T. Jenkins

发表

Design, synthesis, and progress toward optimization of potent small molecule antagonists of CC chemokine receptor 8 (CCR8).

C. Zhang, S. Ghosh, B. Jaffee, 2006, Journal of medicinal chemistry.

Structure-activity relationships of a series of pyrrolo[3,2-d]pyrimidine derivatives and related compounds as neuropeptide Y5 receptor antagonists.

N. Chen, Z. Chen, V. Santora, 2000, Journal of medicinal chemistry.

CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling

Kejie Li, A. Buckler, E. Cahir-McFarland, 2018, Science Signaling.

Design, synthesis, and evaluation of naphthalene-sulfonamide antagonists of human CCR8.

S. Ghosh, T. Ocain, C. Blackburn, 2007, Journal of medicinal chemistry.

Antagonism of chemokine receptor CCR8 is ineffective in a primate model of asthma

T. Ocain, J. Pulido, W. Yin, 2013, Thorax.

Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4.

Ying Sun, P. Raman, Courtney A. Cullis, 2006, Bioorganic & medicinal chemistry letters.

Geminal Acylation with Methyl-Substituted Analogues of 1,2-Bis[(trimethylsilyl)oxy]cyclobutene

D. Burnell, T. Jenkins, S. Crane, 1997 .

Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4.

Ying Sun, P. Raman, Courtney A. Cullis, 2006, Bioorganic & medicinal chemistry letters.

Lewis acid catalyzed geminal acylation reaction of ketones with 1,2-bis((trimethylsilyl)oxy)cyclobutene : direct formation of 2,2-disubstituted 1,3-cyclopentanediones

D. Burnell, T. Jenkins, 1994 .

Synthesis, X-ray Structure, and Properties of Fluorocyclopropane Analogs of the Duocarmycins Incorporating the 9,9-Difluoro-1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (F2CBI) Alkylation Subunit

D. Boger, T. Jenkins, 1996 .

Optimization of novel reversible Bruton's tyrosine kinase inhibitors identified using Tethering-fragment-based screens.

L. Silvian, T. Bohnert, D. Erlanson, 2019, Bioorganic & medicinal chemistry.

Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model.

George H Vandeveer, N. Powell, L. Silvian, 2022, Bioorganic & medicinal chemistry letters.

Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors.

Y. Liu, L. Silvian, T. Bohnert, 2021, Bioorganic & medicinal chemistry.

Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases

L. Silvian, D. Baker, V. Hong, 2010, Protein science : a publication of the Protein Society.

Tyrosine kinase inhibitors pyrimidinyl

Xiangli Shi, Ross A. Miller, A. Thompson, 2013 .