C. Omer

发表

Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency.

A. D. Rodrigues, E S Walsh, J B Gibbs, 2001, Journal of medicinal chemistry.

Identification of Tcf4 residues involved in high-affinity beta-catenin binding.

R. Diehl, A. Kral, C. Omer, 1999, Biochemical and biophysical research communications.

Farnesyltransferase inhibitors and anti-Ras therapy

N. Rosen, N. Kohl, L. Sepp-Lorenzino, 2005, Breast Cancer Research and Treatment.

by a Farnesyl : Protein Transferase Inhibitor Develop Mammary Carcinomas That Can Be Growth-inhibited B Transgenic Mice ras Mouse Mammary Tumor Virus-Ki-Updated

R. Diehl, A. Kral, J. Davide, 2000 .

Biochemical and biological analyses of farnesyl-protein transferase inhibitors.

N. Kohl, J. Gibbs, A. Oliff, 1998, Methods in molecular biology.

Farnesyl: proteintransferase inhibitors as agents to inhibit tumor growth

A. Burkhardt, N. Kohl, R. Lobell, 1997, BioFactors.

CA1A2X-competitive inhibitors of farnesyltransferase as anti-cancer agents.

N. Kohl, C. Omer, 1997, Trends in pharmacological sciences.

Photoreactive Analogues of Prenyl Diphosphates as Inhibitors and Probes of Human Protein Farnesyltransferase and Geranylgeranyltransferase Type I (*)

C. M. Allen, C. Omer, Y. Bukhtiyarov, 1995, The Journal of Biological Chemistry.

The selective Trk inhibitor AZ623 inhibits brain‐derived neurotrophic factor–mediated neuroblastoma cell proliferation and signaling and is synergistic with topotecan

Jeffrey L. Brown, P. Zage, K. Thress, 2011, Cancer.

Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protien transferase

J. Gibbs, D. Pompliano, K. Silverman, 1993, Applied Microbiology and Biotechnology.

Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway

K. Webster, Zhong-ying Liu, Jeffrey L. Brown, 2009, Molecular Cancer Therapeutics.

Antitumor Efficacy of a Farnesyltransferase Inhibitor in Transgenic Mice

J. Windle, N. Kohl, J. Gibbs, 2001 .

Farnesyltransferase inhibitors versus Ras inhibitors.

N. Kohl, J. Gibbs, S. Graham, 1997, Current opinion in chemical biology.

Ferredoxins from two sulfonylurea herbicide monooxygenase systems in Streptomyces griseolus.

C. Omer, J. A. Romesser, R. Lenstra, 1991, Biochemistry.

Genes for two herbicide-inducible cytochromes P-450 from Streptomyces griseolus

C. Dean, J. Tepperman, C. Omer, 1990, Journal of bacteriology.

cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I.

B. Giros, P. Casey, R. Diehl, 1994, The Journal of biological chemistry.

Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: interactive binding between substrates and a preferred kinetic pathway.

J. Shafer, J. Gibbs, D. Pompliano, 1993, Biochemistry.

Direct Proof of the 5′ to 3′ Transcriptional Jump During Reverse Transcription of the Avian Retrovirus Genome by DNA Sequencing

J. Parsons, A. Faras, C. Omer, 1981, Journal of virology.

Isolation and characterization of Streptomyces griseolus deletion mutants affected in cytochrome P-450-mediated herbicide metabolism

C. Omer, J. A. Romesser, P. A. Harder, 1991, Molecular and General Genetics MGG.

Structural Analysis ofPlasmid andChromosomal LociInvolved in Site-Specific Excision andIntegration oftheSLP1Elementof Streptomyces coelicolor

Stanley N Cohen, C. Omer, 1986 .

Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507.

David A. Scott, D. Valle, L. Drew, 2013, Bioorganic & medicinal chemistry letters.

Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor.

R. Diehl, A. Kral, J. Davide, 2000, Cancer research.

Preclinical Models Geranylgeranyl : Protein Transferase Inhibitor Combinations in Evaluation of Farnesyl : Protein Transferase and Updated

A. Kral, D. Heimbrook, J. Davide, 2001 .

Involvement of Directly Repeated Sequences in the Generation of Deletions of the Avian Sarcoma Virus src Gene

K. Pogue-Geile, A. Faras, R. Guntaka, 1983, Journal of virology.

Discovery of aminopiperidine-based Smac mimetics as IAP antagonists.

E. Hennessy, A. Ferguson, B. Aquila, 2012, Bioorganic & medicinal chemistry letters.

Negative growth selection against rodent fibroblasts targeted for genetic inhibition of farnesyl transferase.

G. Prendergast, R. Diehl, A. Kral, 1993, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase.

T. Ciccarone, A. Kral, J. Davide, 1996, Journal of medicinal chemistry.

Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase.

David A. Scott, Audrey M Davies, M. Zinda, 2009, Bioorganic & medicinal chemistry letters.

Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinases.

David A. Scott, Bin Wang, Yongxin Han, 2008, Journal of medicinal chemistry.

Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer.

David A. Scott, P. Lyne, B. Aquila, 2008, Bioorganic & medicinal chemistry letters.

