithine decarboxylase in human promyelocytic leukemia HL-60 cells

K. Lue, T. Hour, Ming-Fu Wang, 2011, Experimental & Molecular Medicine.

Peptidylarginine deiminase 2 promotes T helper 17-like T cell activation and activated T cell-autonomous death (ACAD) through an endoplasmic reticulum stress and autophagy coupling mechanism

Yi-Liang Liu, Guang-Yaw Liu, H. Hung, 2022, Cellular & molecular biology letters.

(JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 , 12 : 2757-2760)Reverse micelles as a model system with which to study leaving group effects on alkaline phosphatase-catalysed hydrolysis

G. Chang, H. Hung, T. Huang, 1997 .

Ornithine decarboxylase functions in both autophagy and apoptosis in response to ultraviolet B radiation injury

M. Jan, Yi-Liang Liu, Guang-Yaw Liu, 2022, Journal of cellular physiology.

Ornithine decarboxylase interferes with macrophage-like differentiation and matrix metalloproteinase-9 expression by tumor necrosis factor alpha via NF-kappaB.

M. Kao, T. Hour, Guang-Yaw Liu, 2008, Leukemia research.

Molecular Interplay between the Dimer Interface and the Substrate-Binding Site of Human Peptidylarginine Deiminase 4

Chu-Cheng Lin, Yi-Liang Liu, Guang-Yaw Liu, 2017, Scientific Reports.

Long, Noncoding RNA SRA Induces Apoptosis of β-Cells by Promoting the IRAK1/LDHA/Lactate Pathway

F. Tsai, Maw-rong Lee, P. Su, 2021, International journal of molecular sciences.

Effects of C-terminal truncation on autocatalytic processing of Bacillus licheniformis γ-glutamyl transpeptidase

Tzu-Fan Wang, Long-Liu Lin, M. Chi, 2010, Biochemistry (Moscow).

The PKC delta inhibitor, rottlerin, induces apoptosis of haematopoietic cell lines through mitochondrial membrane depolarization and caspases' cascade.

T. Hour, Wen-huei Chang, Guang-Yaw Liu, 2005, Life sciences.

Humic Acid Increases Amyloid β-Induced Cytotoxicity by Induction of ER Stress in Human SK-N-MC Neuronal Cells

T. Lai, F. Lu, Guang-Yaw Liu, 2015, International journal of molecular sciences.

Functional Roles of the Tetramer Organization of Malic Enzyme*

H. Hung, Ju-Yi Hsieh, Shaoj Chen, 2009, The Journal of Biological Chemistry.

Aβ stimulates microglial activation through antizyme‐dependent downregulation of ornithine decarboxylase

Guang-Yaw Liu, Yu-Wen Cheng, H. Hung, 2018, Journal of cellular physiology.

Ornithine decarboxylase prevents methotrexate-induced apoptosis by reducing intracellular reactive oxygen species production

M. Kao, C. Liu, P. Hsu, 2005, Apoptosis.

Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: Crosstalk between ODC and BCL-2

M. Kao, T. Hour, P. Hsu, 2006, Apoptosis.

Baicalein, 7,8-Dihydroxyflavone and Myricetin as Potent Inhibitors of Human Ornithine Decarboxylase

Yi-Liang Liu, Guang-Yaw Liu, H. Hung, 2020, Nutrients.

Effects of structural analogues of the substrate and allosteric regulator of the human mitochondrial NAD(P)+-dependent malic enzyme.

H. Hung, Kuo-Liang Su, Kuan-Yu Chang, 2009, Bioorganic & medicinal chemistry.

4-Phenylbutyric Acid (4-PBA) and Lithium Cooperatively Attenuate Cell Death during Oxygen–Glucose Deprivation (OGD) and Reoxygenation

Wei‐Jen Chen, Guang-Yaw Liu, H. Hung, 2015, Cellular and Molecular Neurobiology.

A continuous spectrophotometric assay method for peptidylarginine deiminase type 4 activity.

