S. Edmondson

发表

Discovery of potent and selective orally bioavailable beta-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors.

Joseph L Duffy, Aleksandr Petrov, N. Thornberry, 2005, Bioorganic & medicinal chemistry letters.

Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors.

G. Scapin, N. Thornberry, B. Leiting, 2008, Bioorganic & medicinal chemistry letters.

Potent and selective proline derived dipeptidyl peptidase IV inhibitors.

N. Thornberry, B. Leiting, Sanjeev Kumar, 2004, Bioorganic & medicinal chemistry letters.

4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors.

Aleksandr Petrov, N. Thornberry, B. Leiting, 2004, Bioorganic & medicinal chemistry letters.

Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors.

Aleksandr Petrov, N. Thornberry, B. Leiting, 2006, Bioorganic & medicinal chemistry letters.

(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

G. Scapin, N. Thornberry, R. S. Roy, 2006, Journal of medicinal chemistry.

Selective Dipeptidyl Peptidase IV Inhibitors for the Treatment of Type 2 Diabetes: The Discovery of JANUVIA(™) (Sitagliptin)

Dooseop Kim, S. Edmondson, 2008 .

Sitagliptin (Januvia): A Treatment for Type 2 Diabetes

J. Armstrong, S. Edmondson, Feng Xu, 2010 .

Discovery of PROTAC molecules that selectively degrade the IRAK3 pseudokinase.

Fiona Pachl, O. Tavana, S. Degorce, 2020, Journal of medicinal chemistry.

Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes.

V. Hornak, A. Woods, A. Stamford, 2015, ACS medicinal chemistry letters.

Discovery of phenyl acetamides as potent and selective GPR119 agonists.

V. Hornak, A. Woods, A. Stamford, 2017, Bioorganic & Medicinal Chemistry Letters.

Design and synthesis of novel proline based factor XIa selective inhibitors as leads for potential new anticoagulants.

B. Hawes, Zhuyan Guo, W. Geissler, 2020, Bioorganic & medicinal chemistry letters.

Heterocyclic acetamide and benzamide derivatives as potent and selective beta3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles.

M. Struthers, R. Berger, S. Feighner, 2010, Bioorganic & medicinal chemistry letters.

Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: close analogs of JANUVIA (sitagliptin phosphate).

N. Thornberry, B. Leiting, Dooseop Kim, 2007, Bioorganic & medicinal chemistry letters.

Total Synthesis of Spirotryprostatin A, Leading to the Discovery of Some Biologically Promising Analogues

N. Rosen, L. Sepp-Lorenzino, S. Danishefsky, 1999 .

Synthetic explorations in the saframycin-ecteinascidin series: construction of major chiral subunits through catalytic asymmetric induction

S. Danishefsky, S. Edmondson, J. Padrón, 2000 .

Atherosclerosis: Cholesterol Management

D. Burnett, S. Edmondson, Harry R. Davis, 2021, Burger's Medicinal Chemistry and Drug Discovery.

Potent and Selective TYK2-JH1 Inhibitors Highly Efficacious in Rodent Model of Psoriasis.

Markus K. Dahlgren, J. McElwee, Mee Shelley, 2022, Bioorganic & medicinal chemistry letters.

Discovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes.

F. Ujjainwalla, E. Sherer, R. Nargund, 2016, Bioorganic & medicinal chemistry letters.

Investigation of piperazine benzamides as human β3 adrenergic receptor agonists for the treatment of overactive bladder.

M. Struthers, R. Berger, C. Moyes, 2017, Bioorganic & medicinal chemistry letters.

Design, synthesis, and evaluation of conformationally restricted acetanilides as potent and selective β3 adrenergic receptor agonists for the treatment of overactive bladder.

M. Struthers, R. Berger, C. Moyes, 2014, Journal of medicinal chemistry.

Identification of a novel series of azabenzimidazole-derived inhibitors of spleen tyrosine kinase.

Peng-Fei Wang, J. Patel, B. Barlaam, 2020, Bioorganic & medicinal chemistry letters.

Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists.

M. Reitman, D. Macneil, S. Qian, 2011, Bioorganic & medicinal chemistry letters.

Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors.

M. Tota, J. Metzger, M. Forrest, 2003, Bioorganic & medicinal chemistry letters.

Crystallization and preliminary X-ray diffraction analysis of the catalytic domain of recombinant human phosphodiesterase 3B.

M. Tota, G. Scapin, J. W. Becker, 2004, Acta crystallographica. Section D, Biological crystallography.

2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity.

M. Reitman, D. Macneil, R. Berger, 2008, Bioorganic & medicinal chemistry letters.

Proteolysis targeting chimeras (PROTACs) in 'beyond rule-of-five' chemical space: Recent progress and future challenges.

Bin Yang, S. Edmondson, C. Fallan, 2019, Bioorganic & medicinal chemistry letters.

