E. Walsh

发表

Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency.

A. D. Rodrigues, E S Walsh, J B Gibbs, 2001, Journal of medicinal chemistry.

Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors.

Michael Reilly, Laura Sepp-Lorenzino, Weikang Tao, 2006, Bioorganic & medicinal chemistry letters.

Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP.

Youwei Yan, P. Coleman, L. Kuo, 2007, Bioorganic & medicinal chemistry letters.

Potent inhibitors of farnesyltransferase and geranylgeranyltransferase-I.

J. Davide, R. Lobell, C. Buser, 2002, Bioorganic & medicinal chemistry letters.

Increased levels of glutathione S-transferase pi transcript as a mechanism of resistance to ethacrynic acid.

K. Tew, F. LaCreta, E. Walsh, 1992, The Biochemical journal.

Impact of dietary supplement of Crassostrea gigas extract (JCOE) on glutathione levels and glutathione S-transferase activity in rat tissues.

K. Tew, H. Tapiero, L. Gaté, 1998, In vivo.

2-Arylindole-3-acetamides: FPP-competitive inhibitors of farnesyl protein transferase.

N. Kohl, R. Lobell, C. Buser, 2001, Bioorganic & medicinal chemistry letters.

Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP.

P. Coleman, C. Buser, K. Rickert, 2008, Archives of biochemistry and biophysics.

Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.

John D. Schreier, Youwei Yan, P. Coleman, 2007, Bioorganic & medicinal chemistry letters.

Kinesin spindle protein (KSP) inhibitors. Part V: discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by beta-fluorination to overcome cellular efflux by P-glycoprotein.

P. Coleman, Christopher D. Cox, Weikang Tao, 2007, Bioorganic & medicinal chemistry letters.

Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP.

Youwei Yan, P. Coleman, Christopher D. Cox, 2006, Bioorganic & medicinal chemistry letters.

Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.

A. W. Shaw, T. Ciccarone, L. Beese, 2003, Journal of medicinal chemistry.

Cloning and Characterization of Human Adenosine 5 * -triphosphate-binding Cassette, Sub-family A, Transporter 2 ( ABCA2 ) 1

K. Tew, Zhijiang Chen, M. Belinsky, 2001 .

Development of thioquinazolinones, allosteric Chk1 kinase inhibitors.

Laura Sepp-Lorenzino, Weikang Tao, Youwei Yan, 2009, Bioorganic & medicinal chemistry letters.

Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility.

W. F. Hoffman, Youwei Yan, L. Kuo, 2006, Bioorganic & medicinal chemistry letters.

Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.

Paul J Coleman, Youwei Yan, P. Coleman, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase.

Youwei Yan, S. Stirdivant, L. Kuo, 2007, Bioorganic & medicinal chemistry letters.

Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors.

Lawrence C Kuo, Laura Sepp-Lorenzino, Weikang Tao, 2007, Bioorganic & medicinal chemistry letters.

3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6.

Lawrence C Kuo, Laura Sepp-Lorenzino, Weikang Tao, 2006, Bioorganic & medicinal chemistry letters.

Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase.

J. Davide, N. Kohl, R. Lobell, 2001, Bioorganic & medicinal chemistry letters.

3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.

A. D. Rodrigues, J Christopher Culberson, Ronald Robinson, 2002, Journal of medicinal chemistry.

Cloning and characterization of human adenosine 5'-triphosphate-binding cassette, sub-family A, transporter 2 (ABCA2).

K. Tew, M. Belinsky, E. Walsh, 2001, Cancer research.

Cloning and Characterization of Human Adenosine 5 *-triphosphate-binding Cassette , Sub-family A , Transporter 2 ( ABCA 2 ) 1

K. Tew, Zhijiang Chen, M. Belinsky, 2001 .

Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation.

K. Tew, E. Walsh, S. Ranganathan, 1999, Gene.

Cloning and characterization of human colon glyoxalase-I.

A. Godwin, K. Tew, E. Walsh, 1993, The Journal of biological chemistry.

Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates.

Laura Sepp-Lorenzino, S. Stirdivant, M. Ikuta, 2012, Bioorganic & medicinal chemistry letters.

Pyridyl aminothiazoles as potent Chk1 inhibitors: optimization of cellular activity.

S. Stirdivant, Weikang Tao, L. Sepp-Lorenzino, 2012, Bioorganic & medicinal chemistry letters.

Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer.

Youwei Yan, P. Coleman, Christopher D. Cox, 2008, Journal of medicinal chemistry.

High-performance liquid chromatography/mass spectrometry characterization of Ki4B-Ras in PSN-1 cells treated with the prenyltransferase inhibitor L-778,123.

C. Buser, C. Fernandes, K. Koblan, 2001, Analytical biochemistry.

Glyoxalase I in detoxification: studies using a glyoxalase I transfectant cell line.

K. Tew, E. Walsh, S. Ranganathan, 1995, The Biochemical journal.

Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugates.

B. Carr, L. Sepp-Lorenzino, Rob S. Burke, 2014, Journal of controlled release : official journal of the Controlled Release Society.

An in vivo evaluation of amphiphilic, biodegradable peptide copolymers as siRNA delivery agents.

B. Carr, K. Leander, L. Sepp-Lorenzino, 2014, International journal of pharmaceutics.

Endosomolytic bioreducible poly(amido amine disulfide) polymer conjugates for the in vivo systemic delivery of siRNA therapeutics.

B. Carr, K. Leander, L. Sepp-Lorenzino, 2013, Bioconjugate chemistry.

Novel endosomolytic poly(amido amine) polymer conjugates for systemic delivery of siRNA to hepatocytes in rodents and nonhuman primates.

B. Carr, K. Leander, L. Sepp-Lorenzino, 2014, Bioconjugate chemistry.

Promoter analysis of a human dihydrodiol dehydrogenase.

K. Tew, E. Walsh, P. Ciaccio, 1996, Biochemical and biophysical research communications.