Guang-Yaw Liu, Y. Liao, H. Hung, 2005, Analytical biochemistry.

Partitioning of 4-nitrophenol in aerosol-OT reverse micelles

G. Chang, H. Hung, 1999 .

The Inhibitory Effect of Extra Virgin Olive Oil and Its Active Compound Oleocanthal on Prostaglandin-Induced Uterine Hypercontraction and Pain—Ex Vivo and In Vivo Study

Tsui-Chin Huang, Hsin-Yuan Chen, S. Hsia, 2020, Nutrients.

Structural studies of the pigeon cytosolic NADP+‐dependent malic enzyme

L. Tong, G. Chang, Hanna S. Yuan, 2002, Protein science : a publication of the Protein Society.

Characterization of the functional role of allosteric site residue Asp102 in the regulatory mechanism of human mitochondrial NAD(P)+-dependent malate dehydrogenase (malic enzyme).

M. Kuo, G. Chang, Guang-Yaw Liu, 2005, The Biochemical journal.

Dual functional roles of ATP in the human mitochondrial malic enzyme.

L. Tong, G. Chang, H. Hung, 2004, Biochemistry.

Dual roles of Lys(57) at the dimer interface of human mitochondrial NAD(P)+-dependent malic enzyme.

Jyung-Hurng Liu, H. Hung, Yi-wen Fang, 2009, The Biochemical journal.

Functional role of fumarate site Glu59 involved in allosteric regulation and subunit–subunit interaction of human mitochondrial NAD(P)+‐dependent malic enzyme

H. Hung, Ju-Yi Hsieh, Kuan-Yu Chang, 2009, The FEBS journal.

Functional Roles of Metabolic Intermediates in Regulating the Human Mitochondrial NAD(P)+-Dependent Malic Enzyme

Guang-Yaw Liu, H. Hung, Ju-Yi Hsieh, 2019, Scientific Reports.

Biophysical Characterization of the Dimer and Tetramer Interface Interactions of the Human Cytosolic Malic Enzyme

H. Hung, S. Murugan, 2012, PloS one.

A small-molecule inhibitor suppresses the tumor-associated mitochondrial NAD(P)+-dependent malic enzyme (ME2) and induces cellular senescence

Guang-Yaw Liu, Jyung-Hurng Liu, H. Hung, 2015, Oncotarget.

Human mitochondrial NAD(P)(+)-dependent malic enzyme participates in cutaneous melanoma progression and invasion.

Shih-Ming Huang, Guang-Yaw Liu, H. Hung, 2015, The Journal of investigative dermatology.

Structural characteristics of the nonallosteric human cytosolic malic enzyme.

Jyung-Hurng Liu, H. Hung, N. Chan, 2014, Biochimica et biophysica acta.

Fumarate Analogs Act as Allosteric Inhibitors of the Human Mitochondrial NAD(P)+-Dependent Malic Enzyme

Guang-Yaw Liu, Jyung-Hurng Liu, H. Hung, 2014, PloS one.

Determinants of Nucleotide-Binding Selectivity of Malic Enzyme

H. Hung, Ju-Yi Hsieh, Meng-Chun Chen, 2011, PloS one.

Long-range interaction between the enzyme active site and a distant allosteric site in the human mitochondrial NAD(P)+-dependent malic enzyme.

H. Hung, Ju-Yi Hsieh, Kuo-Liang Su, 2009, Archives of biochemistry and biophysics.

Engineering of the Cofactor Specificities and Isoform-specific Inhibition of Malic Enzyme*

H. Hung, Ju-Yi Hsieh, 2009, Journal of Biological Chemistry.

Influential factor contributing to the isoform‐specific inhibition by ATP of human mitochondrial NAD(P)+‐dependent malic enzyme

Guang-Yaw Liu, H. Hung, Ju-Yi Hsieh, 2008, The FEBS journal.