Covalent inhibition of cyclin dependent kinase 2 (CDK2) through modification of a non-catalytic lysine side chain

G. O'Doherty, Qibin Su, S. Edmondson, 2019 .

Discovery of Potent and Selective Orally Bioavailable β-Substituted Phenylalanine Derived Dipeptidyl Peptidase IV Inhibitors.

S. Edmondson, 2005 .

Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.

M. Struthers, R. Berger, C. Moyes, 2016, Journal of medicinal chemistry.

The Total Synthesis of Spirotryprostatin A.

S. Danishefsky, S. Edmondson, 1998, Angewandte Chemie.

Photoredox Catalysis: 1,4-Conjugate Addition of N-Methyl Radicals to Electron-Deficient Olefins via Decarboxylation of N-Substituted Acetic Acids.

S. Tentarelli, A. Gopalsamy, H. Hatoum-Mokdad, 2020, Organic letters.

Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors.

N. Thornberry, B. Leiting, S. Xu, 2007, Bioorganic & medicinal chemistry letters.

Total Synthesis of Spirotryprostatin A, Leading to the Discovery of Some Biologically Promising Analogues.

N. Rosen, L. Sepp-Lorenzino, S. Danishefsky, 1999 .

N‐Methylmorpholine N‐Oxide

S. Edmondson, M. R. Sivik, 2008 .

A concise route to the tetracyclic core of phorbol

D. Sauer, D. Friedrich, L. Paquette, 1994 .

The Total Synthesis of Spirotryprostatin A.

S. Danishefsky, S. Edmondson, 1998, Angewandte Chemie.

Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.

A. Woods, D. Zaller, N. Thornberry, 2005, Diabetes.

Studies Directed toward the Synthesis of the Unusual Antileukemic Diterpene Jatrophatrione. 1. A Solution to the Problem of Chirality Merger during Elaboration of the Entire Carbotricyclic Framework.

L. Paquette, R. Skerlj, S. Edmondson, 1999, The Journal of organic chemistry.

β 3 -AR Agonists for the Treatment of Overactive Bladder

S. Edmondson, 2017 .

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.

Fiona Pachl, A. Pike, M. O’Connor, 2021, Journal of medicinal chemistry.

Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes.

F. Ujjainwalla, E. Sherer, A. Howard, 2016, ACS medicinal chemistry letters.

Discovery of Chromane Propionic Acid Analogues as Selective Agonists of GPR120 with in Vivo Activity in Rodents.

Charles L. Jayne, F. Ujjainwalla, T. Akiyama, 2017, ACS medicinal chemistry letters.

Optimization of a Series of Potent, Selective and Orally Bioavailable SYK Inhibitors.

David M. Wilson, Peng-Fei Wang, S. Fawell, 2009, Bioorganic & medicinal chemistry letters.

Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity.

M. Tota, G. Scapin, Suresh B. Singh, 2004, Biochemistry.

Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β3 adrenergic receptor agonists.

M. Struthers, S. Galloway, S. Feighner, 2011, Bioorganic & medicinal chemistry letters.

Discovery of benzamides as potent human β3 adrenergic receptor agonists.

M. Struthers, A. Weber, G. Salituro, 2016, Bioorganic & medicinal chemistry letters.

Arsenic(III) Fluoride

S. Edmondson, 2001 .

Pharmacological Characterization of a Novel Beta 3 Adrenergic Agonist, Vibegron: Evaluation of Antimuscarinic Receptor Selectivity for Combination Therapy for Overactive Bladder

M. Struthers, J. Demartino, J. Woods, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Studies Directed toward the Synthesis of the Unusual Antileukemic Diterpene Jatrophatrione. 2. Functionalization of Advanced Polycyclic Precursors to the 9-Epi and 8,9-Dehydro Congeners.

R. Rogers, L. Paquette, S. Edmondson, 1999, The Journal of organic chemistry.

Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors.

G. Scapin, N. Thornberry, B. Leiting, 2006, Bioorganic & medicinal chemistry letters.

Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors.

G. Scapin, N. Thornberry, R. S. Roy, 2009, Bioorganic & medicinal chemistry letters.

Potent and selective proline derived dipeptidyl peptidase IV inhibitors.

N. Thornberry, B. Leiting, Sanjeev Kumar, 2004, Bioorganic & Medicinal Chemistry Letters.

Aminopiperidine‐Fused Imidazoles as Dipeptidyl Peptidase‐IV Inhibitors.

S. Edmondson, 2009 .

Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279.

J. McElwee, Phani Ghanakota, Wenyan Miao, 2023, Journal of Medicinal Chemistry.

Discovery of imidazole carboxamides as potent and selective CCK1R agonists.

M. Reitman, D. Macneil, S. Qian, 2008, Bioorganic & medicinal chemistry letters.

NanoClick: A High Throughput, Target-Agnostic Peptide Cell Permeability Assay.

A. Peier, D. Lane, J. Hermes, 2021, ACS chemical biology.

2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity.

M. Reitman, D. Macneil, R. Berger, 2008, Bioorganic & medicinal chemistry letters.

Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists.

M. Reitman, D. Macneil, S. Qian, 2011, Bioorganic & Medicinal Chemistry Letters.