R. Bednar

发表

NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles.

Menghang Xia, Bohumil Bednar, Kenneth D Anderson, 2004, Journal of medicinal chemistry.

Chemical modification A probe of the structure and function of the subunits of DPN-dependent isocitrate dehydrogenase.

R. Colman, R. Bednar, 1982, The Journal of biological chemistry.

3-Bromo-2-ketoglutarate: a substrate and affinity label for diphosphopyridine nucleotide dependent isocitrate dehydrogenase.

F. C. Hartman, R. Colman, R. Bednar, 1982, Biochemistry.

Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1).

J. Barrow, K. Rittle, R. Freidinger, 2002, Bioorganic & medicinal chemistry letters.

Identification of low molecular weight GP IIb/IIIa antagonists that bind preferentially to activated platelets.

J. Shafer, R. Gould, G. Hartman, 1998, The Journal of pharmacology and experimental therapeutics.

Discovery of [(2R,5R)‐5‐{[(5‐Fluoropyridin‐2‐yl)oxy]methyl}‐2‐methylpiperidin‐1‐yl][5‐methyl‐2‐(pyrimidin‐2‐yl)phenyl]methanone (MK‐6096): A Dual Orexin Receptor Antagonist with Potent Sleep‐Promoting Properties

Steven V. Fox, John D. Schreier, S. Doran, 2012, ChemMedChem.

Flow cytometric measurement of kinetic and equilibrium binding parameters of arginine-glycine-aspartic acid ligands in binding to glycoprotein IIb/IIIa on platelets.

P. A. McQueney, R. Gould, G. Hartman, 1997, Cytometry.

Arginine-Glycine-Aspartic Acid Mimics Can Identify a Transitional Activation State of Recombinant αIIbβ3 in Human Embryonic Kidney 293 Cells

L. Duong, R. Gould, R. Bednar, 1997 .

Arginine-Glycine-Aspartic Acid Mimics Can Identify a Transitional Activation State of Recombinant (cid:97) IIb (cid:98) 3 in Human Embryonic Kidney 293 Cells

R. Gould, R. Bednar, B. Bednar, 1997 .

Fibrinogen receptor antagonist-induced thrombocytopenia in chimpanzee and rhesus monkey associated with preexisting drug-dependent antibodies to platelet glycoprotein IIb/IIIa

P. Jumes, R. Gould, G. Hartman, 1999 .

Discovery of a Potent, CNS‐Penetrant Orexin Receptor Antagonist Based on an N,N‐Disubstituted‐1,4‐diazepane Scaffold that Promotes Sleep in Rats

John D. Schreier, S. Doran, J. Renger, 2009, ChemMedChem.

Proline bis-amides as potent dual orexin receptor antagonists.

J. Renger, P. Coleman, D. Reiss, 2008, Bioorganic & medicinal chemistry letters.

Fibrinogen receptor antagonist-induced thrombocytopenia in chimpanzee and rhesus monkey associated with preexisting drug-dependent antibodies to platelet glycoprotein IIb/IIIa.

P. Jumes, R. Gould, G. Hartman, 1999, Blood.

Non-peptide GPIIb/IIIa inhibitors. 20. Centrally constrained thienothiophene alpha-sulfonamides are potent, long acting in vivo inhibitors of platelet aggregation.

R. Gould, G. Hartman, S. Gaul, 1999, Journal of medicinal chemistry.

Synthesis, characterization, and reactions of 2′-, 3′-, and 5′-(2-bromoethyl)-AMP: Potential affinity labels for nucleotide binding sites in enzymes

R. Colman, R. Bednar, 1982 .

Novel CGRP receptor antagonists from central amide replacements causing a reversal of preferred chirality.

J. Vacca, H. Selnick, R. Bednar, 2010, Bioorganic & medicinal chemistry letters.

Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists.

A. Dilella, T. Mcdonald, D. Reiss, 2011, ACS chemical neuroscience.

Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist.

A. Dilella, N. Liverton, C. Claiborne, 2007, Journal of medicinal chemistry.

Nonpeptide glycoprotein IIB/IIIA inhibitors: 18. Indole alpha-sulfonamide acids are potent inhibitors of platelet aggregation

R. Gould, G. Hartman, J. Hutchinson, 1997 .

Nonpeptide GPIIb/IIIa inhibitors. 10. Centrally constrained alpha-sulfonamides are potent inhibitors of platelet aggregation

R. Gould, G. Hartman, S. Gaul, 1996 .

Discovery and initial structure-activity relationships of trisubstituted ureas as thrombin receptor (PAR-1) antagonists.

J. Barrow, R. Freidinger, P. Nantermet, 2001, Bioorganic & medicinal chemistry letters.

Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists.