Determinants of the Dual Cofactor Specificity and Substrate Cooperativity of the Human Mitochondrial NAD(P)+-dependent Malic Enzyme

G. Chang, Guang-Yaw Liu, H. Hung, 2006, Journal of Biological Chemistry.

Metal‐Induced reversible structural interconversion of human mitochondrial NAD(P)+‐Dependent malic enzyme

L. Tong, G. Chang, H. Hung, 2004, Proteins.

Single nucleotide variants lead to dysregulation of the human mitochondrial NAD(P)+-dependent malic enzyme

M. Ho, Yi-Liang Liu, Guang-Yaw Liu, 2021, iScience.

Potent and competitive inhibition of malic enzymes by lanthanide ions.

L. Tong, D. L. Floyd, G. Chang, 2000, Biochemical and biophysical research communications.

Curcumin induces apoptosis through an ornithine decarboxylase-dependent pathway in human promyelocytic leukemia HL-60 cells.

M. Kao, T. Hour, Guang-Yaw Liu, 2008, Life sciences.

Structural basis of antizyme-mediated regulation of polyamine homeostasis

S. Tzeng, Guang-Yaw Liu, H. Hung, 2015, Proceedings of the National Academy of Sciences.

Differentiation of the slow‐binding mechanism for magnesium ion activation and zinc ion inhibition of human placental alkaline phosphatase

G. Chang, H. Hung, 2001, Protein science : a publication of the Protein Society.

Multiple unfolding intermediates of human placental alkaline phosphatase in equilibrium urea denaturation.

G. Chang, H C Hung, G G Chang, 2001, Biophysical journal.

Biphasic denaturation of human placental alkaline phosphatase in guanidinium chloride

G. Chang, H. Hung, 1998, Proteins.

A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22.

J. Norris, E. Karlson, V. Holers, 2016, JCI insight.

Ornithine decarboxylase attenuates leukemic chemotherapy drugs-induced cell apoptosis and arrest in human promyelocytic HL-60 cells.

Guang-Yaw Liu, P. Hsu, Y. Liao, 2008, Leukemia research.

Pine (Pinus morrisonicola Hayata) needle extracts sensitize GBM8901 human glioblastoma cells to temozolomide by downregulating autophagy and O(6)-methylguanine-DNA methyltransferase expression.

Y. Chang, Guang-Yaw Liu, H. Hung, 2014, Journal of agricultural and food chemistry.

Regulation of polyamine homeostasis through an antizyme citrullination pathway

Guang-Yaw Liu, H. Hung, Chien-Yun Lee, 2021, Journal of cellular physiology.

Critical Factors in Human Antizymes that Determine the Differential Binding, Inhibition, and Degradation of Human Ornithine Decarboxylase

Yen-Chin Liu, Guang-Yaw Liu, H. Hung, 2019, Biomolecules.

Multifaceted interactions and regulation between antizyme and its interacting proteins cyclin D1, ornithine decarboxylase and antizyme inhibitor

Guang-Yaw Liu, H. Hung, Yen-Chin Liu, 2015, Oncotarget.

Determinants of the Differential Antizyme-Binding Affinity of Ornithine Decarboxylase

Yen-Chin Liu, Guang-Yaw Liu, H. Hung, 2011, PloS one.

Minimal Antizyme Peptide Fully Functioning in the Binding and Inhibition of Ornithine Decarboxylase and Antizyme Inhibitor

Guang-Yaw Liu, H. Hung, Chih-Li Lin, 2011, PloS one.

Critical Factors Governing the Difference in Antizyme-Binding Affinities between Human Ornithine Decarboxylase and Antizyme Inhibitor

Yen-Chin Liu, Guang-Yaw Liu, H. Hung, 2011, PloS one.

Critical Factors Determining Dimerization of Human Antizyme Inhibitor*

Guang-Yaw Liu, Y. Liao, H. Hung, 2009, The Journal of Biological Chemistry.

Antizyme, a natural ornithine decarboxylase inhibitor, induces apoptosis of haematopoietic cells through mitochondrial membrane depolarization and caspases’ cascade

M. Kao, T. Hour, P. Hsu, 2006, Apoptosis.

Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4

Guang-Yaw Liu, H. Hung, Chien-Yun Lee, 2017, Scientific Reports.