3-amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor.

David A. Scott, L. Drew, L. Dakin, 2011, Bioorganic & medicinal chemistry letters.

Phenobarbital and sulfonylurea-inducible operons encoding herbicide metabolizing cytochromes P-450 in Streptomyces griseolus.

N. Patel, C. Omer, 1992, Gene.

Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.

A. Kral, D. Heimbrook, J. Davide, 2001, Cancer research.

Mechanism of release of the avian retrovirus tRNATrp primer molecule from viral DNA by ribonuclease H during reverse transcription

A. Faras, C. Omer, 1982, Cell.

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

A. Kral, J. Davide, N. Kohl, 1995, Nature Medicine.

Site-specific insertion of biologically functional adventitious genes into the Streptomyces lividans chromosome

S. Cohen, C. Omer, D. Stein, 1988, Journal of bacteriology.

Selection of Potent Inhibitors of Farnesyl-protein Transferase from a Synthetic Tetrapeptide Combinatorial Library*

R. Cortese, J. Gibbs, A. Pessi, 1996, The Journal of Biological Chemistry.

Involvement of retrovirus reverse transcriptase-associated RNase H in the initiation of strong-stop (+) DNA synthesis and the generation of the long terminal repeat

C. Omer, R. Resnick, A. Faras, 1984, Journal of virology.

Restriction endonuclease and nucleotide sequence analyses of molecularly cloned unintegrated avian tumor virus DNA: structure of large terminal repeats in circle junctions

R. Katz, S. A. Mitsialis, J. Weis, 1982, Journal of virology.

Protein prenylation in eukaryotic microorganisms: genetics, biology and biochemistry

C. Omer, J. Gibbs, 1994, Molecular microbiology.

Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases.

C. M. Allen, G. Prendergast, S. Powers, 1993, Biochemistry.

Evidence for involvement of an RNA primer in initiation of strong-stop plus DNA synthesis during reverse transcription in vitro

C. Omer, R. Resnick, A. Faras, 1984, Journal of virology.

Plasmid formation in Streptomyces: Excision and integration of the SLP1 replicon at a specific chromosomal site

Stanley N Cohen, C. Omer, 2004, Molecular and General Genetics MGG.

Discovery and optimization of a novel series of potent mutant B-Raf(V600E) selective kinase inhibitors.

Allan Wu, Edward Hennessy, Jon Read, 2013, Journal of medicinal chemistry.

Cloning, nucleotide sequence determination and expression of the genes encoding cytochrome P‐450soy (soyC) and ferredoxinsoy (soyB) from Streptomyces griseus

M. Trower, F. Sariaslani, C. Omer, 1993, Molecular microbiology.

Cloning, nucleotide sequence determination and expression of the genes encoding cytochrome P‐450soy and ferredoxinsoy (soyB) from Streptomyces griseus

M. Trower, F. Sariaslani, C. Omer, 1992, Molecular microbiology.

NMR studies of novel inhibitors bound to farnesyl‐protein transferase

M. Bogusky, S. Pitzenberger, K. Koblan, 1995, Protein science : a publication of the Protein Society.

Analysis of recombination occurring at SLP1 att sites

M. Brasch, S. Cohen, C. Omer, 1988, Journal of bacteriology.

Structural analysis of plasmid and chromosomal loci involved in site-specific excision and integration of the SLP1 element of Streptomyces coelicolor

S. Cohen, C. Omer, 1986, Journal of bacteriology.

3-amido-4-anilinoquinolines as CSF-1R kinase inhibitors 2: Optimization of the PK profile.

David A. Scott, L. Drew, L. Dakin, 2009, Bioorganic & medicinal chemistry letters.

Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582).

E. Hennessy, V. Oza, B. Aquila, 2013, Journal of medicinal chemistry.

Farnesyltransferase inhibitors: a new class of cancer chemotherapeutics.

N. Kohl, J. Gibbs, S. Graham, 1996, Biochemical Society transactions.

Bacterial expression and purification of human protein prenyltransferases using epitope-tagged, translationally coupled systems.

R. Diehl, A. Kral, C. Omer, 1995, Methods in enzymology.

Mutational Analysis of Conserved Residues of the β-Subunit of Human Farnesyl:Protein Transferase*

R. Diehl, A. Kral, N. Kohl, 1997, The Journal of Biological Chemistry.

Actinomycete cytochromes P‐450 involved in oxidative metabolism: Biochemistry and molecular biology∗

F. Sariaslani, C. Omer, 1992 .

Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors.

E. Hennessy, B. Aquila, A. Hird, 2014, Bioorganic & medicinal chemistry letters.

Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors.

Bin Wang, Yongxin Han, P. Lyne, 2012, ACS medicinal chemistry letters.

Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway

K. Webster, Zhong-ying Liu, P. Zage, 2009, Molecular Cancer Therapeutics.

Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase.

David A. Scott, Audrey M Davies, M. Zinda, 2009, Bioorganic & medicinal chemistry letters.

Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinases.

David A. Scott, Bin Wang, Yongxin Han, 2008, Journal of medicinal chemistry.