I. M. Bell

发表

Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency.

A. D. Rodrigues, E S Walsh, J B Gibbs, 2001, Journal of medicinal chemistry.

Activity at Cardiovascular Ion Channels: A Key Issue for Drug Discovery

I. M. Bell, M. Bilodeau, A. Lagrutta, 2012 .

The Influence of pH on Zirconia Formed from Zirconium(IV) Acetate Solution: Characterization by X-Ray Powder Diffraction and Raman Spectroscopy

C. Ponton, F. Berry, S. Skinner, 1999 .

The Discovery and Synthesis of the CGRP Receptor Antagonist MK-3207

M. McLaughlin, I. M. Bell, P. Bulger, 2016 .

Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen.

Peter S. Kutchukian, A. W. Shaw, Jing Li, 2020, ACS medicinal chemistry letters.

Pharmacological Properties of MK-3207, a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist

J. Vacca, C. Regan, Y. S. Tang, 2010, Journal of Pharmacology and Experimental Therapeutics.

Biochemical and structural characterization of a novel class of inhibitors of the type 1 insulin-like growth factor and insulin receptor kinases.

S. Stirdivant, L. Kuo, P. Darke, 2005, Biochemistry.

Novel oxazolidinone calcitonin gene-related peptide (CGRP) receptor antagonists for the acute treatment of migraine.

H. Selnick, M. Fraley, D. Gauvreau, 2015, Bioorganic & medicinal chemistry letters.

Identification of a novel RAMP-independent CGRP receptor antagonist.

J. Vacca, S. Graham, R. Z. Rutledge, 2011, Bioorganic & medicinal chemistry letters.

Characterization of Ubrogepant: A Potent and Selective Antagonist of the Human Calcitonin Gene‒Related Peptide Receptor

E. Hostetler, C. Regan, M. Fraley, 2020, The Journal of Pharmacology and Experimental Therapeutics.

[(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor.

Sandra M. Sanabria-Bohórquez, L. Gantert, E. Hostetler, 2013, ACS medicinal chemistry letters.

Pharmacological Characterization of the Novel and Selective α7 Nicotinic Acetylcholine Receptor–Positive Allosteric Modulator BNC375

J. Uslaner, F. Thomson, A. Harvey, 2020, The Journal of Pharmacology and Experimental Therapeutics.

MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.

J. Vacca, H. Selnick, S. Graham, 2012, Bioorganic & medicinal chemistry letters.

Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: optimization of the 4-substituted piperidine.

J. Vacca, S. Graham, R. Z. Rutledge, 2006, Bioorganic & medicinal chemistry letters.

Activators of α7 nAChR as Potential Therapeutics for Cognitive Impairment.

J. Uslaner, Xiaohai Wang, I. M. Bell, 2020, Current topics in behavioral neurosciences.

Efficient synthesis of 1-heterocyclic-3-aminopyrrolidinones

T. Williams, I. M. Bell, S. N. Gallicchio, 2000 .

Peroxide dependence of the semisynthetic enzyme selenosubtilisin.

D. Hilvert, I. M. Bell, 1993, Biochemistry.

Valence Localization in [M(triphos)(3,5-di-tert-butyl-catecholate)]+ Ions (M=Co,Rh or Ir) Probed by Resonance Raman Spectroscopy.

A. Vlček, R. Clark, P. Barbaro, 1996 .

Vibrational and electronic spectroscopy of the octacyanodimolybdate ion,[Mo2(CN)8]4-

R. Clark, I. M. Bell, D. Humphrey, 1997 .

Potent benzimidazolone-based CGRP receptor antagonists.

Cory R. Theberge, J. Vacca, Victor K. Johnston, 2008, Bioorganic & medicinal chemistry letters.

Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists.

Cory R. Theberge, J. Vacca, J. Hochman, 2006, Bioorganic & medicinal chemistry letters.

Raman spectroscopic library of natural and synthetic pigments (pre- ≈ 1850 AD)

Robin J. H. Clark, Ian M. Bell, Peter J. Gibbs, 1997 .

The discovery of highly potent CGRP receptor antagonists.

Cory R. Theberge, J. Vacca, Victor K. Johnston, 2009, Bioorganic & medicinal chemistry letters.

Kinetic studies on the peroxidase activity of selenosubtilisin.

D. Hilvert, I. M. Bell, Z. Wu, 1993, Biochemistry.

Electronic, Raman and resonance Raman spectroscopy of [NBu4][RuBr4(MeCN)2]

R. Clark, I. M. Bell, D. Humphrey, 1999 .

Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase.