Functional Roles of the Non-Catalytic Calcium-Binding Sites in the N-Terminal Domain of Human Peptidylarginine Deiminase 4

Guang-Yaw Liu, Y. Liao, H. Hung, 2013, PloS one.

Functional Role of Dimerization of Human Peptidylarginine Deiminase 4 (PAD4)

Guang-Yaw Liu, H. Hung, Yu-Hsiu Chiang, 2011, PloS one.

Vimentin Is Involved in Peptidylarginine Deiminase 2-Induced Apoptosis of Activated Jurkat Cells

Guang-Yaw Liu, P. Hsu, Y. Liao, 2014, Molecules and cells.

Structural variation manipulates the differential oxidative susceptibility and conformational stability of apolipoprotein E isoforms

G. Chang, C. Chou, Guang-Yaw Liu, 2007, Proteins.

Targeting human mitochondrial NAD(P)+-dependent malic enzyme (ME2) impairs energy metabolism and redox state and exhibits antileukemic activity in acute myeloid leukemia

Guang-Yaw Liu, H. Hung, Yung-Lung Chang, 2023, Cellular Oncology.

Functional Roles of Metabolic Intermediates in Regulating the Human Mitochondrial NAD(P)+-Dependent Malic Enzyme

Guang-Yaw Liu, H. Hung, Ju-Yi Hsieh, 2019, Scientific Reports.

Functional roles of ATP-binding residues in the catalytic site of human mitochondrial NAD(P)+-dependent malic enzyme.

G. Chang, Guang-Yaw Liu, H. Hung, 2005, Biochemistry.

4-Phenylbutyric Acid (4-PBA) and Lithium Cooperatively Attenuate Cell Death during Oxygen–Glucose Deprivation (OGD) and Reoxygenation

Wei‐Jen Chen, Guang-Yaw Liu, H. Hung, 2015, Cellular and Molecular Neurobiology.

Ornithine decarboxylase prevents dibenzoylmethane‐induced apoptosis through repressing reactive oxygen species generation

K. Lu, Guang-Yaw Liu, Y. Hung, 2011, Journal of biochemical and molecular toxicology.

Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4

Guang-Yaw Liu, H. Hung, Chien-Yun Lee, 2017, Scientific Reports.

Equilibrium protein folding-unfolding process involving multiple intermediates

Hwei-Jen Lee, G. Chang, Guang-Yaw Liu, 2003, Bulletin of mathematical biology.

Suppression of the human malic enzyme 2 modifies energy metabolism and inhibits cellular respiration

M. Ho, Guang-Yaw Liu, H. Hung, 2023, Communications biology.

Functional Roles of the Dimer-Interface Residues in Human Ornithine Decarboxylase

Guang-Yaw Liu, H. Hung, Chih-Li Lin, 2014, PloS one.

Reverse micelles as life-mimicking systems.

G. Chang, H. Hung, T. Huang, 2000, Proceedings of the National Science Council, Republic of China. Part B, Life sciences.

The Pluripotency Factor Nanog Protects against Neuronal Amyloid β-Induced Toxicity and Oxidative Stress through Insulin Sensitivity Restoration

T. Lai, Guang-Yaw Liu, H. Hung, 2020, Cells.

Solvent kinetic isotope effects of human placental alkaline phosphatase in reverse micelles.

G. Chang, H. Hung, T. Chang, 1998, The Biochemical journal.

(Apoptosis, 10:569-581)Ornithine decarboxylase prevents tumor necrosis factor alpha-induced apoptosis by decreasing intracellular reactive oxygen species

P. Hsu, Y. Hung, Y. Liao, 2005 .

Functional role of fumarate site Glu59 involved in allosteric regulation and subunit–subunit interaction of human mitochondrial NAD(P)+‐dependent malic enzyme

H. Hung, Ju-Yi Hsieh, Kuan-Yu Chang, 2009, The FEBS journal.