G. Kwei

发表

Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment.

Karen Holmes, Kathy Lyons, Joseph Kessler, 2004, Bioorganic & medicinal chemistry letters.

Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.

T. Baillie, Yong Zhang, Wei Tang, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Lymphatic uptake of MK-386, a sterol 5α-reductase inhibitor, from aqueous and lipid formulations

T. Olah, G. Kwei, Elisabeth R. Reiss, 1998 .

Biologically Active Conjugates of Drugs and Toxic Chemicals

R. Thurman, F. Kauffman, G. Kwei, 1994 .

Pharmacokinetics and Interactions of a Novel CCR5 Receptor Antagonist with Ritonavir in Rats and Monkeys: Role of CYP3A and P-glycoprotein

T. Baillie, Jiunn H. Lin, Sanjeev Kumar, 2002 .

Metabolism of a thiazole benzenesulfonamide derivative, a potent and elective agonist of the human beta3-adrenergic receptor, in rats: identification of a novel isethionic acid conjugate.

T. Baillie, A. Weber, Wei Tang, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Suppression of benzo[a]pyrene metabolism by accumulation of triacylglycerols in rat hepatocytes: effect of high-fat and food-restricted diets.

R. Thurman, F. Kauffman, G. Kwei, 1991, Carcinogenesis.

Conjugation of benzo(a)pyrene 7,8-dihydrodiol-9,10-epoxide in infant Swiss-Webster mice.

R. Thurman, F. Kauffman, G. Kwei, 1992, Cancer research.

Stimulation of binding of benzo[a]pyrene metabolites to DNA by diet-induced peroxidative stress.

L. Bjeldanes, G. Kwei, 1990, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists.

D. Hazuda, Ping Chen, W. Schleif, 2004, Bioorganic & medicinal chemistry letters.

Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds.

D. Hazuda, W. Schleif, E. Emini, 2004, Bioorganic & medicinal chemistry letters.

Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains.

Karen Holmes, Joseph Kessler, Anthony Carella, 2004, Bioorganic & medicinal chemistry letters.

Influence of physicochemical properties and intestinal region on the absorption of 3-fluoro-2-pyrimidylmethyl 3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chloropyrazin-2-one-1-acetamide, a water insoluble thrombin inhibitor, in dogs.

C. Lindemann, S. Karki, G. Kwei, 2004, International journal of pharmaceutics.

Discovery of a potent, highly selective, and orally efficacious small-molecule activator of the insulin receptor.

D. Moller, V. Ding, B. Zhang, 2000, Journal of medicinal chemistry.

Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitors.

I. Kariv, C. Moxham, Thomas A. Miller, 2012, Bioorganic & medicinal chemistry letters.

Supramolecular Behavior of the Amphiphilic Drug (2R)-2-Ethylchromane-2-Carboxylic Acid Arginine Salt (a Novel PPARα/γ Dual Agonist)

J. Remenar, G. Kwei, Martha E Ellison, 2005, Pharmaceutical Research.

Pharmacokinetics and Interactions of a Novel Antagonist of Chemokine Receptor 5 (CCR5) with Ritonavir in Rats and Monkeys: Role of CYP3A and P-Glycoprotein

T. Baillie, Sanjeev Kumar, P. Pearson, 2002, Journal of Pharmacology and Experimental Therapeutics.

The role of biopharmaceutics in the development of a clinical nanoparticle formulation of MK-0869: a Beagle dog model predicts improved bioavailability and diminished food effect on absorption in human.

Gloria Kwei, Udit Batra, D. Storey, 2004, International journal of pharmaceutics.

Regiospecific Intestinal Absorption of the HIV Protease Inhibitor L-735,524 in Beagle Dogs

Gloria Kwei, I. Chen, G. Kwei, 1995, Pharmaceutical Research.

Disposition of ivermectin and cyclosporin A in CF-1 mice deficient in mdr1a P-glycoprotein.

D. Umbenhauer, T R Pippert, D R Umbenhauer, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Identification of Novel Metabolites of Colchicine in Rat Bile Facilitated by Enhanced Online Radiometric Detection

Valentina V Jeliazkova-Mecheva, G. Kwei, A. Harsch, 2008, Drug Metabolism and Disposition.

Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor.

S K Balani, J. Lin, M. Chiba, 1996, Drug metabolism and disposition: the biological fate of chemicals.

The pharmacokinetics of a thiazole benzenesulfonamide beta 3-adrenergic receptor agonist and its analogs in rats, dogs, and monkeys: improving oral bioavailability.

A. Weber, Wei Tang, G. Kwei, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Advances in Brief Conjugation of Benzo ( a ) pyrene 7 , 8-dihydrodiol-9 , 10-epoxide in Infant Swiss-Webster Mice 1

R. Thurman, F. Kauffman, G. Kwei, 2006 .

The liver plays a central role in the mechanism of chemical carcinogenesis due to polycyclic aromatic hydrocarbons.

R. Thurman, F. Kauffman, J. T. te Koppele, 1991, Carcinogenesis.

A Rapid Assay for Urinary Metabolites of Benzo[a]pyrene (B[a]P)

F. Kauffman, A. Greenberg, G. Kwei, 1995 .

Summary workshop report: biopharmaceutics classification system--implementation challenges and extension opportunities.

Mei-Ling Chen, Guohua Zhang, Lawrence X. Yu, 2004, Journal of pharmaceutical sciences.

Interaction of diclofenac and quinidine in monkeys: stimulation of diclofenac metabolism.

R. Miller, T. Baillie, Wei Tang, 1999, The Journal of pharmacology and experimental therapeutics.

Food restriction increases detoxification of polycyclic aromatic hydrocarbons in the rat.

R. Thurman, F. Kauffman, W. Qu, 1992, Carcinogenesis.

Plasma-pooling methods to increase throughput for in vivo pharmacokinetic screening.

C. Hop, C E Hop, Z Wang, 1998, Journal of pharmaceutical sciences.

Enzyme activities associated with carcinogen metabolism in liver and nonhepatic tissues of rats maintained on high fat and food-restricted diets.

R. Thurman, F. Kauffman, G. Kwei, 1991, The Journal of nutrition.

Integrating qualitative and quantitative liquid chromatography/tandem mass spectrometric analysis to support drug discovery.

C E Hop, Q Chen, G Kwei, 1999, Rapid communications in mass spectrometry : RCM.

Chronic catheterization of the intestines and portal vein for absorption experimentation in beagle dogs.

G. Kwei, L. Novak, J. Gehret, 1995, Laboratory animal science.