J. Davide, N. Kohl, R. Lobell, 2001, Bioorganic & medicinal chemistry letters.

Inhibitors of protein prenylation 2000

I. M. Bell, 2000 .

Raman spectroscopic library of natural and synthetic pigments (pre- approximately 1850 AD).

R. Clark, I M Bell, I. M. Bell, 1997, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

New Biocatalysts via Chemical Modification

D. Hilvert, I. M. Bell, 2007 .

Cutaneous Adverse Events Caused by Sulfonamide-Containing Drugs: Reality or Perception?

I. M. Bell, F. Shah, 2020, Journal of medicinal chemistry.

ALIGNMENT OF HG-AR VAN-DER-WAALS MOLECULE PHOTOFRAGMENTS FOLLOWING PHOTODISSOCIATION

C. Quayle, K. Burnett, E. Takacs, 1993 .

Inhibitors of farnesyltransferase: a rational approach to cancer chemotherapy?

I. M. Bell, 2004, Journal of medicinal chemistry.

3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.

A. D. Rodrigues, J Christopher Culberson, Ronald Robinson, 2002, Journal of medicinal chemistry.

Inhibitors of farnesyltransferase and geranylgeranyltransferase-I for antitumor therapy: substrate-based design, conformational constraint and biological activity.

I. M. Bell, C. Dinsmore, 2003, Current topics in medicinal chemistry.

Approaches to Antibody-Catalyzed Cationic Cyclizations: Chemical Studies of Leaving Groups and Cyclization Modes

C. Abell, F. Leeper, I. M. Bell, 1996 .

Role of hERG potassium channel assays in drug development

B. Priest, I. M. Bell, M. García, 2008, Channels.

CGRP Receptor Antagonists for the Treatment of Migraine

G. Dubowchik, I. M. Bell, 2017 .

Calcitonin gene-related peptide receptor antagonists: new therapeutic agents for migraine.

I. M. Bell, 2014, Journal of medicinal chemistry.

Non-peptide calcitonin gene-related peptide receptor antagonists from a benzodiazepinone lead.

J. Vacca, P. Kunapuli, S. Graham, 2006, Bioorganic & medicinal chemistry letters.

In Vivo Quantification of Calcitonin Gene-Related Peptide Receptor Occupancy by Telcagepant in Rhesus Monkey and Human Brain Using the Positron Emission Tomography Tracer [11C]MK-4232

Sandra M. Sanabria-Bohórquez, G. Bormans, L. Gantert, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Design and synthesis of transition-state analogues for a cationic cyclisation

C. Abell, F. Leeper, I. M. Bell, 1994 .

Hyperfine structure effects in probing atomic alignment

C. Quayle, K. Burnett, I. M. Bell, 1995 .

Development of orally active oxytocin antagonists: studies on 1-(1-[4-[1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl]piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and related pyridines.

S Vickers, R. Freidinger, D. Reiss, 1998, Journal of medicinal chemistry.

Development of Orally Active Oxytocin Antagonists: Studies on 1‐(1‐{4‐[1‐(2‐Methyl‐1‐oxidopyridin‐3‐ylmethyl)piperidin‐4‐yloxy] ‐2‐methoxybenzoyl}piperidin‐4‐yl)‐1,4‐dihydrobenz[d][1,3]oxazin‐2‐one (L‐372,662) and Related Pyridines.

I. M. Bell, 1998 .

Novel CGRP receptor antagonists through a design strategy of target simplification with addition of molecular flexibility.

J. Vacca, H. Selnick, I. M. Bell, 2009, Bioorganic & medicinal chemistry letters.

Identification of potent, highly constrained CGRP receptor antagonists.

Steven S. Sharik, Cory R. Theberge, J. Vacca, 2010, Bioorganic & medicinal chemistry letters.

Discovery of MK-3207: A Highly Potent, Orally Bioavailable CGRP Receptor Antagonist.

J. Vacca, C. Regan, T. Prueksaritanont, 2010, ACS medicinal chemistry letters.

The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists.

Cory R. Theberge, J. Vacca, Victor K. Johnston, 2009, Bioorganic & medicinal chemistry letters.

Calcitonin gene-related peptide receptor antagonists: new therapeutic agents for migraine.

I. M. Bell, 2014, Journal of medicinal chemistry.

Ultraviolet spectroscopy of HgAr in a supersonic jet: A new determination of the A 30+ state potential

K. Burnett, D. Stacey, I. M. Bell, 1996 .