F. Scott

发表

A unified model for apical caspase activation.

D. Green, G. Salvesen, D. Sutherlin, 2003, Molecular cell.

XIAP is not required for human tumor cell survival in the absence of an exogenous death signal

R. Peach, J. Sensintaffar, J. Hager, 2010, BMC Cancer.

Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.

Clemencia Pinilla, Kate Welsh, Adel Nefzi, 2004, Cancer cell.

Nicotinamide Rescues Human Embryonic Stem Cell‐Derived Neuroectoderm from Parthanatic Cell Death

G. Salvesen, A. Terskikh, F. Cimadamore, 2009, Stem cells.

Proteinase Inhibitor 6 Cannot Be Secreted, Which Suggests It Is a New Type of Cellular Serpin (*)

P. Bird, J. Hayman, P. Coughlin, 1996, The Journal of Biological Chemistry.

Ozanimod (RPC1063) is a potent sphingosine‐1‐phosphate receptor‐1 (S1P1) and receptor‐5 (S1P5) agonist with autoimmune disease‐modifying activity

R. Peach, H. Rosen, E. Roberts, 2016, British journal of pharmacology.

Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease

R. Peach, P. Gonzalez-Cabrera, H. Rosen, 2016, Mucosal Immunology.

Sphingosine-1-phosphate receptor-1 (S1P 1 ) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease

R. Peach, P. Gonzalez-Cabrera, J. Rivera-Nieves, 2017 .

Sa1221 Rpc1063, a Potent, Selective S1P1 Receptor Modulator, Is Active in a Therapeutic IBD Model and Exhibits Favorable PK/PD Properties in Healthy Volunteers

R. Peach, H. Rosen, M. Boehm, 2013 .

RPC1063, a Potent, Selective S1P1 Receptor Modulator, is Active in Therapeutic Inflammatory Bowel Disease Models and Exhibits Favorable PK/PD Properties in Healthy Volunteers

R. Peach, H. Rosen, M. Boehm, 2009 .

Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate.

S. Boyd, S. Roberts, F. Scott, 2014, Bioscience reports.

Caspase-8 Cleaves Histone Deacetylase 7 and Abolishes Its Transcription Repressor Function*

F. Dequiedt, S. Boyd, G. Salvesen, 2008, Journal of Biological Chemistry.

Caspase assays: identifying caspase activity and substrates in vitro and in vivo.

G. Salvesen, C. Pop, F. Scott, 2008, Methods in enzymology.

Neutralization of Smac/Diablo by Inhibitors of Apoptosis (IAPs)

G. Salvesen, C. Duckett, Rebecca A. Csomos, 2004, Journal of Biological Chemistry.

Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity

D. Green, J. Trapani, R. Johnstone, 2008, Cell Death and Differentiation.

Ozanimod (RPC1063), a selective S1PR1 and S1PR5 modulator, reduces chronic inflammation and alleviates kidney pathology in murine systemic lupus erythematosus

Matthew E. Stokes, G. Opiteck, R. Peach, 2018, PloS one.

Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death.

S. Lipton, J. Yates, R. Riek, 2010, Molecular cell.

Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

G. Salvesen, B. Eckelman, F. Scott, 2006, EMBO reports.

Engineered hybrid dimers: tracking the activation pathway of caspase-7.

M. Bogyo, G. Salvesen, J. Denault, 2006, Molecular cell.

Serine Proteinase Inhibitor 3 and Murinoglobulin I Are Potent Inhibitors of Neuropsin in Adult Mouse Brain*

K. Matsumoto, T. Kishi, P. Bird, 2001, The Journal of Biological Chemistry.

Caspases: Activation, Regulation, and Function

S. Riedl, F. Scott, 2009 .

Chapter 1 Caspases : Activation , Regulation , and Function

S. Riedl, F. Scott, 2009 .

Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation.

C. Duckett, M. O’Riordan, L. Bauler, 2008, Developmental cell.

The Fas/FADD death domain complex structure unravels signaling by receptor clustering

Boguslaw Stec, Guy S. Salvesen, R. Schwarzenbacher, 2008, Nature.

XIAP inhibits caspase‐3 and ‐7 using two binding sites: evolutionarily conserved mechanism of IAPs

G. Salvesen, M. Renatus, J. Denault, 2005, The EMBO journal.

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

Robert Peach, Hugh Rosen, Edward Roberts, 2011, Cell.

Activation and substrate specificity of caspase-14.

J. Mikolajczyk, S. Krajewski, G. Salvesen, 2004, Biochemistry.

Dimer formation drives the activation of the cell death protease caspase 9

R. Liddington, G. Salvesen, M. Renatus, 2001, Proceedings of the National Academy of Sciences of the United States of America.

The intracellular serpin proteinase inhibitor 6 is expressed in monocytes and granulocytes and is a potent inhibitor of the azurophilic granule protease, cathepsin G.

S. Bottomley, P. Bird, C. Hirst, 1999, Blood.

Human ovalbumin serpin evolution: phylogenic analysis, gene organization, and identification of new PI8-related genes suggest that two interchromosomal and several intrachromosomal duplications generated the gene clusters at 18q21-q23 and 6p25.

J. Irving, J. Ragoussis, P. Bird, 1999, Genomics.

A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis

C. Mattos, G. Salvesen, P. Swartz, 2009, The Biochemical journal.

Retraction: The triterpenoid CDDO-Imidazolide induces apoptosis and enhances fludarabine-induced apoptosis of CLL B-cells.

M. Sporn, T. Kipps, John Calvin Reed, 2004, Blood.

Crystal Structure of a Lipid G Protein–Coupled Receptor

Hugh Rosen, Peter Kuhn, Raymond C Stevens, 2012, Science.

Actions of a picomolar short-acting S1P1 agonist in S1P1-eGFP knock-in mice

P. Gonzalez-Cabrera, H. Rosen, F. Scott, 2011, Nature chemical biology.

SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes.

J. Whisstock, P. Bird, Jiuru Sun, 2007, Journal of Biochemistry (Tokyo).

Sequence, organization, chromosomal localization, and alternative splicing of the human serine protease inhibitor gene hurpin (PI13) which is upregulated in psoriasis.

J. Irving, P. Bird, T. Ruzicka, 2001, DNA and cell biology.

Proteinase inhibitor 6 (PI-6) expression in human skin: induction of PI-6 and a PI-6/proteinase complex during keratinocyte differentiation.

P. Bird, P. Coughlin, J. Paddle-Ledinek, 1998, Experimental cell research.

Metabolites of RPC1063 Contribute to In Vivo Efficacy (P05.157)

R. Peach, M. Boehm, F. Scott, 2013 .

Analysis of the minimal specificity of CED-3 using a yeast transcriptional reporter system.

F. Scott, C. Hawkins, Sarah J Westein, 2008, Biochimica et biophysica acta.

Human Gene Mapping Report: Proteinase inhibitor 8 Map position 18q21.3

G. Sutherland, P. Bird, H. Eyre, 1997, Chromosome Research.

Crystal Structure of a Lipid G Protein–Coupled Receptor

R. Stevens, G. Han, Mark T. Griffith, 2012, Science.