J. Baldwin, T. Prueksaritanont, R. Gould, 1997, Journal of medicinal chemistry.

Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia.

John D. Schreier, S. Doran, G. McGaughey, 2010, Journal of medicinal chemistry.

Potent benzimidazolone-based CGRP receptor antagonists.

Cory R. Theberge, J. Vacca, Victor K. Johnston, 2008, Bioorganic & medicinal chemistry letters.

Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists.

Cory R. Theberge, J. Vacca, J. Hochman, 2006, Bioorganic & medicinal chemistry letters.

The discovery of highly potent CGRP receptor antagonists.

Cory R. Theberge, J. Vacca, Victor K. Johnston, 2009, Bioorganic & medicinal chemistry letters.

Cyclic benzamidines as orally efficacious NR2B-selective NMDA receptor antagonists.

N. Liverton, C. Claiborne, K. Nguyen, 2007, Bioorganic & medicinal chemistry letters.

The reaction of 4-iodoacetamidosalicylic acid with TPN-dependent isocitrate dehydrogenase from pig heart.

C. Bacon, R. Colman, R. Bednar, 1981, The Journal of biological chemistry.

3,4-Didehydro-2-ketoglutarate: an affinity label for diphosphopyridine nucleotide dependent isocitrate dehydrogenase.

F. C. Hartman, R. Colman, R. Bednar, 1982, Biochemistry.

Alpha-hydroxy amides as a novel class of bradykinin B1 selective antagonists.

M. Bock, R. M. Dipardo, R. Freidinger, 2008, Bioorganic & medicinal chemistry letters.

Preclinical pharmacology and pharmacokinetics of CERC‐301, a GluN2B‐selective N‐methyl‐D‐aspartate receptor antagonist

R. Mazhari, N. Liverton, L. Kiss, 2015, Pharmacology research & perspectives.

In vitro characterization of novel NR2B selective NMDA receptor antagonists

L. Kiss, P. Bennett, J. Mccauley, 2005, Neurochemistry International.

Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs).

J. Renger, P. Coleman, S. Garson, 2013, Bioorganic & medicinal chemistry letters.

Orally efficacious NR2B-selective NMDA receptor antagonists.

Kenneth D Anderson, R. Freidinger, N. Liverton, 2003, Bioorganic & medicinal chemistry letters.

Automation of In Vitro Dose-Inhibition Assays Utilizing the Tecan Genesis and an Integrated Software Package to Support the Drug Discovery Process

S. Gaul, K. Koblan, R. Bednar, 2003 .

Positive Allosteric Interaction of Structurally Diverse T-Type Calcium Channel Antagonists

Steven V. Fox, S. Doran, J. Renger, 2009, Cell Biochemistry and Biophysics.

Novel CGRP receptor antagonists through a design strategy of target simplification with addition of molecular flexibility.

J. Vacca, H. Selnick, I. M. Bell, 2009, Bioorganic & medicinal chemistry letters.

Reactivity and pH dependence of thiol conjugation to N-ethylmaleimide: detection of a conformational change in chalcone isomerase.

R. Bednar, R. Bednar, 1990, Biochemistry.

Identification of potent, highly constrained CGRP receptor antagonists.

Steven S. Sharik, Cory R. Theberge, J. Vacca, 2010, Bioorganic & medicinal chemistry letters.

The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists.

Cory R. Theberge, J. Vacca, Victor K. Johnston, 2009, Bioorganic & medicinal chemistry letters.

Arginine-glycine-aspartic acid mimics can identify a transitional activation state of recombinant alphaIIb beta3 in human embryonic kidney 293 cells.

L. Duong, R. Gould, R. Bednar, 1997, Molecular pharmacology.

Non-peptide glycoprotein IIb/IIIa inhibitors. 9. Centrally constrained alpha-sulfonamides are useful tools for exploring platelet receptor function

R. Gould, G. Hartman, S. D. Young, 1996 .

Nonpeptide GPIIB/IIIA inhibitors. 16. Thieno[2,3-b]thiophene α-sulfonamides are potent inhibitors of platelet aggregation

G. Hartman, J. D. Prugh, R. Bednar, 1997 .

Identification and characterization of endothelin converting activity from EAHY 926 cells: evidence for the physiologically relevant human enzyme.

A. Stern, R. Bednar, L. Waxman, 1994, Archives of biochemistry and biophysics.

Synthesis and evaluation of novel tricyclic benzo[4.5]cyclohepta[1.2]pyridine derivatives as NMDA/NR2B antagonists.

R. Freidinger, N. Liverton, J. Mccauley, 2009, Bioorganic & medicinal chemistry letters.